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1. 发明申请

WO2014152338A1 TARGETED GASTROINTESTINAL TRACT DELIVERY OF PROBIOTIC ORGANISMS AND/OR THERAPEUTIC AGENTS 审中-公开
标题翻译：有针对性的胃肠道传播和/或治疗药物
公开(公告)号：WO2014152338A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027228
申请日：2014-03-14
申请人： KABADI, Mohan , SCHENTAG, Jerome, J.
发明人： KABADI, Mohan , SCHENTAG, Jerome, J.
IPC分类号： A61K9/48 , A61K47/38 , A61K47/30 , A61P3/00
CPC分类号： A61K9/4808 , A61K9/4816 , A61K9/4866 , A61K9/4891 , A61K35/741 , A61K35/744 , A61K35/745 , A61K35/747
摘要： The present invention relates to the development of a targeted delivery system for the oral delivery of probiotics or therapeutic agent for various indications, including and not limited to active and prophylaxis treatment of Clostridium difficile infection, antibiotic associated diarrhea, irritable bowel syndrome, Crohn's disease, intestinal flora replacement, supplemental flora treatments for patients taking antibiotics, and for restoration of balance and signaling between the intestinal microbiome and the intestinal cells in patients under treatment of metabolic syndrome manifestations, specifically diabetes, insulin resistance, obesity, hyperlipidemia and hypertension. The present invention restores altered probiotic organism imbalances that are characteristic of said diseases among others as well as defines a platform technology development for site specific delivery of probiotic organisms in the GI tract of a mammal, most specifically the ileum and/or right colon of a human subject.
摘要翻译：本发明涉及用于口服递送益生菌或治疗剂用于各种适应症的靶向递送系统的开发，包括但不限于活化和预防艰难梭菌感染，抗生素相关性腹泻，肠易激综合征，克罗恩病，肠道菌群替代，服用抗生素的患者的补充性菌群治疗，以及用于恢复代谢综合征症状治疗的患者中肠微生物群和肠细胞之间的平衡和信号转导，特别是糖尿病，胰岛素抵抗，肥胖，高脂血症和高血压。本发明恢复了所述疾病特征的改变的益生菌生物失衡，以及定义了用于哺乳动物胃肠道中的益生菌生物体的特异性递送的平台技术开发，最特别地是一种哺乳动物的回肠和/或右结肠人类科目。

2. 发明申请

WO2013148258A1 GASTROINTESTINAL SITE-SPECIFIC ORAL VACCINATION FORMULATIONS ACTIVE ON THE ILEUM AND APPENDIX 审中-公开
标题翻译：胃肠和附件活动的胃肠道特异性口服疫苗配方
公开(公告)号：WO2013148258A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/031483
申请日：2013-03-14
申请人： SCHENTAG, Jerome , KABADI, Mohan
发明人： SCHENTAG, Jerome , KABADI, Mohan
IPC分类号： A61K9/48 , A61K47/30 , A61K47/48 , A61K39/12 , A61P35/00
CPC分类号： A61K9/0065 , A61K9/1617 , A61K9/4808 , A61K9/4816 , A61K9/4866 , A61K9/4891 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K39/00 , A61K2039/542 , Y02A50/403 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A50/476 , Y02A50/478 , Y02A50/48 , Y02A50/484 , Y02A50/489 , Y02A50/491
摘要： The invention provides oral vaccine formulations which deliver an antigen in the vicinity of the distal ileum and the area of the ileal Brake and/or the appendix. These vaccines are useful in the treatment and/or prevention of variety of disorders, including viral and bacterial infections and cancers. Related methods of treatment which use the oral vaccine formulations of the invention are also provided.
摘要翻译：本发明提供口服疫苗制剂，其在回肠末端附近和回肠制动器和/或阑尾的区域内递送抗原。这些疫苗可用于治疗和/或预防各种病症，包括病毒和细菌感染和癌症。还提供了使用本发明的口服疫苗制剂的相关治疗方法。

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