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1. 发明申请

WO2009069986A2 GENETICALLY-MODIFIED CELL LINE FOR PRODUCING CLONED MINIATURE PIGS FOR XENOTRANSPLANTATION AND METHOD FOR PREPARING THE SAME. 审中-公开
标题翻译：用于生产用于XENOTRANSPLANTATION的克隆小型皮肤的遗传修饰细胞系及其制备方法。
公开(公告)号：WO2009069986A2
公开(公告)日：2009-06-04
申请号：PCT/KR2008007087
申请日：2008-12-01
申请人： KOREA RES INST OF BIOSCIENCE , LEE KYUNG-KWANG , CHANG MIRA , LEE JEONG WOONG , KANG YONG-KOOK , KANG MAN-JONG , KIM JIN-HOI , SEONG HWAN-HOO , SHIM HOSUP , HWANG SEONGSOO
发明人： LEE KYUNG-KWANG , CHANG MIRA , LEE JEONG WOONG , KANG YONG-KOOK , KANG MAN-JONG , KIM JIN-HOI , SEONG HWAN-HOO , SHIM HOSUP , HWANG SEONGSOO
IPC分类号： C12N15/64
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/025
摘要： The present invention relates to a targeting vector specific for a xenoantigen determining antigen synthesizing gene capable of knock-outing the xenoantigen determining antigen synthesizing gene using homologous recombination technologies and integrating human complement inhibiting gene and/or human CD39 gene at the loci of the xenoantigen determining antigen synthesizing gene.
摘要翻译：本发明涉及一种能够使用同源重组技术敲除异种抗原决定抗原合成基因的异种抗原决定抗原合成基因的靶向载体，并将其与人类补体抑制基因和/或人类CD39基因整合到异种抗原决定基因座抗原合成基因。

2. 发明申请

WO2006057499A1 CATTLE BETA-CASEIN GENE TARGETING VECTOR USING HOMOLOGOUS RECOMBINATION 审中-公开
标题翻译： CATTLE BETA-CASEIN基因导向矢量使用同源重建
公开(公告)号：WO2006057499A1
公开(公告)日：2006-06-01
申请号：PCT/KR2005/003923
申请日：2005-11-18
申请人： Korea Research institute of Bioscience and Biotechnology , HAN, Yong-Mahn , LEE, Kyung-Kwang , CHANG, Mira , KOO, Deog-Bon
发明人： HAN, Yong-Mahn , LEE, Kyung-Kwang , CHANG, Mira , KOO, Deog-Bon
IPC分类号： C12N15/85 , C12N15/00 , C12N15/63 , C07H21/02 , A01H5/00
CPC分类号： C12N15/8771 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2267/01 , C12N15/8509 , C12N2830/008
摘要： The present invention relates to a bovine beta-casein gene targeting vector comprising (1) a first region having a length of 5 to 12 kb which is homologous to the promoter and its flanking nucleic acid sequences of bovine beta-casein gene, and comprising exon 1, intron 1, and exon 2 of bovine beta-casein gene; (2) a region for cloning a nucleic acid coding for desired proteins; (3) a region for coding a positive selection marker; (4) a second region having a length of 2.8 to 3.5 kb which is homologous to the nucleic acid sequences of bovine beta-casein gene, and comprising exon 5, 6, 7 and 8, and intron 5, 6 and 7 of bovine beta-casein gene; wherein the nucleic acid segment corresponding to the first region is located upstream to the nucleic acid segment corresponding to the second region in the 5' -3' arrangement of beta-casein gene. The present invention also relates to method producing the transgenic cattle which is bovine beta-casein gene-targeted with a gene coding a desired protein using the said vector and obtaining a large scale of a desired protein from the milk of the said transgenic cattle.
摘要翻译：本发明涉及一种牛β-酪蛋白基因靶向载体，其包含（1）长度为5至12kb的第一区，其与牛β-酪蛋白基因的启动子及其侧翼核酸序列同源，并且包含外显子 1，牛β酪蛋白基因的内含子1和外显子2; （2）克隆编码所需蛋白质的核酸的区域; （3）用于编码正选择标记的区域; （4）具有与牛β-酪蛋白基因的核酸序列同源的2.8至3.5kb长度的第二区域，并且包含外周血5,6,7和8以及牛β内含子5,6和7 -casein基因; 其中对应于第一区域的核酸区段位于对应于β-酪蛋白基因的5'-3'排列中的第二区域的核酸区段的上游。本发明还涉及生产转基因牛的方法，该转基因牛是使用所述载体用编码所需蛋白质的基因靶向的牛β-酪蛋白基因，并从所述转基因牛的奶中获得大规模的所需蛋白质。

3. 发明申请

WO1996037094A1 PROCESS FOR THE PREPARATION OF ANTIVIRAL PLANT TRANSFORMED WITH LACTOFERRIN GENE 审中-公开
标题翻译：制备用LACTOFERRIN基因转化的抗病植物的方法
公开(公告)号：WO1996037094A1
公开(公告)日：1996-11-28
申请号：PCT/KR1996000074
申请日：1996-05-22
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , LIU, Jang, Ryol , LEE, Kyung, Kwang , YU, Dae, Yeul , LEE, Mi, Hee
发明人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
IPC分类号： A01H01/00
CPC分类号： C07K14/79 , C12N15/8283
摘要： A process for the preparation of an antiviral plant, which comprises transforming a plant with an expression vector containing a lactoferrin(Lf) gene and culturing the transformed plant.
摘要翻译：一种制备抗病毒植物的方法，其包括用含有乳铁蛋白（Lf）基因的表达载体转化植物并培养转化的植物。

4. 发明申请

WO2009069986A3 GENETICALLY-MODIFIED CELL LINE FOR PRODUCING CLONED MINIATURE PIGS FOR XENOTRANSPLANTATION AND METHOD FOR PREPARING THE SAME. 审中-公开
公开(公告)号：WO2009069986A3
公开(公告)日：2009-06-04
申请号：PCT/KR2008/007087
申请日：2008-12-01
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Kyung-Kwang , CHANG, Mira , LEE, Jeong Woong , KANG, Yong-Kook , KANG, Man-Jong , KIM, Jin-Hoi , SEONG, Hwan-Hoo , SHIM, Hosup , HWANG, Seongsoo
发明人： LEE, Kyung-Kwang , CHANG, Mira , LEE, Jeong Woong , KANG, Yong-Kook , KANG, Man-Jong , KIM, Jin-Hoi , SEONG, Hwan-Hoo , SHIM, Hosup , HWANG, Seongsoo
IPC分类号： C12N15/64
摘要： The present invention relates to a targeting vector specific for a xenoantigen determining antigen synthesizing gene capable of knock-outing the xenoantigen determining antigen synthesizing gene using homologous recombination technologies and integrating human complement inhibiting gene and/or human CD39 gene at the loci of the xenoantigen determining antigen synthesizing gene.

5. 发明申请

WO2006057466A1 BETA-CASEIN GENE TARGETING VECTOR USING HOMOLOGOUS RECOMBINATION 审中-公开
标题翻译： BETA-CASEIN基因靶向载体使用同源重组
公开(公告)号：WO2006057466A1
公开(公告)日：2006-06-01
申请号：PCT/KR2004/003034
申请日：2004-11-23
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , HAN, Yong-Mahn , LEE, Kyung-Kwang , CHANG, Mira , KOO, Deog-Bon
发明人： HAN, Yong-Mahn , LEE, Kyung-Kwang , CHANG, Mira , KOO, Deog-Bon
IPC分类号： C12N15/85
CPC分类号： C12N15/8771 , A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2267/01 , C12N15/8509 , C12N2830/008
摘要： The present invention relates to a beta-casein gene targeting vector comprising (1) a first region having a length of 5 to 12 kb which is homologous to the promoter and its flanking nucleic acid sequences of beta-casein gene; (2) a region for cloning a nucleic acid coding for desired proteins; (3) a region for coding a positive selection marker; (4) a second region having a length of 2 to 4 kb which is homologous to the nucleic acid sequences of beta-casein gene; wherein the nucleic acid segment corresponding to the first region is located upstream to the nucleic acid segment corresponding to the second region in the 5'-3' arrangement of beta-casein gene, animal cells which are gene-targeted with the said vector and embryos which are nuclear-transferred with the said animal cells. The present invention also relates to a method for obtaining a desired protein from the milk of transgenic animal which is prepared by implanting the said embryos.
摘要翻译：本发明涉及β-酪蛋白基因靶向载体，其包含（1）与启动子及其β-酪蛋白基因的侧翼核酸序列同源的长度为5至12kb的第一区域; （2）克隆编码所需蛋白质的核酸的区域; （3）用于编码正选择标记的区域; （4）与β-酪蛋白基因的核酸序列同源的长度为2〜4kb的第二区域; 其中对应于第一区域的核酸区段位于与β-酪蛋白基因的5'-3'排列中的第二区域相对应的核酸区段的上游，所述动物细胞与所述载体和胚胎进行基因靶向其与所述动物细胞进行核转移。本发明还涉及从通过植入所述胚胎制备的转基因动物的乳中获得所需蛋白质的方法。

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