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1. 发明申请

WO2019173238A1 SYSTEM AND METHOD FOR EXTRACTING A TARGET MOIETY FROM A SAMPLE USING ACOUSTIC DROPLET EJECTION 审中-公开
公开(公告)号：WO2019173238A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020596
申请日：2019-03-04
申请人： LABCYTE, INC.
发明人： OLECHNO, Joseph D. , ELLSON, Richard N.
IPC分类号： C12N15/10 , G01N1/40 , G01N35/10
摘要： A method and system are provided for extracting a target analyte from a sample using acoustic ejection technology. The method involves applying focused acoustic energy to a fluid reservoir housing a fluid composition that contains a target analyte and comprises an upper region and a lower region, where the concentration of the target analyte in the upper region differs from that in the lower region. The focused acoustic energy is applied in a manner that is effective to result in the ejection of a fluid droplet from from the fluid composition into a droplet receiver, wherein the concentration of the analyte in the droplet corresponds to either the concentration of the analyte in the upper region or the concentration of the analyte in the lower region, and wherein the concentration of the analyte is substantially uniform throughout the droplet. The fluid composition may comprise an ionic liquid, used in the extraction of ionic target analytes. Related methods and an acoustic extraction system are also provided.

2. 发明申请

WO2015108807A9 SAMPLE CONTAINERS WITH IDENTIFICATION MARK 审中-公开
标题翻译：具有识别标志的样品容器
公开(公告)号：WO2015108807A9
公开(公告)日：2016-06-09
申请号：PCT/US2015010980
申请日：2015-01-12
申请人： LABCYTE INC
发明人： MAJLOF LARS , ELLSON RICHARD N
IPC分类号： B01L3/00 , G01N35/00 , G06K19/00 , G09F7/16
CPC分类号： B01L3/50 , B01L3/54 , B01L3/5453 , B01L2300/021 , G01N2035/00752 , G06K19/06028 , G06K19/06037 , G09F7/165
摘要： A container may include a tubular sidewall defining interior and exterior surfaces of the container, and including first and second regions disposed relative to one another along a major axis of the tubular sidewall. An identification mark may be embedded within the tubular sidewall at sectors about the tubular sidewall within the first region. Each sector may have a width, and the identification mark is machine readable by a reader viewing any arbitrary one or more of the sectors. Also provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.
摘要翻译：容器可以包括限定容器的内部和外部表面的管状侧壁，并且包括沿着管状侧壁的长轴线相对于彼此设置的第一和第二区域。识别标记可以在管状侧壁内围绕第一区域内的管状侧壁的扇区嵌入。每个扇区可以具有宽度，并且识别标记由阅读器观看任意一个或多个扇区的机器可读取。本文还提供了通常为管状容器，优选地包括限定在其中的多个储存器。容器可以适于声音喷射设置在多个储存器的至少一个储存器中的流体。或者，容器可以适于使用非声学液体处理方法来提取设置在多个储存器的至少一个储存器内的流体。

3. 发明申请

WO2019191587A3 FLUID IMPERMEABLE ULTRASONIC TRANSDUCER 审中-公开
公开(公告)号：WO2019191587A3
公开(公告)日：2019-10-03
申请号：PCT/US2019/024837
申请日：2019-03-29
申请人： LABCYTE INC.
发明人： HADIMIOGLU, Babur , DAULTON, Jay , ELLSON, Richard N.
IPC分类号： B06B1/06 , G10K11/30 , G10K11/02
摘要： A fluid impermeable transducer includes an assembly of a transducer head and a casing, and an actuator disposed in the casing rearward of the back of the transducer head and operable to transmit acoustic energy through the transducer head. The transducer head and casing define a working portion of the transducer that is fluid impermeable.

4. 发明申请

WO2015108807A1 SAMPLE CONTAINERS WITH IDENTIFICATION MARK 审中-公开
标题翻译：具有识别标志的样品容器
公开(公告)号：WO2015108807A1
公开(公告)日：2015-07-23
申请号：PCT/US2015/010980
申请日：2015-01-12
申请人： LABCYTE, INC.
发明人： MAJLOF, Lars , ELLSON, Richard, N.
IPC分类号： B01L3/00 , G06K19/00 , G09F7/16 , G01N35/00
CPC分类号： B01L3/50 , B01L3/54 , B01L3/5453 , B01L2300/021 , G01N2035/00752 , G06K19/06028 , G06K19/06037 , G09F7/165
摘要： A container may include a tubular sidewall defining interior and exterior surfaces of the container, and including first and second regions disposed relative to one another along a major axis of the tubular sidewall. An identification mark may be embedded within the tubular sidewall at sectors about the tubular sidewall within the first region. Each sector may have a width, and the identification mark is machine readable by a reader viewing any arbitrary one or more of the sectors. Also provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.
摘要翻译：容器可以包括限定容器的内部和外部表面的管状侧壁，并且包括沿着管状侧壁的长轴线相对于彼此设置的第一和第二区域。识别标记可以在管状侧壁内围绕第一区域内的管状侧壁的扇区嵌入。每个扇区可以具有宽度，并且识别标记由阅读器观看任意一个或多个扇区的机器可读取。本文还提供了通常为管状容器，优选地包括限定在其中的多个储存器。容器可以适于声音喷射设置在多个储存器的至少一个储存器中的流体。或者，容器可以适于使用非声学液体处理方法来提取设置在多个储存器的至少一个储存器内的流体。

5. 发明申请

WO2011094310A2 FOCUS-ACTIVATED ACOUSTIC EJECTION 审中-公开
标题翻译：焦点激发声音喷射
公开(公告)号：WO2011094310A2
公开(公告)日：2011-08-04
申请号：PCT/US2011/022576
申请日：2011-01-26
申请人： LABCYTE INC. , ELLSON, Richard, N.
发明人： ELLSON, Richard, N.
IPC分类号： B41J2/135
CPC分类号： B01L3/56 , B41J2/04536 , B41J2/04575 , B41J2/04596
摘要： To ejecting a droplet from a reservoir, the reservoir holding a fluid is moved with respect to an acoustic ejector. As the reservoir and ejector move closer together, the acoustic ejector sends one or more interrogation pulses towards the reservoir. Based on the interrogation pulses, the system determines when the movement of the reservoir has placed a free surface of the fluid in a position where a droplet can be ejected.
摘要翻译：为了从储存器喷射液滴，保持流体的储存器相对于声学喷射器移动。当储存器和喷射器靠近在一起时，声学喷射器向贮存器发送一个或多个询问脉冲。基于询问脉冲，系统确定储存器的运动何时将流体的自由表面放置在可以喷射液滴的位置。

6. 发明申请

WO2020092407A1 ACOUSTIC DROPLET EJECTION OF NON-NEWTONIAN FLUIDS 审中-公开
公开(公告)号：WO2020092407A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058620
申请日：2019-10-29
申请人： LABCYTE INC.
发明人： DATWANI, Sammy S. , RICHE, Carson T. , BLAUWKAMP, Marsha N. , BLONIGAN, Justin
IPC分类号： B01L3/02 , B41J2/01
摘要： Methods of ejecting droplets containing a non-Newtonian fluid by an acoustic droplet ejector can include applying a tone burst of focused acoustic energy to a fluid reservoir containing a non-Newtonian fluid at sufficient amplitude to effect droplet ejection according to a tone burst pattern. The tone burst pattern may include three discrete tone burst segments, the first tone burst segment having greater duration than the second and third segments, and third segment having greater duration than the second segment. The exact durations and amplitudes of the tone burst segments can be tuned to influence the ejection properties.

7. 发明申请

WO2019104235A1 SYSTEM AND METHOD FOR THE ACOUSTIC LOADING OF AN ANALYTICAL INSTRUMENT USING A CONTINUOUS FLOW SAMPLING PROBE 审中-公开
公开(公告)号：WO2019104235A1
公开(公告)日：2019-05-31
申请号：PCT/US2018/062337
申请日：2018-11-21
申请人： LABCYTE, INC. , DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： DATWANI, Sammy , ARNOLD, Donald W. , GHISLAIN, Lucien P. , LIU, Chang , COVEY, Thomas
IPC分类号： G01N29/14 , G01N35/10
CPC分类号： H01J49/0454 , B01L3/0268 , B01L2400/0439 , H01J49/0031 , H01J49/0404 , H01J49/165
摘要： A system and method are provided for loading a sample into an analytical instrument using acoustic droplet ejection ("ADE") in combination with a continuous flow sampling probe. An acoustic droplet ejector is used to eject small droplets of a fluid sample containing an analyte into the sampling tip of a continuous flow sampling probe, where the acoustically ejected droplet combines with a continuous, circulating flow stream of solvent within the flow probe. Fluid circulation within the probe transports the sample through a sample transport capillary to an outlet that directs the analyte away from the probe to an analytical instrument, e.g., a device that detects the presence, concentration quantity, and/or identity of the analyte. When the analytical instrument is a mass spectrometer or other type of device requiring the analyte to be in ionized form, the exiting droplets pass through an ionization region, e.g., an electrospray ion source, prior to entering the mass spectrometer or other analytical instrument. The method employs active flow control and enables real-time kinetic measurements.

8. 发明申请

WO2018053350A9 HIGH-EFFICIENCY TRANSFECTION OF BIOLOGICAL CELLS USING SONOPORATION 审中-公开
公开(公告)号：WO2018053350A9
公开(公告)日：2018-03-22
申请号：PCT/US2017/051909
申请日：2017-09-15
申请人： LABCYTE INC.
发明人： HARDEE, Jennifer M. , ELLSON, Richard N. , STEARNS, Richard G. , HADIMIOGLU, Babur , OLECHNO, Joseph D. , BLAUWKAMP, Marsha N.
IPC分类号： C12N15/87
摘要： A method is provided for achieving transfection of host cells using sonoporation. An acoustic radiation generator is positioned in acoustic coupling relationship with respect to a reservoir containing host cells to be transfected, exogenous material to be incorporated into the host cells, and a cell-compatible fluid medium. The acoustic radiation generator is activated to generate acoustic radiation and direct the acoustic radiation into the reservoir in a manner effective to enable transfection of the host cells with the exogenous material.

9. 发明申请

WO2006099122A1 FLUID CONTAINERS WITH RESERVOIRS IN THEIR CLOSURES AND METHODS OF USE 审中-公开
标题翻译：流体容器在其封闭物中的储存和使用方法
公开(公告)号：WO2006099122A1
公开(公告)日：2006-09-21
申请号：PCT/US2006/008572
申请日：2006-03-10
申请人： LABCYTE INC. , ELLSON, Richard, N. , MILLER, Michael, F. , BRAMWELL, Arlen, Mark
发明人： ELLSON, Richard, N. , MILLER, Michael, F. , BRAMWELL, Arlen, Mark
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L2200/142 , B01L2300/041 , B01L2300/042 , B01L2300/047 , B01L2300/0829 , B01L2300/10
摘要： Fluid containers are disclosed which have fluid reservoirs in their closures. These reservoirs are advantageous to hold sacrificial fluid which lessens the loss of the fluid of interest to the outside through evaporation. The reservoirs may have openings to the inside or outside of the container, or to both. Reservoirs with openings to the outside serve to reduce evaporative loss by raising the partial pressure of fluid in the vicinity of the contact between the closure and the remainder of the container. The reservoirs may be refÊllable without opening the container. In one embodiment a fluid reservoir allows the zone of contact between the closure and the remainder of the container to be immersed in fluid, so that gases seeking to escape the interior of the container must pass through fluid. In a further embodiment a closure for a container comprises at least two closure members. The relative position of the closure members with respect to each other is altered upon mating of the closure and container. The alteration of the relative position of the closure members may result in one or more of the members approaching the container more closely. The alteration may result in one or more of the members pressing against the container.
摘要翻译：公开了在其封闭件中具有流体储存器的流体容器。这些储存器有利于保持牺牲流体，其通过蒸发减少感兴趣的流体的损失。储存器可以具有到容器的内部或外部的开口，或者具有到两者的开口。具有向外部开口的容器用于通过提高封闭件和容器的其余部分之间的接触附近的流体的分压来减少蒸发损失。储存器可以在不打开容器的情况下被重新装入。在一个实施例中，流体储存器允许封闭件和容器的其余部分之间的接触区浸没在流体中，使得试图逃离容器内部的气体必须通过流体。在另一实施例中，用于容器的封闭件包括至少两个闭合构件。封闭件相对于彼此的相对位置在封盖和容器配合时被改变。关闭构件的相对位置的改变可能导致一个或多个构件更接近容器。改变可能导致一个或多个构件压靠容器。

10. 发明申请

WO2022183045A1 SYSTEMS AND METHODS FOR CHARGED DROPLET DETECTION AND CONTROL 审中-公开
公开(公告)号：WO2022183045A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/017988
申请日：2022-02-25
申请人： LABCYTE INC.
发明人： GHISLAIN, Lucien P. , SAGUN, Wilfredo T. , CHOE, Eunchul , STEARNS, Richard G.
IPC分类号： G01N15/14 , B01L3/02
摘要： System and methods are described herein for detecting positions or trajectories and/or controlling directions of charged droplets during travel. The systems and methods are useful for determining the locations of the charged droplets in real-time based on signals induced in the electrodes of a sensor surrounding an aperture through which the charged droplet passes in flight from the source well to the target. The signals from the sensor electrodes can be measured and used to determine a position or trajectory of the droplet. The systems and methods are useful for modifying trajectories of the charged droplets in real-time, such as based on determined positions identified as having a trajectory deviating from the target. The trajectories can be modified by applying voltages to electrodes surrounding an aperture through which the charged droplet passes in flight from the source well to the target.

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