专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2018017598A1 COLLAGEN-MIMETIC PEPTIDE MEDIATED DELIVERY OF NUCLEIC ACID CARRIERS FOR EFFICIENT DELIVERY FROM COLLAGEN 审中-公开
标题翻译：胶原 - 模拟肽介导的核酸载体递送用于有效地从胶原递送
公开(公告)号：WO2018017598A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/042645
申请日：2017-07-18
申请人： KIICK, Kristi , SULLIVAN, Millicent , URELLO, Morgan
发明人： KIICK, Kristi , SULLIVAN, Millicent , URELLO, Morgan
IPC分类号： A01N37/18 , A61K38/00
CPC分类号： A61K47/6455 , C07K14/78 , C12N15/87
摘要： The present invention provides a composition for delivering a polynucleotide into cells via a polyplex. The polyplex comprises the polynucleotide and a polymer. The composition comprises the polyplex, a collagen-mimetic peptide (CMP) and collagen fragments. The CMP is bound to the polyplex and the collagen fragments. Also provided are the uses of the composition in methods of delivering a polynucleotide into cells as well as methods of improving wound healing in a subject, enhancing cell proliferation in a subject, enhancing production of extracellular matrix by cells in a subject and/or enhancing cell migration by cells in a subject.
摘要翻译：本发明提供了用于通过聚合物将多核苷酸递送到细胞中的组合物。多聚复合物包含多核苷酸和聚合物。该组合物包含聚复合物，胶原模拟肽（CMP）和胶原片段。 CMP与多聚复合物和胶原蛋白片段结合。还提供了组合物在将多核苷酸递送入细胞的方法中的用途以及改善受试者的伤口愈合，增强受试者中的细胞增殖，增强受试者中细胞产生细胞外基质和/或增强细胞细胞在受试者中的迁移。

2. 发明申请

WO2017020025A1 THERMORESPONSIVE BIOCONJUGATES AND THEIR CONTROLLED DELIVERY OF CARGO 审中-公开
标题翻译：温控生物燃料及其控制的货物运输
公开(公告)号：WO2017020025A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/044917
申请日：2016-07-29
申请人： KIICK, Kristi , LUO, Tianzhi
发明人： KIICK, Kristi , LUO, Tianzhi
IPC分类号： C07K14/78 , A61K47/00 , A61K38/39
CPC分类号： C07K14/78 , A61K38/00 , A61K41/0028 , A61K47/62 , A61K47/6931
摘要： The present invention provides a bioconjugate. The bioconjugate comprises a first molecule comprising an elastin-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule. The bioconjugate is self-assembled into particles, which are disassembled when the temperature is increased. Also provided is a method for delivering a bioconjugate to a target matrix, comprising (a) introducing a bioconjugate self-assembled into particles to a target matrix, wherein the bioconjugate comprises a first molecule comprising an elastin-like peptide (ELP), a second molecule capable of self-associating into an oligomer, and a linker connecting the first molecule with the second molecule, and (b) increasing the temperature of the target matrix to disassemble the particles at the target matrix.
摘要翻译：本发明提供生物共轭物。生物缀合物包含包含弹性蛋白样肽（ELP）的第一分子，能够自缔合成低聚物的第二分子和连接第一分子与第二分子的连接体。生物共轭物自组装成颗粒，当温度升高时它们被分解。还提供了将生物缀合物递送到靶基质的方法，包括（a）将自组装成颗粒的生物缀合物导入靶基质，其中生物缀合物包含包含弹性蛋白样肽（ELP）的第一分子，第二能够自缔合成低聚物的分子和将第一分子与第二分子连接的连接体，和（b）提高目标基质的温度以分解靶基质上的颗粒。

3. 发明申请

WO2018017598A8 COLLAGEN-MIMETIC PEPTIDE MEDIATED DELIVERY OF NUCLEIC ACID CARRIERS FOR EFFICIENT DELIVERY FROM COLLAGEN 审中-公开
公开(公告)号：WO2018017598A8
公开(公告)日：2018-01-25
申请号：PCT/US2017/042645
申请日：2017-07-18
申请人： KIICK, Kristi , SULLIVAN, Millicent , URELLO, Morgan
发明人： KIICK, Kristi , SULLIVAN, Millicent , URELLO, Morgan
IPC分类号： A01N37/18 , A61K38/00
摘要： The present invention provides a composition for delivering a polynucleotide into cells via a polyplex. The polyplex comprises the polynucleotide and a polymer. The composition comprises the polyplex, a collagen-mimetic peptide (CMP) and collagen fragments. The CMP is bound to the polyplex and the collagen fragments. Also provided are the uses of the composition in methods of delivering a polynucleotide into cells as well as methods of improving wound healing in a subject, enhancing cell proliferation in a subject, enhancing production of extracellular matrix by cells in a subject and/or enhancing cell migration by cells in a subject.

4. 发明申请

WO2015168090A1 MULTIMODE DEGRADABLE HYDROGELS FOR CONTROLLED RELEASE OF CARGO SUBSTANCES 审中-公开
标题翻译：用于控制释放货物的多重可降解水凝胶
公开(公告)号：WO2015168090A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/027942
申请日：2015-04-28
申请人： KIICK, Kristi, L. , KLOXIN, April, M. , KHARKAR, Prathamesh, M. , SIVAMANI, Raja , MAVERAKIS, Emanual
发明人： KIICK, Kristi, L. , KLOXIN, April, M. , KHARKAR, Prathamesh, M. , SIVAMANI, Raja , MAVERAKIS, Emanual
IPC分类号： A61K41/00 , C08G75/00 , A61K47/34
CPC分类号： A61K41/0042 , A61K9/06 , A61K41/0019 , A61K47/10 , A61K47/34 , A61K47/42 , C08G65/33327 , C08G65/3344 , C08G2210/00 , C08G2650/04
摘要： A responsive hydrogel-based material may be used as a carrier system for the in situ delivery of various cargo substances, including bioactive moieties. The hydrogel structure, which includes photodegradable and thioether moieties in its three dimensional network, enables finely tuned local release of cargo substances as a function of the in vivo tissue environment (e.g., enzyme concentration or reducing environment) and externally applied stimuli (e.g., light) by selective spatiotemporal hydrogel degradation.
摘要翻译：可以使用响应性水凝胶基材料作为用于原位输送各种货物物质（包括生物活性部分）的载体系统。在其三维网络中包括可光降解和硫醚部分的水凝胶结构使得能够精细调节作为体内组织环境（例如，酶浓度或还原环境）和外部施加的刺激（例如，光）的货物物质的局部释放）通过选择性时空水凝胶降解。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式