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1. 发明申请

WO2003010202A1 CONCATAMERIC IMMUNOADHESION 审中-公开
标题翻译：综合免疫球蛋白
公开(公告)号：WO2003010202A1
公开(公告)日：2003-02-06
申请号：PCT/KR2002/001427
申请日：2002-07-26
申请人： MEDEXGEN CO. LTD. , CHUNG, Yong-Hoon , HAN, Ji-Woong , LEE, Hye-Ja , CHOI, Eun-Yong , KIM, Jin-Mi
发明人： CHUNG, Yong-Hoon , HAN, Ji-Woong , LEE, Hye-Ja , CHOI, Eun-Yong , KIM, Jin-Mi
IPC分类号： C07K16/46
CPC分类号： C07K14/70507 , A61K2039/505 , C07K14/70521 , C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention disclosed dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment of an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA constructs, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention disclosed pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form.
摘要翻译：公开了包含两个可溶性结构域的连续蛋白质，其中生物活性蛋白质的可溶性结构域的C末端与生物活性蛋白质的相同可溶性结构域或不同可溶性结构域的N末端连接。此外，本发明公开了通过在两个单体蛋白质的铰链区上形成分子间二硫键而形成的二聚体蛋白质，该两个单体蛋白质通过将免疫应答涉及免疫应答的两个相同的可溶细胞外区域的连接体连接到免疫球蛋白分子的Fc片段而形成，糖基化蛋白质，编码单体蛋白的DNA构建体，含有DNA构建体的重组表达质粒，用重组表达质粒转化或转染的宿主细胞，以及通过培养宿主细胞制备二聚体蛋白质的方法。此外，本发明公开了包含二聚蛋白或其糖基化形式的药物或诊断组合物。

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