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1. 发明申请

WO2010008135A1 ORAL SOFT CAPSULE OF ACECLOFENAC HAVING IMPROVED STABILITY 审中-公开
标题翻译：具有改善稳定性的ACECLOFENAC口服软胶囊
公开(公告)号：WO2010008135A1
公开(公告)日：2010-01-21
申请号：PCT/KR2009/002249
申请日：2009-04-29
申请人： KOREA UNITED PHARM, INC , CHOI, Youn-Woong , CHO, Sang-Min , HA, Dae-Chul , AN, Seung-Ho
发明人： CHOI, Youn-Woong , CHO, Sang-Min , HA, Dae-Chul , AN, Seung-Ho
IPC分类号： A61K9/48 , A61K31/353 , A61K9/107 , A61K47/00 , A61K9/52 , A61K9/64 , A61K9/66
CPC分类号： A61K9/4858 , A61K31/216
摘要： The present invention relates to an aceclofenac-containing soft capsule formulation having improved stability and the preparation thereof, and more particularly to a method of preparing a soft capsule by dissolving or dispersing aceclofenac, which is unstable in an aqueous solution, in oil or a mixture of oils. The aceclofenac-containing soft capsule contains an aceclofenac-containing liquid composition prepared by mixing and solubilizing aceclofenac, oil and a suspending agent. The soft capsule can maintain stability for 3 years or more and has improved active ingredient dissolution compared to existing soft capsules, thus increasing the bioavailability of the active ingredient.
摘要翻译：本发明涉及具有改进的稳定性及其制备的含有醋氯芬酸的软胶囊制剂，更具体地涉及通过将在水溶液中不稳定的醋氯芬酸溶解或分散在油或混合物中来制备软胶囊的方法的油。含有醋氯芬酸的软胶囊含有通过混合和增溶醋氯芬酸，油和悬浮剂制备的含有醋氯芬酸的液体组合物。软胶囊可以保持3年以上的稳定性，并且与现有的软胶囊相比具有改善的活性成分溶解度，从而提高活性成分的生物利用度。

2. 发明申请

WO2005058282A1 DOUBLE PELLET FORMULATION OF PROTON PUMP INHIBITORS AND CLARITHROMYCIN FOR THE TREATMENT OF GASTROINTESTINAL ULCER, AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：用于治疗胃肠道溃疡的原料泵抑制剂和克拉霉素的双重颗粒配方及其生产方法
公开(公告)号：WO2005058282A1
公开(公告)日：2005-06-30
申请号：PCT/KR2004/001792
申请日：2004-07-19
申请人： KOREA UNITED PHARM, INC , AHN, Ki-Young , GIL, Young-Sig , YU, Chang-Hun , KIM, Hye-Kyeong , AHN, Geon-Seok , HONG, Seok-Cheon , YANG, Geun-Woo
发明人： AHN, Ki-Young , GIL, Young-Sig , YU, Chang-Hun , KIM, Hye-Kyeong , AHN, Geon-Seok , HONG, Seok-Cheon , YANG, Geun-Woo
IPC分类号： A61K9/16
CPC分类号： A61K9/5078 , A61K9/5026 , A61K9/5047
摘要： The present invention relates to a double pellet formulation effective for the treatment of various peptic ulcers, including a peptic ulcer caused by Helicobactor pylori , as well as a preparing method thereof. More particularly, the present invention relates to a double pellet formulation in which layers separated from each other are formed in one pellet, and a proton pump inhibitor and antibiotic clarithromycin are contained in the separated layers, respectively, such that upon administration of the formulation, the drugs can be released in different sites of the living body in a more stable form, thus maximizing a therapeutic effect against various peptic ulcers, including a peptic ulcer caused by Helicobactor pylori , as well as a preparing method thereof.
摘要翻译：本发明涉及可用于治疗各种消化性溃疡的双重丸剂制剂，包括由幽门螺杆菌幽门螺杆菌引起的消化性溃疡及其制备方法。更具体地说，本发明涉及双沉淀制剂，其中在一个颗粒中形成彼此分离的层，分离层中包含质子泵抑制剂和抗生素克拉霉素，使得在给药制剂时，药物可以以更稳定的形式释放到生物体的不同部位，从而最大化对由幽门螺旋杆菌引起的消化性溃疡的各种消化性溃疡的治疗效果以及其制备方法。

3. 发明申请

WO2004080440A1 PROCESS FOR THE PREPARING OF HARDCAPSULE FORMULATION CONTAINING LANSOPRAZOLE 审中-公开
标题翻译：制备含有兰曲唑硬脂酸制剂的方法
公开(公告)号：WO2004080440A1
公开(公告)日：2004-09-23
申请号：PCT/KR2003/000835
申请日：2003-04-25
申请人： KOREA UNITED PHARM, INC. , CHO, Dong-Hyun , GIL, Young-Sig , YU, Chang-Hun , HONG, Seok-Cheon
发明人： CHO, Dong-Hyun , GIL, Young-Sig , YU, Chang-Hun , HONG, Seok-Cheon
IPC分类号： A61K9/48
CPC分类号： A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5078
摘要： The present invention relates to a method for producing a new hard capsule preparation containing lansoprazole, which has excellent stability and is administered in an easy and simple manner. The method comprises the steps of: dissolving or dispersing lansoprazole in oil or fatty acid; adding the lansoprazole solution to a swollen polymer solution containing an emulsifying agent and an alkalifying agent; stirring the resulting mixture; adding additives to the stirred material to produce an emulsion; injecting the emulsion into an aqueous calcium chloride solution to form a film on a granule of the emulsion; filtering and washing the granule to remove calcium ions; freeze-drying the washed granule to produce a pellet; forming a film and an enteric coating layer on the pellet; forming a film and an enteric coating layer on the pellet; and filling the resulting pellet in a hard gelatin capsule.
摘要翻译：本发明涉及一种含有兰索拉唑的新型硬胶囊制剂的制备方法，其具有优异的稳定性，并且以简单和简单的方式给药。该方法包括以下步骤：将兰索拉唑溶解或分散在油或脂肪酸中; 将兰索拉唑溶液加入含有乳化剂和碱化剂的溶胀聚合物溶液中; 搅拌所得混合物; 向搅拌的材料中加入添加剂以产生乳液; 将乳液注入氯化钙水溶液中以在乳剂颗粒上形成膜; 过滤并洗涤颗粒以除去钙离子; 冷冻干燥洗涤过的颗粒以产生颗粒; 在丸粒上形成膜和肠溶衣层; 在丸粒上形成膜和肠溶衣层; 并将所得丸粒填充在硬明胶胶囊中。

4. 发明申请

WO2004047834A1 FORMULATION AND MANUFACTURING PROCESS OF SOLUBILIZED ACECLOFENAC SOFT CAPSULES 审中-公开
标题翻译：溶解ACECLOFENAC软胶囊的配方和制造工艺
公开(公告)号：WO2004047834A1
公开(公告)日：2004-06-10
申请号：PCT/KR2003/000533
申请日：2003-03-20
申请人： KOREA UNITED PHARM, INC. , GIL, Young-Sig , HONG, Seok-Cheon , YU, Chang-Hun , CHO, Dong-Hyun , SHIN, Hyun-Jong
发明人： GIL, Young-Sig , HONG, Seok-Cheon , YU, Chang-Hun , CHO, Dong-Hyun , SHIN, Hyun-Jong
IPC分类号： A61K31/216
CPC分类号： A61K31/216
摘要： The present invention relates to a method for the solubilization of aceclofenac, wherein water-insoluble aceclofenac is added to a solvent mixture of polyethylene glycols, ethanolamines, basic amino acids such as arginine, Tween and glycerin, and also to a solubilized aceclofenac-containing liquid composition prepared therefrom. Furthermore, the present invention relates to a solubilized aceclofenac-containing soft capsule, which is prepared by mixing 1-30 parts by weight, based on the total weight of the contents of the soft capsule, of aceclofenac, 10-90 parts by weight of polyethylene glycols, 1-70 parts by weight of ethanolamines, 1-70 parts by weight of basic amino acids, 1-40 parts by weight of Tween and 2-15 parts by weight of glycerin at a certain temperature range so as to prepare a solubilized aceclofenac-containing liquid composition; and filling the solubilized aceclofenac-containing liquid composition in a gelatin soft capsule.
摘要翻译：本发明涉及一种用于溶解醋氯芬酸的方法，其中向聚乙二醇，乙醇胺，碱性氨基酸例如精氨酸，吐温和甘油的溶剂混合物中加入水不溶性的醋氯芬酸，以及加入含醋氯芬酸的液体由其制备的组合物。此外，本发明涉及一种溶解的含醋氯芬酸的软胶囊，其通过将1-30重量份，基于软胶囊的内容物的总重量，醋氯芬酸，10-90重量份的聚乙二醇，1-70重量份乙醇胺，1-70重量份碱性氨基酸，1-40重量份吐温和2-15重量份甘油，在一定温度范围内，以制备溶解的含醋氯芬酸的液体组合物; 并将含有溶解的含醋氯芬酸的液体组合物填充在明胶软胶囊中。

5. 发明申请

WO2012148181A3 COMPOSITION FOR THE CONTROLLED-RELEASE OF DRUGS 审中-公开
标题翻译：用于控制释放药物的组合物
公开(公告)号：WO2012148181A3
公开(公告)日：2012-12-20
申请号：PCT/KR2012003223
申请日：2012-04-26
申请人： KOREA UNITED PHARM INC , CHOI YOUN-WOONG , CHO SANG MIN , MIN BYUNG GU , PARK JIN HA , KIM BO KYUNG
发明人： CHOI YOUN-WOONG , CHO SANG MIN , MIN BYUNG GU , PARK JIN HA , KIM BO KYUNG
IPC分类号： A61K9/22 , A61K9/20 , A61K47/30 , A61K47/38
CPC分类号： A61K9/2054 , A61K9/2013 , A61K9/2027
摘要： The present invention relates to a composition for the controlled-release of drugs. More particularly, the composition for the controlled-release of drugs according to the present invention expands the capacity for the controlled-release of a matrix-type polymer for controlled-release via a carbomer in which said polymer for controlled-release forms a basic frame and in which sol-gel transition occurs in accordance with a pH level. The composition of the present invention is characterized in that it comprises: a solubilizing agent for the event the drug to be released is highly insoluble, and a disintegrating agent for sufficient initial release. The composition for the controlled-release of drugs according to the present invention uses a carbomer which maintains the controlled-release of conventional matrix structures having polymers for controlled-release and which has sol-gel transition properties, thus preventing a sudden release of a drug caused by a collapse of the matrix structure during a late stage of elution. In addition, the composition of the present invention uses a solubilizing agent to solve the problem of a highly insoluble drug failing to dissolve even after being released, and also uses a disintegrating agent to improve the speed of the initial release, which is the limiting factor in controlled-release preparations.
摘要翻译：本发明涉及用于药物控制释放的组合物。更具体地说，根据本发明的用于药物控制释放的组合物通过卡波姆扩大了用于控制释放的基质型聚合物的释放能力，其中所述控释聚合物形成基本框架并且其中根据pH水平发生溶胶 - 凝胶转变。本发明的组合物的特征在于，它包括：用于释放药物高度不溶性的增溶剂，以及用于充分初始释放的崩解剂。根据本发明的用于药物控制的组合物使用卡波姆，其维持具有用于控制释放的聚合物的常规基质结构的控制释放，并且具有溶胶 - 凝胶转变特性，从而防止药物的突然释放由洗脱后期的基体结构的崩溃引起的。此外，本发明的组合物使用增溶剂来解决即使在剥离后不能溶解的高度不溶性药物的问题，并且还使用崩解剂来提高初始释放的速度，这是限制因素在控释制剂中。

6. 发明申请

WO2004087112A1 MANUFACTURING METHOD AND FORMULATION FOR BITTER TASTE MASKED ORAL DOSAGE FORM OF CLARITHROMYCIN 审中-公开
标题翻译：枸杞子口服药物口服剂量制剂的制备方法及配方
公开(公告)号：WO2004087112A1
公开(公告)日：2004-10-14
申请号：PCT/KR2003/000814
申请日：2003-04-22
申请人： KOREA UNITED PHARM, INC. , CHO, Dong-Hyun , GIL, Young-Sig , HONG, Seok-Cheon , YU, Chang-Hun
发明人： CHO, Dong-Hyun , GIL, Young-Sig , HONG, Seok-Cheon , YU, Chang-Hun
IPC分类号： A61K9/30
CPC分类号： A61K9/2081 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K31/7048 , Y02A50/478
摘要： The present invention relates to a clarithromycin containing oral pharmaceutical composition and a method for preparing the same, where the bitter taste of clarithromycin, which is a macrolide antibiotic showing an unpleasant bitter taste upon oral administration, is masked. In the oral pharmaceutical composition of the present invention, clarithromycin as an active ingredient is coated with a water-insoluble polymer, so that the dissolution rate of clarithromycin is maintained at the same level as prior preparations while the bitter taste of clarithromycin is masked.
摘要翻译：本发明涉及含有克拉霉素的口服药物组合物及其制备方法，其中口服给药时显示令人不快的苦味的大环内酯类抗生素克拉霉素的苦味被掩蔽。在本发明的口服药物组合物中，作为活性成分的克拉霉素用水不溶性聚合物涂布，使克拉霉素的溶解速度维持在与以前的制剂相同的水平，而克拉霉素的苦味被掩蔽。

7. 发明申请

WO2011152652A2 ACECLOFENAC SLOW-RELEASE PREPARATION PROVIDING AN OPTIMUM PHARMACOLOGICAL CLINICAL EFFECT WHEN ADMINISTERED ONCE A DAY 审中-公开
标题翻译： ACECLOFENAC缓释制剂在一天内施用时提供最佳的药理学临床效果
公开(公告)号：WO2011152652A2
公开(公告)日：2011-12-08
申请号：PCT/KR2011003989
申请日：2011-06-01
申请人： KOREA UNITED PHARM INC , LEE BEOM JIN , JUNG WON-TAE , CHOI YOUN WOONG , NAM KYU YEOL , CHO SANG-MIN , JANG JAE SANG , CHOI MINJI
发明人： LEE BEOM JIN , JUNG WON-TAE , CHOI YOUN WOONG , NAM KYU YEOL , CHO SANG-MIN , JANG JAE SANG , CHOI MINJI
IPC分类号： A61K9/22 , A61K9/20 , A61K31/216 , A61K47/38
CPC分类号： A61K9/209 , A61K31/216
摘要： The present invention relates to a controlled-release preparation administered orally once a day that exhibits an optimum pharmacological clinical effect, featuring two-layer tablets, dual tablets and multilayered tablets having a fast-release layer comprising aceclofenac, a water-soluble additive, a non-soluble additive, a solubilizer, a disintegrator and a filler, and a slow-release layer comprising aceclofenac, a slow-release base, a disintegrator, a binder, a filler, a fluidizer, a solubilizer and a lubricant.
摘要翻译：本发明涉及具有最佳药理临床效果的一天一次口服的控释制剂，其特征在于具有快速释放层的双层片剂，双片剂和多层片剂，其包含醋氯芬酸，水溶性添加剂，不溶性添加剂，增溶剂，崩解剂和填料，以及包含醋氯芬酸，缓释碱，崩解剂，粘合剂，填料，流化剂，增溶剂和润滑剂的缓释层。

8. 发明申请

WO2005032516A1 FORMULATION AND MANUFACTURING PROCESS OF SELF-MICROEMULSIFIED ACECLOFENAC SOFT CAPSULES 审中-公开
标题翻译：自组装ACECLOFENAC软胶囊的制备和制造工艺
公开(公告)号：WO2005032516A1
公开(公告)日：2005-04-14
申请号：PCT/KR2004/001791
申请日：2004-07-19
申请人： KOREA UNITED PHARM, INC , GIL, Young-Sig , YU, Chang-Hun , CHOUNG, Ki-Hoon , AHN, Geon-Seok , HONG, Seok-Cheon , AHN, Ki-Young , YANG, Geun-Woo
发明人： GIL, Young-Sig , YU, Chang-Hun , CHOUNG, Ki-Hoon , AHN, Geon-Seok , HONG, Seok-Cheon , AHN, Ki-Young , YANG, Geun-Woo
IPC分类号： A61K9/107
CPC分类号： A61K9/127 , A61K9/4866
摘要： The present invention relates to a method for preparing a self-microemulsifying composition by dissolving water-poorly soluble aceclofenac in a mixed solvent of polyethylene glycol, a polyoxyethylene castor oil derivative (trade name: Cremophor, HCO), isosorbide dimethylether, middle chain fatty acid, butylated hydroxyanisole, butylated hydroxytoluene and tocopherol, and the like, as well as a method for preparing an aceclofenac-containing formulation having increased stability and improved drug solubility, by filling the composition into a soft capsule. The present invention allows the preparation of a solubilized aceclofenac-containing composition having a characteristic and advantage in that it has high in vivo drug absorption rate and thus shows a more rapid therapeutic effect than that of the prior art formulation, as well as the preparation of a soft capsule formulation containing this composition.
摘要翻译：本发明涉及一种通过将不溶于水的醋氯芬酸溶解在聚乙二醇，聚氧乙烯蓖麻油衍生物（商品名：Cremophor，HCO），异山梨醇二甲醚，中链脂肪酸的混合溶剂中制备自微乳化组合物的方法，丁基化羟基苯甲醚，丁基化羟基甲苯和生育酚等，以及通过将组合物填充到软胶囊中而制备具有增加的稳定性和改善的药物溶解性的含醋氯芬酸的制剂的方法。本发明允许制备具有特征和优点的溶解的含醋氯芬酸的组合物，其具有高体内药物吸收速率，因此显示比现有技术制剂更快的治疗效果，以及制备含有该组合物的软胶囊制剂。

9. 发明申请

WO2004007518A1 ERYTHROMYCIN A 9-O-PSEUDOSACCHARINYLOXIME DERIVATIVES AND PROCESS FOR THE PREPARATION OF CLARITHROMYCIN USING THE SAME 审中-公开
标题翻译：红霉素A 9-O-磷酸胆碱酯衍生物及其制备使用其的克拉霉素的方法
公开(公告)号：WO2004007518A1
公开(公告)日：2004-01-22
申请号：PCT/KR2003/000813
申请日：2003-04-22
申请人： KOREA UNITED PHARM, INC. , SHIN, Dong-Seong , RYOO, Ui-Sang , AN, Seung-Ho
发明人： SHIN, Dong-Seong , RYOO, Ui-Sang , AN, Seung-Ho
IPC分类号： C07H17/08
CPC分类号： C07H17/08 , Y02P20/55
摘要： The present invention relates to new erythromycin A 9-O-pseudosaccharinyloxime derivatives represented by Formula 1, and to a new method for preparing 6-O-methylerythromycin A (clarithromycin) as macrolide compound, represented by Formula 2, using the same: wherein R 1 is hydrogen or a methyl group, and R 2 is a trimethylsilyl group.
摘要翻译：本发明涉及由式1表示的新型红霉素A 9-O-假糖基肟衍生物和由式2表示的大环内酯类化合物的6-O-甲基红霉素A（克拉霉素）的新方法，其使用其中R <1>是氢或甲基，R 2是三甲基甲硅烷基。

10. 发明申请

WO2010090371A1 ACECLOFENAC-CONTAINING CONTROLLED-RELEASE ORAL DRUG PREPARATIONS AND THEIR MANUFACTURING PROCESS 审中-公开
标题翻译：含有控释的口服药物制剂及其制造过程
公开(公告)号：WO2010090371A1
公开(公告)日：2010-08-12
申请号：PCT/KR2009/002251
申请日：2009-04-29
申请人： KOREA UNITED PHARM, INC , LEE, Beom-Jin , CHOI, Youn-Woong , MIN, Byung-Gu , AN, Seung-Ho
发明人： LEE, Beom-Jin , CHOI, Youn-Woong , MIN, Byung-Gu , AN, Seung-Ho
IPC分类号： A61K9/24 , A61K9/22 , A61K47/30 , A61K9/54
CPC分类号： A61K9/209
摘要： Disclosed herein are single-layer and double-layer tablets, which release aceclofenac in a controlledmanner so as to achieve ideal drug release close to a straight line. Also, the tablets promote drug absorption in the stomach by controlling pH, contain aceclofenac with improved stability and haveboth immediate-release properties and sustained-release properties. Specifically, provided is an aceclofenac sustained-release tablet which is composed of an immediate-release layer containing aceclofenac, a water-soluble additive, a pH-controlling agent, a disintegrant, a filler and a lubricant and of a sustained-release layer containing aceclofenac, a release-controlling polymer, an oil-soluble surfactant, a filler and a lubricant, wherein the pH-controlling agent is sodium hydrogen carbonate, and the release-controlling polymer is a mixture of hydroxypropylmethylcellulose and carbomer.
摘要翻译：本文公开了单层和双层片剂，其在受控制剂中释放乙氯芬酸以便实现靠近直线的理想药物释放。此外，片剂通过控制pH促进胃中的药物吸收，含有改善的稳定性的乙酰苯胺酸，并且具有即时释放性质和持续释放性质。具体地说，本发明提供了一种醋氯芬酸缓释片剂，其由含有醋氯芬酸的速释层，水溶性添加剂，pH控制剂，崩解剂，填充剂和润滑剂以及缓释层醋氯芬酸，释放控制性聚合物，油溶性表面活性剂，填充剂和润滑剂，其中所述pH控制剂为碳酸氢钠，所述释放控制聚合物为羟丙基甲基纤维素和卡波姆的混合物。

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