专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011126646A3 IMPROVED BACKDRILLING OF MULTILAYER PRINTED CIRCUIT BOARDS 审中-公开
公开(公告)号：WO2011126646A3
公开(公告)日：2011-10-13
申请号：PCT/US2011/027483
申请日：2011-03-08
申请人： FLEXTRONICS AP, LLC , LAU, Cheuk Ping
发明人： LAU, Cheuk Ping
IPC分类号： H05K3/40 , B23B41/00
摘要： Methods of backdrilling printed circuit boards (PCBs) to remove via stubs and related apparatuses. The method may include removing a via stub through a combination of backdrilling and chemical etching. The backdrilling may remove a masking layer from the via stub. Portions of an underlying layer may remain in the region of the via stub after the backdrilling is completed. The remaining portions of the underlying layer may be removed in a subsequent etching process thereby removing the via stub from the PCB. As the backdrilling step may be used for the limited purpose of removing the outer layer and portions of the underlying layer remaining in the via can be tolerated, the diameter of the backdrilling need not be as large as traditional backdrilling where all layers within the via must be ensured of being completely removed.

2. 发明申请

WO1995018132A1 DIARYL 5,6-FUSED HETEROCYCLIC ACIDS AS LEUKOTRIENE ANTAGONISTS 审中-公开
标题翻译： DIARYL 5,6-FUSED杂环酸作为紫苏酮拮抗剂
公开(公告)号：WO1995018132A1
公开(公告)日：1995-07-06
申请号：PCT/CA1994000716
申请日：1994-12-22
申请人： MERCK FROSST CANADA INC. , YOUNG, Robert, N. , LABELLE, Marc , LEBLANC, Yves , LAU, Cheuk, K. , DUFRESNE, Claude , GAREAU, Yves , XIANG, Yi, Bin
发明人： MERCK FROSST CANADA INC.
IPC分类号： C07D495/04
CPC分类号： C07D491/04 , C07D495/04 , C07D513/04
摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
摘要翻译：具有式（I）的化合物是白细胞三烯作用的拮抗剂。这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。它们也可用于治疗心绞痛，脑痉挛，肾小球肾炎，肝炎，内毒素血症，葡萄膜炎和同种异体移植排斥。

3. 发明申请

WO2011126646A2 IMPROVED BACKDRILLING OF MULTILAYER PRINTED CIRCUIT BOARDS 审中-公开
标题翻译：改进多层印刷电路板的背板
公开(公告)号：WO2011126646A2
公开(公告)日：2011-10-13
申请号：PCT/US2011027483
申请日：2011-03-08
申请人： FLEXTRONICS AP LLC , LAU CHEUK PING
发明人： LAU CHEUK PING
IPC分类号： H05K3/40 , B23B41/00
CPC分类号： H05K1/0251 , H05K3/0047 , H05K3/429 , H05K2203/0207 , Y10T29/49156 , Y10T29/49165 , Y10T29/49167
摘要： Methods of backdrilling printed circuit boards (PCBs) to remove via stubs and related apparatuses. The method may include removing a via stub through a combination of backdrilling and chemical etching. The backdrilling may remove a masking layer from the via stub. Portions of an underlying layer may remain in the region of the via stub after the backdrilling is completed. The remaining portions of the underlying layer may be removed in a subsequent etching process thereby removing the via stub from the PCB. As the backdrilling step may be used for the limited purpose of removing the outer layer and portions of the underlying layer remaining in the via can be tolerated, the diameter of the backdrilling need not be as large as traditional backdrilling where all layers within the via must be ensured of being completely removed.
摘要翻译：背板印刷电路板（PCB）通过短线和相关设备去除的方法。该方法可以包括通过反钻和化学蚀刻的组合去除通孔短截线。回钻可以从通孔短截线去除掩模层。在回钻完成之后，下层的部分可能保留在通孔短截线的区域中。可以在随后的蚀刻工艺中去除下层的剩余部分，从而从PCB去除通孔短截线。由于回钻步骤可用于去除外层的有限目的，并且残留在通孔中的下层的部分可以被允许，所以回钻的直径不需要像传统的回钻一样大，其中通孔内的所有层必须确保被完全清除。

4. 发明申请

WO2007061764A3 TRICYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES 审中-公开
公开(公告)号：WO2007061764A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/044527
申请日：2006-11-17
申请人： MERCK & CO., INC. , MERCK FROSST CANADA LTD. , TRUCHON, Jean-Francois , LACHANCE, Nicolas , LAU, Cheuk , LEBLANC, Yves , MELLON, Christophe , ROY, Patrick , ISABEL, Elise , OTTE, Ryan, D. , YOUNG, Jonathan, R.
发明人： TRUCHON, Jean-Francois , LACHANCE, Nicolas , LAU, Cheuk , LEBLANC, Yves , MELLON, Christophe , ROY, Patrick , ISABEL, Elise , OTTE, Ryan, D. , YOUNG, Jonathan, R.
IPC分类号： A61K31/551 , C07D487/02
摘要： The present invention provides inhibitors of kinases, specifically IκB kinases, JAKl , JAK2, JAK3 and TYK2. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting said kinase activity by administering the compound to a patient in need of treatment for myeloproliferative disorders, cancer or NF-κB-mediated diseases.

5. 发明申请

WO1996037469A1 N-BENZYLINDOL-3-YL PROPANIC ACID DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS 审中-公开
标题翻译：作为CYCLOOXYGENASE-2抑制剂的N-苄基吲哚-3-基丙酸衍生物
公开(公告)号：WO1996037469A1
公开(公告)日：1996-11-28
申请号：PCT/CA1996000326
申请日：1996-05-21
申请人： MERCK FROSST CANADA INC. , LAU, Cheuk, K. , BLACK, Cameron , GUAY, Daniel , GAUTHIER, Jacques-Yves , LEBLANC, Yves , ROY, Patrick , DUCHARME, Yves , HAMEL, Pierre
发明人： MERCK FROSST CANADA INC.
IPC分类号： C07D209/22
CPC分类号： C07D401/12 , C07D209/22 , C07D403/06 , C07D413/06
摘要： The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutcial compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
摘要翻译：本发明包括式（I）的新化合物以及治疗环加氧酶-2介导的疾病的方法，其包括向需要这种治疗无效治疗有效量的式（I）的化合物的患者施用。本发明还包括用于治疗包含式（I）化合物的环氧合酶-2介导的疾病的某些药物组合物。

6. 发明申请

WO1996037468A1 N-BENZYL-3-INDOLEACETIC ACIDS AS CYCLOOXYGENASE-2-INHIBITORS AND ANTIINFLAMMATORY DRUGS 审中-公开
标题翻译： N-苄基-3-间苯二酚作为环孢菌素-2抑制剂和抗炎药物
公开(公告)号：WO1996037468A1
公开(公告)日：1996-11-28
申请号：PCT/CA1996000325
申请日：1996-05-21
申请人： MERCK FROSST CANADA INC. , LAU, Cheuk, K. , BLACK, Cameron , BELLEY, Michel
发明人： MERCK FROSST CANADA INC.
IPC分类号： C07D209/22
CPC分类号： C07D209/22
摘要： The invention encompasses the novel compound of Formula (I) as well as a method of treating inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of inflammation and, in particular, cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
摘要翻译：本发明包括式（I）的新型化合物以及治疗炎症，特别是环氧合酶-2介导的疾病的方法，包括向需要这种治疗无效治疗有效量的化合物的患者施用的式（I）。本发明还包括用于治疗炎症的某些药物组合物，特别是包含式（I）化合物的环氧合酶-2介导的疾病。

7. 发明申请

WO2009079797A1 COMPOUNDS AND METHOD FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的化合物和方法
公开(公告)号：WO2009079797A1
公开(公告)日：2009-07-02
申请号：PCT/CA2008/002293
申请日：2008-12-24
申请人： CRITICAL OUTCOME TECHNOLOGIES, INC. , DANTER, Wayne R. , LAU, Cheuk, Kun
发明人： DANTER, Wayne R. , LAU, Cheuk, Kun
IPC分类号： C07D403/12 , A61K31/50 , A61K31/501 , A61P35/00 , C07D237/08 , C07D401/14
CPC分类号： C07D237/08 , C07D401/14 , C07D403/12
摘要： The invention relates to a compound of Formula (I) and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof, wherein X is selected from S or O; R 5 is selected from a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, or (Formula II) and the remaining substituents are described herein; and a composition comprising the thiosemicarbazone and/or the semicarbazone. The invention also relates to a method of administration of a thiocarbazone and/or a semicarbazone; and use thereof to treat a cancer.
摘要翻译：本发明涉及式（I）化合物和/或其药学上可接受的盐，水合物，溶剂合物，互变异构体，旋光异构体，E-异构体，Z-异构体或其组合，其中X选自S或O; R5选自取代或未取代的芳族基团，取代或未取代的杂芳族基团或（式II），其余取代基如本文所述; 以及包含缩氨基硫脲和/或缩氨基脲的组合物。本发明还涉及硫卡巴酮和/或缩氨基脲的给药方法; 并用其治疗癌症。

8. 发明申请

WO2005056582A1 PTP1B PHOTOPROBES 审中-公开
公开(公告)号：WO2005056582A1
公开(公告)日：2005-06-23
申请号：PCT/CA2004/002100
申请日：2004-12-09
申请人： MERCK FROSST CANADA & CO. , RAMACHANDRAN, Chidambaram , THERIEN, Michel , LAU, Cheuk, K. , ZAMBONI, Robert
发明人： RAMACHANDRAN, Chidambaram , THERIEN, Michel , LAU, Cheuk, K. , ZAMBONI, Robert
IPC分类号： C07K05/04
CPC分类号： C07K5/0827 , A61K38/00 , C07F9/3882 , C07F9/4056 , C07K5/06191 , C12Q1/42
摘要： Photoaffinity probes (photoprobes) of the PTP1B enzyme contain the trifluoromethylphenyl diazirene photophore attached to compounds which bind to the PTP1B enzyme. The photoprobes bind irreversibly to the PTP1B enzyme upon irradiation, and can be used to study the binding of compounds to the PTP1B enzyme. Compounds that bind to the PTP1B enzyme may inhibit PTP1B and may be useful in the treatment of type 2 diabetes.
摘要翻译： PTP1B酶的光亲和性探针（光电探测器）含有与结合PTP1B酶的化合物连接的三氟甲基苯基二氮烯光电光。光电子照射后不可逆地与PTP1B酶结合，可用于研究化合物与PTP1B酶的结合。与PTP1B酶结合的化合物可能抑制PTP1B，可用于治疗2型糖尿病。

9. 发明申请

WO2004022526A1 CATHEPSIN CYSTEINE PROTEASE INHIBITORS 审中-公开
公开(公告)号：WO2004022526A1
公开(公告)日：2004-03-18
申请号：PCT/CA2003/001346
申请日：2003-09-03
申请人： MERCK FROSST CANADA & CO. , BOYD, Michael , GAGNON, Marc , LAU, Cheuk , MELLON, Christophe , SCHEIGETZ, John
发明人： BOYD, Michael , GAGNON, Marc , LAU, Cheuk , MELLON, Christophe , SCHEIGETZ, John
IPC分类号： C07C255/25
CPC分类号： C07C255/29 , C07C255/25 , C07C255/54 , C07C259/10 , C07C311/29 , C07C317/22 , C07C317/24 , C07C317/44 , C07C323/19 , C07C323/22 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07D211/22 , C07D211/94 , C07D213/30 , C07D213/61 , C07D213/79 , C07D213/89 , C07D215/14 , C07D215/60 , C07D233/22 , C07D239/26 , C07D241/16 , C07D277/24 , C07D295/088 , C07D295/192 , C07D295/205 , C07D295/26 , C07D333/16 , C07D401/04
摘要： This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. They have the following structure: Formula (I).
摘要翻译：本发明涉及半胱氨酸蛋白酶抑制剂的类别，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中表示骨吸收抑制的疾病，例如骨质疏松症。它们具有以下结构：式（I）。

10. 发明申请

WO2003075836A3 CATHEPSIN CYSTEINE PROTEASE INHIBITORS 审中-公开
公开(公告)号：WO2003075836A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/006147
申请日：2003-02-28
申请人： MERCK FROSST CANADA & CO. , AXYS PHARMACEUTICALS, INC. , BAYLY, Christopher, I. , BLACK, Cameron , LEGER, Serge , LI, Chun Sing , MCKAY, Dan , MELLON, Christophe , GAUTHIER, Jacques Yves , LAU, Cheuk , THERIEN, Michel , TRUONG, Vouy-Linh , GREEN, Michael, J. , HIRSCHBEIN, Bernard, L. , JANC, James, W. , PALMER, James, T. , BASKARAN, Chitra
发明人： BAYLY, Christopher, I. , BLACK, Cameron , LEGER, Serge , LI, Chun Sing , MCKAY, Dan , MELLON, Christophe , GAUTHIER, Jacques Yves , LAU, Cheuk , THERIEN, Michel , TRUONG, Vouy-Linh , GREEN, Michael, J. , HIRSCHBEIN, Bernard, L. , JANC, James, W. , PALMER, James, T. , BASKARAN, Chitra
IPC分类号： A61K31/275
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式