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1. 发明申请

WO0008047A8 DEPSIPEPTIDE DERIVATIVES BEARING PIPERAZINONE RINGS 审中-公开
标题翻译：含哌嗪酮环的哌普生衍生物
公开(公告)号：WO0008047A8
公开(公告)日：2000-05-04
申请号：PCT/JP9904205
申请日：1999-08-04
申请人： NISSHIN FLOUR MILLING CO , YANAI MAKOTO , SUZUKI MASASHI , OSHIDA NORIO , KAWAMURA KOJI , HIRAMOTO SHIGERU , YASUDA ORIE , KINOSHITA NOBUHIRO , SHINGAI AKIKO , TAKASU MASAKO
发明人： YANAI MAKOTO , SUZUKI MASASHI , OSHIDA NORIO , KAWAMURA KOJI , HIRAMOTO SHIGERU , YASUDA ORIE , KINOSHITA NOBUHIRO , SHINGAI AKIKO , TAKASU MASAKO
IPC分类号： A61K38/00 , C07K5/02 , C07K5/078 , C07K5/062 , A61K31/50 , A61K38/06 , C07D241/08 , C07K5/072 , C07K5/083
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/0207
摘要： Novel depsipeptide derivatives bearing piperazinone rings in the molecule, represented by general formula (1) wherein X1 is N(R4)-CO, N(R5)-CH2, CH2-CO, CH2-CH2, CH=CH, CH2-CH(OH) or CH(OH)-CH(OH); R1 is C5-C20 alkyl or alkoxy(C5-C15)alkyl(C1-C4); R2 to R5 are each hydrogen or C1-C6 alkyl; and A is (2), (3) or (4): -X2-CH(R11)-X3-CH(R12)-NH-R13. These derivatives exhibit apolipoprotein E production accelerating activities, thus being useful as remedies for nerve injury, dementia and hyperlipidemia.
摘要翻译：由通式（1）表示的分子中带有哌嗪酮环的新型缩酚酸肽衍生物，其中X1是N（R4）-CO，N（R5）-CH2，CH2-CO，CH2-CH2，CH = CH，CH2- OH）或CH（OH）-CH（OH）; R1是C5-C20烷基或烷氧基（C5-C15）烷基（C1-C4）; R2至R5各自为氢或C1-C6烷基; （2），（3）或（4）：-X2-CH（R11）-X3-CH（R12）-NH-R13。这些衍生物表现出载脂蛋白E产生促进活性，因此可用作神经损伤，痴呆和高脂血症的治疗剂。

2. 发明申请

WO1997049724A1 CYCLIC DEPSIPEPTIDES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 审中-公开
标题翻译：循环阻断剂和含有它们作为活性成分的药物
公开(公告)号：WO1997049724A1
公开(公告)日：1997-12-31
申请号：PCT/JP1997002194
申请日：1997-06-25
申请人： NISSHIN FLOUR MILLING CO., LTD. , YANAI, Makoto , SUZUKI, Masashi , OSHIDA, Norio , KAWAMURA, Koji , HIRAMOTO, Shigeru , YASUDA, Orie , KINOSHITA, Nobuhiro , SHINGAI, Akiko , KANAI, Masako
发明人： NISSHIN FLOUR MILLING CO., LTD.
IPC分类号： C07K07/06
CPC分类号： C07K7/06 , A61K38/00
摘要： Cyclic depsipeptides represented by general formula (1) or pharmacologically acceptable salts thereof, wherein R represents linear or branched C5-20 alkyl or linear or branched C5-15 alkoxymethyl; A, B, D, E and F independently represent each alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently represent each aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently represent each 0 or 1. These compounds are produced by the conventional methods for synthezing peptides. They are useful as apolipoprotein E production promoters, remedies for nerve injury, remedies for dementia, apolipoprotein B production inhibitors, apolipoprotein A1 production promoters and remedies for hyperlipemia.
摘要翻译：由通式（1）表示的环状缩酚酸肽或其药学上可接受的盐，其中R表示直链或支链的C 5-20烷基或直链或支链的C 5-15烷氧基甲基; A，B，D，E和F独立地表示丙氨酸，缬氨酸，亮氨酸，异亮氨酸，苯丙氨酸等; W和Z独立地表示各天冬氨酸，天冬酰胺，谷氨酸或谷氨酰胺; m和n独立地表示0或1.这些化合物通过用于合成肽的常规方法制备。它们可用作载脂蛋白E生产促进剂，神经损伤补救剂，痴呆症药物，载脂蛋白B生产抑制剂，载脂蛋白A1生产促进剂和高脂血症治疗药物。

3. 发明申请

WO1997049722A1 DEPSIPEPTIDES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 审中-公开
标题翻译：其含有作为活性成分的药物和药物
公开(公告)号：WO1997049722A1
公开(公告)日：1997-12-31
申请号：PCT/JP1997002195
申请日：1997-06-25
申请人： NISSHIN FLOUR MILLING CO., LTD. , YANAI, Makoto , SUZUKI, Masashi , OSHIDA, Norio , KAWAMURA, Koji , HIRAMOTO, Shigeru , YASUDA, Orie , KINOSHITA, Nobuhiro , SHINGAI, Akiko , KANAI, Masako
发明人： NISSHIN FLOUR MILLING CO., LTD.
IPC分类号： C07K05/02
CPC分类号： C07K5/1021 , A61K38/00 , C07K5/06043 , C07K5/06052 , C07K5/06104 , C07K5/101 , C07K7/06 , C07K11/00
摘要： Depsipeptides represented by general formula (1) or pharmacologically acceptable salts thereof, wherein R1 represents linear or branched C5-20 alkyl or linear or branched C5-15 alcoxymethyl; R2 represents -A-B, -A-B-W, -A-B-W-D or -A-B-W-D-E; and R3 represents hydroxy, lower alkoxy, benzyloxy, -Z, -Z-G or -Z-G-J, wherein A, B, D, E, G and J independently represent each an amino acid residue selected from among alanine, valine, leucine, isoleucine, serine, threonine, lysine, hydroxylysine, arginine, cysteine, methionine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamic acid, glutamine, etc. optionally bonded to N-(C1-4 alkyl); W and Z independently represent each an animo acid residue selected from among aspartic acid, asparagine, glutamic acid, glutamine, alanine, serine, and lysine. These depsipeptides have the effects of promoting apolipoprotein E production and are useful as remedies for nerve injury and, in particular, remedies for dementia. They are also useful as remedies for hyperlipemia.
摘要翻译：由通式（1）表示的多肽或其药理学上可接受的盐，其中R 1表示直链或支链的C 5-20烷基或直链或支链的C 5-15烷氧基甲基; R2代表-A-B，-A-B-W，-A-B-W-D或-A-B-W-D-E; 并且R 3表示羟基，低级烷氧基，苄氧基，-Z，-ZG或-ZGJ，其中A，B，D，E，G和J各自独立地表示选自丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，任选地键合到N-（C 1-4烷基）上的苏氨酸，赖氨酸，羟赖氨酸，精氨酸，半胱氨酸，甲硫氨酸，苯丙氨酸，酪氨酸，天冬氨酸，天冬酰胺，谷氨酸，谷氨酰胺等。 W和Z独立地表示各自选自天冬氨酸，天冬酰胺，谷氨酸，谷氨酰胺，丙氨酸，丝氨酸和赖氨酸中的一个酸性残基。这些脱脂肽具有促进载脂蛋白E产生的作用，并且可用作神经损伤的补救措施，特别是用于痴呆的补救措施。它们也可用作高脂血症的补救措施。

4. 发明申请

WO2007081044A1 ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS 审中-公开
标题翻译：电子图像形成装置
公开(公告)号：WO2007081044A1
公开(公告)日：2007-07-19
申请号：PCT/JP2007/050625
申请日：2007-01-11
申请人： CANON KABUSHIKI KAISHA , KAWAMURA, Koji
发明人： KAWAMURA, Koji
IPC分类号： G03G21/16 , G03G15/01 , G03G21/18
CPC分类号： G03G21/1853 , G03G15/0194 , G03G21/1623 , G03G21/1825 , G03G2221/1684 , G03G2221/169 , G03G2221/1861 , G03G2221/1869
摘要： An electrophotographic image forming apparatus (100) to which a plurality of process cartridge (s) are detachably mountable, the cartridge (s) including an electrophotographic photosensitive drum (1) , a developing roller (3a) , a first frame (5) supporting the drum, and a second frame (3) supporting the developing roller which is movable between a contact position where the developing roller contacts the drum and a spacing position where the developing roller is spaced from the drum, the apparatus including a drawing member (35) to which the plurality of cartridges are detachably mountable, the drawing member being movable in a substantially horizontal direction perpendicular to an axial- direction of the drum between a mount position where the cartridges are mounted in a main assembly of the apparatus and a drawn position where the drawing member is drawn out of the main assembly; a spacer member (92) movable between a retracted position where the spacer member is retracted from a movement path of the cartridge to permit movement of the cartridge mounted on the drawing member and an operating position where the spacer member is in the movement path to move the second frame between the contact position and the spacing position.
摘要翻译：一种电子照相图像形成装置（100），多个处理盒可拆卸地安装到该电子照相成像装置上，该盒包括电子照相感光鼓（1），显影辊（3a），第一框架（5）滚筒和支撑显影辊的第二框架（3），该显影辊可在显影辊接触滚筒的接触位置与显影辊与滚筒间隔开的间隔位置之间移动，该装置包括一个牵引件（35）），所述多个盒可拆卸地安装到所述盒上，所述拉伸构件可在垂直于所述滚筒轴向的基本上水平的方向上移动，所述基本水平方向在所述盒安装在所述装置的主组件中的安装位置与所述拉出位置绘图构件从主组件中拉出; 间隔构件（92），其可在缩回位置和缩回位置之间移动，所述间隔构件从所述盒的移动路径缩回以允许安装在所述绘图构件上的所述盒的移动以及所述间隔构件在所述移动路径中移动的操作位置接触位置和间隔位置之间的第二框架。

5. 发明申请

WO1991013976A1 PROCESS FOR PRODUCING PURIFIED TISSUE PLASMINOGEN ACTIVATOR OR ITS DERIVATIVE 审中-公开
标题翻译：生产纯化的组织培养基激活剂或其衍生物的方法
公开(公告)号：WO1991013976A1
公开(公告)日：1991-09-19
申请号：PCT/JP1991000319
申请日：1991-03-08
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KAWAUCHI, Yasushi , KAWAMURA, Koji , SUZUKI, Yoriko , MORINAGA, Tetuo , FURUICHI, Kiyoshi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C12N09/64
CPC分类号： C12N9/6459 , C12Y304/21069
摘要： An industrially advantageous process for producing highly pure tissue plasminogen activator (TPA) or its derivatives readily at low cost, which comprises treating a liquid containing TPA or its derivatives either by affinity chromatography, hydrophobic chromatography, cation exchange chromatography and, if necessary, anion exchange chromatography, or with a chromatographic gel comprising cellulose sulfate or cross-linked polysaccharide sulfate.
摘要翻译：一种在低成本下容易生产高纯度组织纤溶酶原激活剂（TPA）或其衍生物的工业上有利的方法，其包括通过亲和层析，疏水层析，阳离子交换层析和必要时阴离子交换处理含TPA或其衍生物的液体色谱法或含有硫酸锌或交联多糖硫酸盐的色谱凝胶。

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