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1. 发明申请

WO2016036551A1 CONFINEMENT OR MOVEMENT OF AN OBJECT USING FOCUSED ULTRASOUND WAVES TO GENERATE AN ULTRASOUND INTENSITY WELL 审中-公开
标题翻译：使用聚焦超声波对物体进行约束或运动以产生超声波强度
公开(公告)号：WO2016036551A1
公开(公告)日：2016-03-10
申请号：PCT/US2015/046875
申请日：2015-08-26
申请人： MAXWELL, Adam, D. , SAPOZHNIKOV, Oleg, A. , KREIDER, Wayne , BAILEY, Michael, R.
发明人： MAXWELL, Adam, D. , SAPOZHNIKOV, Oleg, A. , KREIDER, Wayne , BAILEY, Michael, R.
IPC分类号： G10K11/20
CPC分类号： G10K11/008 , A61B17/225 , A61B17/2255 , A61B2017/22028 , G10K11/20 , G10K11/24 , G10K11/30 , G10K11/346 , G10K15/00 , H03H9/6483
摘要： A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens includes a plurality of segments. Each of the plurality of segments has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the segment.
摘要翻译：一种方法包括将聚焦的超声波发射到介质中，以形成在介质中良好地显示第一声压范围的超声强度，以及（ii）围绕超声强度的介质的周围区域，并显示出第二声压范围超过第一声压范围。该方法还包括将物体限制在超声强度之内。此外，声透镜被配置为声学耦合到声换能器。声透镜具有相对于增加的声透镜的方位角成比例地变化的纵向厚度。声学透镜被配置为声学耦合到声学换能器。声透镜包括多个段。多个段中的每一个具有相对于节段的增加的方位角成比例地增加的变化的纵向厚度。

2. 发明申请

WO2015148966A1 BOILING HISTOTRIPSY METHODS AND SYSTEMS FOR UNIFORM VOLUMETRIC ABLATION OF AN OBJECT BY HIGH-INTENSITY FOCUSED ULTRASOUND WAVES WITH SHOCKS 审中-公开
标题翻译：通过高强度聚焦的超声波与冲击对平均体积消除对象的沸腾感知方法和系统
公开(公告)号：WO2015148966A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/023069
申请日：2015-03-27
申请人： KHOKHLOVA, Vera , BAILEY, Michael, R. , FARR, Navid , KHOKHLOVA, Tatiana, D. , KREIDER, Wayne , MAXWELL, Adam, D. , PARTANEN, Ari , SAPOZHNIKOV, Oleg, A. , SCHADE, George, R. , WANG, Yak-Nam
发明人： KHOKHLOVA, Vera , BAILEY, Michael, R. , FARR, Navid , KHOKHLOVA, Tatiana, D. , KREIDER, Wayne , MAXWELL, Adam, D. , PARTANEN, Ari , SAPOZHNIKOV, Oleg, A. , SCHADE, George, R. , WANG, Yak-Nam
IPC分类号： A61B17/22
CPC分类号： A61N7/02 , A61B17/22004 , A61B2017/22007
摘要： An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.
摘要翻译：示例性方法包括产生聚焦在焦点处的声学超声波。该方法还包括将焦点顺序地引导到物体的不同部分上以在物体的不同部分处形成相应的冲击波。该方法还包括经由相应的冲击波，使物体的不同部分沸腾并形成相应的蒸气腔。该方法还包括引起包括不同部分的物体的区域的基本均匀的消融。通过相应的冲击波与相应的蒸气腔的相互作用引起基本均匀的消融。还公开了与示例性方法相关的示例消融系统和示例性非暂时性计算机可读介质。

3. 发明申请

WO2016205627A1 MRI-BASED FEEDBACK CONTROL OF ULTRASOUND BASED MECHANICAL FRACTIONATION OF BIOLOGICAL TISSUE 审中-公开
标题翻译：基于超声波生物组织机械分析的基于MRI的反馈控制
公开(公告)号：WO2016205627A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/038052
申请日：2016-06-17
申请人： PARTANEN, Ari , KREIDER, Wayne , KHOKHLOVA, Vera
发明人： PARTANEN, Ari , KREIDER, Wayne , KHOKHLOVA, Vera
IPC分类号： A61B5/055 , A61B8/00
CPC分类号： A61B5/055 , A61B5/0035 , A61B5/01 , A61B5/02 , A61N7/00 , G01R33/4814 , G01R33/50 , G01R33/5602 , G01R33/56358
摘要： Disclosed herein are example embodiments of devices, systems, and methods for mechanical fractionation of biological tissue using magnetic resonance imaging (MRI) feedback control. The examples may involve displaying an image representing first MRI data corresponding to biological tissue, and receiving input identifying one or more target regions of the biological tissue to be mechanically fractionated via exposure to first ultrasound waves. The examples may further involve applying the first ultrasound waves and, contemporaneous to or after applying the first ultrasound waves, acquiring second MRI data corresponding to the biological tissue. The examples may also involve determining, based on the second MRI data, one or more second parameters for applying second ultrasound waves to the biological tissue, and applying the second ultrasound waves to the biological tissue according to the one or more second parameters.
摘要翻译：本文公开了使用磁共振成像（MRI）反馈控制来生物组织的机械分级分离的装置，系统和方法的示例性实施方案。示例可以包括显示表示对应于生物组织的第一MRI数据的图像，以及接收通过暴露于第一超声波来机械分割的生物组织的一个或多个目标区域的输入。这些实施例还可以包括施加第一超声波，并且在应用第一超声波之后或之后同时获取对应于生物组织的第二MRI数据。这些示例还可以包括基于第二MRI数据确定用于将第二超声波施加到生物组织的一个或多个第二参数，以及根据一个或多个第二参数将第二超声波应用于生物组织。

4. 发明申请

WO2015148938A3 METHOD AND SYSTEM FOR MRI-BASED TARGETING, MONITORING, AND QUANTIFICATION OF THERMAL AND MECHANICAL BIOEFFECTS IN TISSUE INDUCED BY HIGH INTENSITY FOCUSED ULTRASOUND 审中-公开
标题翻译：用于基于MRI的高强度聚焦超声诱导的组织中热和机械生物学的基于MRI的靶向，监测和定量的方法和系统
公开(公告)号：WO2015148938A3
公开(公告)日：2015-11-26
申请号：PCT/US2015023021
申请日：2015-03-27
申请人： PARTANEN ARI , KHOKHLOVA VERA , FARR NAVID , LEE DONGHOON , KREIDER WAYNE , KHOKHLOVA TATIANA , MAXWELL ADAM , WANG YAK-NAM , SCHADE GEORGE , BAILEY MICHAEL
发明人： PARTANEN ARI , KHOKHLOVA VERA , FARR NAVID , LEE DONGHOON , KREIDER WAYNE , KHOKHLOVA TATIANA , MAXWELL ADAM , WANG YAK-NAM , SCHADE GEORGE , BAILEY MICHAEL
IPC分类号： A61B8/00 , A61N7/02
CPC分类号： A61B5/055 , A61B5/0042 , A61B5/015 , A61B5/4836 , A61B2090/374 , A61B2576/026 , A61N7/02 , G01R33/288 , G01R33/4804 , G01R33/4814 , G01R33/50 , G01R33/5602 , G01R33/56341
摘要： Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as "boiling histotripsy" (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
摘要翻译：公开了用于生物材料的高强度聚焦超声（HIFU）机械分级的计划，实时监测，控制和后处理评估的用于磁共振成像（MRI）技术的系统和方法的示例实施例。称为“沸腾组织切除术”（BH）的HIFU的适应形式可用于引起生物材料的机械分级。与传统的HIFU相比，其导致纯热消融，BH可以以一定程度的控制和精确度产生生物组织的治疗性破坏，从而允许实时准确地测量和监测该过程以及治疗的结果使用各种MRI技术进行评估。实时监控还允许BH的实时控制。

5. 发明申请

WO2015148938A2 METHOD AND SYSTEM FOR MRI-BASED TARGETING, MONITORING, AND QUANTIFICATION OF THERMAL AND MECHANICAL BIOEFFECTS IN TISSUE INDUCED BY HIGH INTENSITY FOCUSED ULTRASOUND 审中-公开
标题翻译：用于基于MRI的高强度聚焦超声引发的组织中靶向，监测和量化热和机械生物效应的方法和系统
公开(公告)号：WO2015148938A2
公开(公告)日：2015-10-01
申请号：PCT/US2015/023021
申请日：2015-03-27
申请人： PARTANEN, Ari , KHOKHLOVA, Vera , FARR, Navid , LEE, Donghoon , KREIDER, Wayne , KHOKHLOVA, Tatiana , MAXWELL, Adam , WANG, Yak-Nam , SCHADE, George , BAILEY, Michael
发明人： PARTANEN, Ari , KHOKHLOVA, Vera , FARR, Navid , LEE, Donghoon , KREIDER, Wayne , KHOKHLOVA, Tatiana , MAXWELL, Adam , WANG, Yak-Nam , SCHADE, George , BAILEY, Michael
IPC分类号： A61B8/12 , A61B5/055
CPC分类号： A61B5/055 , A61B5/0042 , A61B5/015 , A61B5/4836 , A61B2090/374 , A61B2576/026 , A61N7/02 , G01R33/288 , G01R33/4804 , G01R33/4814 , G01R33/50 , G01R33/5602 , G01R33/56341
摘要： Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as "boiling histotripsy" (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
摘要翻译：用于磁共振成像（MRI）技术的系统和方法的示例实施例用于对生物材料的高强度聚焦超声（HIFU）机械分级的计划，实时监测，控制和后处理评估被披露。 HIFU的适应形式被称为“沸腾组织碎裂” （BH）可用于引起生物材料的机械分馏。与导致纯热消融的传统HIFU相反，BH可以以一定程度的控制和精确度产生对生物组织的治疗性破坏，从而允许实时准确地测量和监测该过程以及治疗的结果使用各种MRI技术进行评估。实时监控还可以实时控制BH。

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