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1. 发明申请

WO1992009634A1 NON-A NON-B HEPATITIS VIRUS ANTIGEN PROTEIN 审中-公开
标题翻译：非乙型肝炎病毒抗原蛋白
公开(公告)号：WO1992009634A1
公开(公告)日：1992-06-11
申请号：PCT/JP1991001662
申请日：1991-11-29
申请人： TORAY INDUSTRIES, INCORPORATED , ARIMA, Terukatsu , SATO, Atsushi , IDA, Nobuo , KAZAMI, Jun
发明人： TORAY INDUSTRIES, INCORPORATED
IPC分类号： C07K15/04
CPC分类号： C07K14/005 , A61K38/00 , C12N2770/24222
摘要： Novel non-A non-B hepatitis virus antigen proteins represented by S29 antigen obtained from the serum of a patient with chronic non-A non-B hepatitis. They can be prepared by the genetic recombination technology or chemical synthesis. As they specifically react with the serum of a patient with non-A non-B hepatitis, they can be used in the inspection of such hepatitis.

2. 发明申请

WO2005100349A3 POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：多环吡啶作为钾离子通道调节剂
公开(公告)号：WO2005100349A3
公开(公告)日：2006-03-16
申请号：PCT/US2005012837
申请日：2005-04-13
申请人： ICAGEN INC , ASTELLAS PHARMA INC , WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
发明人： WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
IPC分类号： A61K31/4427 , A61P9/10 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C07D419/14 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环吡啶属。本发明的调节剂在治疗和诊断方法中都有用。

3. 发明申请

WO1990001542A1 LUCIFERASE, LUCIFERASE-CODING GENE, AND PROCESS FOR PREPARING LUCIFERASE 审中-公开
标题翻译： LUCIFERASE，LUCIFERASE-CODING GENE，AND PROCESS FOR PREPARING LUCIFERASE
公开(公告)号：WO1990001542A1
公开(公告)日：1990-02-22
申请号：PCT/JP1989000811
申请日：1989-08-09
申请人： TORAY INDUSTRIES, INC. , KAZAMI, Jun , NAKAMURA, Haruji , GOTO, Toshio
发明人： TORAY INDUSTRIES, INC.
IPC分类号： C12N09/02
CPC分类号： C12N9/0069 , C12Q1/6897 , C12Y113/12006
摘要： Luciferase having the amino acid sequence of Fig. 1 and a gene coding it are disclosed. In addition, a recombinant vector DNA wherein the luciferase-coding gene is connected to the downstream portion of a promoter capable of expressing in each host cell, a transformant obtained by transforming each host cell by the vector DNA, and a process for preparing luciferase using such transformants are also disclosed.
摘要翻译：具有图1氨基酸序列的荧光素酶 1和编码它的基因被公开。此外，其中荧光素酶编码基因连接到能够在每个宿主细胞中表达的启动子的下游部分的重组载体DNA，通过载体DNA转化每个宿主细胞获得的转化体和使用以下方法制备荧光素酶的方法：还公开了这些转化体。

4. 发明申请

WO2005100349A2 POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：作为钾离子通道调节剂的多环吡啶
公开(公告)号：WO2005100349A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/012837
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
发明人： WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
IPC分类号： C07D417/14
CPC分类号： C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环吡啶类。本发明的调节剂可用于治疗和诊断方法。

5. 发明申请

WO2005099711A1 POLYCYCLIC PYRIMIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：多环吡啶作为离子通道调节剂
公开(公告)号：WO2005099711A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012696
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiadong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
发明人： WANG, Xiadong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
IPC分类号： A61K31/506
CPC分类号： C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention provides a genus of polycyclic pyrimidines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环嘧啶属。本发明的调节剂在治疗和诊断方法中都有用。

6. 发明申请

WO1997022595A1 ARYLETHENESULFONAMIDE DERIVATIVES AND DRUG COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：芳香酰胺衍生物和含有其的药物组合物
公开(公告)号：WO1997022595A1
公开(公告)日：1997-06-26
申请号：PCT/JP1996003701
申请日：1996-12-19
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , HARADA, Hironori , KAZAMI, Jun-ichi , WATANUKI, Susumu , TSUZUKI, Ryuji , SUDOU, Katsumi , TANAKA, Akihiro
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D239/46
CPC分类号： C07D239/47 , C07D239/52 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D417/04
摘要： Novel arylethenesulfonamide derivatives having a high affinity for drugs, especially endoserine receptors, and represented by general formula (I); pharmacologically acceptable salts thereof; and drugs comprising the same as the active ingredient, especially endoserine receptor antagonists, wherein Ar represents optionally substituted aryl or optionally substituted five- or six-membered heteroaryl; X represents oxygen, sulfur, or the group represented by -NH-; Y represents oxygen or sulfur; R1 represents hydrogen, lower alkyl optionally substituted with halogeno, cycloalkyl, optionally substituted aryl, or optionally substituted five- or six-membered heteroaryl; R2 represents lower alkyl, lower alkenyl, or lower alkynyl each optionally substituted with one to three groups selected among hydroxy, lower alkoxys, cycloakyls, halogens, carboxy, and lower alkoxycarbonyls; R3 represents phenyl optionally substituted with one to four groups selected among optionally halogenated lower alkyls, lower alkoxys, halogens, lower alkylthios, lower alkylsulfinyls, lower alkanesulfonyls, carboxy, lower alkoxycarbonyls, and carbamoyl; and R4 and R5 are the same or different and each represents hydrogen or lower alkyl.
摘要翻译：用于药物，特别是内啡肽受体的高亲和力的由通式（I）表示的新型芳酰基磺酰胺衍生物; 其药理学上可接受的盐; 和包含与活性成分相同的药物，特别是内啡肽受体拮抗剂，其中Ar表示任选取代的芳基或任选取代的五元或六元杂芳基; X表示氧，硫或-NH-表示的基团; Y表示氧或硫; R 1表示氢，任选被卤代，环烷基，任选取代的芳基或任选取代的五元或六元杂芳基取代的低级烷基; 每个任选被一至三个选自羟基，低级烷氧基，环烷基，卤素，羧基和低级烷氧基羰基的基团取代的低级烷基，低级烯基或低级炔基; R 3表示任选被一至四个选自任选卤代的低级烷基，低级烷氧基，卤素，低级烷硫基，低级烷基亚磺酰基，低级烷磺酰基，羧基，低级烷氧基羰基和氨基甲酰基的基团取代的苯基。且R 4和R 5相同或不同，各自表示氢或低级烷基。

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