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1. 发明申请

WO2015156768A1 ACOUSTICALLY COUPLED TRANSMITTER FOR DOWNHOLE TELEMETRY 审中-公开
标题翻译：用于井下电报的主动联轴器
公开(公告)号：WO2015156768A1
公开(公告)日：2015-10-15
申请号：PCT/US2014/033217
申请日：2014-04-07
申请人： KYLE, Donald , FRIPP, Michael Linley , WERKHEISER, Gregory Thomas
发明人： KYLE, Donald , FRIPP, Michael Linley , WERKHEISER, Gregory Thomas
IPC分类号： E21B47/16 , G01V1/40
CPC分类号： E21B47/16 , G01V1/40 , G01V1/46 , G01V1/48 , G08C19/22 , H04L41/083
摘要： An in-well type acoustic telemetry system includes an elongate tubular housing, an elongate transmitter in the tubular housing, a receiver in the tubular housing, and a spring between the transmitter and the housing biasing the transmitter into acoustic coupling to the housing. The transmitter is adapted to generate an output acoustic signal by linearly fluctuating in response to an electrical signal. The receiver is adapted to generate another electrical signal by linearly fluctuating in response to an input acoustic signal.
摘要翻译：井内型声学遥测系统包括细长管状壳体，管状壳体中的细长变送器，管状壳体中的接收器，以及在发射器和壳体之间的弹簧，其将发射器偏置到与壳体的声耦合。发射机适于通过响应于电信号的线性波动来产生输出声信号。接收器适于通过响应于输入声信号的线性波动而产生另一电信号。

2. 发明申请

WO2014150226A1 GENETIC LOCI ASSOCIATED WITH FROGEYE LEAF SPOT RESISTANCE AND BROWN STEM ROT RESISTANCE AND METHODS OF USE 审中-公开
标题翻译：遗传位置与FROGEYE LEAF SPOT RESISTANCE和BROWN STEM ROT RESISTANCE和使用方法相关
公开(公告)号：WO2014150226A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/022631
申请日：2014-03-10
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , FABRIZIUS, Martin A. , HAN, Feng , KYLE, Donald , SHENDELMAN, Joshua M. , SPEAR, Jordan D. , STEPHENS, Paul A. , XIA, Yun
发明人： FABRIZIUS, Martin A. , HAN, Feng , KYLE, Donald , SHENDELMAN, Joshua M. , SPEAR, Jordan D. , STEPHENS, Paul A. , XIA, Yun
IPC分类号： C12Q1/68 , C12N15/29
CPC分类号： C12Q1/6895 , A01H1/04 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172
摘要： Various methods and compositions are provided for identifying and/or selecting soybean plants or soybean germplasm with improved resistance to Frogeye Leaf Spot and/or Brown Stem Rot. In certain embodiments, the method comprises detecting at least one marker locus that is associated with resistance to Frogeye Leaf Spot and/or Brown Stem Rot. In other embodiments, the method further comprises detecting at least one marker profile or haplotype associated with resistance to Frogeye Leaf Spot and/or Brown Stem Rot. In further embodiments, the method comprises crossing a selected soybean plant with a second soybean plant. Further provided are markers, primers, probes and kits useful for identifying and/or selecting soybean plants or soybean germplasm with improved resistance to Frogeye Leaf Spot and/or Brown Stem Rot.
摘要翻译：提供了用于鉴定和/或选择大豆植物或大豆种质的各种方法和组合物，其具有对Frogeye Leaf Spot和/或Brown Stem Rot具有改善的抗性。在某些实施方案中，该方法包括检测与对Frogeye Leaf Spot和/或Brown Stem Rot的抗性相关的至少一个标记基因座。在其它实施方案中，该方法还包括检测与对Frogeye Leaf Spot和/或Brown Stem Rot的抗性相关联的至少一种标记谱或单元型。在另外的实施方案中，该方法包括使选定的大豆植物与第二大豆植物杂交。还提供了可用于鉴定和/或选择大豆植物或大豆种质的标记，引物，探针和试剂盒，其具有改善的对Frogeye Leaf Spot和/或Brown Stem Rot的抗性。

3. 发明申请

WO2012023033A3 MCH-I RESTRICTED EPITOPES CONTAINING NON-NATURAL AMINO ACID RESIDUES 审中-公开
标题翻译：含有非天然氨基酸残基的MCH-I限制性外显子
公开(公告)号：WO2012023033A3
公开(公告)日：2012-09-07
申请号：PCT/IB2011001909
申请日：2011-08-18
申请人： PURDUE PHARMA LP , KYLE DONALD J , SOLTIS DANIEL A , TUSSEY LYNDA G
发明人： KYLE DONALD J , SOLTIS DANIEL A , TUSSEY LYNDA G
IPC分类号： C12N9/12 , A61K39/00 , A61P31/00 , A61P35/00 , C07K14/47 , C12N9/02 , G01N33/50 , G01N33/68
CPC分类号： A61K39/0005 , A61K39/00 , C07K7/06 , C07K14/4747 , C07K14/4748 , C12N9/0077 , C12N9/1241 , G01N33/505 , G01N33/6878 , G01N2333/70539 , G01N2500/04 , G01N2500/10
摘要： The invention provides for the synthesis of more effective generators of a T-cell immune response by providing peptide derivatives that are MHC class I -restricted antigens. The peptide derivatives of the present invention are prepared or derived from a parent peptide of 8 to 11 amino acid residues in length, wherein the peptide derivative contains a non- natural amino acid substituted in place of a naturally- occurring amino acid residue at one or more primary anchor positions in the parent peptide or at position 6, position 7, or the C- terminus. The exemplary polypeptides are derived from the survivin, hTERT, CYP1B1 and MART - 1 antigens.
摘要翻译：本发明提供通过提供作为MHC I类受限抗原的肽衍生物合成更有效的T细胞免疫应答发生剂。本发明的肽衍生物制备或衍生自长度为8至11个氨基酸残基的母体肽，其中肽衍生物含有取代的非天然氨基酸代替天然存在的氨基酸残基在一个或多个在母体肽中或在位置6，位置7或C-末端具有更多的主要锚定位置。示例性多肽衍生自存活蛋白，hTERT，CYP1B1和MART-1抗原。

4. 发明申请

WO2012038813A1 BUPRENORPHINE ANALOGS 审中-公开
标题翻译：保护素类似物
公开(公告)号：WO2012038813A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/002208
申请日：2011-09-20
申请人： PURDUE PHARMA L.P. , KYLE, Donald, J. , TAFESSE, Laykea
发明人： KYLE, Donald, J. , TAFESSE, Laykea
IPC分类号： C07D489/12 , A61K31/485 , A61P25/04
CPC分类号： C07D489/12
摘要： The present invention is directed to Buprenorphine Analog compounds of the Formula (I), Formula (IA) or Formula (IB) shown below, wherein R 1 , R 2 , R 8 , R 3a , R 3 b , G, X, Z and Y are as defined herein. Compounds of the Invention are useful for treating pain, constipation, and other conditions modulated by activity of opioid and ORL-1 receptors.
摘要翻译：本发明涉及如下所示的式（I），式（IA）或式（IB）的丁丙诺啡类似物化合物，其中R 1，R 2，R 8，R 3a，R 3b，G，X，Z和Y为本文定义。本发明的化合物可用于治疗由阿片样物质和ORL-1受体的活性调节的疼痛，便秘和其它状况。

5. 发明申请

WO2011158108A2 ARYL SUBSTITUTED INDOLES AND THE USE THEREOF 审中-公开
标题翻译： ARYL取代的吲哚及其用途
公开(公告)号：WO2011158108A2
公开(公告)日：2011-12-22
申请号：PCT/IB2011/001382
申请日：2011-06-16
申请人： PURDUE PHARMA L.P. , KYLE, Donald, J. , NI, Chiyou , TAFESSE, Laykea , YAO, Jiangchao
发明人： KYLE, Donald, J. , NI, Chiyou , TAFESSE, Laykea , YAO, Jiangchao
CPC分类号： C07D209/20 , C07B59/002 , C07B2200/05 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D231/56 , C07D401/12 , C07D413/06 , C07D471/04 , G01N33/5008
摘要： The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R 1 , and Z 1 -Z 5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译：本发明涉及式（I）的芳基和杂芳基取代的化合物及其药学上可接受的盐，前药或溶剂化物，其中G，R1和Z1-Z5如说明书所述定义。本发明还涉及式（I）化合物用于治疗对钠通道阻断作出反应的病症。本发明的化合物特别适用于治疗疼痛。

6. 发明申请

WO2011094205A1 HPPD-INHIBITOR HERBICIDE TOLERANCE 审中-公开
标题翻译： HPPD-抑制剂除草剂耐量
公开(公告)号：WO2011094205A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022395
申请日：2011-01-25
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , BOGNER, Mark , CHAKY, Julian , KLAIBER, Jennifer, A. , KYLE, Donald , VOGT, Mark D.
发明人： BOGNER, Mark , CHAKY, Julian , KLAIBER, Jennifer, A. , KYLE, Donald , VOGT, Mark D.
IPC分类号： C12Q1/68 , A01H5/00 , C12N15/11
CPC分类号： C12N15/8274 , C07K14/415 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172
摘要： This invention relates generally to the detection of genetic differences among soybeans. More particularly, the invention relates to soybean quantitative trait loci (QTL) for tolerance or sensitivity to HPPD-inhibitor herbicides, such as mesotrione and isoxazole herbicides, to soybean plants possessing these QTLs, which map to a novel chromosomal region, and to genetic markers that are indicative of phenotypes associated with tolerance, improved tolerance, susceptibility, or increased susceptibility. Methods and compositions for use of these markers in genotyping of soybean and selection are also disclosed, as are methods and compositions for use of these markers in selection and use of herbicides for weed control. Also disclosed are isolated polynucleotides and polypeptides relating to such tolerance or sensitivity and methods of introgressing such tolerance into a plant by breeding or transgenically or by a combination thereof. Plant cells, plants, and seeds produced are also provided.
摘要翻译：本发明一般涉及大豆遗传差异的检测。更具体地说，本发明涉及对具有这些QTL的大豆植物（其映射到新的染色体区域）以及遗传标记对HPPD抑制剂除草剂如甲基磺草酮和异恶唑除草剂的耐受性或敏感性的大豆数量性状位点（QTL）指示与耐受性相关的表型，改善的耐受性，易感性或增加的易感性。还公开了使用这些标记物进行大豆基因分型和选择的方法和组合物，以及这些标记物用于选择和使用除草剂进行杂草控制的方法和组合物。还公开了与这种耐受性或敏感性相关的分离的多核苷酸和多肽以及通过育种或转基因或通过其组合向植物中渗入这种耐受性的方法。还提供了生产的植物细胞，植物和种子。

7. 发明申请

WO2011087721A1 WELL TOOLS OPERABLE VIA THERMAL EXPANSION RESULTING FROM REACTIVE MATERIALS 审中-公开
标题翻译：良好的工具可能通过从反应材料结果热膨胀
公开(公告)号：WO2011087721A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/061047
申请日：2010-12-17
申请人： HALLIBURTON ENERGY SERVICES, INC. , WRIGHT, Adam , FRIPP, Michael, L. , KYLE, Donald, G. , IRANI, Cyrus, A.
发明人： WRIGHT, Adam , FRIPP, Michael, L. , KYLE, Donald, G. , IRANI, Cyrus, A.
IPC分类号： E21B7/14
CPC分类号： E21B36/008 , E21B23/04 , E21B47/011 , E21B47/06 , E21B49/081
摘要： Methods of actuating a well tool can include releasing chemical energy from at least one portion of a reactive material, thermally expanding a substance in response to the released chemical energy, and applying pressure to a piston as a result of thermally expanding the substance, thereby actuating the well tool, with these steps being repeated for each of multiple actuations of the well tool. A well tool actuator can include a substance contained in a chamber, one or more portions of a reactive material from which chemical energy is released, and a piston to which pressure is applied due to thermal expansion of the substance in response to each release of chemical energy. A well tool actuator which can be actuated multiple times may include multiple portions of a gas generating reactive material, and a piston to which pressure is applied due to generation of the gas.
摘要翻译：致动井工具的方法可以包括从反应性材料的至少一部分释放化学能，响应于释放的化学能热膨胀物质，以及由于热膨胀物质而向活塞施加压力，从而致动井工具，对于井工具的多个致动中的每一个都重复这些步骤。良好的工具致动器可以包括容纳在腔室中的物质，释放化学能的反应性材料的一个或多个部分以及由于物质的热膨胀而响应于每次化学物质释放施加压力的活塞能源。可以多次启动的井工具致动器可以包括气体产生反应性材料的多个部分，以及由于产生气体而施加压力的活塞。

8. 发明申请

WO2010117724A3 WELL SCREENS CONSTRUCTED UTILIZING PRE-FORMED ANNULAR ELEMENTS 审中-公开
公开(公告)号：WO2010117724A3
公开(公告)日：2010-10-14
申请号：PCT/US2010/029053
申请日：2010-03-29
申请人： HALLIBURTON ENERGY SERVICES, INC. , FRIPP, Michael, L. , SIMONDS, Floyd, R. , LOPEZ, Jean-Marc , HAMID, Syed , KYLE, Donald, G. , DYKSTRA, Jason
发明人： FRIPP, Michael, L. , SIMONDS, Floyd, R. , LOPEZ, Jean-Marc , HAMID, Syed , KYLE, Donald, G. , DYKSTRA, Jason
IPC分类号： E21B43/08 , E21B43/12
摘要： Construction of well screens utilizing pre-formed annular-shaped elements. A well screen includes a filter layer configured to filter fluid flowing through the well screen and a drainage layer which radially supports the filter layer, the drainage layer including multiple individual annular-shaped elements. Another well screen includes a drainage layer configured to support the filter layer, with the drainage layer including at least one cavity molded therein. Another well screen includes a base pipe and a layer made up of multiple individual annular-shaped elements stacked coaxially on the base pipe. A cavity is formed in at least one of the elements.

9. 发明申请

WO2010014229A1 BUPRENORPHINE ANALOGS 审中-公开
标题翻译：保护素类似物
公开(公告)号：WO2010014229A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/004391
申请日：2009-07-30
申请人： PURDUE PHARMA L.P. , KYLE, Donald, J. , GOEHRING, R., Richard , FUNDYTUS, Marian, E.
发明人： KYLE, Donald, J. , GOEHRING, R., Richard , FUNDYTUS, Marian, E.
IPC分类号： C07D489/12 , A61K31/485 , A61P25/04
CPC分类号： C07D489/12 , C07D489/02
摘要： The present invention is directed to Buprenorphine Analog compounds of the Formula I, Formula II or Formula III shown below, wherein R 1 , R 2 , R 8 , R 3 , R 3a , R 3b , X, Z and Y are as defined herein., R1 H3CO (I) OCH3 OCH3 (III) Compounds of the Invention are useful for treating pain and other conditions modulated by activity of opioid and ORLl receptors.
摘要翻译：本发明涉及下列式I，式II或式III的丁丙诺啡类似物，其中R1，R2，R8，R3，R3a，R3b，X，Z和Y如本文所定义，R1H3CO（I ）OCH 3 OCH 3（III）本发明化合物可用于治疗由阿片样物质和ORL1受体活性调节的疼痛和其它状况。

10. 发明申请

WO2009018379A1 DIELECTRIC SPECTROSCOPY ASSAYS FOR SCREENING OF ION CHANNEL LIGANDS 审中-公开
标题翻译：用于筛选离子通道配体的电介质光谱测定
公开(公告)号：WO2009018379A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071645
申请日：2008-07-30
申请人： PURDUE PHARMA L.P. , NEW JERSEY INSTITUTE OF TECHNOLOGY , PRODAN, Camelia , ILYIN, Victor, I. , KYLE, Donald, J. , CARLIN, Kevin, P. , WU, Gang
发明人： PRODAN, Camelia , ILYIN, Victor, I. , KYLE, Donald, J. , CARLIN, Kevin, P. , WU, Gang
IPC分类号： C12N13/00 , G01N33/543
CPC分类号： G01N33/6872 , G01N33/5008
摘要： A method for measuring membrane potential using dielectric spectroscopy is described. A new theoretical model allows for the determination of membrane potential from low-frequency impedance measurements to provide a non-evasive method which is both rapid and inexpensive.
摘要翻译：描述了使用介电光谱测量膜电位的方法。新的理论模型允许从低频阻抗测量中确定膜电位，以提供快速和便宜的非回避方法。

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