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1. 发明申请

WO2013037132A1 PREPARATION OF METHACRYLIC ACID 审中-公开
标题翻译：甲基丙烯酸的制备
公开(公告)号：WO2013037132A1
公开(公告)日：2013-03-21
申请号：PCT/CN2011/079765
申请日：2011-09-16
申请人： EVONIK ROEHM GMBH , BALDUF, Torsten , KOESTNER, Martin , ZHANG, Wenxing , GROEN, Heidi , HENGSTERMANN, Axel , KRAPFL, Maya
发明人： BALDUF, Torsten , KOESTNER, Martin , ZHANG, Wenxing , GROEN, Heidi , HENGSTERMANN, Axel , KRAPFL, Maya
IPC分类号： C07C51/42 , C07C51/43 , C07C57/04 , C07C57/07
CPC分类号： C07C51/43 , C07C57/04
摘要： The invention relates to a process for preparation of methacrylic acid, comprising process steps a) providing a crude methacrylic acid-comprising aqueous solution comprising at least one impurity at least partially dissolved therein; b) precipitation of at least a part of the at least one impurity from the crude methacrylic acid-comprising aqueous solution to form at least one solid impurity and a mother liquor; c) separation of at least a part of the at least one solid impurity from the mother liquor to obtain a purified methacrylic acid-comprising aqueous solution and a solid impurity; d) separation of methacrylic acid from the purified methacrylic acid-comprising aqueous solution.
摘要翻译：本发明涉及一种制备甲基丙烯酸的方法，包括方法步骤a）提供包含至少部分溶解于其中的至少一种杂质的含粗甲基丙烯酸的水溶液; b）从含粗甲基丙烯酸的水溶液中沉淀至少一部分所述至少一种杂质以形成至少一种固体杂质和母液; c）从母液中分离出至少一部分固体杂质，得到纯化的含甲基丙烯酸的水溶液和固体杂质; d）从纯化的含甲基丙烯酸的水溶液中分离甲基丙烯酸。

2. 发明申请

WO2006084695A3 TETRACYCLINE-CONTROLLED INSERTION ELEMENT FOR SYSTEMATIC MUTAGENESIS 审中-公开
标题翻译：用于系统MUTAGENESIS的TETRACYCLINE控制插入元件
公开(公告)号：WO2006084695A3
公开(公告)日：2006-11-02
申请号：PCT/EP2006001163
申请日：2006-02-09
申请人： UNIV FRIEDRICH ALEXANDER ER , HILLEN WOLFGANG , BERTRAM RALPH , KOESTNER MARTIN
发明人： HILLEN WOLFGANG , BERTRAM RALPH , KOESTNER MARTIN
IPC分类号： C12N15/82 , C12N15/71 , C12N15/74 , C12N15/85
CPC分类号： C12N15/8216 , C12N15/635 , C12N2800/30 , C12N2800/90 , C12N2820/55 , C12N2830/003
摘要： The present invention relates to an insertion element, wherein said insertion element is a recombinant nucleic acid molecule which comprises, in 5' ? 3' arrangement: (i) a first recombines binding site; (ii) a resistance gene, operatively linked to a promoter and, optionally, to transcription control sequences; (iii) a tetracycline-controlled promoter; and (iv) a second recombines binding site, wherein said tetracycline-controlled promoter is oriented to allow transcription in direction of the second recombines binding site. The present invention also relates to a method for the generation of a conditional knock-out mutant of a cell, comprising the steps of: (a) introducing a nucleic acid molecule comprising the insertion element of the present invention into a cell, wherein the insertion element is transfected into the cell concomitant with purified recombines; (b) integrating the insertion element into the cellular genome; and (c) selecting cells for resistance against a substrate for which the resistance gene of the insertion element confers resistance; wherein prior to or concomitant with step (a) an expression construct for a tetracycline-sensitive (poly)peptide is introduced into the cell, said (poly)peptide being capable of binding to the tetracycline-controlled promoter of the insertion element and of modulating its expression. Finally, the present invention relates to a cell containing the insertion element of the present invention, to a method for identifying genetic determinants of pathogen survival and to a method for the generation of a transgenic animal and plant.
摘要翻译：本发明涉及插入元件，其中所述插入元件是重组核酸分子，其包含在5' 3'排列：（i）首先重组结合位点; （ii）可操作地连接到启动子和任选地转录控制序列的抗性基因; （iii）四环素控制的启动子; 和（iv）第二重组结合位点，其中所述四环素受控启动子被取向以允许在第二重组结合位点的方向上转录。本发明还涉及一种用于产生细胞的条件敲除突变体的方法，包括以下步骤：（a）将包含本发明的插入元件的核酸分子导入细胞中，其中插入元素被转染到细胞中，伴随着纯化的重组; （b）将插入元件整合到细胞基因组中; 和（c）选择针对插入元件的抗性基因赋予抗性的底物的抗性的细胞; 其中在步骤（a）之前或伴随着步骤（a），将四环素敏感（多）肽的表达构建体引入细胞中，所述（多）肽能够结合插入元件的四环素受控启动子并调节其表达。最后，本发明涉及含有本发明的插入元件的细胞，鉴定鉴定病原体存活的遗传决定因素的方法以及产生转基因动物和植物的方法。

3. 发明申请

WO2010063520A1 METHOD FOR PRODUCING A CARBOXYLIC ACID AMIDE FROM A CARBONYL COMPOUND AND HYDROCYANIC ACID 审中-公开
标题翻译：用于从羰基化合物和氰化氢制备甲酰胺
公开(公告)号：WO2010063520A1
公开(公告)日：2010-06-10
申请号：PCT/EP2009064279
申请日：2009-10-29
申请人： EVONIK ROEHM GMBH , MAY ALEXANDER , KOESTNER MARTIN , BECKER JOERG , SCHALLENBERG JOERG , SIEGERT HERMANN , VOGEL BERND
发明人： MAY ALEXANDER , KOESTNER MARTIN , BECKER JOERG , SCHALLENBERG JOERG , SIEGERT HERMANN , VOGEL BERND
IPC分类号： C07C231/06 , C07C67/327 , C07C69/54 , C07C253/06 , C07C253/30 , C07C255/13
CPC分类号： C07C231/06 , C07C231/065 , C07C231/14 , C07C253/00 , C07C233/09 , C07C255/16
摘要： The invention relates to a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid, comprising the steps of A) reacting a carbonyl compound with hydrocyanic acid to produce a hydroxycarboxylic acid nitrile, B) hydrolysis of the hydroxycarboxylic acid nitrile obtained in step A) in the presence of a catalyst comprising manganese dioxide, wherein a molar excess of carbonyl compound is used in relation to the hydrocyanic acid to react the carbonyl compound with hydrocyanic acid according to step A), and the reaction mixture obtained in step A) is not purified by distillation before the hydrolysis according to step B) is carried out. The invention furthermore relates to a method for producing alkyl(meth)acrylates from polymers, moulding compounds and moulded bodies, wherein a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid is carried out in accordance with the method described above.
摘要翻译：本发明涉及一种方法，用于从羰基化合物和氢氰酸，其包括与氰化氢的羰基化合物用于生产Hydroxycarbonsäurenithls的反应的步骤A）制备羧酸酰胺，B）在催化剂的存在下，在步骤A中获得）Hydroxycarbonsäurenitrils的水解，包括二氧化锰，其特征在于用于与根据步骤氰化氢的羰基化合物的反应），摩尔过量的羰基化合物相对于所述氰化氢和在步骤a）不通过蒸馏在水解之前将根据步骤b纯化的）获得的反应混合物中进行。此外，本发明涉及制备烷基（甲基）丙烯酸酯，聚合物，成型在其中执行用于产生由羰基化合物，并根据上述方法氢氰酸羧酸酰胺的方法的化合物和模制品的方法。

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