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1. 发明申请

WO2009009718A1 METHODS OF IDENTIFYING MODULATORS OF ION CHANNELS 审中-公开
标题翻译：识别离子通道调节剂的方法
公开(公告)号：WO2009009718A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069752
申请日：2008-07-11
申请人： SRU BIOSYSTEMS, INC. , BINDER, Brant , LAING, Lance, G.
发明人： BINDER, Brant , LAING, Lance, G.
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/54373
摘要： The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
摘要翻译：本发明提供用于鉴定离子通道调节剂的方法，而不使用过表达离子通道蛋白的重组细胞系或检测标记的使用。

2. 发明申请

WO2007019024A2 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
标题翻译：基于GRATING的传感器组合无标签绑定检测和荧光放大和读取传感器系统
公开(公告)号：WO2007019024A2
公开(公告)日：2007-02-15
申请号：PCT/US2006028473
申请日：2006-07-20
申请人： SRU BIOSYSTEMS INC , SCHULZ STEPHEN C , CUNNINGHAM BRIAN T , LAING LANCE G , LI PETER Y , BINDER BRANT , JOGIKALMATH GANGADHAR , BORSODY ALEX
发明人： SCHULZ STEPHEN C , CUNNINGHAM BRIAN T , LAING LANCE G , LI PETER Y , BINDER BRANT , JOGIKALMATH GANGADHAR , BORSODY ALEX
IPC分类号： G01N21/55 , G01N21/64
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/7743 , Y10S435/808 , Y10S436/805 , Y10T436/143333
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label -free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。其它实施例针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。一个实施例包括优化用于收集无标记检测数据的第一光源，为收集ER荧光放大数据而优化的第二光源和至少一个检测器。在一个实施例中，检测器是成像系统，并且包括用于收集ER和无标签数据的CCD照相机。在其他实施例中，至少一个检测器采用用于收集无标签数据的光谱仪的形式和用于收集ER数据的光电倍增管。在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

3. 发明申请

WO2010075033A1 METHODS OF DETECTION OF CHANGES IN CELLS 审中-公开
标题翻译：检测细胞变化的方法
公开(公告)号：WO2010075033A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/067880
申请日：2009-12-14
申请人： SRU BIOSYSTEMS, INC. , WAGNER, Rick , FERNANDEZ, Rafael , CUNNINGHAM, Brian, T. , LAING, Lance
发明人： WAGNER, Rick , FERNANDEZ, Rafael , CUNNINGHAM, Brian, T. , LAING, Lance
IPC分类号： G01N33/543
CPC分类号： G01N21/63 , C40B30/04 , C40B30/10 , G01N21/4788 , G01N21/7743 , G01N33/54373
摘要： Methods are provided to detect changes in cells without the use of detection labels In one embodiment, detection of responses of cells to stimuli comprises immobilizing one or more extracellular matrix ligands to a surface of a coloπmetric resonant reflectance biosensor or a grating-based waveguide biosensor, and adding the cells having cell surface receptors specific for the one or more extracellular matrix ligands to the biosensor Changes in cells are then detected by the biosensor before and after introduction of stimuli to the biosensor.
摘要翻译：提供了用于检测细胞中的变化而不使用检测标记的方法。在一个实施方案中，细胞对刺激物的响应的检测包括将一个或多个细胞外基质配体固定在电化学共振反射生物传感器或基于光栅的波导生物传感器的表面上，并将具有一种或多种细胞外基质配体特异性的细胞表面受体的细胞加入到生物传感器中。然后在生物传感器引入刺激之前和之后，通过生物传感器检测细胞的变化。

4. 发明申请

WO2010005600A1 METHODS FOR IDENTIFYING MODULATORS OF ION CHANNELS 审中-公开
标题翻译：识别离子通道调节剂的方法
公开(公告)号：WO2010005600A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/030412
申请日：2009-01-08
申请人： SRU BIOSYSTEMS, INC. , LAING, Lance G. , WAGNER, Rick , FERNANDEZ, Rafael , YUZAKOV, Alexander
发明人： LAING, Lance G. , WAGNER, Rick , FERNANDEZ, Rafael , YUZAKOV, Alexander
IPC分类号： A61B6/00
CPC分类号： G01N33/56988 , G01N33/6872 , G01N2500/00
摘要： The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
摘要翻译：本发明提供用于鉴定离子通道调节剂的方法，而不使用过表达离子通道蛋白的重组细胞系或检测标记的使用。

5. 发明申请

WO2006127167A2 PROTEOLIPID MEMBRANE & LIPID MEMBRANE BIOSENSOR 审中-公开
标题翻译： PROTEOLIPID膜和脂膜生物传感器
公开(公告)号：WO2006127167A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/013926
申请日：2006-04-12
申请人： SRU BIOSYSTEMS, INC. , BAIRD, Cheryl, L. , WANG, Guo, Bin , LAING, Lance , JOGIKALMATH, Gangadhar , GERSTENMAIER, John
发明人： BAIRD, Cheryl, L. , WANG, Guo, Bin , LAING, Lance , JOGIKALMATH, Gangadhar , GERSTENMAIER, John
CPC分类号： G01N33/5432 , G01N33/54373 , G01N33/551 , G01N33/92
摘要： The invention provides compositions and methods for detection of interaction of molecules.
摘要翻译：本发明提供了用于检测分子相互作用的组合物和方法。

6. 发明申请

WO2010132890A9 DETECTION OF CHANGES IN CELL POPULATIONS AND MIXED CELL POPULATIONS 审中-公开
标题翻译：检测细胞群体和混合细胞群体的变化
公开(公告)号：WO2010132890A9
公开(公告)日：2011-03-24
申请号：PCT/US2010035152
申请日：2010-05-17
申请人： SRU BIOSYSTEMS INC , SHAMAH STEVEN , LAING LANCE G , YUZHAKOV ALEXANDER , WAGNER RICK , ABODEELY MARLA , ROCKNEY BENNET , SCHULZ STEPHEN C , PADALIA ZINKAL , GETMAN MICHAEL , SANDBERG ERIC
发明人： SHAMAH STEVEN , LAING LANCE G , YUZHAKOV ALEXANDER , WAGNER RICK , ABODEELY MARLA , ROCKNEY BENNET , SCHULZ STEPHEN C , PADALIA ZINKAL , GETMAN MICHAEL , SANDBERG ERIC
IPC分类号： G01N33/543 , G01N33/50 , G01N33/566
CPC分类号： G01N33/54373 , G01N21/7743 , G01N33/5044 , G01N33/5064 , G01N33/5073
摘要： The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
摘要翻译：本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。

7. 发明申请

WO2008060347A1 SIMULTANEOUS ASPIRATOR AND DISPENSER FOR MULTIWELL PLATES AND SIMILAR DEVICES 审中-公开
标题翻译：同时用于多层板和类似设备的辅助器和分配器
公开(公告)号：WO2008060347A1
公开(公告)日：2008-05-22
申请号：PCT/US2007/019566
申请日：2007-09-07
申请人： SRU BIOSYSTEMS, INC. , LAING, Lance, G. , SMITH, Timothy, F. , GERSTENMAIER, John , JOGIKALMATH, Gangadhar
发明人： LAING, Lance, G. , SMITH, Timothy, F. , GERSTENMAIER, John , JOGIKALMATH, Gangadhar
IPC分类号： G01N35/00
CPC分类号： G01N35/1074 , G01N35/1011
摘要： A device for simultaneously dispensing a solution containing a sample to a test device and aspirating the sample from the device. In one embodiment the device is hand-held and includes a control mechanism, e.g., button for activating the dispensing and aspiration of the sample. The testing device may take the form of a multi-well plate with a plurality of wells arranged in rows and columns, with the bottom of the wells formed as a photonic crystal biosensor.. The device can be configured with dispense and aspirate manifolds and associated dispense and aspirate ports which are positioned in all the wells along a row or column of wells so as to simultaneously aspirate and dispense solution to all the wells in a row or column of the multi-well plate.
摘要翻译：一种用于将含有样品的溶液同时分配到测试装置并从该装置抽吸样品的装置。在一个实施例中，该装置是手持式的并且包括控制机构，例如用于激活样品的分配和抽吸的按钮。测试装置可以采用具有排列成行和列的多个孔的多孔板的形式，阱的底部形成为光子晶体生物传感器。该装置可以配置有分配和抽吸歧管并且相关联分配和抽吸位于沿着一列或多列井的所有井中的端口，以便同时吸取并分配溶液到多孔板的一列或多列中的所有孔。

8. 发明申请

WO2006085958A2 INTEGRATION OF DIRECT BINDING SENSORS WITH MASS SPECTROMETRY FOR FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF MOLECULES 审中-公开
标题翻译：直接结合传感器与质谱联用分子功能和结构表征
公开(公告)号：WO2006085958A2
公开(公告)日：2006-08-17
申请号：PCT/US2005/022719
申请日：2005-06-28
申请人： SRU BIOSYSTEMS, INC. , LI, Peter , LIN, Bo , WILLIAMS, Chris , LAING, Lance
发明人： LI, Peter , LIN, Bo , WILLIAMS, Chris , LAING, Lance
IPC分类号： G01N21/27 , G01N33/487 , G01N33/543
CPC分类号： G01N33/6848 , G01N21/27 , G01N33/542 , G01N33/543 , G01N33/54373
摘要： The invention provides methods for the detection, quantification, identification and structural analysis of one or more molecules. Mass spectrometry (MS) is not a universal detector as all molecules do not ionize equally well leading to poor signal to quantity information. MS can be optimized to identify the specific mass of a binding component when the presence of a material is known. Colorimetric resonant reflectance optical sensors provide a universal mass detector in that nearly all biological masses give equally proportional signals. The combined methods allow selection and or detection with quantification of all masses binding to the sensor with the ability to identify specific molecules by their individual masses and structure analyses.
摘要翻译：本发明提供了用于一种或多种分子的检测，定量，鉴定和结构分析的方法。质谱（MS）不是一种通用的检测器，因为所有分子都不能很好地电离，导致信号量差的信息。当材料的存在已知时，MS可以被优化以识别结合成分的特定质量。比色共振反射光学传感器提供了一个通用质量检测器，几乎所有的生物质量都可以提供同等比例的信号。这些组合方法允许选择和检测所有与传感器结合的质量，并能够通过各自的质量和结构分析来识别特定分子。

9. 发明申请

WO2010132890A1 DETECTION OF CHANGES IN CELL POPULATIONS AND MIXED CELL POPULATIONS 审中-公开
标题翻译：检测细胞群体和混合细胞群体的变化
公开(公告)号：WO2010132890A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/035152
申请日：2010-05-17
申请人： SRU BIOSYSTEMS, INC , SHAMAH, Steven , LAING, Lance, G. , YUZHAKOV, Alexander , WAGNER, Rick , ABODEELY, Marla , ROCKNEY, Bennet , SCHULZ, Stephen, C. , PADALIA, Zinkal , GETMAN, Michael , SANDBERG, Eric
发明人： SHAMAH, Steven , LAING, Lance, G. , YUZHAKOV, Alexander , WAGNER, Rick , ABODEELY, Marla , ROCKNEY, Bennet , SCHULZ, Stephen, C. , PADALIA, Zinkal , GETMAN, Michael , SANDBERG, Eric
IPC分类号： G01N33/543 , G01N33/566 , G01N33/50
CPC分类号： G01N33/54373 , G01N21/7743 , G01N33/5044 , G01N33/5064 , G01N33/5073
摘要： The invention provides methods of label-free detection of changes in cell populations and mixed cell populations.
摘要翻译：本发明提供了无标记检测细胞群体和混合细胞群体变化的方法。

10. 发明申请

WO2010090640A1 HIGH-DENSITY POLYMER SURFACE COATING TO IMMOBILISE CHEMICAL OR BIOLOGICAL MOLECULES 审中-公开
标题翻译：高密度聚合物表面涂层化学或生物分子
公开(公告)号：WO2010090640A1
公开(公告)日：2010-08-12
申请号：PCT/US2009/033266
申请日：2009-02-05
申请人： SRU BIOSYSTEMS, INC. , WANG, Guobin, Frank , LAING, Lance
发明人： WANG, Guobin, Frank , LAING, Lance
IPC分类号： C09D133/02 , C09D133/14 , C09D161/00 , C09D161/20 , C09D139/02
CPC分类号： C09D133/02 , C08F220/06 , C09D139/02
摘要： A method for providing high-density polymer surface for attaching proteins or peptides, and binding proteins, peptides, DNAs, cells, small molecules, and other chemical or biological molecules that are of interests in the areas of proteomic, genomic, pharmaceutical, drug discovery, and diagnostic studies.
摘要翻译：提供用于附着蛋白质或肽的高密度聚合物表面和结合蛋白质，肽，DNA，细胞，小分子以及在蛋白质组学，基因组学，药物学和药物发现领域有兴趣的其它化学或生物分子的方法和诊断研究。

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