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1. 发明申请

WO2011005484A3 HIGH SPEED LOW POWER MAGNETIC DEVICES BASED ON CURRENT INDUCED SPIN-MOMENTUM TRANSFER 审中-公开
标题翻译：基于电流感应电动势传输的高速低功率磁性装置
公开(公告)号：WO2011005484A3
公开(公告)日：2011-03-03
申请号：PCT/US2010039373
申请日：2010-06-21
申请人： UNIV NEW YORK , KENT ANDREW , STEIN DANIEL , BEAUJOUR JEAN-MARC
发明人： KENT ANDREW , STEIN DANIEL , BEAUJOUR JEAN-MARC
IPC分类号： H01L27/115 , H01L21/8247 , H01L27/10
CPC分类号： G11C11/16 , G11C11/161 , G11C11/1673 , G11C11/1675 , G11C11/5607
摘要： A high speed and low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity and/or magnetization direction. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer. The fixed and freee magnetic layers may have magnetization directions of a substantially non-zero angle relative to the layer normal. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to read out the information stored in the device.
摘要翻译：一种用于使用自旋极化电流来控制和切换用于存储器单元的磁性装置中的磁区的磁化方向和/或螺旋度的高速和低功率方法。磁性装置包括具有固定磁性螺旋度和/或磁化方向的参考磁性层和具有可变磁性和/或磁化方向的自由磁性层。固定磁性层和自由磁性层优选由非磁性层分离。固定和自由磁性层可以具有相对于层法线基本上非零角度的磁化方向。可以将电流施加到装置以引起改变装置的磁状态的扭矩，使得其可以用作写入信息的磁存储器。测量取决于装置的磁状态的电阻来读出存储在装置中的信息。

2. 发明申请

WO2008008541A8 METHODS TO ELICIT, ENHANCE AND SUSTAIN IMMUNE RESPONSES AGAINST MHC CLASS-I RESTRICTED EPITOPES, FOR PROPHYLACTIC OR THERAPEUTIC PURPOSES 审中-公开
标题翻译：方法来提高，增强和保持对MHC类限制性外周血管的免疫应答，用于预防或治疗用途
公开(公告)号：WO2008008541A8
公开(公告)日：2009-10-01
申请号：PCT/US2007016075
申请日：2007-07-14
申请人： MANNKIND CORP , BOT ADRIAN IAN , SMITH KENT ANDREW
发明人： BOT ADRIAN IAN , SMITH KENT ANDREW
IPC分类号： A61K31/675 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K39/00
CPC分类号： A61K31/7068 , A61K31/675 , A61K31/704 , A61K31/7076 , A61K39/0011 , A61K45/06 , A61K2039/5154 , A61K2039/55561 , A61K2300/00
摘要： Embodiments of the present invention relate to methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-l restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response. The methods and compositions disclosed herein, can be used for prophylactic or therapeutic purposes. Further embodiments provide methods of treating a cell proliferative disease, such as cancer by providing to a subject in need thereof a therapeutic strategy comprising an immunogenic composition in combination with a chemotherapeutic agent.
摘要翻译：本发明的实施方案涉及用于诱导，携带和/或扩增针对癌抗原的MHC class-1限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。本文公开的方法和组合物可用于预防或治疗目的。另外的实施方案提供了通过向有需要的受试者提供包含与化学治疗剂组合的免疫原性组合物的治疗策略来治疗细胞增殖性疾病例如癌症的方法。

3. 发明申请

WO2008100598A3 A METHOD FOR ENHANCING T CELL RESPONSE 审中-公开
标题翻译：一种增强细胞应答的方法
公开(公告)号：WO2008100598A3
公开(公告)日：2008-12-31
申请号：PCT/US2008002044
申请日：2008-02-15
申请人： MANNKIND CORP , KUNDIG THOMAS , BOT ADRIAN , SMITH KENT ANDREW , QIU ZHIYONG
发明人： KUNDIG THOMAS , BOT ADRIAN , SMITH KENT ANDREW , QIU ZHIYONG
IPC分类号： A61K39/00 , A61K39/145
CPC分类号： A61K39/39 , A61K2039/5152 , A61K2039/5154 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55577
摘要： Embodiments of the invention disclosed herein relate to methods and compositions for exponentially increasing antigenic stimulation of class I MHC CD8+ T cell responses over that based in the art. Some embodiments relate to an immunogenic composition that enhances an immune response in a subject. In some embodiments, the immunogenic composition comprises an antigen in combination with an immunopotentiator or a biological response modifier (BRM). Overall, the invention disclosed herein demonstrates that increasing antigenic stimulation in a manner independent of the dose of the antigen enhances immunogenicity.
摘要翻译：本文公开的本发明的实施方案涉及用于指数增加I类MHC CD8 + T细胞应答的抗原刺激的方法和组合。一些实施方案涉及增强受试者的免疫应答的免疫原性组合物。在一些实施方案中，免疫原性组合物包含与免疫增强剂或生物反应调节剂（BRM）组合的抗原。总的来说，本文公开的发明证明以与抗原剂量无关的方式增加抗原刺激增强了免疫原性。

4. 发明申请

WO2005020251A2 HIGH SPEED LOW POWER MAGNETIC DEVICES BASED CURRENT INDUCED SPIN-MOMENTUM TRANSFER 审中-公开
标题翻译：基于高速低功率磁电装置的电流感应旋转传递
公开(公告)号：WO2005020251A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/026894
申请日：2004-08-18
申请人： NEW YORK UNIVERSITY , KENT, Andrew , GONZALEZ GARCIA, Enrique , OZYILMAZ, Barbaros
发明人： KENT, Andrew , GONZALEZ GARCIA, Enrique , OZYILMAZ, Barbaros
IPC分类号： H01F
CPC分类号： H01F10/325 , B82Y10/00 , B82Y25/00 , G11C11/161 , G11C11/1673 , G11C11/1675 , G11C11/5607 , H01F10/123 , H01F10/3286 , H01L29/82 , H01L43/08
摘要： The present invention generally relates to the field of magnetic for memory cells that can serve as non-volatile memory. More specially, the present invention describes a high speed and low power method by which a spin polarized electrical current can be used to control and switch the magnetization direction of a magnetic region in such a device. The magnetic device comprises a pinned magnetic layer with a fixed magnetization direction, a free magnetic layer with a free magnetization direction, and a read-out magnetic layer with a fixed magnetization direction. The pinned magnetic layer and the free magnetic layer are separated by a non-magnetic layer, and the free magnetic layer and the read-out magnetic layer are separated by another non-magnetic layer. The magnetization directions of the pinned and free layers generally do not point along the same axis. The non-magnetic layers minimize the magnetic interaction between the magnetic layers. A current is applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to thereby read out the information stored in the device.
摘要翻译：本发明一般涉及可用作非易失性存储器的用于存储器单元的磁场领域。更具体地，本发明描述了可以使用自旋极化电流来控制和切换这种装置中的磁性区域的磁化方向的高速和低功率方法。磁性装置包括具有固定磁化方向的固定磁性层，具有自由磁化方向的自由磁性层和具有固定磁化方向的读出磁性层。固定磁性层和自由磁性层由非磁性层分离，自由磁性层和读出磁性层被另一个非磁性层分离。被钉扎和自由层的磁化方向通常不沿着相同的轴线。非磁性层使磁性层之间的磁性相互作用最小化。电流被施加到装置以引起改变装置的磁状态的扭矩，使得它可以用作写入信息的磁存储器。测量取决于装置的磁状态的电阻，从而读出存储在装置中的信息。

5. 发明申请

WO2014153064A1 PRECESSIONAL MAGNETIZATION REVERSAL IN A MAGNETIC TUNNEL JUNCTION WITH A PERPENDICULAR POLARIZER 审中-公开
标题翻译：一个具有极性极化的磁性隧道连接的反向磁化反应
公开(公告)号：WO2014153064A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/028917
申请日：2014-03-14
申请人： NEW YORK UNIVERSITY , KENT, Andrew , LIU, Huanlong
发明人： KENT, Andrew , LIU, Huanlong
IPC分类号： G11C11/16
CPC分类号： G11C11/161 , G11C11/165 , G11C11/1675 , H01L43/08
摘要： A magnetic device that includes a perpendicular magnetized polarizing layer configured to provide a first spin-torque and an in-plane magnetized free layer having a magnetization vector having at least a first stable state and a second stable state. The magnetic device also includes a reference layer configured to provide a second spin-torque. The first spin-torque and the second spin-torque can combine. The in-plane magnetized free layer and the reference layer form a magnetic tunnel junction and the combined first spin-torque and second spin-torque influences the magnetic state of the in-plane magnetized free layer. An application of a voltage pulse, having either positive or negative polarity and a selected amplitude and duration, through the magnetic device causes the magnetization vector to oscillate between the first stable state and the second stable state for a portion of the duration regardless of an initial state of the magnetization vector.
摘要翻译：一种磁性装置，其包括被配置为提供具有至少第一稳定状态和第二稳定状态的磁化矢量的第一自旋扭矩和面内磁化自由层的垂直磁化偏振层。磁性装置还包括被配置为提供第二自旋扭矩的参考层。第一自旋扭矩和第二自旋扭矩可以组合。面内磁化自由层和参考层形成磁性隧道结，组合的第一自旋转矩和第二自旋转矩影响面内磁化自由层的磁状态。通过磁性装置施加具有正极性或负极性以及所选择的幅度和持续时间的电压脉冲使得磁化矢量在持续时间的一部分期间在第一稳定状态和第二稳定状态之间振荡，而不管初始磁化矢量的状态。

6. 发明申请

WO2009059071A3 HIGH SPEED LOW POWER MAGNETIC DEVICES BASED ON CURRENT INDUCED SPIN-MOMENTUM TRANSFER 审中-公开
公开(公告)号：WO2009059071A3
公开(公告)日：2009-05-07
申请号：PCT/US2008/081893
申请日：2008-10-30
申请人： NEW YORK UNIVERSITY , KENT, Andrew , OZYILMAZ, Barbaros , GONZALEZ GARCIA, Enrique
发明人： KENT, Andrew , OZYILMAZ, Barbaros , GONZALEZ GARCIA, Enrique
IPC分类号： G11C11/15 , H01L27/115
摘要： A high speed and low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer, and the reference layer includes an easy axis perpendicular to the reference layer. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to thereby read out the information stored in the device.

7. 发明申请

WO2009059071A2 HIGH SPEED LOW POWER MAGNETIC DEVICES BASED ON CURRENT INDUCED SPIN-MOMENTUM TRANSFER 审中-公开
标题翻译：基于电流感应电动势传输的高速低功率磁性装置
公开(公告)号：WO2009059071A2
公开(公告)日：2009-05-07
申请号：PCT/US2008081893
申请日：2008-10-30
申请人： UNIV NEW YORK , KENT ANDREW , OZYILMAZ BARBAROS , GONZALEZ GARCIA ENRIQUE
发明人： KENT ANDREW , OZYILMAZ BARBAROS , GONZALEZ GARCIA ENRIQUE
IPC分类号： G11C11/15 , H01L27/11
CPC分类号： G11C11/5607 , G11C11/161 , G11C11/1673 , G11C11/1675
摘要： A high speed and low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer, and the reference layer includes an easy axis perpendicular to the reference layer. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to thereby read out the information stored in the device.
摘要翻译：一种用于使用自旋极化电流来控制和切换用于存储器单元的磁性装置中的磁区的磁化方向和/或螺旋度的高速和低功率方法。磁性装置包括具有固定磁性螺旋度和/或磁化方向的参考磁性层和具有可变磁性的自由磁性层。固定磁性层和自由磁性层优选由非磁性层分离，并且参考层包括垂直于参考层的简易轴。可以将电流施加到装置以引起改变装置的磁状态的扭矩，使得其可以用作写入信息的磁存储器。测量取决于装置的磁状态的电阻，从而读出存储在装置中的信息。

8. 发明申请

WO2008115291A2 ELECTRONIC DEVICES BASED ON CURRENT INDUCED MAGNETIZATION DYNAMICS IN SINGLE MAGNETIC LAYERS 审中-公开
标题翻译：基于电流感生单磁层磁化动力学的电子器件
公开(公告)号：WO2008115291A2
公开(公告)日：2008-09-25
申请号：PCT/US2007/083676
申请日：2007-11-05
申请人： NEW YORK UNIVERSITY , KENT, Andrew , OZYILMAZ, Barbaros
发明人： KENT, Andrew , OZYILMAZ, Barbaros
IPC分类号： G11B5/33
CPC分类号： H01L43/08 , G11C11/161 , G11C11/1673 , G11C11/1675 , H01F1/404 , H01F10/193
摘要： The present invention generally relates to magnetic devices used in memory and information processing applications, such as giant magneto-resistance (GMR) devices and tunneling magneto-resistance devices. More specifically, the present invention is directed to a single ferromagnetic layer device in which an electrical current is used to control and change magnetic configurations as well as induce high frequency magnetization dynamics. The magnetic layer includes full spin-polarized magnetic material, which may also have non¬ uniform magnetization. The non-uniform magnetization is achieved by varying the shape or roughness of the magnetic material. The present invention may be used in memory cells, as well as high frequency electronics, such as compact microwave sources, detectors, mixers and phase shifters.
摘要翻译：本发明一般涉及在存储器和信息处理应用中使用的磁性器件，例如巨磁阻（GMR）器件和隧道磁阻器件。更具体地说，本发明涉及单个铁磁层器件，其中使用电流来控制和改变磁配置以及引起高频磁化动态。磁性层包括完全自旋极化的磁性材料，其也可以不具有; 均匀的磁化。不均匀的磁化是通过改变磁性材料的形状或粗糙度来实现的。本发明可以用于存储单元以及高频电子设备，例如小型微波源，检测器，混频器和移相器。

9. 发明申请

WO2008008541A3 METHODS TO ELICIT, ENHANCE AND SUSTAIN IMMUNE RESPONSES AGAINST MHC CLASS-I RESTRICTED EPITOPES, FOR PROPHYLACTIC OR THERAPEUTIC PURPOSES 审中-公开
公开(公告)号：WO2008008541A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/016075
申请日：2007-07-16
申请人： MANNKIND CORPORATION , BOT, Adrian, Ian , SMITH, Kent, Andrew
发明人： BOT, Adrian, Ian , SMITH, Kent, Andrew
IPC分类号： A61K31/675 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K39/00
摘要： Embodiments of the present invention relate to methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-l restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response. The methods and compositions disclosed herein, can be used for prophylactic or therapeutic purposes. Further embodiments provide methods of treating a cell proliferative disease, such as cancer by providing to a subject in need thereof a therapeutic strategy comprising an immunogenic composition in combination with a chemotherapeutic agent.

10. 发明申请

WO2008008541A2 METHODS TO ELICIT, ENHANCE AND SUSTAIN IMMUNE RESPONSES AGAINST MHC CLASS-I RESTRICTED EPITOPES, FOR PROPHYLACTIC OR THERAPEUTIC PURPOSES 审中-公开
标题翻译：针对预防或治疗目的引发，加强和维持对MHC I类限制性表位的免疫应答的方法
公开(公告)号：WO2008008541A2
公开(公告)日：2008-01-17
申请号：PCT/US2007016075
申请日：2007-07-14
申请人： MANNKIND CORP , BOT ADRIAN IAN , SMITH KENT ANDREW
发明人： BOT ADRIAN IAN , SMITH KENT ANDREW
CPC分类号： A61K31/7068 , A61K31/675 , A61K31/704 , A61K31/7076 , A61K39/0011 , A61K45/06 , A61K2039/5154 , A61K2039/55561 , A61K2300/00
摘要： Embodiments of the present invention relate to methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-l restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response. The methods and compositions disclosed herein, can be used for prophylactic or therapeutic purposes. Further embodiments provide methods of treating a cell proliferative disease, such as cancer by providing to a subject in need thereof a therapeutic strategy comprising an immunogenic composition in combination with a chemotherapeutic agent.
摘要翻译：本发明的实施方案涉及用于诱导，携带和/或扩增对癌抗原的MHC-I类限制性表位的免疫应答以产生有效的抗癌免疫应答的方法和组合物。本文公开的方法和组合物可以用于预防或治疗目的。其他实施方案提供了通过向有需要的受试者提供包含免疫原性组合物与化学治疗剂组合的治疗策略来治疗细胞增殖性疾病例如癌症的方法。

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