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1. 发明申请

WO2003105768A2 METHODS OF REDUCING HYPOGLYCEMIC EPISODES IN THE TREATMENT OF DIABETES MELLITUS 审中-公开
标题翻译：降低糖尿病患者血糖升高的方法
公开(公告)号：WO2003105768A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018763
申请日：2003-06-13
申请人： NOBEX CORPORATION , STILL, James, Gordon , KOSUTIC, Gordana
发明人： STILL, James, Gordon , KOSUTIC, Gordana
IPC分类号： A61K
CPC分类号： A61K47/64 , A61K47/60
摘要： The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the subject, wherein: i) the amount of the insulin polypeptide-oligomer conjugate reduces the number and/or severity of hypoglycemic episodes experienced by the subject during a given time period when compared with the number and/or severity of hypoglycemic episodes that would have been experienced during a similar time period by the subject or by subjects in a control group parenterally administered insulin or an insulin analog in an amount that provides a substantially equivalent level of glycemic control; and ii) the oligomer of the insulin polypeptide-oligomer conjugate comprises a hydrophilic moiety and a lipophilic moiety.
摘要翻译：本发明提供了用于减少需要治疗糖尿病的受试者经历的降血糖发作的组合物和方法，所述方法包括口服给予受试者一定量的胰岛素多肽 - 低聚物缀合物，其中：i）胰岛素的量多肽 - 低聚物缀合物减少受试者在给定时间段期间经历的降血糖发作的次数和/或严重程度，与受试者在相似时间段期间经历的降血糖事件的数量和/或严重程度相比，对照组中的受试者肠胃外施用胰岛素或胰岛素类似物，其量提供基本相当水平的血糖控制; 和ii）胰岛素多肽 - 低聚物缀合物的寡聚物包含亲水部分和亲脂部分。

2. 发明申请

WO2003105768A3 METHODS OF REDUCING HYPOGLYCEMIC EPISODES IN THE TREATMENT OF DIABETES MELLITUS 审中-公开
公开(公告)号：WO2003105768A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018763
申请日：2003-06-13
申请人： NOBEX CORPORATION , STILL, James, Gordon , KOSUTIC, Gordana
发明人： STILL, James, Gordon , KOSUTIC, Gordana
IPC分类号： A61K38/28
摘要： The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the subject, wherein: i) the amount of the insulin polypeptide-oligomer conjugate reduces the number and/or severity of hypoglycemic episodes experienced by the subject during a given time period when compared with the number and/or severity of hypoglycemic episodes that would have been experienced during a similar time period by the subject or by subjects in a control group parenterally administered insulin or an insulin analog in an amount that provides a substantially equivalent level of glycemic control; and ii) the oligomer of the insulin polypeptide-oligomer conjugate comprises a hydrophilic moiety and a lipophilic moiety.

3. 发明申请

WO2005004792A3 MIXTURES OF CALCITONIN DRUG-OLIGOMER CONJUGATES AND METHODS OF USE IN PAIN TREATMENT 审中-公开
标题翻译：降钙素类药物 - 低聚物共轭物的混合物及其在疼痛治疗中的应用
公开(公告)号：WO2005004792A3
公开(公告)日：2005-09-01
申请号：PCT/US2004016784
申请日：2004-05-27
申请人： NOBEX CORP , KOSUTIC GORDANA , EKWURIBE NNOCHIRI N , PRICE CHRISTOPHER H , ANSARI ASLAM M , ODENBAUGH AMY L
发明人： KOSUTIC GORDANA , EKWURIBE NNOCHIRI N , PRICE CHRISTOPHER H , ANSARI ASLAM M , ODENBAUGH AMY L
IPC分类号： A61K20060101 , A61K38/00 , A61K47/48 , C07K1/113 , C07K7/00 , C07K14/535
CPC分类号： A61K38/23 , A61K47/60
摘要： A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. Moreover, the mixture may be more effective at surviving an in vitro model of intestinal digestion than non-conjugated calcitonin. Furthermore, the mixture may exhibit a higher bioavailability than non-conjugated calcitonin. The compositions of this invention are useful in the treatment of various bone disorders and pain.
摘要翻译：公开了一种缀合物的混合物，其中混合物中的每种缀合物包含偶联至包含聚亚烷基二醇部分的寡聚物的降钙素药物。该混合物可将受试者的血清钙水平降低10,15或甚至20％或更多。此外，该混合物在存活肠消化的体外模型中可能比非共轭降钙素更有效。此外，该混合物可能表现出比非缀合降钙素更高的生物利用度。本发明的组合物可用于治疗各种骨疾病和疼痛。

4. 发明申请

WO2005004792A2 MIXTURES OF CALCITONIN DRUG-OLIGOMER CONJUGATES AND METHODS OF USE IN PAIN TREATMENT 审中-公开
标题翻译：卡米酮类药物与低剂量混合物的混合物及其在疼痛治疗中的应用方法
公开(公告)号：WO2005004792A2
公开(公告)日：2005-01-20
申请号：PCT/US2004/016784
申请日：2004-05-27
申请人： NOBEX CORPORATION , KOSUTIC, Gordana , EKWURIBE, Nnochiri, N. , PRICE, Christopher, H. , ANSARI, Aslam, M. , ODENBAUGH, Amy, L.
发明人： KOSUTIC, Gordana , EKWURIBE, Nnochiri, N. , PRICE, Christopher, H. , ANSARI, Aslam, M. , ODENBAUGH, Amy, L.
IPC分类号： A61K
CPC分类号： A61K38/23 , A61K47/60
摘要： A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. Moreover, the mixture may be more effective at surviving an in vitro model of intestinal digestion than non-conjugated calcitonin. Furthermore, the mixture may exhibit a higher bioavailability than non-conjugated calcitonin. The compositions of this invention are useful in the treatment of various bone disorders and pain.
摘要翻译：公开了混合物的混合物，其中混合物中的每个缀合物包含与包含聚亚烷基二醇部分的低聚物偶联的降钙素药物。该混合物可使受试者中的血清钙水平降低10,15或甚至20％或更多。此外，混合物在存活肠内消化的体外模型方面比非共轭降钙素更有效。此外，该混合物可能表现出比非共轭降钙素更高的生物利用度。本发明的组合物可用于治疗各种骨骼疾病和疼痛。

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