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1. 发明申请

WO2007053904A1 PROCESS TO CONTROL PARTICLE SIZE 审中-公开
标题翻译：控制颗粒尺寸的过程
公开(公告)号：WO2007053904A1
公开(公告)日：2007-05-18
申请号：PCT/AU2006/001687
申请日：2006-11-10
申请人： ALPHAPHARM PTY LTD , KERAMIDAS, Panagiotis (Peter) , MOONEY, Dr Brett, Antony
发明人： MOONEY, Dr Brett, Antony
IPC分类号： A61K9/00 , A61K9/14 , A61K9/20 , A61J3/02
CPC分类号： A61K9/14
摘要： A multi-stage process to control the particle size of a pharmaceutical substance comprising the steps of: passing the pharmaceutical substance through a first stage of a particle size reduction process with a first set of particle size control parameters to obtain a feedstock of reduced median particle size and lesser distribution of median particle size for a second stage of a particle size reduction process; passing the feedstock, through a second stage of a particle size reduction process with a second set of particle size control parameters; optionally, using the product of the second stage or subsequent stages as a feedstock in further stages of a multi-stage particle size reduction process with a set of particle size control parameters for each stage; and collecting a pharmaceutical substance with a median particle size greater than 10µm and with a narrow, reproducible distribution of median particle sizes.
摘要翻译：用于控制药物物质的粒径的多阶段方法包括以下步骤：使第一组粒度控制参数通过药物物质通过第一阶段的粒度降低过程，以获得减少的中值粒子的原料颗粒尺寸减小过程的第二阶段的中值粒度的大小和较小的分布; 使原料通过具有第二组粒度控制参数的粒径减小过程的第二阶段; 任选地，使用第二阶段或后续阶段的产物作为进料，在多阶段粒径减小过程的进一步阶段中，每一阶段具有一组粒度控制参数; 并收集中值粒径大于10μm的药物物质，并具有中等粒径的可重复分布。

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