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1. 发明申请

WO2011044186A9 HUMAN SINGLE-CHAIN T CELL RECEPTORS 审中-公开
公开(公告)号：WO2011044186A9
公开(公告)日：2011-04-14
申请号：PCT/US2010/051559
申请日：2010-10-06
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , KRANZ, David M. , AGGEN, David H.
发明人： KRANZ, David M. , AGGEN, David H.
IPC分类号： C07K14/435 , C12N15/70
摘要： A soluble human single-chain T cell receptor (TCR) having the structure: Vα2-L-Vβ or Vβ-L-Vα2, wherein L is a linker peptide that links Vβ with Vα, Vβ is a TCR variable β region, and Vα2 is a TCR variable α region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.

2. 发明申请

WO2011028983A1 TREATMENT OF DISEASES CAUSED BY BACTERIAL EXOTOXINS 审中-公开
标题翻译：治疗由细菌外毒素引起的疾病
公开(公告)号：WO2011028983A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047782
申请日：2010-09-03
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , REGENTS OF THE UNIVERSITY OF MINNESOTA , KRANZ, David, M. , SCHLIEVERT, Patrick
发明人： KRANZ, David, M. , SCHLIEVERT, Patrick
IPC分类号： C07K14/00
CPC分类号： C07K14/7051 , A61K38/00
摘要： Provided are high affinity T cell receptor variable regions that are useful for treating diseases caused by superantigens including atopic dermatitis, pneumonia and delayed wound healing. The variable regions contain mutants that result in high affinity binding to the superantigen.
摘要翻译：提供了可用于治疗由包括特应性皮炎，肺炎和延迟伤口愈合的超级细胞引起的疾病的高亲和力T细胞受体可变区。可变区包含导致与超抗原结合的高亲和力结合的突变体。

3. 发明申请

WO2011037903A1 HIGH SPEED OPTICAL INSPECTION SYSTEM WITH CAMERA ARRAY AND COMPACT, INTEGRATED ILLUMINATOR 审中-公开
标题翻译：具有相机阵列和紧凑型集成照明器的高速光学检测系统
公开(公告)号：WO2011037903A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/049617
申请日：2010-09-21
申请人： CYBEROPTICS CORPORATION , CARUSO, Beverly , HAUGAN, Carl, E. , ROSE, Steven, A. , KRANZ, David, M.
发明人： HAUGAN, Carl, E. , ROSE, Steven, A. , KRANZ, David, M.
IPC分类号： G01N21/88 , G01N21/95
CPC分类号： G01N21/8806 , G01N21/8903 , G01N2021/845 , G01N2021/95638
摘要： An optical inspection system is provided for inspecting a workpiece (10). The system includes a workpiece transport (26) configured to transport the workpiece (10) in a nonstop manner. An illuminator (45) is configured to provide a first strobed illumination field type and a second strobed illumination field type. The illuminator (45) includes a light pipe having a first end proximate the workpiece (10), and a second end opposite the first end and spaced from the first end. The light pipe also has at least one reflective sidewall (70). The first end has an exit aperture and the second end has at least one second end aperture (50) to provide a view of the workpiece (10) therethrough. An array (4) of cameras is configured to digitally image the workpiece (10). The array (4) of cameras is configured to generate a first plurality of images of the workpiece (10) with the first illumination field and a second plurality of images of the workpiece (10) with the second illumination field. A processing device is operably coupled to the illuminator (45) and the array (4) of cameras, the processing device is configured to store at least some of the first and second plurality of images and provide the first and second pluralities to an other device.
摘要翻译：提供了用于检查工件（10）的光学检查系统。该系统包括构造成以不间断的方式输送工件（10）的工件传送（26）。照明器（45）被配置为提供第一选通照明场类型和第二选通照明场类型。照明器（45）包括具有靠近工件（10）的第一端的光管和与第一端相对并与第一端间隔开的第二端。光管还具有至少一个反射侧壁（70）。第一端具有出口孔，并且第二端具有至少一个第二端孔（50），以提供穿过其中的工件（10）的视图。相机的阵列（4）被配置为对工件（10）进行数字成像。相机的阵列（4）被配置为利用第一照明场和具有第二照明场的工件（10）的第二多个图像来生成工件（10）的第一多个图像。处理装置可操作地耦合到相机的照明器（45）和阵列（4），处理装置被配置为存储第一和第二多个图像中的至少一些，并且将第一和第二多个部件提供给另一个装置。

4. 发明申请

WO2009105681A1 NEUTRALIZATION OF STAPHYLOCOCCAL AND STREPTOCOCCAL TOXINS 审中-公开
标题翻译：丝裂霉素和结肠毒素的中和
公开(公告)号：WO2009105681A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/034728
申请日：2009-02-20
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , KRANZ, David, M. , BUONPANE, Rebecca, A. , YANG, Xi , SCHLIEVERT, Patrick, M.
发明人： KRANZ, David, M. , BUONPANE, Rebecca, A. , YANG, Xi , SCHLIEVERT, Patrick, M.
IPC分类号： C07K16/00 , A61K39/00
CPC分类号： C07K14/7051
摘要： Staphyloccocus and Streptococcus bacteria secrete various toxins that act as superantigens by stimulating a large fraction of the host's T cells. The binding of toxins to the variable domains of T cell receptor β chains (Vβ) leads to massive release of inflammatory molecules and, potentially, toxic shock syndrome (TSS). Soluble forms of different Vβ domains able to bind superantigens with high-affinity have previously been generated. However, to neutralize unknown toxins or multiple toxins a broader spectrum antagonist is required. The present invention expresses multiple Vβ domains in tandem as a single-chain protein and neutralizes the clinically important superantigens, particularly staphylococcal enterotoxin B and TSS toxin-1, with a single agent.
摘要翻译：葡萄球菌和链球菌通过刺激大部分宿主的T细胞分泌作为超抗原的各种毒素。毒素与T细胞受体β链（Vβ）的可变区结合导致炎症分子的大量释放和潜在的中毒性休克综合征（TSS）。先前已经产生了能够以高亲和力结合超抗原的不同Vβ结构域的可溶形式。然而，为了中和未知的毒素或多种毒素，需要更广谱的拮抗剂。本发明以单链蛋白串联表达多个Vβ结构域，并用单一试剂中和临床上重要的超抗原，特别是葡萄球菌肠毒素B和TSS毒素-1。

5. 发明申请

WO2007106894A2 NEUTRALIZING AGENTS FOR BACTERIAL TOXINS 审中-公开
标题翻译：中性毒素中和剂
公开(公告)号：WO2007106894A2
公开(公告)日：2007-09-20
申请号：PCT/US2007064085
申请日：2007-03-15
申请人： UNIV ILLINOIS , KRANZ DAVID M , BUONPANE REBECCA A , CHURCHILL HYWYN R O , SUNDBERG ERIC J , MOZA BEENU , SCHLIEVERT PATRICK
发明人： KRANZ DAVID M , BUONPANE REBECCA A , CHURCHILL HYWYN R O , SUNDBERG ERIC J , MOZA BEENU , SCHLIEVERT PATRICK
IPC分类号： C07K14/705
CPC分类号： C07K14/7051 , A61K38/00 , C12N15/1037 , C12N15/1058
摘要： Stabilized variable regions of the T cell receptor and methods of making the same using directed evolution through yeast display are provided. In one embodiment, the variable region is variable beta. In one embodiment, the stabilized T cell receptor variable regions have high affinity for a superantigen, such as TSST-1 or SEB. These T cell receptor variable regions are useful as therapeutics.
摘要翻译：提供了T细胞受体的稳定可变区和使用通过酵母显示进行定向进化的方法。在一个实施方案中，可变区是可变的β。在一个实施方案中，稳定的T细胞受体可变区对超抗原具有高亲和力，例如TSST-1或SEB。这些T细胞受体可变区可用作治疗剂。

6. 发明申请

WO1996034630A1 CONJUGATES OF FOLATE AND ANTI-EFFECTOR CELL ANTIBODIES 审中-公开
标题翻译：胶原和抗体细胞抗体的结合
公开(公告)号：WO1996034630A1
公开(公告)日：1996-11-07
申请号：PCT/US1996006463
申请日：1996-05-06
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , KRANZ, David, M. , ROY, Edward, J. , PATRICK, Todd, A.
发明人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
IPC分类号： A61K47/48
CPC分类号： C07K16/2809 , A61K47/6849
摘要： The present invention provides a process of targeting folate-receptor-positive tumor cells for lysis by binding a conjugate of folate and an anti-T-cell-receptor antibody or an anti-Fc receptor antibody to those cells. A process of lysing folate-receptor-positive tumor cells comprising exposing the cells to a folate/anti-T-cell-receptor antibody in the presence of a population of T-cells is also provided. A process of lysing folate-receptor-positive tumor cells comprising exposing the cells to a folate/anti-Fc receptor antibody in the presence of a population of natural killer cells, monocytes, or macrophages is also provided. Still further, the present invention provides a conjugate of folate to an anti-T-cell-receptor antibody or an anti-Fc receptor antibody.
摘要翻译：本发明提供了通过将叶酸和抗T细胞受体抗体或抗Fc受体抗体的缀合物与这些细胞结合来靶向叶酸受体阳性肿瘤细胞进行裂解的方法。还提供了裂解叶酸受体阳性肿瘤细胞的方法，包括在存在T细胞群的情况下将细胞暴露于叶酸/抗T细胞受体抗体。还提供了裂解叶酸受体阳性肿瘤细胞的方法，包括在存在天然杀伤细胞，单核细胞或巨噬细胞的情况下将细胞暴露于叶酸/抗-Fc受体抗体。此外，本发明提供叶酸与抗T细胞受体抗体或抗Fc受体抗体的缀合物。

7. 发明申请

WO2008115532A1 METHOD FOR MEASURING CENTER OF ROTATION OF A NOZZLE OF A PICK AND PLACE MACHINE USING A COLLIMATED LASER BEAM 审中-公开
标题翻译：使用胶合激光束测量扒手和放置机的喷嘴旋转中心的方法
公开(公告)号：WO2008115532A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/003632
申请日：2008-03-20
申请人： CYBEROPTICS CORPORATION , KRANZ, David, M. , DUQUETTE, David, W. , DAWSON, Matthew, W.
发明人： KRANZ, David, M. , DUQUETTE, David, W. , DAWSON, Matthew, W.
IPC分类号： G01B11/27
CPC分类号： G01B11/272
摘要： A method (100) of measuring and storing a center of rotation of a nozzle (24) in a pick and place machine is provided. The method (100) includes coupling (106) an artifact to the nozzle (24). A substantially collimated laser beam is directed at the artifact, which is rotated while the collimated laser beam is energized. Edges of a shadow cast by the rotating artifact are detected and used to calculate error of a coordinate of the center of rotation of the nozzle (24). A coordinate of the center of rotation of the nozzle is calculated (112) based upon a previous coordinate of the center of rotation and the error. The calculated coordinate of the center of rotation is stored (114) for subsequent measurements.
摘要翻译：提供了一种在拾取和放置机器中测量和存储喷嘴（24）的旋转中心的方法（100）。方法（100）包括将赝像联接（106）到喷嘴（24）。基本上准直的激光束被引导到伪像，其在准直激光束通电时旋转。检测由旋转伪影投射的阴影的边缘，并用于计算喷嘴（24）的旋转中心坐标的误差。基于旋转中心的先前坐标和误差来计算（112）喷嘴的旋转中心的坐标。旋转中心的计算坐标被存储（114）用于随后的测量。

8. 发明申请

WO2011044186A1 HUMAN SINGLE-CHAIN T CELL RECEPTORS 审中-公开
标题翻译：人类单链T细胞受体
公开(公告)号：WO2011044186A1
公开(公告)日：2011-04-14
申请号：PCT/US2010051559
申请日：2010-10-06
申请人： UNIV ILLINOIS , KRANZ DAVID M , AGGEN DAVID H
发明人： KRANZ DAVID M , AGGEN DAVID H
IPC分类号： C07K14/435 , C12N15/70
CPC分类号： C07K14/7051
摘要： A soluble human single-chain T cell receptor (TCR) having the structure: Va2-L-Vß or Vß-L-Va2, wherein L is a linker peptide that links Vß with Va, Vß is a TCR variable ß region, and Va2 is a TCR variable a region of the family 2 is provided. The provided scTCR is useful for many purposes, including the treatment of cancer, viral diseases and autoimmune diseases.
摘要翻译：具有以下结构的可溶性人单链T细胞受体（TCR）：Vα2-L-Vβ或Vβ-L-Va2，其中L是将Vβ与Va连接的连接肽，Vβ是TCR变异β区，Va2 是提供家庭2的一个区域的TCR变量。提供的scTCR可用于许多目的，包括治疗癌症，病毒性疾病和自身免疫性疾病。

9. 发明申请

WO2007106894A3 NEUTRALIZING AGENTS FOR BACTERIAL TOXINS 审中-公开
公开(公告)号：WO2007106894A3
公开(公告)日：2007-09-20
申请号：PCT/US2007/064085
申请日：2007-03-15
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , KRANZ, David M. , BUONPANE, Rebecca A. , CHURCHILL, Hywyn, R., O. , SUNDBERG, Eric J. , MOZA, Beenu , SCHLIEVERT, Patrick
发明人： KRANZ, David M. , BUONPANE, Rebecca A. , CHURCHILL, Hywyn, R., O. , SUNDBERG, Eric J. , MOZA, Beenu , SCHLIEVERT, Patrick
IPC分类号： C12P21/02 , A61K38/18
摘要： Stabilized variable regions of the T cell receptor and methods of making the same using directed evolution through yeast display are provided. In one embodiment, the variable region is variable beta. In one embodiment, the stabilized T cell receptor variable regions have high affinity for a superantigen, such as TSST-1 or SEB. These T cell receptor variable regions are useful as therapeutics.

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