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1. 发明申请

WO2011088836A1 NOVEL 4-(ARYL-4-SULFONYL)-6,6a,7,8,9,10-HEXAHYDRO-4H-4,8,10a-TRIAZA-ACEPHENANTHRYLENE AND 3-ARYLSULFONYL-6,6a,7,8,9,10-HEXAHYDRO-3H-3,8,10a-TRIAZA-CYCLOPENTA[C]FLUORENE DERIVATIVES AS SEROTONIN 5-HT6 LIGANDS 审中-公开
标题翻译：新的4-（ARYL-4-磺基）-6,6a，7,8,9,10-十六氢-4H-4,8,10a-三氮杂 - 丙烯酰亚胺和3-芳基磺酰-6,6a，7,8,9 ，10-HEXAHYDRO-3H-3,8,10a-TRIAZA-CYCLOPENTA [C]荧光素衍生物作为丝氨酸5-HT6配体
公开(公告)号：WO2011088836A1
公开(公告)日：2011-07-28
申请号：PCT/DK2011/050017
申请日：2011-01-20
申请人： H. LUNDBECK A/S , KEHLER, Jan , KROGSGAARD-LARSEN, Niels
发明人： KEHLER, Jan , KROGSGAARD-LARSEN, Niels
IPC分类号： C07D487/14 , A61K31/4985 , A61P25/00
CPC分类号： C07D487/14
摘要： This invention is directed to compounds of formula I or II, which are serotonin 5-HT 6 ligands. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I or II, or a pharmaceutically acceptable salt thereof. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I or II, or a pharmaceutically acceptable salt thereof. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I or II, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及式I或II的化合物，其是5-羟色胺5-HT 6配体。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供制备式I或II化合物或其药学上可接受的盐的方法。本发明还提供了治疗患有神经退行性疾病的受试者的方法，其包括给予受试者治疗有效量的式I或II化合物或其药学上可接受的盐。本发明还提供了治疗患有精神障碍的受试者的方法，其包括向受试者施用治疗有效量的式I或II化合物或其药学上可接受的盐。

2. 发明申请

WO2011088838A1 NOVEL 6,6A,7,8,9,10-HEXAHYDRO-4H-4,8,10A-TRIAZA-ACEPHENANTHRYLENE DERIVATIVES AS DOPAMINE D2 LIGANDS 审中-公开
标题翻译： 6,6A，7,8,9,10-十六氢四氢-4,4,8,10-三氮杂-丙烯酰胺衍生物作为DOPAMINE D2配体
公开(公告)号：WO2011088838A1
公开(公告)日：2011-07-28
申请号：PCT/DK2011/050020
申请日：2011-01-24
申请人： H. LUNDBECK A/S , KEHLER, Jan , KROGSGAARD-LARSEN, Niels
发明人： KEHLER, Jan , KROGSGAARD-LARSEN, Niels
IPC分类号： C07D471/16 , A61K31/4375 , A61P25/00
CPC分类号： C07D471/16
摘要： This invention is directed to compounds, which are dopamine D 2 ligands. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I or formula II, or a pharmaceutically acceptable salt thereof. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I or formula II, or a pharmaceutically acceptable salt thereof. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I or formula II, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及多巴胺D2配体的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供制备式I或式II化合物或其药学上可接受的盐的方法。本发明进一步提供了治疗患有神经退行性疾病的受试者的方法，包括向受试者施用治疗有效量的式I或式II化合物或其药学上可接受的盐。本发明还提供了治疗患有精神障碍的受试者的方法，包括向受试者施用治疗有效量的式I或式II化合物或其药学上可接受的盐。

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