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1. 发明申请

WO2012015158A3 CARGO HOLD OF A VESSEL FOR TRANSPORTING LIQUEFIED GAS 审中-公开
标题翻译：货物携带运输液化气体的容器
公开(公告)号：WO2012015158A3
公开(公告)日：2012-04-12
申请号：PCT/KR2011003674
申请日：2011-05-19
申请人： SAMSUNG HEAVY IND , KIM JI HAN , CHUN SANG EON , HWANG JEONG OH
发明人： KIM JI HAN , CHUN SANG EON , HWANG JEONG OH
IPC分类号： B63B25/16 , B63B3/68 , B65D90/06 , F17C1/12
CPC分类号： B63B25/16 , B63B3/68 , F17C3/04
摘要： The present invention relates to the cargo hold of a vessel for transporting liquefied gas. The cargo hold of a vessel for transporting liquefied gas according to an embodiment of the present invention comprises: a main bulkhead surrounding a holding space for holding liquefied gas; a panel assembly surrounding the main bulkhead; and an outer wall surrounding the panel assembly. The panel assembly comprises: a plurality of first thermally insulated panels disposed a first distance apart; a plurality of first auxiliary bulkheads fixed at one surface thereof to the first thermally insulated panels; a plurality of second thermally insulated panels fixed to another surface of the first auxiliary bulkheads, and disposed at a second distance apart which is greater than the first distance; a bridge pad disposed in spaces between each of the second thermally insulated panels and spaced apart from the second thermally insulated panels; and a second auxiliary bulkhead disposed between the bridge pad and the first auxiliary bulkheads, and having one surface thereof fixed to the bridge pad and a portion of another surface thereof fixed to the first auxiliary bulkheads. A first fixing region is provided in which an adhesive is applied between the first thermally insulated panels and the first auxiliary bulkheads fixed on the first thermally insulated panels, to fix the first thermally insulated panels to the first auxiliary bulkheads; and a first stress distribution region is formed without any adhesive applied thereto in order to prevent damage to the first auxiliary bulkhead or the second auxiliary bulkhead due to thermal expansion or thermal shrinkage of the first thermally insulated panels and bridge pad.
摘要翻译：本发明涉及用于运输液化气体的船舶的货舱。根据本发明实施例的用于运输液化气体的船舶的货舱包括：围绕用于容纳液化气体的容纳空间的主舱壁; 围绕主舱壁的面板组件; 和围绕面板组件的外壁。所述面板组件包括：以第一距离分开设置的多个第一隔热面板; 多个第一辅助隔壁，其一个表面固定到第一隔热面板; 多个第二隔热面板，所述多个第二隔热面板固定到所述第一辅助隔壁的另一个表面，并以大于所述第一距离的第二距离分开布置; 布置在每个所述第二隔热板之间的空间中并且与所述第二隔热板间隔开的桥垫; 以及设置在桥垫和第一辅助隔壁之间的第二辅助隔壁，该第二辅助隔壁的一个表面固定到桥接垫并且其另一个表面的一部分固定到第一辅助隔壁。设置第一固定区域，在所述第一固定区域中，在所述第一绝热板和固定在所述第一绝热板上的所述第一辅助隔板之间施加粘合剂，以将所述第一绝热板固定到所述第一辅助隔板; 并且形成第一应力分布区域而不施加任何粘合剂，以防止由于第一隔热板和桥接垫的热膨胀或热收缩而损坏第一辅助隔壁或第二辅助隔壁。

2. 发明申请

WO2003024956A1 METHOD FOR PREPARING PYRIMIDINONE COMPOUND AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF 审中-公开
标题翻译：制备吡啶酮化合物的方法及其药物接受的盐
公开(公告)号：WO2003024956A1
公开(公告)日：2003-03-27
申请号：PCT/KR2001/001583
申请日：2001-09-21
申请人： BORYUNG PHARMACEUTICAL CO., LTD. , KIM, Sang-lin , KIM, Ji-han , LEE, Jung-bok , YOO, Byoung-wug , TAN, Hyun-kwang
发明人： KIM, Sang-lin , KIM, Ji-han , LEE, Jung-bok , YOO, Byoung-wug , TAN, Hyun-kwang
IPC分类号： C07D401/10
CPC分类号： C07D403/10
摘要： A process for preparing pyrimidinone compound and salts thereof. The method of the present invention enables the convenience to produce the pyrimidinone derivatives in high yields, which pyrimidinone compounds are useful for treating cardiovascular diseases caused by binding angiotensin II to its receptors, through antagonistic activity against angiotensin II receptors.
摘要翻译：嘧啶酮化合物及其盐的制备方法。本发明的方法可以方便地以高产率制备嘧啶酮衍生物，该嘧啶酮化合物可用于通过对血管紧张素II受体的拮抗作用治疗由其结合的血管紧张素II引起的心血管疾病。

3. 发明申请

WO2013015657A3 NOVEL COMPOUND HAVING ANGIOGENESIS INHIBITORY ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：具有血管生成抑制活性的新化合物，其制备方法和包含其的药物组合物
公开(公告)号：WO2013015657A3
公开(公告)日：2013-06-13
申请号：PCT/KR2012006037
申请日：2012-07-27
申请人： BORYUNG PHARM , KIM JI HAN , KIM JE HAK , LEE JOON KWANG , JUNG HAHN-SUN , HAN NAM SEOK , PARK YONG , KANG SEUNG-HOON , JEONG HEE JIN , LEE KYUNG-TAE , CHOI HYE EUN , CHI YONG HA , LEE JOO HAN , PAIK SOO HEUI
发明人： KIM JI HAN , KIM JE HAK , LEE JOON KWANG , JUNG HAHN-SUN , HAN NAM SEOK , PARK YONG , KANG SEUNG-HOON , JEONG HEE JIN , LEE KYUNG-TAE , CHOI HYE EUN , CHI YONG HA , LEE JOO HAN , PAIK SOO HEUI
IPC分类号： C07D213/82 , A61K31/444 , A61P35/00 , C07D401/12
CPC分类号： C07D401/14 , C07D213/82 , C07D401/12 , C07D413/14 , C07D417/14 , C07D495/04
摘要： Provided are a compound of [chemical formula 1] having an angiogenesis inhibitory activity and pharmaceutically acceptable salts thereof, a method for preparing same, and a pharmaceutical composition. The compound of [chemical formula 1] of the present invention exhibits superior angiogenesis inhibitory activity and thus can be valuably used in the prevention and treatment of diseases caused by abnormalities in angiogenesis inhibitory activity.
摘要翻译：提供具有血管生成抑制活性的[化学式1]化合物及其药学上可接受的盐，其制备方法和药物组合物。本发明的[化学式1]的化合物显示出优异的血管生成抑制活性，因此可有效地用于预防和治疗由血管生成抑制活性异常引起的疾病。

4. 发明申请

WO1996008476A1 PYRIMIDINONE DERIVATIVES 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：WO1996008476A1
公开(公告)日：1996-03-21
申请号：PCT/KR1995000121
申请日：1995-09-15
申请人： BORYUNG PHARMACEUTICAL CO., LTD. , PAIK, Woo, Hyun , KIM, Ji, Han , LEE, Jae, Hyoung , JANG, Kyung, Jin , CHO, Kwang, Jae , KANG, Jae, Seog , YOO, Byoung, Wug , PARK, Je, Bum , KIM, Kyung, Jin , LEE, Kun, Ja
发明人： BORYUNG PHARMACEUTICAL CO., LTD.
IPC分类号： C07D239/36
CPC分类号： C07D403/10 , C07D239/36
摘要： This invention relates to pyrimidinone derivatives and the pharmaceutically acceptable salts thereof having remarkable antagonistic action against angiotensin II receptor, and thus useful in treating cardiovascular diseases caused by angiotensin II.
摘要翻译：本发明涉及对血管紧张素II受体具有显着拮抗作用的嘧啶酮衍生物及其药学上可接受的盐，因此可用于治疗由血管紧张素II引起的心血管疾病。

5. 发明申请

WO2011090323A3 NOVEL PREPARATION METHOD OF 2-(2-N-BUTYL-4-HYDROXY-6-METHYL-PYRIMIDIN-5-YL)-N,N-DIMETHYLACETAMIDE 审中-公开
标题翻译： 2-（2-N-丁基-4-羟基-6-甲基 - 嘧啶-5-基）-N，N-二甲基乙酰胺的新型制备方法
公开(公告)号：WO2011090323A3
公开(公告)日：2011-11-10
申请号：PCT/KR2011000401
申请日：2011-01-20
申请人： BORYUNG PHARM , KIM JI-HAN , LEE JOON-KWANG , YOO BYOUNG-WUG , CHOI OK-KYOUNG , KIM HAK-WON , LEE SUN-HWA
发明人： KIM JI-HAN , LEE JOON-KWANG , YOO BYOUNG-WUG , CHOI OK-KYOUNG , KIM HAK-WON , LEE SUN-HWA
IPC分类号： C07D239/36 , C07C235/12 , C07D239/34
CPC分类号： C07D239/36 , C07C231/12 , C07C235/74
摘要： The present invention provides a method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide, comprising reacting a compound of the following formula 2 with pentanamidine or a salt thereof in the presence of a base. [Formula 2] wherein R1 represents C1-C6 linear or branched alkyl or C3-C6 cycloalkyl. Further, the present invention provides a method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide, comprising the steps of: a) reacting 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-acetic acid with a haloformate compound in the presence of a base, and b) reacting the product of Step a) with dimethylamine.
摘要翻译：本发明提供了制备2-（2-正丁基-4-羟基-6-甲基 - 嘧啶-5-基）-N，N-二甲基乙酰胺的方法，包括使下式2的化合物与脒或其盐在碱的存在下。 [式2]其中R1表示C1-C6直链或支链烷基或C3-C6环烷基。此外，本发明提供了制备2-（2-正丁基-4-羟基-6-甲基 - 嘧啶-5-基）-N，N-二甲基乙酰胺的方法，包括以下步骤：a）使2- （2-正丁基-4-羟基-6-甲基 - 嘧啶-5-基） - 乙酸与卤代甲酸酯化合物在碱存在下反应，和b）使步骤a）的产物与二甲胺反应。

6. 发明申请

WO2011090323A2 NOVEL PREPARATION METHOD OF 2-(2-N-BUTYL-4-HYDROXY-6-METHYL-PYRIMIDIN-5-YL)-N,N-DIMETHYLACETAMIDE 审中-公开
标题翻译： 2-（2-N-丁基-4-羟基-6-甲基 - 嘧啶-5-基）-N，N-二甲基乙酰胺的新制备方法
公开(公告)号：WO2011090323A2
公开(公告)日：2011-07-28
申请号：PCT/KR2011/000401
申请日：2011-01-20
申请人： BORYUNG PHARMACEUTICAL CO., LTD , KIM, Ji-Han , LEE, Joon-Kwang , YOO, Byoung-Wug , CHOI, Ok-Kyoung , KIM, Hak-Won , LEE, Sun-Hwa
发明人： KIM, Ji-Han , LEE, Joon-Kwang , YOO, Byoung-Wug , CHOI, Ok-Kyoung , KIM, Hak-Won , LEE, Sun-Hwa
IPC分类号： C07D239/36 , C07D239/34 , C07C235/12
CPC分类号： C07D239/36 , C07C231/12 , C07C235/74
摘要： The present invention provides a method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide, comprising reacting a compound of the following formula 2 with pentanamidine or a salt thereof in the presence of a base. [Formula 2] wherein R 1 represents C 1 -C 6 linear or branched alkyl or C 3 -C 6 cycloalkyl. Further, the present invention provides a method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide, comprising the steps of: a) reacting 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-acetic acid with a haloformate compound in the presence of a base, and b) reacting the product of Step a) with dimethylamine.
摘要翻译：本发明提供制备2-（2-正丁基-4-羟基-6-甲基 - 嘧啶-5-基）-N，N-二甲基乙酰胺的方法，该方法包括使化合物的下式2与戊烷脒或其盐在碱存在下进行反应。 [式2]其中R 1代表C 1 -C 6直链或支链烷基或C 3 -C 6环烷基。此外，本发明提供了制备2-（2-正丁基-4-羟基-6-甲基 - 嘧啶-5-基）-N，N-二甲基乙酰胺的方法，包括以下步骤：a）使2- （2-正丁基-4-羟基-6-甲基 - 嘧啶-5-基） - 乙酸与卤代甲酸酯化合物在碱存在下反应，和b）使步骤a）的产物与二甲胺反应。 p>

7. 发明申请

WO2010147302A3 NOVEL INTERMEDIATES OF VORICONAZOLE AND PREPARATION METHOD OF VORICONAZOLE USING THE SAME 审中-公开
标题翻译：新戊酰唑的新型中间体及其使用的五唑酮的制备方法
公开(公告)号：WO2010147302A3
公开(公告)日：2011-03-10
申请号：PCT/KR2010002715
申请日：2010-04-29
申请人： BORYUNG PHARM , CHOI OK KYOUNG , PARK YONG , LEE JOON KWANG , KIM JI HAN , TAN HYUN KWANG
发明人： CHOI OK KYOUNG , PARK YONG , LEE JOON KWANG , KIM JI HAN , TAN HYUN KWANG
IPC分类号： C07D401/06 , A61K31/4196 , A61K31/506 , A61K47/40
CPC分类号： C07D403/10 , C07D239/38 , C07D403/06
摘要： The present invention provides compounds of Formulas 2 and 4 as novel intermediates of Voriconazole, and a preparation method of Voriconazole using the same. The novel intermediates of the present invention are environmentally friendly because pungent and unpleasant odors particular to thiols are eliminated, and allow Voriconazole to be prepared at high purities and high yields.
摘要翻译：本发明提供式2和化合物4作为伏立康唑的新中间体，以及使用其的伏立康唑的制备方法。本发明的新型中间体是环境友好的，因为硫醇特别的刺激性和令人不愉快的气味被消除，并且允许伏立康唑以高纯度和高产率制备。

8. 发明申请

WO2008032995A1 CLOPIDOGREL(+)-CAMPHORSULFONATE SALT, METHOD OF PREPARING THE SAME AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：柠檬酸盐（+） - 山梨糖醇盐，其制备方法和包含其的药物组合物
公开(公告)号：WO2008032995A1
公开(公告)日：2008-03-20
申请号：PCT/KR2007/004441
申请日：2007-09-14
申请人： BORYUNG PHARMACEUTICAL CO., LTD , KIM, Sang-Lin , TAN, Hyun-Kwang , KIM, Ji-Han , LA, Sung-Bum , LEE, Joon-Kwang , KIM, Gyu-IL , HAN, Nam-Suk , CHOI, Il-Kyun , KANG, Sin-Tack , SONG, Jong-Hwa , KIM, Mi-Soon , CHI, Yong-Ha , LEE, Joo-Han
发明人： KIM, Sang-Lin , TAN, Hyun-Kwang , KIM, Ji-Han , LA, Sung-Bum , LEE, Joon-Kwang , KIM, Gyu-IL , HAN, Nam-Suk , CHOI, Il-Kyun , KANG, Sin-Tack , SONG, Jong-Hwa , KIM, Mi-Soon , CHI, Yong-Ha , LEE, Joo-Han
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present invention provides a crystalline clopidogrel (+)-camphorsulfonate salt, a method of preparing the same, and a composition containing the same as effective ingredient for treating and preventing platelet related vascular disorder. The clopidogrel (+)-camphorsulfonate salt of the present invention has excellent pharmaceutical effect, and is pharmaceutically stable due to their optical purity, thermostable, and non-hygroscopic.
摘要翻译：本发明提供结晶氯吡格雷（+） - 樟脑磺酸盐，其制备方法和含有与治疗和预防血小板相关血管疾病有效成分相同的组合物。本发明的氯吡格雷（+） - 樟脑磺酸盐具有优异的药物作用，由于其光学纯度，耐热性和非吸湿性而具有药学稳定性。

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