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1. 发明申请

WO2010087564A3 METHOD FOR INDUCING IMPROVED DOPAMINERGIC NEURONS BY MUTANT NURR1 GENE EXPRESSION 审中-公开
标题翻译：用突变NURR1基因表达诱导改良的多巴胺能神经元的方法
公开(公告)号：WO2010087564A3
公开(公告)日：2010-09-23
申请号：PCT/KR2009006013
申请日：2009-10-19
申请人： UNIV SOGANG IND UNIV COOP FOUN , LEE YONG-SUNG , LEE SANG-HUN , PARK CHANG-HWAN , JO A-YOUNG
发明人： LEE YONG-SUNG , LEE SANG-HUN , PARK CHANG-HWAN , JO A-YOUNG
IPC分类号： C12N15/12
CPC分类号： C07K14/70567 , C12N5/0619 , C12N2501/38
摘要： The present invention provides a method for inducing dopaminergic neurons. The method comprises in vitro gene transfection to enable expression of a mutant Nurr1 gene in neural precursor cells, in which Akt-phosphorylation is significantly reduced by mutation of the conserved Akt-phosphorylation site of a Nurr1 protein. Further, the present invention provides transfected neural precursor cells enabling expression of the mutant Nurr1 gene in which Akt-phosphorylation is significantly reduced by mutation of the conserved Akt-phosphorylation site of the Nurr1 protein. In addition, the present invention provides a dopaminergic neural cell population induced from the neural precursor cells by expressing the mutant Nurr1 gene in the neural precursor cells. According to the present invention, the induction of the mutant protein expression in the neural precursor cells can generate dopaminergic neurons which are able to maintain Nurr1 protein concentration stably and natural Nurr1 function. The dopaminergic neurons produced by the mutant Nurr1 gene are resistant to toxic stimulation and ensure improved in vitro and in vivo viability after transplanting into a rat brain.
摘要翻译：本发明提供了诱导多巴胺能神经元的方法。该方法包括体外基因转染以使得能够在神经前体细胞中表达突变体Nurr1基因，其中Akt磷酸化通过突变Nurr1蛋白的保守Akt磷酸化位点而显着降低。此外，本发明提供了能够表达突变Nurr1基因的转染的神经前体细胞，其中Akt磷酸化通过突变Nurr1蛋白的保守Akt磷酸化位点而显着降低。另外，本发明提供了通过在神经前体细胞中表达突变型Nurr1基因而从神经前体细胞诱导的多巴胺能神经细胞群。根据本发明，神经前体细胞中突变蛋白表达的诱导可产生能够维持Nurr1蛋白浓度稳定和天然Nurr1功能的多巴胺能神经元。由突变型Nurr1基因产生的多巴胺能神经元对毒性刺激具有抗性，并且确保了在移植入大鼠脑之后改善了体外和体内活力。

2. 发明申请

WO2004058796A1 PROMOTER FOR THE PRODUCTION OF HYALURONIC ACID CONTAINING GINSENOSIDE COMPOUND K 审中-公开
标题翻译：用于生产含有羟基苯甲酸酯化合物的羟丙酸钾的促进剂
公开(公告)号：WO2004058796A1
公开(公告)日：2004-07-15
申请号：PCT/KR2003/001889
申请日：2003-09-16
申请人： AMOREPACIFIC CORPORATION , KIM, Su-Jong , KANG, Byung-Young , CHO, Si-Young , CHANG, Hui-Kyoung , SUNG, Dae-Seok , YEOM, Myeong-Hoon , WOE, Kwang-Sik , KIM, Duck-Hee , KIM, Han-Kon , SIM, Young-Chul , KANG, Hak-Hee , LEE, Yong-Sung
发明人： KIM, Su-Jong , KANG, Byung-Young , CHO, Si-Young , CHANG, Hui-Kyoung , SUNG, Dae-Seok , YEOM, Myeong-Hoon , WOE, Kwang-Sik , KIM, Duck-Hee , KIM, Han-Kon , SIM, Young-Chul , KANG, Hak-Hee , LEE, Yong-Sung
IPC分类号： C07J17/00
CPC分类号： A61K31/704 , A61K8/735 , A61Q19/08
摘要： There are provided a promoter containing ginsenoside compound K for the production of hyaluronic acid, and more particularly, a new efficacy of 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (compound K), a chief metabolite of ginseng saponin, to increase the expression of hyaluronic acid synthase gene in human cell and thereby to promote the production of hyaluronic acid, and an anti-aging agent containing the promoter for the production of hyaluronic acid as an effective ingredient.
摘要翻译：提供了含有人参皂苷化合物K用于制备透明质酸的促进剂，更具体地说，是20-O-β-D-吡喃葡萄糖基-20（S） - 原人参二醇（化合物K），人参的主要代谢物的新功效皂角苷，以增加人细胞中透明质酸合酶基因的表达，从而促进透明质酸的生成，以及含有用于生产透明质酸作为有效成分的促进剂的抗老化剂。

3. 发明申请

WO2009048282A2 METHOD AND KIT FOR DIAGNOSIS OF HORMONAL SKIN AGING 审中-公开
标题翻译：用于诊断人体皮肤老化的方法和工具包
公开(公告)号：WO2009048282A2
公开(公告)日：2009-04-16
申请号：PCT/KR2008/005945
申请日：2008-10-09
申请人： AMOREPACIFIC CORPORATION , KIM, Su Jong , HWANG, Jung Sun , HWANG, Jae Sung , LEE, Yong Sung
发明人： KIM, Su Jong , HWANG, Jung Sun , HWANG, Jae Sung , LEE, Yong Sung
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6893 , G01N2500/04 , G01N2800/20
摘要： Disclosed are a kit for diagnosing skin aging using one or more polynucleotides or their complementary polynucleotides that hybridize with a gene sequence, a pair of primers for the gene sequence; or one or more monoclonal antibodies binding to the polypeptide encoded by the gene, which are used to identify the genes of which the expression pattern is changed in a skin keratin-forming cell by female hormone and used to diagnose degree of skin aging caused by female hormonal deficiency by using the information, and a method using the same.
摘要翻译：公开了一种用于使用与基因序列杂交的一个或多个多核苷酸或其互补多核苷酸诊断皮肤老化的试剂盒，用于该基因序列的一对引物; 或与该基因编码的多肽结合的一种或多种单克隆抗体，其用于鉴定在雌激素的皮肤角质形成细胞中表达模式发生改变的基因，并用于诊断由雌性激素引起的皮肤老化程度通过使用信息的激素缺乏，以及使用该信息的方法。

4. 发明申请

WO2011049353A3 SYSTEM AND METHOD FOR PROVIDING ELECTRONIC LEARNING CONTENT 审中-公开
标题翻译：提供电子学习内容的系统和方法
公开(公告)号：WO2011049353A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007165
申请日：2010-10-19
申请人： DVSKOREA CO LTD , DAEGYO CONSTRUCTION CO LTD , HISTUDY CO LTD , LEE YONG SUNG
发明人： LEE YONG SUNG
IPC分类号： G06Q50/00
CPC分类号： G09B7/02 , G09B5/06
摘要： According to the present invention, a method for providing electronic learning content enables users to be provided with virtual learning content without restrictions in time or space so that users may feel as though they are taking actual classes. Therefore, the method of the present invention can provide students with remedial and substitution learning effects when employed in schools. The method of the present invention enables teachers to mutually monitor lesson content, thus improving the teaching capabilities of teachers, and the thus-monitored content can be utilized as material for evaluating teachers in schools, and can prevent violence in the classroom.
摘要翻译：根据本发明，提供电子学习内容的方法使得用户能够在时间或空间上没有限制地提供虚拟学习内容，使得用户可能感觉到他们正在接受实际课程。因此，本发明的方法可以在学校中为学生提供补救和替代学习效果。本发明的方法使教师能够相互监督课程内容，从而提高教师的教学能力，从而将这些内容用作评估学校教师的材料，并可以防止教室中的暴力。

5. 发明申请

WO2009048282A3 METHOD AND KIT FOR DIAGNOSIS OF HORMONAL SKIN AGING 审中-公开
标题翻译：用于诊断激素皮肤老化的方法和试剂盒
公开(公告)号：WO2009048282A3
公开(公告)日：2009-09-17
申请号：PCT/KR2008005945
申请日：2008-10-09
申请人： AMOREPACIFIC CORP , KIM SU JONG , HWANG JUNG SUN , HWANG JAE SUNG , LEE YONG SUNG
发明人： KIM SU JONG , HWANG JUNG SUN , HWANG JAE SUNG , LEE YONG SUNG
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6893 , G01N2500/04 , G01N2800/20
摘要： Disclosed are a kit for diagnosing skin aging using one or more polynucleotides or their complementary polynucleotides that hybridize with a gene sequence, a pair of primers for the gene sequence; or one or more monoclonal antibodies binding to the polypeptide encoded by the gene, which are used to identify the genes of which the expression pattern is changed in a skin keratin-forming cell by female hormone and used to diagnose degree of skin aging caused by female hormonal deficiency by using the information, and a method using the same.
摘要翻译：公开了一种用于诊断皮肤老化的试剂盒，其使用与基因序列，基因序列的一对引物杂交的一种或多种多核苷酸或它们的互补多核苷酸; 或与由该基因编码的多肽结合的一种或多种单克隆抗体，其用于鉴定表达模式在皮肤角质形成细胞中由雌激素改变的基因，并用于诊断由雌性引起的皮肤老化程度使用该信息的激素缺乏症以及使用该信息的方法。

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