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1. 发明申请

WO03011176A3 CORRECTING LARGE VISUAL AXIS OFFSET ERRORS 审中-公开
标题翻译：校正大视觉轴偏移错误
公开(公告)号：WO03011176A3
公开(公告)日：2003-07-10
申请号：PCT/US0224016
申请日：2002-07-30
申请人： LASERSIGHT TECH INC
发明人： MARROU LANCE R
IPC分类号： A61B3/00 , A61F9/01
CPC分类号： A61F9/008 , A61B3/00 , A61F2009/00872
摘要： A method is provided to correct visual axis offset errors. Such errors in the visual axis offset are large if they significantly affect the patient's vision. The visual axis offset is the difference between the visual axis and the reference axis, commonly the pupillary axis. Although correcting the visual axis offset error may be most often performed by refractive surgery, the visual axis offset error may also be corrected in spectacles or contacts lenses. A benefit of correcting large visual axis offset errors secondary to patient vision is aesthetic appeal. Significant visual axis correction may require patient training. Although this may not compensate entirely for amblyopic vision, it may alleviate part of the dysfunction. Another benefit of correcting larger visual axis errors is providing the patient with a larger area of better vision within the aperture.
摘要翻译：提供了一种方法来校正视轴偏移误差。视轴偏移中的这些误差如果明显影响患者的视力则会很大。视轴偏移是视轴与参考轴之间的差异，通常是瞳孔轴。尽管校正视轴偏移误差最常由屈光手术进行，但也可以在眼镜或隐形眼镜中校正视轴偏移误差。纠正患者视力继发的大视轴偏移错误的好处是美学吸引力。显着的视轴校正可能需要患者培训。虽然这可能不会完全补偿弱视视力，但可能会减轻部分功能障碍。纠正较大视轴错误的另一个好处是为患者提供更大的视野范围内更好的视力。

2. 发明申请

WO03011111A3 DETERMINING A TARGET OPTICAL ZONE FOR ABALATION BASED ON THE STILES-CRAWFORD EFFECT 审中-公开
标题翻译：基于Scrive-CroWord效应确定目标光学区的消除
公开(公告)号：WO03011111A3
公开(公告)日：2003-07-10
申请号：PCT/US0224013
申请日：2002-07-30
申请人： LASERSIGHT TECH INC
发明人： MARROU LANCE R
IPC分类号： A61B3/11 , A61B19/00 , A61F9/01 , A61B13/00
CPC分类号： A61B3/112 , A61B34/10 , A61F9/00804 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： The optimal optical zone for a patient is determined based upon the Stiles-Crawford effect and patient-specific scotopic pupil parameters. This invention is especially useful in refractive surgery where the chosen optical zone is crucial and affects both the depth and volume of the abalation. This optimal optical zone may be used in the creation of corrective lenses and other ocular surgery in addition to refractive surgery. Provided with the optimal optical zone, a refractive surgeon may better choose the sugical parameters for the treatment. Current methods consist of choosing a default value for all patients or only choosing the scotopic pupil diameter or contour, either of wich may not be optimal and may lead to a deeper or bigger treatment.
摘要翻译：基于Stiles-Crawford效应和患者特异性暗视瞳孔参数确定患者的最佳光学区。本发明在屈光手术中特别有用，其中所选择的光学区域是关键的并且影响消融的深度和体积。除了屈光手术之外，该最佳光学区域可用于产生矫正镜片和其他眼部手术。提供最佳光学区域时，屈光外科医生可以更好地选择用于治疗的糖质参数。目前的方法包括为所有患者选择默认值或仅选择暗视瞳孔直径或轮廓，其中任何一种可能都不是最佳的，并且可能导致更深或更大的治疗。

3. 发明申请

WO0057799A9 BLADE INSERTION APPARATUS FOR KERATOMES 审中-公开
标题翻译：刀片刀片插入装置
公开(公告)号：WO0057799A9
公开(公告)日：2002-06-20
申请号：PCT/US0007705
申请日：2000-03-23
申请人： LASERSIGHT TECH INC
发明人： MEADOR RANDALL M , KLIEWER MICHAEL L , SMITH STAN L
IPC分类号： A61F9/013 , A61B17/32
CPC分类号： A61F9/013
摘要： An apparatus (10), and technique for inserting a blade (26) into a keratome includes a blade holder (24), and a blade (26) having a cutting edge (30), the blade (26) being coupled with the blade holder (24) thereby defining a blade holder assembly (12). A housing assembly (12) is provided. The blade holder assembly (22) is disposed in the housing assembly (12) for movement with respect to the housing assembly (12). The housing assembly (12) is constructed, and arranged to protect the cutting edge (30) of the blade (24), and to receive a keratome. An ejector (44) is constructed, and arranged to move the blade holder assembly (22) in the housing assembly (12), and into a keratome (37) when a keratome (37) is received by the housing assembly (12). Thereafter, the injector (44) moves the keratome (37) from the housing assembly (12).
摘要翻译：一种用于将刀片（26）插入到角质层中的装置（10）和技术包括刀片保持器（24）和具有切割刃（30）的刀片（26），刀片（26）与刀片从而限定了刀片保持器组件（12）。提供了壳体组件（12）。叶片保持器组件（22）设置在壳体组件（12）中，用于相对于壳体组件（12）运动。壳体组件（12）被构造和布置成保护叶片（24）的切割边缘（30）并接收角膜。当外壳组件（12）接纳角膜磨损（37）时，构造一个推出器（44），以将刀片保持器组件（22）移动到壳体组件（12）中并进入角膜组件（37）。此后，注射器（44）从壳体组件（12）移动角膜组件（37）。

4. 发明申请

WO03011121A9 HEIGHT RECONSTRUCTION FROM AXIAL DISTANCE DATA USING AN ELLIPSE ARC-STEP METHOD 审中-公开
标题翻译：使用ELLIPSE ARC-STEP方法从轴距离数据高度重建
公开(公告)号：WO03011121A9
公开(公告)日：2003-04-10
申请号：PCT/US0224014
申请日：2002-07-30
申请人： LASERSIGHT TECH INC
发明人： SMITH MICHAEL J , MARROU LANCE R
IPC分类号： A61B3/107 , A61B3/10
CPC分类号： A61B3/107
摘要： A method is provided for reconstructing the height data from the radial distance data gathered by a corneal measurement device such as a corneal topographer or videokeratometer. The present invention performs the height reconstruction using an algorithm that is more accurate than the prior art. The prior art uses the circle arc-step or midpoint height reconstruction algorithms, while the present invention teaches the ellipse arc-step height reconstruction. This is important because it is now known that the eye surface is better modeled with an ellipsoid approximation than a spherical approximation.
摘要翻译：提供了一种用于从角膜测量装置如角膜地形图或视频角膜计收集的径向距离数据重建高度数据的方法。本发明使用比现有技术更精确的算法来执行高度重建。现有技术使用圆弧或中点高度重建算法，而本发明教导了椭圆弧段高度重建。这是重要的，因为现在已知眼睛表面更好地用椭圆近似而不是球面近似来建模。

5. 发明申请

WO0124728A3 PROLATE SHAPED CORNEAL RESHAPING 审中-公开
标题翻译：抛光形状矫正
公开(公告)号：WO0124728A3
公开(公告)日：2002-05-02
申请号：PCT/US0027425
申请日：2000-10-05
申请人： LASERSIGHT TECH INC
发明人： HOLLADAY JACK T , SMITH MICHAEL , TERRY TRAVIS , MARROU LANCE
IPC分类号： A61B3/107 , A61B3/125 , A61F9/01 , A61B18/18
CPC分类号： A61B3/125 , A61B3/0025 , A61B3/107 , A61F9/00804 , A61F2009/00872 , A61F2009/00882
摘要： Apparatus (300) and techniques for performing prolate shaped corneal reshaping. In accordance with the techniques, an ablation scanning (380) laser system includes fitter (320) modules to fit input refractive or topographical measurement data to a three (3) variable ellipsoid model. This provides pre- and post-operative approximations of a cornea. A desired prolate shaped ablation profile is determined based on a desired prolate ellipsoidal shape. In accordance with the principles of the present invention, the spheroequivalent ellipsoid model has only three degrees of freedom (not four as in a conventional biconic technique) to define a desired ablation profile, providing extremely accurate and predictable long term vision correction. To arrive at an ellipsoid model having only three numbers of freedom, a spheroequivalent (SEQ) value of asphericity QSEQ is generated. The spheroequivalent eccentricity QSEQ value replaces two degrees of freedom (i.e., eccentricities) in an otherwise conventional biconic modeling system, leaving only three (3) variables to determine for a best fit ellipsoidal modeling of a cornea possible, and to limit results to regular astigmatism that can be corrected with optical spherocylinders.
摘要翻译：装置（300）和用于进行长角形角膜重塑的技术。根据这些技术，消融扫描（380）激光系统包括装配器（320）模块，以将输入折射或形貌测量数据拟合到三（3）个可变椭圆体模型。这提供角膜前和术后近似值。基于期望的椭圆形椭圆形形状来确定期望的长扁形切削轮廓。根据本发明的原理，球形等效椭圆体模型仅具有三个自由度（不是传统双锥技术中的四个），以限定期望的消融轮廓，提供非常精确和可预测的长期视力矫正。为了得到仅具有三个自由度的椭球模型，产生非球面性QSEQ的球状当量（SEQ）值。球形等效偏心QSEQ值代替了另外传统的双锥形建模系统中的两个自由度（即偏心度），只剩下三（3）个变量来确定可能的角膜的最佳拟合椭圆模型，并将结果限于常规散光可以用光学柱塞校正。

6. 发明申请

WO0150945A3 LASER FLUENCE COMPENSATION OF A CURVED SURFACE 审中-公开
标题翻译：弯曲表面的激光柔性补偿
公开(公告)号：WO0150945A3
公开(公告)日：2002-01-24
申请号：PCT/US0100812
申请日：2001-01-11
申请人： LASERSIGHT TECH INC
发明人： KLIEWER MICHAEL L , SMITH MICHAEL J
IPC分类号： A61F9/008 , A61F9/01 , B23K26/073
CPC分类号： B23K26/073 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882
摘要： A laser system and techniques which compensate for laser fluence drop off or losses of irradiation as an ablating laser beam is traversed on a curved surface (10) (e.g., on corneal tissue). The disclosed ablating laser system and techniques compensated for fluence differentials from pulse-to-pulse by adjusting an appropriate parameter of a laser beam. In the preferred embodiment, the number of pulses imparted in the periphery, the size or shape of the ablating laser beam is adjusted with, e.g., a variable aperture (30) placed in the beam delivery path, by changing a magnification of relay optics (40) in the beam delivery path, or by increasing a number of ablation spots in peripheral portions of an ablation zone as compared with the number of ablation spots in a central portion of the ablation zone.
摘要翻译：激光系统和补偿激光能量密度的技术作为消融激光束的照射或损失在弯曲表面（10）（例如角膜组织）上穿过。所公开的烧蚀激光系统和技术通过调整激光束的适当参数来补偿从脉冲到脉冲的注量差。在优选实施例中，通过改变中继光学器件的放大倍数来调节在周边施加的脉冲数量，烧蚀激光束的尺寸或形状，例如，放置在光束传送路径中的可变孔径（30） 40），或者通过增加与消融区域的中心部分中的消融斑点的数量相比，消融区域的周边部分中的消融斑点的数量。

7. 发明申请

WO9934740A9 SMOOTH AND UNIFORM LASER ABLATION APPARATUS AND METHOD 审中-公开
标题翻译：平滑和均匀的激光消除装置和方法
公开(公告)号：WO9934740A9
公开(公告)日：2000-02-17
申请号：PCT/US9900119
申请日：1999-01-06
申请人： LASERSIGHT TECH INC
发明人： TANG FUQIAN
IPC分类号： A61F9/01 , A61B17/36
CPC分类号： A61F9/008 , A61F9/00802 , A61F2009/00872 , A61F2009/00897
摘要： The present invention is a laser beam delivery system, a method for smoothly and uniformly ablating tissue, e.g., for reshaping a cornea of an eye, even in the face of real-world conditions such as a moving eye. The method includes defining a plurality of scan lines (22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44) in an ablation zone (135) on the tissue and defining a plurality of laser beam ablation points (46, 49, 48) along each of the scan lines. An ablating laser beam is scanned along a series of non-adjacent scan lines (22, 26, 30, 34, 38, 42) of the plurality of scan lines and tissue is intermittently ablated at non-adjacent ones of the laser beam ablation points (46, 48) on each non-adjacent scan line. In another aspect of the invention, an ablation zone (135) is divided into a plurality of domains (70). An average depth of ablation in each of the domains (70) is determined. Tissue is ablated by controlling a number of ablating laser beam pulses in each domain (70) in proportion to the average depth of ablation in each domain (70).
摘要翻译：本发明是一种激光束传送系统，即使在诸如移动眼睛等现实世界的情况下，也可平滑地均匀地消除组织的方法，例如用于重塑眼睛的角膜。该方法包括在组织上的消融区域（135）中限定多个扫描线（22,24,26,28,30,32,34,36,38,40,42,44），并且限定多个激光沿着每条扫描线的光束消融点（46,49,48）。沿着多条扫描线的一系列不相邻的扫描线（22,26,30,34,38,42）扫描烧蚀的激光束，并且组织在不相邻的激光束消融点间断地消融（46,48）在每个不相邻的扫描线上。在本发明的另一方面，消融区域（135）被分成多个域（70）。确定每个结构域（70）中的平均消融深度。通过在每个区域（70）中控制与每个区域（70）中的平均消融深度成比例的每个区域（70）中的多个消融的激光束脉冲来消融组织。

8. 发明申请

WO03011175A3 TECHNIQUE FOR REMOVAL OF MATERIAL TO ACHIEVE A DESIRED SHAPE WITH A LASER 审中-公开
标题翻译：用激光去除材料以达到所需形状的技术
公开(公告)号：WO03011175A3
公开(公告)日：2003-07-31
申请号：PCT/US0224015
申请日：2002-07-30
申请人： LASERSIGHT TECH INC
发明人： SMITH MICHAEL J , MARROU LANCE R
IPC分类号： A61F9/01 , A61B18/20
CPC分类号： A61F9/008 , A61F9/00804 , A61F2009/00872 , A61F2009/00897
摘要： Methods are provided for material sculpting with a device which functions similar to a laser on human cornea or plastic that reduces surface roughness and computational overhead. These methods are based upon teaching of volumetric ablation based upon layer slices of the volume. The first method demonstrates how to apply the slice based sculpting to a regularly spaced sampling grid using stochastic perturbing from the grid points. The second method demonstrates how to apply a directly volumetric sculpting approach where a discrete estimate of the average beam size and shape is made and applied directly to the volume to ablate until all of the required volume is removed.
摘要翻译：提供了用于材料雕刻的方法，其具有类似于人角膜或塑料上的激光功能的装置，其减少表面粗糙度和计算开销。这些方法是基于基于体积的层切片的体积消融的教导。第一种方法演示了如何使用来自网格点的随机扰动将基于切片的雕刻应用于规则间隔的采样网格。第二种方法演示了如何应用直接体积雕刻方法，其中制作平均光束尺寸和形状的离散估计，并直接应用于体积以消除直到所有所需体积被去除。

9. 发明申请

WO02082980A9 STEREOSCOPIC MEASUREMENT OF CORNEA AND ILLUMINATION PATTERNS 审中-公开
标题翻译：脊柱和照明模式的立体测量
公开(公告)号：WO02082980A9
公开(公告)日：2003-01-30
申请号：PCT/US0211913
申请日：2002-04-16
申请人： LASERSIGHT TECH INC
发明人： LIU DAVID , SARVER EDWIN J , TROENDLE DALE
IPC分类号： A61B3/107 , A61B3/117 , A61B3/10
CPC分类号： A61B3/117 , A61B3/107 , A61B3/14
摘要： A stereoscopic eye measurement system and method for measurement of corneal characteristics, anterior chamber depth and lens characteristics in a single acquisition. The system and method use a stereoscopic camera configuration comprising center camera (102) and two side cameras (104) and (106) to capture the images of IR pupil, of the intersection of a structured illumination pattern provided by light sources (108) and (109) with the cornea (130) and lens (134), and of the Placido reflection off the cornea. The projection pattern may be a cross pattern, a dot array, a dot + cross pattern, or a starburst pattern. The system uses a large pupil in order to obtain images of the lens. The system uses different focal points to achieve the best images of corneal topography, corneal layering and lens surfaces and a combination of corneal topography, corneal layering, pupil and the lens.
摘要翻译：用于单次采集中角膜特征，前房深度和镜片特征的测量的立体眼测量系统和方法。该系统和方法使用包括中心相机（102）和两个侧面相机（104）和（106）的立体照相机配置，以捕获由光源（108）提供的结构化照明图案和（109）与角膜（130）和透镜（134）以及平角镜反射离开角膜。投影图案可以是交叉图案，点阵列，点+交叉图案或星爆图案。该系统使用大瞳孔以获得镜头的图像。该系统使用不同的焦点来获得角膜地形，角膜分层和镜片表面的最佳图像以及角膜地形，角膜层，瞳孔和透镜的组合。

10. 发明申请

WO02082980A2 STEREOSCOPIC MEASUREMENT OF CORNEA AND ILLUMINATION PATTERNS 审中-公开
标题翻译：脊柱和照明模式的立体测量
公开(公告)号：WO02082980A2
公开(公告)日：2002-10-24
申请号：PCT/US0211913
申请日：2002-04-16
申请人： LASERSIGHT TECH INC
发明人： LIU DAVID , SARVER EDWIN J , TROENDLE DALE
IPC分类号： A61B3/107 , A61B3/117 , A61B3/10
CPC分类号： A61B3/117 , A61B3/107 , A61B3/14
摘要： A stereoscopic eye measurement system and method for measurement of corneal characteristics, anterior chamber depth and lens characteristics in a single acquisition. The system and method use a stereoscopic camera configuration to capture the images of IR pupil, of the intersection of a structured illumination pattern with the cornea and lens , and of the Placido reflection off the cornea. The projection pattern may be a cross pattern, a dot array, a dot + cross pattern, or a starburst pattern. The system uses a large pupil in order to obtain images of the lens. The system uses different focal points to achieve the best images of corneal topography, corneal layering and lens surfaces and a combination of corneal topography, corneal layering, pupil and the lens.
摘要翻译：用于单次采集中角膜特征，前房深度和镜片特征的测量的立体眼测量系统和方法。该系统和方法使用立体摄像机配置来捕获IR光瞳的图像，结构化照明图案与角膜和晶状体的相交，以及角膜上的平片反射。投影图案可以是交叉图案，点阵列，点+交叉图案或星爆图案。该系统使用大瞳孔以获得镜头的图像。该系统使用不同的焦点来实现角膜地形，角膜分层和镜片表面的最佳图像以及角膜地形，角膜分层，瞳孔和透镜的组合。

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