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1. 发明申请

WO2010034790A1 PROTEASE INHIBITORS 审中-公开
标题翻译： PROTEASE抑制剂
公开(公告)号：WO2010034790A1
公开(公告)日：2010-04-01
申请号：PCT/EP2009/062408
申请日：2009-09-24
申请人： MEDIVIR AB , ODÉN, Lourdes, Salvadore , JOHANSSON, Per-Olof , KAHNBERG, Pia , NILSSON, Magnus , SAMUELSSON, Bertil , GRABOWSKA, Urszula
发明人： ODÉN, Lourdes, Salvadore , JOHANSSON, Per-Olof , KAHNBERG, Pia , NILSSON, Magnus , SAMUELSSON, Bertil , GRABOWSKA, Urszula
IPC分类号： C07D491/048 , A61K31/496 , A61P19/00
CPC分类号： C07D277/40 , C07D491/048 , C07D495/04
摘要： Compounds of the formula II: wherein R 1 forms an ethynyl bond and R 2 is H or C 3 -C 6 cycloalkyl which is optionally substituted with one or two substituents independently selected from methyl, CF 3 , OMe or halo; R 3 is C 1 -C 3 alkyl or C 3 -C 6 cycloalkyl, either of which is optionally substituted with one or two methyl and/or a fluoro, trifluoromethyl or methoxy, when R 3 is C 3 -C 6 cycloalkyl it may alternatively be gem subsituted with fluoro; R 4 is methyl or fluoro; m is 0, 1 or 2; E is a bond, A 1 is CH or N, A 2 is CR 6 R 7 or NR 6 , provided at least one of A 1 and A 2 comprises N; n is 0 or 1 such that the ring containing A 1 and A 2 is a saturated, nitrogen-containing ring of 5 or 6 ring atoms; R 6 is H, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 3 alkyl-O-C 1 -C 3 alkyl, or when A 2 is C, R 6 can also be C 1 -C 4 alkoxy or F; R 7 is H, C 1 -C 4 alkyl or F or a pharmaceutically acceptable salt, N-oxide or hydrate thereof, have utility in the treatment of disorders characterized by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis, rheumatoid arthritis or bone metastases.
摘要翻译：式II化合物：其中R1形成乙炔基，R2是H或任选被一个或两个独立地选自甲基，CF 3，OMe或卤素的取代基取代的C 3 -C 6环烷基; R 3是C 1 -C 3烷基或C 3 -C 6环烷基，当R 3是C 3 -C 6环烷基时，它们任选被一个或两个甲基和/或氟，三氟甲基或甲氧基取代，也可以被氟取代; R4是甲基或氟; m为0,1或2; E是键，A1是CH或N，A2是CR6R7或NR6，条件是A1和A2中的至少一个包括N; n为0或1，使得含有A 1和A 2的环是5或6个环原子的饱和的含氮环; R6是H，C1-C4烷基，C1-C4卤代烷基，C1-C3烷基-O-C1-C3烷基，或当A2是C时，R6也可以是C1-C4烷氧基或F; R7是H，C1-C4烷基或F或其药学上可接受的盐，N-氧化物或其水合物，可用于治疗组织蛋白酶K不适当表达或活化的疾病，例如骨质疏松症，骨关节炎，类风湿性关节炎或骨骼转移。

2. 发明申请

WO1997022546A1 LIFT MAST ROLLER ASSEMBLY FOR A LIFT STRUCTURE OF A FORK LIFT TRUCK 审中-公开
标题翻译：用于提升卡车的提升结构的升降机滚子总成
公开(公告)号：WO1997022546A1
公开(公告)日：1997-06-26
申请号：PCT/SE1996001696
申请日：1996-12-18
申请人： AB SKF , HOLMQVIST, Torbjörn , JOHANSSON, Per-Olof
发明人： AB SKF
IPC分类号： B66F09/08
CPC分类号： F16C13/006 , B66F9/08
摘要： A lift mast roller assembly (10) for a lift structure of a fork lift truck, comprising in combination an axle bar (9) fixedly attached to a component of a lift mast structure of the fork lift truck and a substantially annular lift mast roller (13), journalled on said axle bar (9) in a rolling bearing (12) having an inner race ring (24), an outer race ring (20) and a number of rollers (21) disposed therebetween, wherein the inner race ring (24) is fitted with a tight fit on the axle bar (9), the outer race ring (20) is axially affixed relative to the lift mast roller (13), and the rolling bearing is a self-aligning roller bearing wherein the rollers (21) and race tracks provided in the race rings (20, 21) have correspondingly curved longitudinal section profiles with radius of curvature substantially greater than the greatest distance between the central bearing axis and the surfaces of the race tracks, wherein the rollers are axially moveable without restrictions from axial limitations.
摘要翻译：一种用于叉车的提升结构的提升桅杆辊组件（10），其包括固定地附接到叉车的提升桅杆结构的部件的轴杆（9）和基本上环形的提升桅杆辊（ 13），其轴承在具有内座圈（24），外座圈（20）和设置在其间的多个辊（21）的滚动轴承（12）中的所述轴杆（9）上，其中，所述内圈（24）在轴杆（9）上装配有紧密配合，外座圈（20）相对于提升桅杆辊（13）轴向固定，并且滚动轴承是自调心滚子轴承，其中，设置在赛道环（20,21）中的滚子（21）和赛道具有相应的弯曲的纵向截面轮廓，其曲率半径基本上大于中心轴承轴线和赛道的表面之间的最大距离，其中滚子轴向移动而不受轴向限制的限制。

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