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1. 发明申请

WO2012129228A3 NOVEL RETRO-INVERSO LEPTIN PEPTIDE ANTAGONISTS 审中-公开
标题翻译：新的RETRO-INVERSO瘦素肽拮抗剂
公开(公告)号：WO2012129228A3
公开(公告)日：2012-11-22
申请号：PCT/US2012029805
申请日：2012-03-20
申请人： BOSTON BIOMEDICAL RES INST INC , LEAVIS PAUL C
发明人： LEAVIS PAUL C
IPC分类号： A61K38/10
CPC分类号： A61K38/2271
摘要： Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence. Further disclosed are truncations, modifications and retro-inversions of the peptides of the present invention.
摘要翻译：本文公开了包含瘦素序列的肽及其用于预防瘦素应答细胞中的ObR信号传导的方法。本发明的瘦蛋白肽结合但不激活瘦素应答细胞中的ObR信号传导，从而抑制瘦素对瘦素应答细胞中ObR信号传导的上调作用。肽的施用有效地防止了已施用了肽的哺乳动物的胚胎植入。本文还公开了用于鉴定ObR的肽拮抗剂的方法，其中所述肽包含瘦素序列。进一步公开了本发明的肽的截短，修饰和逆向倒位。

2. 发明申请

WO2012129228A2 NOVEL RETRO-INVERSO LEPTIN PEPTIDE ANTAGONISTS 审中-公开
公开(公告)号：WO2012129228A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/029805
申请日：2012-03-20
申请人： BOSTON BIOMEDICAL RESEARCH INSTITUTE, INC. , LEAVIS, Paul, C.
发明人： LEAVIS, Paul, C.
IPC分类号： A61K38/17 , A61P43/00
CPC分类号： A61K38/2271
摘要： Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence. Further disclosed are truncations, modifications and retro-inversions of the peptides of the present invention.
摘要翻译：本文公开了包含瘦蛋白序列的肽和其用于预防瘦素应答细胞中的ObR信号传导的方法。本发明的瘦蛋白肽在瘦素应答细胞中结合但不激活ObR信号传导，从而抑制瘦素对瘦素反应细胞中ObR信号传导的上调作用。肽的施用有效地防止已经给予肽的哺乳动物中的胚胎植入。本文还公开了用于鉴定ObR的肽拮抗剂的方法，其中所述肽包含瘦蛋白序列。进一步公开的是本发明的肽的截短，修饰和逆转。

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