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1. 发明申请

WO2011155692A3 CONTAINER FOR CULTURING CELLS AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：培养细胞容器及其制备方法
公开(公告)号：WO2011155692A3
公开(公告)日：2012-02-16
申请号：PCT/KR2011002228
申请日：2011-03-31
申请人： POSTECH ACAD IND FOUND , KIM DONG SUNG , PARK KWANG SOOK , CHO DONG-WOO , RHA MOONWOO , CHA KYOUNG JE , LEE BONG-KEE , LEE SOO HONG , KANG SUN WOONG
发明人： KIM DONG SUNG , PARK KWANG SOOK , CHO DONG-WOO , RHA MOONWOO , CHA KYOUNG JE , LEE BONG-KEE , LEE SOO HONG , KANG SUN WOONG
IPC分类号： C12M1/22 , C12M3/00 , C12N5/02 , C12N5/074
CPC分类号： C12M23/10 , B29C45/0055 , B32B37/10 , C12M23/20 , C12M25/06 , C12N5/0068 , C12N2535/00 , Y10T156/1041
摘要： The present invention relates to a container for culturing cells which has increased efficiency in culturing and differentiating stem cells and various other types of cells. The container for culturing cells according to an embodiment of the present invention comprises a surface for culturing cells on which adult stem cells are attached to be cultured and differentiated, wherein said surface includes projections disposed thereon and configured as duplications of those found on lotus leaf surfaces.
摘要翻译：本发明涉及一种培养细胞的容器，其具有提高培养和分化干细胞和各种其它类型细胞的效率。根据本发明实施方案的用于培养细胞的容器包括用于培养其上附着有成体干细胞的细胞的培养和分化的表面，其中所述表面包括设置在其上的突起并且被配置为在莲花叶表面上发现的突起的重复。

2. 发明申请

WO2011099736A2 METHOD FOR MANUFACTURING TISSUE-RECONSTRUCTION SCAFFOLD USING BIODEGRADABLE POLYMER HAVING THERMAL STABILITY 审中-公开
标题翻译：使用具有热稳定性的可生物降解聚合物制造组织重建SCAFFOLD的方法
公开(公告)号：WO2011099736A2
公开(公告)日：2011-08-18
申请号：PCT/KR2011000799
申请日：2011-02-08
申请人： COLLEGE MEDICINE POCHON CHA UNIV IND ACAD COOP FOUND , LEE SOO-HONG , KANG SUN-WOONG , KIM JIN-SU , CHA BYUNG-HYUN
发明人： LEE SOO-HONG , KANG SUN-WOONG , KIM JIN-SU , CHA BYUNG-HYUN
IPC分类号： A61L27/14 , A61L27/38 , A61L27/56 , C12N11/02
CPC分类号： A61L27/56 , A61L27/58
摘要： The present invention relates to a method for manufacturing a porous scaffold for tissue-reconstruction, the method comprising the steps of performing a heat treatment on biodegradable polymers and stacking the heat-treated biodegradable polymers obtained thereby, wherein the heat treatment is performed on modified biodegradable polymers which have been obtained by substituting a hydrogen of a terminal hydroxy group of the biodegradable polymer with a C1~C4 alkylcarbonyl group.
摘要翻译：本发明涉及一种用于组织重建的多孔支架的制造方法，所述方法包括以下步骤：对可生物降解的聚合物进行热处理，并堆叠由此得到的经热处理的可生物降解的聚合物，其中对经改性的可生物降解通过用C 1 -C 4烷基羰基取代生物可降解聚合物的末端羟基的氢而获得的聚合物。

3. 发明申请

WO2009025487A2 MANUFACTURING OF METAL RING FOR PIPE SEALING AND METAL RING THEREOF 审中-公开
标题翻译：制造金属环用于管道密封和金属环
公开(公告)号：WO2009025487A2
公开(公告)日：2009-02-26
申请号：PCT/KR2008004826
申请日：2008-08-20
申请人： LEE SOO HONG , YUN HAN KYUNG
发明人： LEE SOO HONG , YUN HAN KYUNG
IPC分类号： B21F3/00
CPC分类号： B21F37/00 , B21D39/04 , B21D53/20
摘要： The present invention relates to a method of manufacturing a metal ring for pipe connection and a metal ring formed by the method, and the object of the present invention is to provide a method of manufacturing a metal ring for pipe connection, in which method, at the time of production of the metal ring, the manufacturing is simple, separate facility is not required, and while a lot of metal rings can be manufactured in a short period, the crushing and the burr never cccur at all so that the quality is excellent and unoform, and the metal ring of a variety of shapes and sizes can be freely and selectively manufactured according to neccesity without any limitation of sectional shape, and the present invention proposes a method of manufacturing a metal ring for pipe connection and a metal ring formed by the method, which method, to manufacture a metal ring of appropriate size according to the usage of the metal ring, comprises a material selection process for selecting a steel wire which is a raw material, a coiling fabricating process for forming said steel wire into a circular shape by using a coiling machine so that said steel wire has an appropriate diameter, and a severing process for severing said steel wire, which was coiling fabricated, so as to manufacture a metal ring of a doughnut shape, wherein said processes are sequentially progressed.
摘要翻译：本发明涉及一种制造用于管连接的金属环的方法和由该方法形成的金属环，并且本发明的目的是提供一种制造用于管连接的金属环的方法，其中在金属环的生产时间短，制造简单，不需要单独的设备，并且在短时间内制造大量金属环的同时，破碎和毛刺根本不会发生，因此质量优异并且可以根据需要自由选择性地制造各种形状和尺寸的金属环，而不受任何截面形状的限制，并且本发明提出了一种制造用于管连接的金属环和形成金属环的方法通过该方法根据金属环的用途制造适当尺寸的金属环的方法包括用于选择钢丝的材料选择工艺 h是原材料，用卷取机将所述钢丝成形为圆形以便使所述钢丝具有合适的直径的卷取加工过程，以及用于切断卷绕加工的所述钢丝的切断过程以制造环形的金属环，其中所述过程顺序地进行。

4. 发明申请

WO2011081328A2 CONSTRUCT FOR TISSUE RECONSTRUCTION AND KIT FOR PRODUCING A CONSTRUCT FOR TISSUE RECONSTRUCTION 审中-公开
标题翻译：用于组织重建的构造和用于组织组织重建的构造的工具包
公开(公告)号：WO2011081328A2
公开(公告)日：2011-07-07
申请号：PCT/KR2010008969
申请日：2010-12-15
申请人： COLLEGE MEDICINE POCHON CHA UNIV IND ACAD COOP FOUND , LEE SOO-HONG , KANG SUN-WOONG , KIM JIN-SU , HAN IN-BO , SHIN DONG-AH
发明人： LEE SOO-HONG , KANG SUN-WOONG , KIM JIN-SU , HAN IN-BO , SHIN DONG-AH
IPC分类号： A61L27/44 , A61F2/02 , A61L27/34 , A61L27/54 , A61L27/56
CPC分类号： A61L27/54 , A61L27/34 , A61L27/56 , A61L2300/64 , C08L89/00 , C08L5/08
摘要： The present invention provides a construct for tissue reconstruction, comprising a coating layer formed by coating a surface of a frame of a polymer support having voids, with hyaluronic acids or salts thereof and fibrinogens, wherein (i) the coating layer comprises: cells; cell growth factors; or cells and cell growth factors, (ii) the coating layer is cross-linked by thrombin, and (iii) the construct has voids of 10 µm to 1,000 µm. In addition, the present invention provides a kit for producing a construct for tissue reconstruction, which is cross-linked by thrombin and has voids of 10 µm to 1,000 µm.
摘要翻译：本发明提供了用于组织重建的构建体，其包括通过用透明质酸或其盐和纤维蛋白原涂覆具有空隙的聚合物载体的框架的表面而形成的涂层，其中（i）所述涂层包括：细胞; 细胞生长因子; 或细胞和细胞生长因子，（ii）涂层通过凝血酶交联，和（iii）构建体具有10μm至1,000μm的空隙。此外，本发明提供了一种用于组织重建用构件的制备工具，其通过凝血酶交联并具有10μm〜1000μm的空隙。

5. 发明申请

WO2010134771A2 STRUCTURE FOR CONNECTING A PIPE-CONNECTING LINK COUPLER 审中-公开
标题翻译：连接管接头连接器的结构
公开(公告)号：WO2010134771A2
公开(公告)日：2010-11-25
申请号：PCT/KR2010003200
申请日：2010-05-20
申请人： YUN HAN KYUNG , LEE SOO HONG
发明人： YUN HAN KYUNG , LEE SOO HONG
IPC分类号： F16L23/10 , F16L23/06 , F16L23/08 , F16L23/16
CPC分类号： F16L23/08
摘要： The present invention relates to a coupler connection structure for interconnecting pipes. Particularly, the coupler connection structure comprises a circular coupler link body segmented into three parts which connected via respective hinges. The circular coupler link body has a flange with a guide groove corresponding to a guide protrusion protruding from the flange, such that two flanges are coupled together in a firmer and safer manner, and such that a firmer and safer coupling can be visually recognized. The coupler connection structure of the present invention achieves improved water-tightness by a packing fitted between lap joint balancing portions of a lap joint.
摘要翻译：本发明涉及一种用于互连管道的联接器连接结构。特别地，耦合器连接结构包括分为三个部分的圆形耦合器连接体，其通过相应的铰链连接。环形联接器本体具有凸缘，其具有与从凸缘突出的引导突起相对应的引导槽，使得两个凸缘以更加安全和更安全的方式联接在一起，并且可以在视觉上识别更坚固和更安全的联接。本发明的联接器连接结构通过配合在搭接部的搭接部平衡部之间的密封件来实现改善的防水性。

6. 发明申请

WO2007139357A1 METHOD FOR CULTURING HUMAN EMBRYONIC STEM CELLS 审中-公开
标题翻译：培养人胚胎干细胞的方法
公开(公告)号：WO2007139357A1
公开(公告)日：2007-12-06
申请号：PCT/KR2007/002640
申请日：2007-05-31
申请人： CHABIOTECH CO., LTD. , COLLEGE OF MEDICINE POCHON CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , CHUNG, Hyung-Min , LEE, Soo-Hong , KIM, Si-Nae , KIM, Min-Jeong
发明人： CHUNG, Hyung-Min , LEE, Soo-Hong , KIM, Si-Nae , KIM, Min-Jeong
IPC分类号： C12N5/08 , C12N5/00
CPC分类号： C12N5/0606 , C12N2533/30 , C12N2533/52 , C12N2533/54 , C12N2533/56
摘要： The present invention relates to a method for culturing human embryonic stem cells (hESCs) in a hESC culture medium comprising a porous membrane, feeder cells being attached to a bottom of the porous membrane and a method for recovering human embryonic stem cells using the same.
摘要翻译：本发明涉及一种在包含多孔膜的hESC培养基中培养人胚胎干细胞（hESC）的方法，所述多孔膜附着有饲养细胞，并且使用该胚胎干细胞回收人胚胎干细胞的方法。

7. 发明申请

WO2009035217A1 PROCESS FOR DIFFERENTIATION OF VASCULAR ENDOTHELIAL PROGENITOR CELLS FROM EMBRYOID BODIES DERIVED FROM EMBRYONIC STEM CELLS USING HYPOXIC MEDIA CONDITION 审中-公开
标题翻译：使用HYPOXIC MEDIA CONDITION从胚胎干细胞衍生的EMBRYOID体中分离血管内皮祖细胞的方法
公开(公告)号：WO2009035217A1
公开(公告)日：2009-03-19
申请号：PCT/KR2008/004723
申请日：2008-08-14
申请人： CHABIOTECH CO., LTD. , CHUNG, Hyung-Min , KIM, Ju-Mi , LEE, Soo-Hong , MOON, Sung-Hwan
发明人： CHUNG, Hyung-Min , KIM, Ju-Mi , LEE, Soo-Hong , MOON, Sung-Hwan
IPC分类号： C12N5/08
CPC分类号： C12N5/0691 , C12N2500/02 , C12N2506/02
摘要： The present invention provides a process for differentiation of vascular endothelial progenitor cells from embryoid bodies derived from embryonic stem cells, the process comprising: (a) treating a culture medium comprising embryoid bodies derived from embryonic stem cells such that the concentration of oxygen dissolved in the culture medium is in the range of about 1 ppm to about 5 ppm; (b) culturing the culture medium prepared in step (a) in an incubator in which the oxygen (O 2 ) tension is equal to or less than about 15 % to differentiate the embryoid bodies into vascular endothelial progenitor cells; and (c) isolating the vascular endothelial progenitor cells from the culture medium obtained in step (b).
摘要翻译：本发明提供从源自胚胎干细胞的胚状体分化血管内皮祖细胞的方法，该方法包括：（a）处理包含来源于胚胎干细胞的胚状体的培养基，使得溶于培养基在约1ppm至约5ppm的范围内; （b）在氧（O 2）张力等于或小于约15％的培养箱中培养步骤（a）中制备的培养基，以将胚状体分化成血管内皮祖细胞; 和（c）从步骤（b）中获得的培养基中分离血管内皮祖细胞。

8. 发明申请

WO2009014340A3 PROCESS FOR DIFFERENTIATING EMBRYONIC STEM CELLS USING POROUS MEMBRANE 审中-公开
标题翻译：用多孔膜分化胚胎干细胞的方法
公开(公告)号：WO2009014340A3
公开(公告)日：2009-03-19
申请号：PCT/KR2008004159
申请日：2008-07-16
申请人： COLLEGE MEDICINE POCHON CHA UNIV IND ACAD COOP FOUND , LEE SOO-HONG , AHN SEONG-EUN , LEE DAE-HEE
发明人： LEE SOO-HONG , AHN SEONG-EUN , LEE DAE-HEE
IPC分类号： C12N5/0735 , C12N5/077
CPC分类号： C12N5/0606 , C12N5/0654 , C12N2502/03 , C12N2502/1394 , C12N2506/02 , C12N2533/30 , C12N2533/52 , C12N2533/54 , C12N2533/70 , C12N2533/90
摘要： The present invention provides a process for differentiating embryonic stem cells by co-culturing embryonic stem cells or an embryoid body derived from embryonic stem cells in a differentiation culture medium comprising feeder cells, wherein the culture medium comprises a porous membrane having the feeder cells attached to a bottom of the porous membrane, and the embryonic stem cells or embryoid body are co-cultured on the porous membrane; and a process for recovering cells differentiated from embryonic stem cells using the same.
摘要翻译：本发明提供了一种通过在包含饲养细胞的分化培养基中共培养胚胎干细胞或源自胚胎干细胞的胚状体来分化胚胎干细胞的方法，其中所述培养基包含多孔膜，所述多孔膜的饲养细胞附着于多孔膜的底部和胚胎干细胞或拟胚体在多孔膜上共培养; 以及使用该方法回收从胚胎干细胞分化的细胞的方法。

9. 发明申请

WO2009014340A2 PROCESS FOR DIFFERENTIATING EMBRYONIC STEM CELLS USING POROUS MEMBRANE 审中-公开
标题翻译：使用多孔膜分化胚胎干细胞的方法
公开(公告)号：WO2009014340A2
公开(公告)日：2009-01-29
申请号：PCT/KR2008/004159
申请日：2008-07-16
申请人： COLLEGE OF MEDICINE POCHON CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , LEE, Soo-Hong , AHN, Seong-Eun , LEE, Dae-Hee
发明人： LEE, Soo-Hong , AHN, Seong-Eun , LEE, Dae-Hee
IPC分类号： C12N5/08
CPC分类号： C12N5/0606 , C12N5/0654 , C12N2502/03 , C12N2502/1394 , C12N2506/02 , C12N2533/30 , C12N2533/52 , C12N2533/54 , C12N2533/70 , C12N2533/90
摘要： The present invention provides a process for differentiating embryonic stem cells by co-culturing embryonic stem cells or an embryoid body derived from embryonic stem cells in a differentiation culture medium comprising feeder cells, wherein the culture medium comprises a porous membrane having the feeder cells attached to a bottom of the porous membrane, and the embryonic stem cells or embryoid body are co-cultured on the porous membrane; and a process for recovering cells differentiated from embryonic stem cells using the same.
摘要翻译：本发明提供了一种通过在包含饲养细胞的分化培养基中共培养胚胎干细胞或衍生自胚胎干细胞的胚状体来分化胚胎干细胞的方法，其中所述培养基包括多孔膜，所述多孔膜具有附着于多孔膜的底部和胚胎干细胞或胚状体共同培养在多孔膜上; 以及使用其从胚胎干细胞分化的细胞的回收方法。

10. 发明申请

WO2009025487A3 MANUFACTURING OF METAL RING FOR PIPE SEALING AND METAL RING THEREOF 审中-公开
公开(公告)号：WO2009025487A3
公开(公告)日：2009-02-26
申请号：PCT/KR2008/004826
申请日：2008-08-20
申请人： LEE, Soo Hong , YUN, Han Kyung
发明人： LEE, Soo Hong , YUN, Han Kyung
IPC分类号： B21F3/00
摘要： The present invention relates to a method of manufacturing a metal ring for pipe connection and a metal ring formed by the method, and the object of the present invention is to provide a method of manufacturing a metal ring for pipe connection, in which method, at the time of production of the metal ring, the manufacturing is simple, separate facility is not required, and while a lot of metal rings can be manufactured in a short period, the crushing and the burr never cccur at all so that the quality is excellent and unoform, and the metal ring of a variety of shapes and sizes can be freely and selectively manufactured according to neccesity without any limitation of sectional shape, and the present invention proposes a method of manufacturing a metal ring for pipe connection and a metal ring formed by the method, which method, to manufacture a metal ring of appropriate size according to the usage of the metal ring, comprises a material selection process for selecting a steel wire which is a raw material, a coiling fabricating process for forming said steel wire into a circular shape by using a coiling machine so that said steel wire has an appropriate diameter, and a severing process for severing said steel wire, which was coiling fabricated, so as to manufacture a metal ring of a doughnut shape, wherein said processes are sequentially progressed.

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