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1. 发明申请

WO2013040047A1 BIOPOLYMER FILMS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：生物聚合物膜及其制备和使用方法
公开(公告)号：WO2013040047A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/054880
申请日：2012-09-12
申请人： CORNELL UNIVERSITY , ROSENBLATT, Mark, I. , LAWRENCE, Brian , LEVY, Brian
发明人： ROSENBLATT, Mark, I. , LAWRENCE, Brian , LEVY, Brian
IPC分类号： A61K39/395
CPC分类号： A61L27/3604 , A61L2430/16
摘要： The present invention provides for silk-derived devices (e.g., films, lenses, etc.) for insertion in an eye and methods for correcting vision of a patient. The films are placed within or on the retracting components of the eye (e.g., as corneal inlays or corneal onlays), or can be applied to the surface of another ocular device (e.g., an intraocular lens). The silk films are designed to provide optimized light transmission and refraction, thus allowing for effective distance, intermediate and/or near vision correction. The correction may be permanent, if it remains satisfactory, or may he reversed by removing the present device from the eye.
摘要翻译：本发明提供用于插入眼睛的丝衍生装置（例如胶片，镜片等）以及用于矫正患者视力的方法。将膜放置在眼睛的缩回部件内或之上（例如，作为角膜嵌体或角膜嵌体），或者可以施加到另一个眼部装置（例如，眼内透镜）的表面。丝膜被设计成提供优化的光透射和折射，从而允许有效的距离，中间和/或近视力校正。纠正可能是永久性的，如果仍然令人满意，或者可以通过从眼睛中移除本装置来反转。

2. 发明申请

WO2009148454A1 METHOD OF MODIFYING A LENS 审中-公开
标题翻译：修改镜片的方法
公开(公告)号：WO2009148454A1
公开(公告)日：2009-12-10
申请号：PCT/US2008/066022
申请日：2008-06-06
申请人： SABIC INNOVATIVE PLASTICS IP B.V. , LAWRENCE, Brian Lee , BODEN, Eugene, Pauling
发明人： LAWRENCE, Brian Lee , BODEN, Eugene, Pauling
IPC分类号： B29D11/00
CPC分类号： B29D11/00355
摘要： The present invention provides a method of modifying a lens, for example an ophthalmic lens (14). The method comprises providing an optically transparent lens comprising an organic polymer composition containing a photochemical Iy active dye. The optically transparent lens is irradiated with light having a wavelength and an intensity sufficient to transform at least a portion of the photochemically active dye into a photoproduct or photoproducts within the irradiated volume elements of the optically transparent lens to produce refractive index variations in a modified optically transparent lens (15). In certain embodiments, the modified optically transparent lens is subjected to a stabilization step to provide a light stable modified optically transparent lens. Stabilization is required only when the starting photochemically active dye and/or the photoproduct (s) are unstable under ambient conditions.
摘要翻译：本发明提供一种改变透镜的方法，例如眼科镜片（14）。该方法包括提供包含含有光化学活性染料的有机聚合物组合物的光学透明透镜。光学透明透镜被光照射，其具有足以将至少一部分光化学活性染料转变成光学透明透镜的照射体积元素内的光产物或光产物的波长和强度，以在光学上改变光学上的折射率变化透明透镜（15）。在某些实施方案中，对经修饰的光学透明透镜进行稳定化步骤以提供光稳定的光学透明透镜。只有当起始光化学活性染料和/或光产物在环境条件下不稳定时才需要稳定化。

3. 发明申请

WO2008127402A3 BIOPOLYMER SENSOR AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：生物聚合物传感器及其制造方法
公开(公告)号：WO2008127402A3
公开(公告)日：2009-02-05
申请号：PCT/US2007083620
申请日：2007-11-05
申请人： TUFTS COLLEGE , KAPLAN DAVID , OMENETTO FIORENZO , LAWRENCE BRIAN , CRONIN-GOLUMB MARK , GEORGAKOUDI IRENE
发明人： KAPLAN DAVID , OMENETTO FIORENZO , LAWRENCE BRIAN , CRONIN-GOLUMB MARK , GEORGAKOUDI IRENE
IPC分类号： B29C41/02 , G01N33/544
CPC分类号： B29D11/0074 , B29C41/02
摘要： A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
摘要翻译：一种制备生物聚合物传感器的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，在生物聚合物基质中添加生物材料，提供基材，将基质溶液浇铸在基材上，并将生物聚合物基质溶液干燥在基材上形成凝固的生物聚合物传感器。还提供了一种生物聚合物传感器，其包括具有嵌入的生物材料的固化的生物聚合物膜。

4. 发明申请

WO2008036295A3 METHOD FOR STORING HOLOGRAPHIC DATA 审中-公开
标题翻译：存储全息数据的方法
公开(公告)号：WO2008036295A3
公开(公告)日：2008-07-03
申请号：PCT/US2007020263
申请日：2007-09-19
申请人： GEN ELECTRIC , LAWRENCE BRIAN L , DUBOIS MARK , BODEN EUGENE P , RICHARDS WILLIAM D , MCCLOSKEY PATRICK J , ALIZADEH AZAR , SHI XIAOLEI
发明人： LAWRENCE BRIAN L , DUBOIS MARK , BODEN EUGENE P , RICHARDS WILLIAM D , MCCLOSKEY PATRICK J , ALIZADEH AZAR , SHI XIAOLEI
IPC分类号： G03H1/00 , G11B7/246
CPC分类号： G03H1/02 , G03H1/30 , G03H2001/0264 , G03H2001/0417 , G03H2222/54 , G03H2260/12 , G03H2270/53 , G11B7/0065 , G11B7/24044 , G11B7/245 , G11B7/246 , G11B7/248 , G11B20/10 , G11B2220/2504
摘要： A method for storing holographic data, said method comprising: step (A) providing an optically transparent substrate comprising a polymer composition and a light absorbing chromophore, said polymer composition comprising a continuous phase and a dispersed phase, said dispersed phase being less than about 200 nm in size; and step (B) irradiating a volume element of the optically transparent substrate with a holographic interference pattern, wherein the pattern has a first wavelength and an intensity both sufficient to cause a phase change in at least a portion of the dispersed phase within the volume element of the substrate to produce within the irradiated volume element refractive index variations corresponding to the holographic interference pattern, thereby producing an optically readable datum corresponding to the volume element.
摘要翻译：一种用于存储全息数据的方法，所述方法包括：步骤（A）提供包括聚合物组合物和光吸收发色团的光学透明基底，所述聚合物组合物包含连续相和分散相，所述分散相小于约200 nm尺寸; 并且步骤（B）用全息干涉图案照射光学透明基底的体积元件，其中所述图案具有第一波长和强度，其足以引起体积元件内的至少一部分分散相的相变以在与所述全息干涉图案相对应的所述照射的体积元素折射率变化中产生，从而产生与所述体积元素对应的光学可读数据。

5. 发明申请

WO2006066768A1 LUBRICATING SYSTEMS 审中-公开
标题翻译：润滑系统
公开(公告)号：WO2006066768A1
公开(公告)日：2006-06-29
申请号：PCT/EP2005/013422
申请日：2005-12-13
申请人： INFINEUM INTERNATIONAL LIMITED , LAWRENCE, Brian , LOCKE, Christopher
发明人： LAWRENCE, Brian , LOCKE, Christopher
IPC分类号： C10M141/06 , C10M175/00 , C10N10/02 , C10N30/04 , C10N40/25
CPC分类号： C10M175/0091 , C10M133/56 , C10M141/06 , C10M2201/062 , C10M2215/28 , C10M2219/00 , C10N2210/02 , C10N2220/021 , C10N2230/04 , C10N2230/42 , C10N2230/45 , C10N2230/52 , C10N2240/10 , C10N2240/102
摘要： A lubricant containing a minor amount of a polyalkene-substituted succinimide of Mn 1800 to 2800, as a first base, is circulated through a lubricating system so that the succinimide forms salts with at least a portion of combustion acids therein. The lubricant is then contacted with an immobilised second base, stronger than the first base, that displaces at least a portion of the succinimide from the salts to form retained second base:combustion acid salts and release the succinimide into the lubricant.
摘要翻译：含有少量作为第一碱的Mn188〜2800的聚烯烃取代琥珀酰亚胺的润滑剂通过润滑系统循环使得琥珀酰亚胺与其中的至少一部分燃烧酸形成盐。然后将润滑剂与固定的第二碱基接触，比第一碱更强，使得至少一部分琥珀酰亚胺从盐中移出以形成保留的第二碱：燃烧酸盐并将琥珀酰亚胺释放到润滑剂中。

6. 发明申请

WO2005106434A1 AUTHENTICATION SYSTEM, DATA DEVICE, AND METHODS FOR USINGTHE SAME 审中-公开
标题翻译：认证系统，数据设备及其使用方法
公开(公告)号：WO2005106434A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/013353
申请日：2005-04-20
申请人： GENERAL ELECTRIC COMPANY , GASCOYNE, David , LAWRENCE, Brian , MARUVADA, Sriramakrishna , POTYRAILO, Radislav , SCHOTTLAND, Philippe , SZE, Micah, Sakiestewa , WISNUDEL, Marc, Brian
发明人： GASCOYNE, David , LAWRENCE, Brian , MARUVADA, Sriramakrishna , POTYRAILO, Radislav , SCHOTTLAND, Philippe , SZE, Micah, Sakiestewa , WISNUDEL, Marc, Brian
IPC分类号： G01N21/64
CPC分类号： G01N21/643 , G01N21/645 , G01N21/9506 , G01N2021/1753 , G01N2021/6417 , G01N2021/6439 , G01N2021/6471 , G01N2201/0627 , G11B19/122 , G11B23/281
摘要： An authentication system may comprise: a first light source, a second light source, and at least three optically filtered light sensing devices for detecting analog emission intensity in a spectral sensitivity range, wherein each light sensing device is in operable communication with the first light source and/or the second light source. The first light source having a first light source spectral distribution and can be capable of providing sufficient excitation to produce a photoluminescent emission from a medium comprising a luminescent tag and a color. The second light source having a visible multi-wavelength spectral distribution and capable of providing sufficient visible multi-wavelength illumination of the medium to generate a second analog response, wherein the second analog response is different from the photoluminescent emission. Each light sensing device having a different device spectral sensitivity range which includes at least a portion of the visible multiwavelength spectral distribution, with the device spectral sensitivity range of at least one of the light sensing devices including at least a portion of a desired photoluminescent emission wavelength range.
摘要翻译：认证系统可以包括：第一光源，第二光源和用于检测光谱灵敏度范围中的模拟发射强度的至少三个光学滤波光感测装置，其中每个光感测装置与第一光源可操作地连通和/或第二光源。第一光源具有第一光源光谱分布，并且能够提供足够的激发以从包含发光标签和颜色的介质产生光致发光发射。所述第二光源具有可见的多波长光谱分布并能够提供所述介质的足够的可见多波长照明以产生第二模拟响应，其中所述第二模拟响应与所述光致发光发射不同。每个光感测装置具有不同的装置光谱灵敏度范围，其包括可见多波长光谱分布的至少一部分，其中至少一个光感测装置的装置光谱灵敏度范围包括期望的光致发光发射波长的至少一部分范围。

7. 发明申请

WO0167561A3 OPTICAL WAVEGUIDE AMPLIFIER 审中-公开
标题翻译：光波导放大器
公开(公告)号：WO0167561A3
公开(公告)日：2002-01-31
申请号：PCT/US0106726
申请日：2001-03-02
申请人： MOLECULAR OPTOELECTRONICS CORP , LAWRENCE BRIAN L
发明人： LAWRENCE BRIAN L
IPC分类号： H01S3/02 , H01S3/063 , H01S3/094
CPC分类号： H01S3/063 , H01S3/02 , H01S3/094003
摘要： An optical amplifier (100) with integrated optical waveguide, pump source and other, optional components for amplifying an input optical signal coupled from a fiber optic. The amplifier includes a housing (160) having these components mounted therein, and appropriate optics (120, 130, 150) for coupling the input and output optical signals to and from the appropriate ports, and for carrying an optical pump signal from its source (140) to the waveguide. The optical waveguide disclosed is a channel waveguide amplification chip (110), having a relatively small size; and the pump source disclosed is a laser diode capable of generating the optical pump signal internal to the housing with only electrical (e.g., power) signals applied thereto from outside of the housing. Other optional components may be provided for cooperative optical processing in the amplifier housing such as isolators, gain flattening filters, and optical taps for monitoring. The disclosed optical amplifier offers size and cost advantages over other known systems.
摘要翻译：具有集成光波导，泵浦源和其他用于放大从光纤耦合的输入光信号的可选组件的光放大器（100）。放大器包括具有安装在其中的这些部件的壳体（160）和用于将输入和输出光信号耦合到适当端口的光学系统（120,130,150），并用于从其源（用于承载光泵信号） 140）到波导。所公开的光波导是具有相对较小尺寸的通道波导放大芯片（110）; 并且所公开的泵浦源是能够仅从壳体外部向其施加电（例如，功率）信号的能够在壳体内部产生光泵浦信号的激光二极管。可以提供其他可选部件用于放大器外壳中的协同光学处理，例如隔离器，增益平坦化滤光器和用于监视的光学抽头。所公开的光放大器提供了超过其他已知系统的尺寸和成本优点。

8. 发明申请

WO9943121A8 COMMUNICATIONS LINK OPTICAL AMPLIFICATION AND DISPERSION COMPENSATION 审中-公开
标题翻译：通信链路光学放大和分辨率补偿
公开(公告)号：WO9943121A8
公开(公告)日：2000-08-24
申请号：PCT/US9903835
申请日：1999-02-19
申请人： MOLECULAR OPTOELECTRONICS CORP , LAWRENCE BRIAN L , SHIMAZU MICHAEL H
发明人： LAWRENCE BRIAN L , SHIMAZU MICHAEL H
IPC分类号： H01S3/067 , H04B10/17 , H01S3/00 , G02B6/26
CPC分类号： H04B10/291 , H01S3/06708 , H04B2210/258
摘要： Fiber optic communication links are disclosed, employing non-invasive fiber optic amplification technology. An amplifier stage (1024) is provided having a plurality of signal paths into which differing wavelength windows of an input optical signal are demultiplexed. At least one of the paths (e.g., 1310 nm) includes a fiber optic (30) and an associated fiber optic amplifier (1054). A channel overlay waveguide (60) is employed for amplification of optical energy evanescently coupled to the overlay waveguide from the fiber optic (30).
摘要翻译：公开了采用非侵入式光纤放大技术的光纤通信链路。提供具有多个信号路径的放大器级（1024），其中输入光信号的不同波长窗口被解复用。至少一个路径（例如，1310nm）包括光纤（30）和相关联的光纤放大器（1054）。通道覆盖波导（60）被用于从光纤（30）瞬时耦合到覆盖波导的光能的放大。

9. 发明申请

WO2008127405A3 MICROFLUIDIC DEVICE WITH A CYLINDRICAL MICROCHANNEL AND A METHOD FOR FABRICATING SAME 审中-公开
标题翻译：具有圆柱微通道的微流体装置及其制造方法
公开(公告)号：WO2008127405A3
公开(公告)日：2009-02-12
申请号：PCT/US2007083646
申请日：2007-11-05
申请人： TUFTS COLLEGE , KAPLAN DAVID , OMENETTO FIORENZO , LAWRENCE BRIAN , CRONIN-GOLUMB MARK , GEORGAKOUDI IRENE
发明人： KAPLAN DAVID , OMENETTO FIORENZO , LAWRENCE BRIAN , CRONIN-GOLUMB MARK , GEORGAKOUDI IRENE
IPC分类号： B29C39/02 , B29D11/00 , G01N21/01 , G01N33/543
CPC分类号： B29D11/0074 , B01L3/502707 , B01L2300/0816 , B01L2300/12 , B01L2300/163 , B29C39/02 , B81B2201/058 , B81B2201/06 , B81C1/00071 , G01J3/02 , G01J3/0237 , G01J3/0256 , G01J3/06 , G01J3/10 , G01J3/1804 , G01J3/42 , G01N33/54386 , G01N2021/0346
摘要： A method of manufacturing a microfluidic device having at least one cylindrical microchannel (32) includes providing a substrate (12), casting an uncured polymer matrix solution. (LO) onto the substrate, embedding an elongated rod (14) in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated rod to form the cylindrical microchannel. in. the solidified body. In. another embodiment, the method includes forming an optical feature on a surface of the microfluidic device. A microfluidic device is also provided, the device including a polymer body, and at least one cylindrical microchannel in the polymer body, the cylindrical microchannel having1 a diameter between approximately 40?m and 250?m, inclusive. An additional microfluidic device is provided that functions' as an optsfluidic spectrometer. The optofluidic spectrometer includes a polymer body, a diffraction grating integrated, within. the palymer _ body, and. a cylindrical micrsdianpel bebipd the- diffraction., grating on the polymer body.
摘要翻译：制造具有至少一个圆柱形微通道（32）的微流体装置的方法包括提供衬底（12），铸造未固化的聚合物基质溶液。（LO）到衬底上，将细长棒（14）嵌入未固化的聚合物基质溶液中，固化聚合物基质溶液以形成凝固体，并提取细长棒以形成圆柱形微通道。凝固的身体。在。另一实施例，该方法包括在微流体装置的表面上形成光学特征。还提供了一种微流体装置，该装置包括聚合物主体和聚合物主体中的至少一个圆柱形微通道，该圆柱形微通道具有直径在约40μm至250μm之间的直径。提供额外的微流体装置作为选择流体光谱仪。光流体光谱仪包括聚合物体，集成的衍射光栅。 palymer _身体，和。圆柱形micrsdianpel bebipd衍射，光栅在聚合物主体上。

10. 发明申请

WO2008127403A3 BIOPOLYMER OPTOFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：生物聚合物光致变色器件及其制造方法
公开(公告)号：WO2008127403A3
公开(公告)日：2008-12-24
申请号：PCT/US2007083634
申请日：2007-11-05
申请人： TUFTS COLLEGE , KAPLAN DAVID , OMENETTO FIORENZO , LAWRENCE BRIAN , CRONIN-GOLUMB MARK , GEORGAKOUDI IRENE
发明人： KAPLAN DAVID , OMENETTO FIORENZO , LAWRENCE BRIAN , CRONIN-GOLUMB MARK , GEORGAKOUDI IRENE
IPC分类号： B29C39/02 , B29D11/00 , G01N21/01 , G01N33/543 , G02B1/04
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.
摘要翻译：一种制备生物聚合物光流体装置的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，提供基材，将生物聚合物基质溶液浇铸在基材上，将通道模具嵌入生物聚合物基质溶液中，干燥生物聚合物基质固化生物聚合物光流体装置的解决方案，以及提取嵌入式通道模具以在凝固的生物聚合物光流体装置中提供流体通道。根据另一方面，提供了由生物聚合物制成并且在其中具有用于输送流体的通道的光流体装置。

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