专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008137910A2 MATRIX STABILIZATION OF AGGREGATION-BASED ASSAYS 审中-公开
标题翻译：基于聚集的测定的矩阵稳定性
公开(公告)号：WO2008137910A2
公开(公告)日：2008-11-13
申请号：PCT/US2008/062838
申请日：2008-05-07
申请人： MASSACHUSETTS INSTUTUTE OF TECHNOLOGY , KIM, Grace, Y. , VASSILIOU, Christophoros, C. , DANIEL, Karen, D. , CIMA, Michael, J.
发明人： KIM, Grace, Y. , VASSILIOU, Christophoros, C. , DANIEL, Karen, D. , CIMA, Michael, J.
IPC分类号： G01N33/558
CPC分类号： G01N33/558
摘要： Methods and apparatus for stabilization of aggregation-based assays are described. In various embodiments, anti-analytes are dispersed within a matrix. A solution containing analytes brought into contact with the matrix, so that analytes may permeate throughout at least a portion of the matrix. In some embodiments, the anti- analytes and analytes are mobile within the matrix. As aggregates form and increase in size, the aggregates become substantially immobile within the matrix. As a result, signals representative of an amount of aggregation within the matrix can remain substantially constant. In various aspects, matrix-stabilized aggregation-based assays provide for reliable quantitative analysis of analyte concentration with test solutions.
摘要翻译：描述了基于聚集的测定法的稳定化方法和装置。在各种实施方案中，抗分析物分散在基质内。含有与基质接触的分析物的溶液，使得分析物可渗透至基质的至少一部分。在一些实施方案中，抗分析物和分析物在基质内是可移动的。随着聚集体的形成和尺寸的增加，聚集体在基质内基本上不能移动。结果，表示矩阵内的聚集量的信号可以保持基本恒定。在各个方面，基于基质稳定聚集的测定提供了使用测试溶液的分析物浓度的可靠定量分析。

2. 发明申请

WO2012027384A3 COLOR-CODED PROSTHETIC VALVE SYSTEM AND METHODS FOR USING THE SAME 审中-公开
标题翻译：彩色编码的前置阀系统及其使用方法
公开(公告)号：WO2012027384A3
公开(公告)日：2012-06-07
申请号：PCT/US2011048828
申请日：2011-08-23
申请人： EDWARDS LIFESCIENCES CORP , LAU JACKIE , PETERSON JOHN , KIM GRACE , MIGLIAZZA JOHN F , OBA TRAVIS
发明人： LAU JACKIE , PETERSON JOHN , KIM GRACE , MIGLIAZZA JOHN F , OBA TRAVIS
IPC分类号： A61F2/24 , A61F2/82
CPC分类号： A61F2/2412 , A61F2/0095 , A61F2/2418 , A61F2/2427 , A61F2/2496 , A61F2250/0064 , A61F2250/0087 , A61F2250/0097
摘要： A color-coded bioprosthetic valve system having a valve with an annular sewing ring, and a valve holder system with a holder sutured to the ring of the valve, a post operatively connected to the holder, and an adapter sutured to the post and having a color associated with the valve model and/or size. For example, the adapter may be blue to indicate that the valve of the system is a mitral valve of a particular type and/or size. The system may also include a flex handle that is configured to engage with the adapter. The handle has a color associated with the adapter such that a user is able to visually determine that the handle color matches the valve model. For example, the handle may have a grip that is colored blue to match the blue color of the adapter. Accordingly, the color-coded system enables users to confirm easily that the correct accessories such as the sizer or flex handle are being used with the correct valve.
摘要翻译：一种颜色编码的生物假体瓣膜系统，其具有带有环形缝合环的阀，以及具有固定在阀的环上的保持器系统的阀保持器系统，可操作地连接到保持器的柱，以及缝合到柱的适配器，与阀门模型和/或尺寸相关联的颜色。例如，适配器可以是蓝色的，以指示系统的阀是特定类型和/或尺寸的二尖瓣。该系统还可以包括配置成与适配器接合的柔性手柄。手柄具有与适配器相关联的颜色，使得用户能够在视觉上确定手柄颜色与阀模型匹配。例如，手柄可以具有蓝色的手柄以匹配适配器的蓝色。因此，颜色编码系统使用户能够容易地确认正确的配件如尺寸调节器或柔性手柄正在与正确的阀门一起使用。

3. 发明申请

WO2012034130A2 METHODS AND COMPOSITIONS FOR NUCLEIC ACID DETECTION 审中-公开
标题翻译：核酸检测方法和组合物
公开(公告)号：WO2012034130A2
公开(公告)日：2012-03-15
申请号：PCT/US2011/051248
申请日：2011-09-12
申请人： QIAGEN , LIU, Guozhen , PENG, Quan , WANG, Yexun , RULLI, Samuel, J. , LO, Jing-Yi , GARDNER, Rachel , KIM, Grace, J.
发明人： LIU, Guozhen , PENG, Quan , WANG, Yexun , RULLI, Samuel, J. , LO, Jing-Yi , GARDNER, Rachel , KIM, Grace, J.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6886 , C12Q1/703 , C12Q1/706 , C12Q1/707 , C12Q2521/345
摘要： The present application relates to Multicomponent Nucleic Acid Enzymes (MNAzymes), which may be used for detecting, identifying and/or quantifying targets. More particularly, this application provides methods of designing and making more reliable MNAzymes, as well as compositions comprising MNAzyme components and methods of using MNAzymes.
摘要翻译：本申请涉及多组分核酸酶（MNAzyme），其可用于检测，鉴定和/或定量靶。更具体地说，本申请提供了设计和制造更可靠的MNAzyme的方法，以及包含MNAzyme组分的组合物和使用MNAzyme的方法。

4. 发明申请

WO2011143238A2 PROSTHETIC HEART VALVE 审中-公开
标题翻译：前置心脏瓣膜
公开(公告)号：WO2011143238A2
公开(公告)日：2011-11-17
申请号：PCT/US2011035952
申请日：2011-05-10
申请人： EDWARDS LIFESCIENCES CORP , CAO HENGCHU , CONKLIN BRIAN S , SCHMIDT PAUL A , KIM GRACE MYONG , DAVIDSON JAMES A , TRAN HOA TRINH , TAM KRISTY LUONG
发明人： CAO HENGCHU , CONKLIN BRIAN S , SCHMIDT PAUL A , KIM GRACE MYONG , DAVIDSON JAMES A , TRAN HOA TRINH , TAM KRISTY LUONG
IPC分类号： A61F2/24 , A61B17/32 , A61L27/04 , A61M29/02
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2427
摘要： Disclosed prosthetic valves can comprise a sewing ring configured to secure the valve to an implantation site. Some disclosed valves comprise a resiliently collapsible frame having a neutral configuration and a collapsed deployment configuration. Some disclosed frames can self-expand to the neutral configuration when released from the collapsed deployment configuration. Collapsing a disclosed valve can provide convenient access to the sewing ring, such as for securing the valve to the implantation site, as well as for the insertion of the valve through relatively small surgical incisions.
摘要翻译：公开的假体瓣膜可以包括构造成将瓣膜固定到植入部位的缝合环。一些公开的阀包括具有中性构型和折叠展开构型的弹性可折叠框架。当从折叠部署配置释放时，一些公开的框架可以自扩展到中立配置。折叠所公开的阀可以方便地进入缝合环，例如用于将瓣膜固定到植入部位，以及通过相对较小的手术切口插入瓣膜。

5. 发明申请

WO2008137910A3 MATRIX STABILIZATION OF AGGREGATION-BASED ASSAYS 审中-公开
标题翻译：基于聚合分析的矩阵稳定化
公开(公告)号：WO2008137910A3
公开(公告)日：2008-12-24
申请号：PCT/US2008062838
申请日：2008-05-07
申请人： MASSACHUSETTS INSTUTUTE OF TEC , KIM GRACE Y , VASSILIOU CHRISTOPHOROS C , DANIEL KAREN D , CIMA MICHAEL J
发明人： KIM GRACE Y , VASSILIOU CHRISTOPHOROS C , DANIEL KAREN D , CIMA MICHAEL J
IPC分类号： G01N33/558 , G01N33/547
CPC分类号： G01N33/558
摘要： Methods and apparatus for stabilization of aggregation-based assays are described. In various embodiments, anti-analytes are dispersed within a matrix. A solution containing analytes brought into contact with the matrix, so that analytes may permeate throughout at least a portion of the matrix. In some embodiments, the anti- analytes and analytes are mobile within the matrix. As aggregates form and increase in size, the aggregates become substantially immobile within the matrix. As a result, signals representative of an amount of aggregation within the matrix can remain substantially constant. In various aspects, matrix-stabilized aggregation-based assays provide for reliable quantitative analysis of analyte concentration with test solutions.
摘要翻译：描述了用于稳定基于聚集的测定的方法和装置。在各种实施例中，抗分析物分散在基质中。含有分析物的溶液与基质接触，使得分析物可渗透至整个基质的至少一部分。在一些实施方案中，抗分析物和分析物在基质内是可移动的。随着聚集体形成并且尺寸增加，聚集体在基体内基本上不动。结果，表示矩阵内的聚集量的信号可以保持基本恒定。在各个方面，基质稳定的基于聚集的测定提供了用测试溶液进行的分析物浓度的可靠定量分析。

6. 发明申请

WO2007103258A2 FLEXIBLE SLEEVE, ADJUSTABLE CONTACT SURFACE, AND FLUID CONTACT MONITOR FOR CATHETER 审中-公开
标题翻译：柔性套筒，可调节的接触表面和流体接触式监视器
公开(公告)号：WO2007103258A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005508
申请日：2007-03-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ESKURI, Alan, D. , JOHNSON, Christopher , HARRIS, Chad , HAWK, Matthew, L. , KIM, Grace
发明人： ESKURI, Alan, D. , JOHNSON, Christopher , HARRIS, Chad , HAWK, Matthew, L. , KIM, Grace
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/0045 , A61M25/0069 , A61M25/0084 , A61M25/0138
摘要： A catheter is provided for the injection of therapeutic agents at a target site within a patient's body. The catheter includes a first elongated shaft having a distal end and a proximal end and a lumen extending therebetween. The catheter also includes a second elongated shaft in the form of a needle slidingly disposed in the first elongated shaft, the needle having a distal end and a proximal and a lumen extending therebetween. The catheter may include a flexible sleeve, wherein the flexible sleeve compresses along the inside of a curve and elongates along the outside of a curve. The catheter may additionally or alternatively include an adjustable distal tissue contact surface, wherein the position of the distal tissue contact surface may be adjusted with respect to a stop surface for stopping the advancement of a needle. The catheter may additionally or alternatively include a fluid pressure contact monitor.
摘要翻译：提供导管，用于在患者体内的靶位置处注射治疗剂。导管包括第一细长轴，其具有远端和近端以及在其间延伸的内腔。导管还包括滑动地设置在第一细长轴中的针形式的第二细长轴，所述针具有远端和近端以及在其间延伸的内腔。导管可以包括柔性套管，其中柔性套筒沿着曲线的内部压缩并沿着曲线的外侧延伸。导管可另外地或替代地包括可调节的远端组织接触表面，其中远端组织接触表面的位置可以相对于止动表面进行调整，以阻止针的前进。导管可以附加地或可选地包括流体压力接触监视器。

7. 发明申请

WO2014071030A1 VOLATILE MATERIAL DISPENSER HAVING A FACEPLATE 审中-公开
标题翻译：挥发性物质分配器
公开(公告)号：WO2014071030A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/067793
申请日：2013-10-31
申请人： S.C. JOHNSON & SON, INC. , GORDON, William, F. , JAWORSKI, Thomas , MECKER, Alex , MICHAELS, Kenneth, W. , HENDON, Nathan, P. , LEBAS, Sandrine , KIM, Grace , RATHBONE, Jonathan , BANGSUND, Krista , KOBELI, Lea , MINNIS, Sydney , TSENG, In, Shr
发明人： GORDON, William, F. , JAWORSKI, Thomas , MECKER, Alex , MICHAELS, Kenneth, W. , HENDON, Nathan, P. , LEBAS, Sandrine , KIM, Grace , RATHBONE, Jonathan , BANGSUND, Krista , KOBELI, Lea , MINNIS, Sydney , TSENG, In, Shr
IPC分类号： A61L9/03 , A61L9/12
CPC分类号： A61L9/03 , A61L9/12 , A61L2209/12 , A61L2209/133
摘要： A volatile material dispenser includes a housing and a dispensing mechanism disposed within the housing for emitting a volatile material. A faceplate is attached to the housing and provides an aesthetically pleasing look to the volatile material dispenser.
摘要翻译：挥发性材料分配器包括壳体和设置在壳体内用于发射挥发性材料的分配机构。面板附接到壳体并且向挥发性材料分配器提供美观的外观。

8. 发明申请

WO2012027384A2 COLOR-CODED PROSTHETIC VALVE SYSTEM AND METHODS FOR USING THE SAME 审中-公开
标题翻译：彩色假牙瓣膜系统及使用该系统的方法
公开(公告)号：WO2012027384A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/048828
申请日：2011-08-23
申请人： EDWARDS LIFESCIENCES CORPORATION , LAU, Jackie , PETERSON, John , KIM, Grace , MIGLIAZZA, John, F. , OBA, Travis
发明人： LAU, Jackie , PETERSON, John , KIM, Grace , MIGLIAZZA, John, F. , OBA, Travis
IPC分类号： A61F2/24 , A61F2/82
CPC分类号： A61F2/2412 , A61F2/0095 , A61F2/2418 , A61F2/2427 , A61F2/2496 , A61F2250/0064 , A61F2250/0087 , A61F2250/0097
摘要： A color-coded bioprosthetic valve system having a valve with an annular sewing ring, and a valve holder system with a holder sutured to the ring of the valve, a post operatively connected to the holder, and an adapter sutured to the post and having a color associated with the valve model and/or size. For example, the adapter may be blue to indicate that the valve of the system is a mitral valve of a particular type and/or size. The system may also include a flex handle that is configured to engage with the adapter. The handle has a color associated with the adapter such that a user is able to visually determine that the handle color matches the valve model. For example, the handle may have a grip that is colored blue to match the blue color of the adapter. Accordingly, the color-coded system enables users to confirm easily that the correct accessories such as the sizer or flex handle are being used with the correct valve.
摘要翻译：一种颜色编码的生物人造瓣膜系统，其具有带环形缝合环的瓣膜，以及具有缝合到瓣膜环的保持器的瓣膜保持器系统，可操作地连接到保持器的柱，以及适配器缝合到柱上并具有与阀模型和/或尺寸相关的颜色。例如，适配器可以是蓝色的，以指示系统的瓣膜是特定类型和/或尺寸的二尖瓣。该系统还可以包括被配置为与适配器接合的柔性手柄。手柄具有与适配器相关联的颜色，使得用户能够可视地确定手柄颜色与阀模型匹配。例如，手柄可以具有蓝色的把手，以匹配适配器的蓝色。因此，颜色编码系统使用户能够轻松确认正确的配件，如尺寸测定仪或弹性手柄正在使用正确的阀门。

9. 发明申请

WO2010138448A1 SYSTEMS AND METHODS FOR MAKING AND USING IMAGE-GUIDED INTRAVASCULAR AND ENDOCARDIAL THERAPY SYSTEMS 审中-公开
标题翻译：制造和使用图像引导的血管内和外科治疗系统的系统和方法
公开(公告)号：WO2010138448A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/035944
申请日：2010-05-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KIM, Grace , TEO, Tat-Jin , HUIBREGTSE, Barbara
发明人： KIM, Grace , TEO, Tat-Jin , HUIBREGTSE, Barbara
IPC分类号： A61B8/12
CPC分类号： A61B5/4839 , A61B8/12 , A61B8/445
摘要： A catheter assembly includes a catheter and a delivery element The catheter has a distal end with a distal tip, a proximal end, and a longitudinal length, the catheter includes a body that defines a central lumen extending along the catheter to the distal end. The catheter also includes a forward-facing transducer array disposed at the distal tip of the catheter. The transducer array is configured and arranged for transforming applied electrical signals to acoustic signals and also for transforming received echo signals to electrical signals. At least one catheter conductor is electrically coupled to the transducer array and extends along the catheter. The delivery element is disposed in the lumen of the catheter. The delivery element includes a distal tip that is configured and arranged for contacting patient tissue, The distal tip of the delivery element is configured and arranged to extend beyond the distal tip of the catheter.
摘要翻译：导管组件包括导管和输送元件。导管具有远端，其具有远侧末端，近端和纵向长度，导管包括限定沿着导管延伸到远端的中心腔的主体。导管还包括设置在导管的远端的前向换能器阵列。换能器阵列被配置和布置用于将施加的电信号转换成声信号，并且还用于将接收到的回波信号变换为电信号。至少一个导管导体电耦合到换能器阵列并且沿导管延伸。输送元件设置在导管的内腔中。递送元件包括构造和布置成用于接触患者组织的远侧末端。输送元件的远侧末端被构造和布置成延伸超过导管的远侧末端。

10. 发明申请

WO2010014755A1 METHODS AND COMPOUNDS FOR ENHANCING ANTI-CANCER THERAPY 审中-公开
标题翻译：用于增强抗癌治疗的方法和化合物
公开(公告)号：WO2010014755A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052160
申请日：2009-07-29
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO , GRAHAM, Douglas, Kim , LINGER, Rachel , DERYCKERE, Deborah , SATHER, Susan, Louise , KEATING, Amy , KIM, Grace , BRANDAO, Luis
发明人： GRAHAM, Douglas, Kim , LINGER, Rachel , DERYCKERE, Deborah , SATHER, Susan, Louise , KEATING, Amy , KIM, Grace , BRANDAO, Luis
IPC分类号： C12Q1/68
CPC分类号： C07K16/3061 , A61K39/39558 , A61K2039/505 , C12N15/1138 , C12N2310/14 , C12N2310/531 , A61K2300/00
摘要： The invention provides methods of treating neoplastic disorders in a mammal through the inhibition of Mer and/or AxI receptor tyrosine kinases as well as compounds and compositions useful for inhibiting these kinases in these methods. These treatment methods may be combined with the administration of one or more chemo therapeutic agent(s) to enhance the efficacy or minimize the toxicities of the chemotherapeutic agent(s).
摘要翻译：本发明提供通过抑制Mer和/或AxI受体酪氨酸激酶以及在这些方法中用于抑制这些激酶的化合物和组合物来治疗哺乳动物的肿瘤性疾病的方法。这些治疗方法可以与施用一种或多种化学治疗剂组合以增强化疗剂的功效或最小化化学治疗剂的毒性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式