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1. 发明申请

WO2008077092A2 COMBINED EFFECTS OF TOPIRAMATE AND ONDANSETRON ON ALCOHOL CONSUMPTION 审中-公开
标题翻译：环丙沙星和沙丁胺醇对酒精消耗的联合作用
公开(公告)号：WO2008077092A2
公开(公告)日：2008-06-26
申请号：PCT/US2007088100
申请日：2007-12-19
申请人： UNIV VIRGINIA , JOHNSON BANKOLE A , TOURIRINE NASSIMA AIT-DAOUD
发明人： JOHNSON BANKOLE A , TOURIRINE NASSIMA AIT-DAOUD
IPC分类号： A61K31/551
CPC分类号： A61K31/485 , A61K31/4178 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： The present invention provides for the use of combinations of drugs to treat addictive disorders. More specifically, the present invention relates the use of drugs in conjunction with behavioral intervention to treat alcohol-related diseases and disorders as well as treatment of obesity and regulating weight.
摘要翻译：本发明提供了药物组合用于治疗成瘾性疾病的用途。更具体地说，本发明涉及药物与行为干预联合使用以治疗酒精相关疾病和病症以及治疗肥胖和调节体重。

2. 发明申请

WO2009026381A3 METHOD, COMPUTER PROGRAM PRODUCT AND SYSTEM FOR INDIVIDUAL ASSESSMENT OF ALCOHOL SENSITIVITY 审中-公开
标题翻译：方法，计算机程序产品和用于单独评估酒精灵敏度的系统
公开(公告)号：WO2009026381A3
公开(公告)日：2009-12-30
申请号：PCT/US2008073738
申请日：2008-08-20
申请人： UNIV VIRGINIA , JOHNSON BANKOLE A , TIOURIRINE NASSIMA AIT-DAOUD , BRETON MARC D , KOVATCHEV BORIS P
发明人： JOHNSON BANKOLE A , TIOURIRINE NASSIMA AIT-DAOUD , BRETON MARC D , KOVATCHEV BORIS P
IPC分类号： G06G7/48 , G06F19/12
CPC分类号： G06F19/12
摘要： Methods/computer methods and systems/computer systems for the evaluation of two idiosyncratic indices of alcohol intoxication: the Alcohol Sensitivity Index (ASI), and the brain-specific Cognitive Alcohol Sensitivity Index (CASI). The two indices are based on the new Metabolic and Cognitive Minimal Models of Alcohol Dynamics, and are derived from specific clinical protocols, accompanied by specific data analysis procedures. The two indices may be derived from specific clinical and cognitive assessment protocols, accompanied by specific data analysis procedures based on the new metabolic and cognitive minimal models of alcohol dynamics.
摘要翻译：方法/计算机方法和系统/计算机系统评估酒精中毒的两个特质指数：酒精敏感指数（ASI）和大脑特异性认知酒精敏感指数（CASI）。这两个指数基于新的酒精动力学新代谢和认知最小模型，并且来源于特定的临床方案，并附有特定的数据分析程序。这两个指标可以来自特定的临床和认知评估协议，伴随着基于酒精动力学新的代谢和认知最小模型的特定数据分析程序。

3. 发明申请

WO2008077092A8 COMBINED EFFECTS OF TOPIRAMATE AND ONDANSETRON ON ALCOHOL CONSUMPTION 审中-公开
标题翻译： TOPIRAMATE和ONDANSETRON对酒精消费的组合效应
公开(公告)号：WO2008077092A8
公开(公告)日：2009-08-20
申请号：PCT/US2007088100
申请日：2007-12-19
申请人： UNIV VIRGINIA , JOHNSON BANKOLE A , TIOURIRINE NASSIMA AIT-DAOUD
发明人： JOHNSON BANKOLE A , TIOURIRINE NASSIMA AIT-DAOUD
IPC分类号： A61K31/00
CPC分类号： A61K31/485 , A61K31/4178 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： The present invention provides for the use of combinations of drugs to treat addictive disorders. More specifically, the present invention relates the use of drugs in conjunction with behavioral intervention to treat alcohol-related diseases and disorders as well as treatment of obesity and regulating weight.
摘要翻译：本发明提供药物组合用于治疗成瘾性疾病的用途。更具体地，本发明涉及药物与行为干预联合用于治疗酒精相关疾病和病症以及治疗肥胖症并调节体重的用途。

4. 发明申请

WO2009108837A2 SEROTONIN TRANSPORTER GENE AND TREATMENT OF ALCOHOLISM 审中-公开
标题翻译：血清素转运蛋白基因与酒精中毒治疗
公开(公告)号：WO2009108837A2
公开(公告)日：2009-09-03
申请号：PCT/US2009035420
申请日：2009-02-27
申请人： UNIV VIRGINIA , JOHNSON BANKOLE A
发明人： JOHNSON BANKOLE A
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/4178 , A61K45/06 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6872 , G01N33/942 , G01N2800/307 , G01N2800/50
摘要： The gene responsible for encoding SERT has a functional polymorphism at the 5'-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3' UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.
摘要翻译：负责编码SERT的基因在5'调控启动子区域具有功能多态性，其导致长（L）和短（S）两种形式。假设LL-基因型在酒精使用的早期发作中起关键作用。本发明公开了基于L或短基因型以及SERT基因的单核苷酸多态性（3'UTR SNP rs1042173）的治疗和诊断的差异。本发明证明了使用药物昂丹司琼和类似药物基于SERT基因多态性变化进行治疗的功效以及诊断滥用酒精和其他成瘾相关疾病和病症的易感性的方法。

5. 发明申请

WO2009026381A2 METHOD, COMPUTER PROGRAM PRODUCT AND SYSTEM FOR INDIVIDUAL ASSESSMENT OF ALCOHOL SENSITIVITY 审中-公开
标题翻译：方法，计算机程序产品和用于个人评估酒精灵敏度的系统
公开(公告)号：WO2009026381A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/073738
申请日：2008-08-20
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , JOHNSON, Bankole A. , TIOURIRINE, Nassima Ait-Daoud , BRETON, Marc D. , KOVATCHEV, Boris P.
发明人： JOHNSON, Bankole A. , TIOURIRINE, Nassima Ait-Daoud , BRETON, Marc D. , KOVATCHEV, Boris P.
IPC分类号： G06F19/00
CPC分类号： G06F19/12
摘要： Methods/computer methods and systems/computer systems for the evaluation of two idiosyncratic indices of alcohol intoxication: the Alcohol Sensitivity Index (ASI), and the brain-specific Cognitive Alcohol Sensitivity Index (CASI). The two indices are based on the new Metabolic and Cognitive Minimal Models of Alcohol Dynamics, and are derived from specific clinical protocols, accompanied by specific data analysis procedures. The two indices may be derived from specific clinical and cognitive assessment protocols, accompanied by specific data analysis procedures based on the new metabolic and cognitive minimal models of alcohol dynamics.
摘要翻译：方法/计算机方法和系统/计算机系统，用于评估酒精中毒的两种特异性指标：酒精敏感指数（ASI）和脑特异性认知酒精敏感性指数（CASI）。这两个指标基于酒精动力学的新型代谢和认知最小模型，并且来自具体的临床方案，并伴有特定的数据分析程序。这两个指标可能来自特定的临床和认知评估方案，并伴随着基于酒精动力学的新代谢和认知最小模型的特定数据分析程序。

6. 发明申请

WO2013036721A1 MOLECULAR GENETIC APPROACH TO TREATMENT AND DIAGNOSIS OF ALCOHOL AND DRUG DEPENDENCE 审中-公开
标题翻译：分子遗传学方法治疗和诊断酒精和药物依赖
公开(公告)号：WO2013036721A1
公开(公告)日：2013-03-14
申请号：PCT/US2012/054090
申请日：2012-09-07
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , JOHNSON, Bankole A.
发明人： JOHNSON, Bankole A.
IPC分类号： C07K14/705
CPC分类号： A61K31/4178 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides compositions and methods useful for diagnosing, treating, and monitoring alcohol dependence and disorders and susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The present invention also relates to methods and assays useful for determining whether a subject has a predisposition to developing an addictive disease or disorder, determining whether a subject will be responsive to particular treatments, and compositions and methods useful for treating a subject in need of treatment. The present invention also relates to compositions and methods useful for treating subjects having an addictive disease or disorder (or who are predisposed thereto) based on identification of genetic markers indicative of a subject being predisposed to such disease or disorder or being predisposed to responding to treatment thereof.
摘要翻译：本发明提供了用于诊断，治疗和监测酒精依赖性和障碍以及对酒精依赖性障碍的易感性以及与药物有关的依赖性和病症的组合物和方法。本发明还涉及用于确定受试者是否具有发展成瘾性疾病或病症倾向性，确定受试者是否对特定治疗有反应的方法和测定，以及可用于治疗需要治疗的受试者的组合物和方法。本发明还涉及用于治疗患有成瘾性疾病或病症（或倾向于患有此类疾病或受体易感患者）的受试者的组合物和方法，其基于识别指示受试者易患这种疾病或病症或倾向于对治疗作出反应的遗传标记它们。

7. 发明申请

WO2012003462A4 MOLECULAR GENETIC APPROACH TO TREATMENT AND DIAGNOSIS OF ALCOHOL AND DRUG DEPENDENCE 审中-公开
标题翻译：分子遗传学方法治疗和诊断酒精和药物依赖
公开(公告)号：WO2012003462A4
公开(公告)日：2012-03-22
申请号：PCT/US2011042823
申请日：2011-07-01
申请人： JOHNSON BANKOLE A
发明人： JOHNSON BANKOLE A
IPC分类号： C12Q1/68
CPC分类号： A61K31/4178 , A61K31/7048 , C12Q1/6883 , C12Q1/6888 , C12Q2600/106 , C12Q2600/172 , G06F19/18
摘要： Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotoin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.
摘要翻译：提供了有助于诊断，治疗和监测酒精依赖和紊乱，对酒精依赖性障碍的易感性以及与药物有关的依赖和障碍的组合物和方法。所述方法包括治疗患有血清素受体5-HT3拮抗剂的患者用于此类疾病，其中已知患者的5-羟色胺转运蛋白基因SLC6A4具有特定的基因型。

8. 发明申请

WO2012003462A1 MOLECULAR GENETIC APPROACH TO TREATMENT AND DIAGNOSIS OF ALCOHOL AND DRUG DEPENDENCE 审中-公开
标题翻译：分子遗传学方法治疗酒精依赖和药物依赖的诊断
公开(公告)号：WO2012003462A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042823
申请日：2011-07-01
申请人： JOHNSON, Bankole A.
发明人： JOHNSON, Bankole A.
IPC分类号： C12Q1/68
CPC分类号： A61K31/4178 , A61K31/7048 , C12Q1/6883 , C12Q1/6888 , C12Q2600/106 , C12Q2600/172 , G06F19/18
摘要： Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotoin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.
摘要翻译：提供了用于诊断，治疗和监测酒精依赖性和紊乱，酒精依赖性紊乱易感性以及与药物有关的依赖性和紊乱的组合物和方法。所述方法包括用血清素受体5-HT3拮抗剂治疗患有此类病症的患者，其中患者的血清素转运蛋白基因SLC6A4已知具有特定的基因型。

9. 发明申请

WO2008077092A3 COMBINED EFFECTS OF TOPIRAMATE AND ONDANSETRON ON ALCOHOL CONSUMPTION 审中-公开
公开(公告)号：WO2008077092A3
公开(公告)日：2008-06-26
申请号：PCT/US2007/088100
申请日：2007-12-19
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , JOHNSON, Bankole, A. , TOURIRINE, Nassima, Ait-Daoud
发明人： JOHNSON, Bankole, A. , TOURIRINE, Nassima, Ait-Daoud
IPC分类号： A61K31/00
摘要： The present invention provides for the use of combinations of drugs to treat addictive disorders. More specifically, the present invention relates the use of drugs in conjunction with behavioral intervention to treat alcohol-related diseases and disorders as well as treatment of obesity and regulating weight.

10. 发明申请

WO2010126603A1 SEROTONIN TRANSPORTER GENE AND TREATMENT OF ALCOHOLISM 审中-公开
标题翻译：丝氨酸运输基因和酒精处理
公开(公告)号：WO2010126603A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/001273
申请日：2010-04-30
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , JOHNSON, Bankole A.
发明人： JOHNSON, Bankole A.
IPC分类号： C12Q1/68 , A61K31/4178
CPC分类号： C12Q1/6883 , A61K31/4178 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156
摘要： The gene (SLC6A4) responsible for encoding the serotonin transporter (SERT) has a functional polymorphism at the 5'-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3' UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on diagnosing variations in the polymorphisms of the SERT gene and expression and activity of the SERT gene, as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders, for monitoring treatment and/or abuse (addictive behavior), and for determining which treatment should be used.
摘要翻译：负责编码血清素转运蛋白（SERT）的基因（SLC6A4）在5'-调节启动子区域具有功能多态性，其形成长（L）和短（S）两种形式。假设LL型基因型在酒精使用早期发挥关键作用。本发明公开了基于L或短基因型的治疗和诊断的差异以及SERT基因，3'UTR SNP rs1042173的单核苷酸多态性。本发明证明了基于诊断SERT基因多态性和SERT基因表达和活性的变化的药物昂丹司琼和类似药物治疗的疗效以及用于诊断酒精滥用和其他成瘾易感性的方法相关的疾病和障碍，用于监测治疗和/或滥用（成瘾行为），以及用于确定应使用哪种治疗。

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