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1. 发明申请

WO1997032477A1 USE OF POLYMERS AS BIOCIDES 审中-公开
标题翻译：使用聚合物杀生物的
公开(公告)号：WO1997032477A1
公开(公告)日：1997-09-12
申请号：PCT/EP1997001082
申请日：1997-03-04
申请人： BASF AKTIENGESELLSCHAFT , GEBHARDT, Norbert , ZELLER, Dieter , NILZ, Claudia , STEUERLE, Ulrich , JOHANSEN, Charlotte
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A01N33/04
CPC分类号： A01N33/04 , A01N25/10
摘要： The invention concerns the use as biocides of polymers which contain the following incorporated by polymerization: (a) between 0.1 and 100 mol % vinyl amine units or ethylene imine units; (b) between 0 and 99.9 mol % units of at least one monomer selected from the group comprising open-chain N-vinyl carboxylic acid amides, vinyl formiate, vinyl acetate, vinyl propionate, vinyl alcohol, C1 to C6 alkyl vinyl ether, monoethylenically unsaturated C3 to C8 carboxylic acids, their esters, nitriles, amides and anhydrides, N-vinyl urea, N-vinyl imidazoles and N-vinyl imidazolines; and (c) between 0 and 5 mol % units of monomers having at least two ethylenically unsaturated double bonds. The total of (a), (b) and (c) in mol % is always 100.
摘要翻译：使用包含（a）为0.1〜100摩尔％的乙烯胺单元或乙烯亚胺单元，（B）0至选自由开链N-乙烯基羧酰胺的基团，甲酸乙烯的至少一种单体的99.9％（摩尔）的单元的聚合物的乙酸乙烯酯，丙酸乙烯酯，乙烯醇，C1-C6烷基乙烯基醚，单烯属不饱和的C3-C8羧酸，它们的酯，腈，酰胺和酸酐，N-乙烯基脲，N-乙烯基咪唑和N- vinylimidazolines和（c）0至5 摩尔％的具有至少两个烯属不饱和双键的，以共聚形式中，（a），（b）和（c）是摩尔％始终为100，作为杀生物剂的总和单体的单元。

2. 发明申请

WO2003092736A3 PEPTIDE NUCLEIC ACID CONJUGATES WITH TRANSPORTER PEPTIDES 审中-公开
公开(公告)号：WO2003092736A3
公开(公告)日：2003-11-13
申请号：PCT/DK2003/000280
申请日：2003-05-01
申请人： PANTHECO A/S , TOLBORG, Jakob , FRANDSEN, Torben, Peter , NIELSEN, Bjarne, Rønfeldt , JOHANSEN, Charlotte , KJÆRULFF, Søren
发明人： TOLBORG, Jakob , FRANDSEN, Torben, Peter , NIELSEN, Bjarne, Rønfeldt , JOHANSEN, Charlotte , KJÆRULFF, Søren
IPC分类号： C07K14/00
摘要： The present invention relates to peptide nucleic acid (PNA) conjugates with transporter peptides, to methods for their preparation, to compositions comprising the conjugates and to the use of these conjugates as medicaments and their use in therapy e.g. in the treatment of infections. The invention further concerns cell penetrating peptides and methods of conjugating the peptides with PNA.

3. 发明申请

WO1998000529A1 A RECOMBINANT ENZYME WITH DEXTRANASE ACTIVITIY 审中-公开
标题翻译：一种具有转录酶活性的重组酶
公开(公告)号：WO1998000529A1
公开(公告)日：1998-01-08
申请号：PCT/DK1997000284
申请日：1997-06-30
申请人： NOVO NORDISK A/S , CHRISTENSEN, Tove , FUGLSANG, Claus, Crone , HALKIER, Torben , JOHANSEN, Charlotte
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/46
CPC分类号： C12N9/2454 , A61K8/66 , A61K2800/86 , A61Q11/00
摘要： The present invention relates to a cloned DNA sequence encoding an enzyme with dextranase activity, a recombinant expression vector comprising said DNA sequence, a filamentous fungus host cell, a method for producing said recombinant dextranase, and the isolated and purified enzyme. The invention also relates to compositions comprising the recombinant enzyme, oral care compositions and products and the use for removing of dental plaque.
摘要翻译：本发明涉及编码具有葡聚糖酶活性的酶的克隆DNA序列，包含所述DNA序列的重组表达载体，丝状真菌宿主细胞，生产所述重组葡聚糖酶的方法和分离和纯化的酶。本发明还涉及包含重组酶，口腔护理组合物和产品以及除去牙菌斑的用途的组合物。

4. 发明申请

WO1998000528A1 A RECOMBINANT ENZYME WITH MUTANASE ACTIVITY 审中-公开
标题翻译：具有MUTANASE活性的重组酶
公开(公告)号：WO1998000528A1
公开(公告)日：1998-01-08
申请号：PCT/DK1997000283
申请日：1997-06-30
申请人： NOVO NORDISK A/S , WAHLEITHNER, Jill, Angela , FUGLSANG, Claus, Crone , HALKIER, Torben , JOHANSEN, Charlotte , HANSEN, Mogens, Trier
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/24
CPC分类号： C12Y302/01084 , A23K20/189 , A23L29/06 , A61K8/66 , A61K38/00 , A61K2800/86 , A61Q11/00 , C07K2319/02 , C12N9/2402
摘要： The present invention relates to method for constructing an expression vector comprising a mutanase gene obtained from a filamentous fungus suitable for heterologous production comprising the steps of a) isolating a DNA sequence encoding a mutanase from a filamentous fungus, b) introducing a kex2-site or kex2-like site between the DNA sequences encoding the pro-peptide and the mature region of the mutanase, c) cloning the DNA sequence obtained in step b) into a suitable expression vector. The invention also relates to a recombinant expression vector comprising said mutanase gene sequence and a kex2 cleavage site between the DNA sequence encoding the pro-peptide and the region encoding the mature mutanase, a filamentous fungus host cell, a process for producing recombinant mutanase and a recombinant mutanase. It is also the object of the invention to provide compositions useful in oral care products for humans and animals.
摘要翻译：本发明涉及构建表达载体的方法，该表达载体包含从适于异源生产的丝状真菌获得的齿斑葡聚糖酶基因，包括以下步骤：a）从丝状真菌中分离编码齿斑葡聚糖酶的DNA序列，b）引入kex2位点或编码前肽的DNA序列和变位蓝酶的成熟区的kex2样位点，c）将步骤b）中获得的DNA序列克隆到合适的表达载体中。本发明还涉及一种重组表达载体，其包含所述的木兰糖酶基因序列和编码前肽的DNA序列与编码成熟齿斑葡聚糖酶的区域之间的kex2切割位点，丝状真菌宿主细胞，重组齿斑葡聚糖酶的制备方法和重组齿斑葡聚糖酶。本发明的另一个目的是提供可用于人和动物口腔护理产品的组合物。

5. 发明申请

WO2003092736A2 PEPTIDE NUCLEIC ACID CONJUGATES 审中-公开
标题翻译：肽类核酸结合物（PEPTIDE NUCLEIC ACID CONJUGATES）
公开(公告)号：WO2003092736A2
公开(公告)日：2003-11-13
申请号：PCT/DK2003/000280
申请日：2003-05-01
申请人： PANTHECO A/S , TOLBORG, Jakob , FRANDSEN, Torben, Peter , NIELSEN, Bjarne, Rønfeldt , JOHANSEN, Charlotte , KJÆRULFF, Søren
发明人： TOLBORG, Jakob , FRANDSEN, Torben, Peter , NIELSEN, Bjarne, Rønfeldt , JOHANSEN, Charlotte , KJÆRULFF, Søren
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/66 , C07K5/1024 , C07K7/06 , C07K7/08
摘要： The present invention relates to peptide nucleic acid (PNA) conjugates, to methods for their preparation, to compositions comprising the conjugates and to the use of these conjugates as medicaments and their use in therapy e.g. in the treatment of infections.The invention further concerns cell penetrating peptides and methods of conjugating the peptides with PNA.
摘要翻译：本发明涉及肽核酸（PNA）缀合物，其制备方法，包含缀合物的组合物以及这些缀合物作为药物的用途及其在治疗中的用途。在治疗感染中。本发明还涉及细胞穿透肽和将肽与PNA缀合的方法。

6. 发明申请

WO1996006532A1 A BASIC PROTEIN COMPOSITION FOR KILLING OR INHIBITING MICROBIAL CELLS 审中-公开
标题翻译：用于杀死或抑制微生物细胞的基础蛋白质组合物
公开(公告)号：WO1996006532A1
公开(公告)日：1996-03-07
申请号：PCT/DK1995000351
申请日：1995-09-01
申请人： NOVO NORDISK A/S , JOHANSEN, Charlotte
发明人： NOVO NORDISK A/S
IPC分类号： A01N63/00
CPC分类号： A61Q17/005 , A01N63/02 , A23L2/44 , A23L3/3472 , A23L3/3526 , A23L3/3571 , A61K8/64 , A61K8/66 , A61K2800/524 , C11D3/3719 , C11D3/38636 , C11D3/38654 , C11D3/48 , A01N2300/00
摘要： A composition consisting essentially of a basic protein or peptide capable of killing microbial cell, e.g. a protamine or protamine sulphate, in combination with a cell-wall degrading enzyme and/or an oxidoreductase, e.g. an endoglycosidase Type II, a lysozyme, chitinase, peroxidase enzyme system (EC 1.11.1.7) or laccase enzyme (EC 1.10.3.2), has bactericidal, bacteriostatic, fungicidal and/or fungistatic properties and is useful in detergent and hard surface cleaning compositions and in methods for killing microbial cells present on a hard surface, for killing microbial cells or inhibiting growing microbial cells present on laundry, for killing microbial cells present on humain or animal skin, mucous membranes, wounds, bruises or in the eye; and in preservation of food, beverages, cosmetics, contact lens products, food ingredients or enzyme compositions.
摘要翻译：基本上由能够杀死微生物细胞的碱性蛋白质或肽组成的组合物，例如，与细胞壁降解酶和/或氧化还原酶组合的鱼精蛋白或鱼精蛋白硫酸盐。 II型糖苷内切酶，溶菌酶，几丁质酶，过氧化物酶系统（EC 1.11.1.7）或漆酶（EC 1.10.3.2）具有杀菌，抑菌，杀真菌和/或抑制性能，可用于洗涤剂和硬表面清洁组合物以及用于杀死存在于硬表面上的微生物细胞的方法，用于杀死微生物细胞或抑制存在于衣物上的生长中的微生物细胞，以杀死存在于人类或动物皮肤，粘膜，伤口，瘀伤或眼睛中的微生物细胞; 以及食品，饮料，化妆品，隐形眼镜产品，食品成分或酶组合物的保存。

7. 发明申请

WO1997032480A1 A METHOD OF KILLING OR INHIBITING MICROBIAL CELLS 审中-公开
标题翻译：杀死或抑制微生物细胞的方法
公开(公告)号：WO1997032480A1
公开(公告)日：1997-09-12
申请号：PCT/DK1997000098
申请日：1997-03-05
申请人： NOVO NORDISK A/S , JOHANSEN, Charlotte
发明人： NOVO NORDISK A/S
IPC分类号： A01N63/00
CPC分类号： C11D3/48 , A01N25/10 , A01N33/04 , A01N33/08 , A01N37/12 , A01N37/20 , A01N63/00 , C11D3/3719 , C11D3/3769 , C11D3/38636 , C11D3/38654 , A01N2300/00
摘要： A method of killing or inhibiting the growth of microbial cells present on laundry, hard surfaces, human or animal skin, mucous membranes, teeth, wounds, bruises or in the eye, comprising contacting the cells with a composition comprising a poly-cationic compound, preferably a polyamino acid, a polyvinylamine, a copolymer prepared from vinylamine and one or more carboxylic acid anhydrides, e.g. a polymer comprising 0.1-100 mol% vinyl amine or ethyleneimine units, 0-99.9 mol% units of at least one monomer selected from N-vinylcarboxamides of formula (I) wherein R and R are hydrogen or C1-C6-alkyl; vinyl formate, vinyl acetate, vinyl propionate, vinyl alcohol, C1-C6-alkyl vinyl ether, mono ethylenic unsaturated C3-C8-carboxylic acid, and esters, nitriles, amides and anhydrides thereof, N-vinylurea, N-imidazoles and N-vinyl imidazolines; and 0-5 mol% units of monomers having at least two unsaturated ethylenic double bonds; and one or more enzymes, preferably glycanases, muranases, oxidoreductases, glucanases, proteases, cellulases, amylases, lipases, pectinases and xylanases.
摘要翻译：一种杀死或抑制存在于衣物，硬表面，人或动物皮肤，粘膜，牙齿，伤口，瘀伤或眼睛中的微生物细胞生长的方法，包括使细胞与包含多阳离子化合物，优选聚氨基酸，聚乙烯胺，由乙烯胺和一种或多种羧酸酐制备的共聚物，例如，包含0.1-100mol％乙烯基胺或乙烯亚胺单元的聚合物，0-99.9mol％单元的至少一种选自式（I）的N-乙烯基甲酰胺的单体，其中R 1和R 2是氢或C1- C6烷基; 甲酸乙烯酯，乙酸乙烯酯，丙酸乙烯酯，乙烯醇，C1-C6烷基乙烯基醚，单烯键式不饱和C3-C8-羧酸及其酯，腈，酰胺和酸酐，N-乙烯基脲，N-咪唑和N- 乙烯基咪唑啉; 和0-5mol％的具有至少两个不饱和烯键双键的单体; 和一种或多种酶，优选聚糖酶，杂交酶，氧化还原酶，葡聚糖酶，蛋白酶，纤维素酶，淀粉酶，脂肪酶，果胶酶和木聚糖酶。

8. 发明申请

WO1997042825A1 ANTIMICROBIAL PEROXIDASE COMPOSITIONS 审中-公开
标题翻译：抗微生物过氧化物组合物
公开(公告)号：WO1997042825A1
公开(公告)日：1997-11-20
申请号：PCT/DK1997000205
申请日：1997-05-06
申请人： NOVO NORDISK A/S , JOHANSEN, Charlotte
发明人： NOVO NORDISK A/S
IPC分类号： A01N63/00
CPC分类号： C11D3/48 , A01N63/00 , A01N63/04 , C11D3/38654 , A01N61/00 , A01N59/24 , A01N59/12 , A01N59/00 , A01N43/84 , A01N43/78 , A01N37/40 , A01N2300/00
摘要： Enzymatic compositions comprising a Coprinus peroxidase, hydrogen peroxide or a source of hydrogen peroxide, and an enhancing agent such as an electron donor, e.g. phenothiazine-10-propionic acid; 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate); acetosyringate; C1-8-alkylsyringate; or a water-soluble halide or thiocyanate salt such as potassium iodide, have antimicrobial properties useful e.g. for inhibiting or killing microorganisms present in laundry, on human or animal skin, hair, mucous membranes, oral cavities, teeth, wounds, bruises; and on hard surfaces; and can be used as disinfectant, a preservative for cosmetics, and for cleaning, disinfecting or inhibiting microbial growth on process equipment used for e.g. water treatment, food processing, chemical or pharmaceutical processing, paper pulp processing, and water sanitation.
摘要翻译：包含鬼马鱼过氧化物酶，过氧化氢或过氧化氢源的酶组合物和增强剂如电子给体，例如，吩噻嗪-10-丙酸; 2,2'-连氮 - 双（3-乙基苯并噻唑-6-磺酸酯）; acetosyringate; C1-8-alkylsyringate; 或水溶性卤化物或硫氰酸盐如碘化钾，具有有用的抗微生物性质。用于抑制或杀死存在于衣物，人或动物皮肤，毛发，粘膜，口腔，牙齿，伤口，瘀伤的微生物; 硬表面; 并且可以用作消毒剂，化妆品的防腐剂，以及用于例如用于化妆品的工艺设备上的清洁，消毒或抑制微生物生长。水处理，食品加工，化学或制药加工，纸浆加工和水卫生。

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