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    • 8. 发明申请
    • PROCESS FOR THE PRODUCTION OF CADAVERINE
    • 生产CADAVERINE的过程
    • WO2007113127A1
    • 2007-10-11
    • PCT/EP2007/052783
    • 2007-03-23
    • BASF AKTIENGESELLSCHAFTZELDER, OskarJEONG, Weol KyuKLOPPROGGE, CorinnaHEROLD, AndreaSCHRÖDER, Hartwig
    • ZELDER, OskarJEONG, Weol KyuKLOPPROGGE, CorinnaHEROLD, AndreaSCHRÖDER, Hartwig
    • C12P13/00C12P13/02C12R1/15
    • C12P13/02C12N9/88C12P13/001
    • Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahy- drodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl- diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehy¬ drogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate car¬ boxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1 ,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA syn¬ thetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
    • 通过构建具有失调的赖氨酸脱羧酶基因和选自由天冬氨酸激酶,天冬氨酸二醛脱氢酶,二氢吡啶二羧酸合成酶,二氢吡啶二羧酸还原酶,四氢吡啶二羧酸琥珀酰基酶组成的组(i)中的至少一种去调节基因的重组微生物来生产尸胺的方法, 琥珀酰基 - 氨基 - 酮基庚酸酯转氨酶,琥珀酰基 - 二氨基 - 庚二酸酯去糖基酶,二氨基庚二酸差向异构酶,二氨基庚二酸脱氢酶,精氨酰-tRNA合成酶,二氨基庚二酸脱羧酶,丙酮酸酯酶,磷酸烯醇丙酮酸羧化酶,葡萄糖-6-磷酸脱氢酶,转酮醇酶,转醛醇酶 如果天冬氨酸激酶被释放为基因(i)至少第二个基因(i),除了天冬氨酸激酶以外的其他基因(i),所述第二基因(i)不是天冬氨酸激酶, 不得不放松管制,而且cul。 抚平所述微生物。
    • 9. 发明申请
    • PROCESS FOR THE PRODUCTION OF β-LYSINE
    • 生产β-赖氨酸的方法
    • WO2007101867A1
    • 2007-09-13
    • PCT/EP2007/052138
    • 2007-03-07
    • BASF AKTIENGESELLSCHAFTZELDER, OskarJEONG, Weol KyuKLOPPROGGE, CorinnaHEROLD, AndreaSCHRÖDER, Hartwig
    • ZELDER, OskarJEONG, Weol KyuKLOPPROGGE, CorinnaHEROLD, AndreaSCHRÖDER, Hartwig
    • C12P13/08C12P13/00C12N15/63C12N15/77
    • C12P13/08C12P13/005C12P13/02
    • Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
    • 通过构建具有失调的赖氨酸2,3-氨基变位酶基因的重组微生物和选自由天冬氨酸激酶,天冬氨酸二甲二醇脱氢酶,二氢吡啶二羧酸合酶,二氢吡啶二羧酸还原酶,二氢吡啶二羧酸还原酶组成的组中的至少一种去调节基因的生产赖氨酸的方法, 四氢吡啶二羧酸琥珀酰基酶,琥珀酰 - 氨基 - 酮基庚酸酯转氨酶,琥珀酰 - 二氨基 - 庚二酸二琥珀酰酶,二氨基庚酸酯差向异构酶,二氨基庚二酸脱氢酶,精氨酰-tRNA合成酶,二氨基庚二酸脱羧酶,丙酮酸羧化酶,磷酸烯醇丙酮酸羧化酶,葡萄糖-6-磷酸脱氢酶,转酮酶,转醛醇酶, 磷酸葡糖糖苷酶,果糖1,6-二磷酸酶,高丝氨酸脱氢酶,磷酸烯醇丙酮酸羧激酶,琥珀酰辅酶A合成酶,甲基丙二酰-CoA变位酶,条件是如果天冬氨酸激酶被解除调控为基因(i)至少第二个基因(i)除了天冬氨酸激酶必须 放松管制,培养说 微生物。