专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996025417A1 PENEM DERIVATIVES AND ANTIMICROBIAL AGENT CONTAINING THE SAME 审中-公开
标题翻译： PENEM衍生物和含有该衍生物的抗微生物剂
公开(公告)号：WO1996025417A1
公开(公告)日：1996-08-22
申请号：PCT/JP1996000366
申请日：1996-02-19
申请人： SUNTORY LIMITED , ISHIGURO, Masaji , NAKATSUKA, Takashi , TANAKA, Rie , NAMIKAWA, Koshi , MATSUKI, Shinsuke
发明人： SUNTORY LIMITED
IPC分类号： C07D499/88
CPC分类号： C07D499/88 , Y02P20/55
摘要： A penem derivative represented by general formula (I), or a pharmacologically acceptable salt thereof, wherein R represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aralkyl, optionally substituted aryl, optionally substituted alkylthio, optionally substituted alkenylthio, optionally substituted aralkylthio, optionally substituted arylthio, optionally substituted heterocycle, optionally substituted heterocyclic thio, optionally substituted acylthio, mercapto or hydrogen; and R represents hydrogen or a carboxyl protecting group. Because of having a potent antimicrobial activity particularly on MRSA, the compound (I) is useful as an antimicrobial agent for MRSA against which general antimicrobial agents are not efficacious.
摘要翻译：任选取代的芳烷基，任选取代的芳基，任选取代的烷硫基，任选取代的烯基硫代，任选取代的烷基，任选取代的烷基，任选取代的烷基，芳烷硫基，任选取代的芳硫基，任选取代的杂环，任选取代的杂环硫基，任选取代的酰硫基，巯基或氢; R 2表示氢或羧基保护基。由于特别是对MRSA具有有效的抗微生物活性，所以化合物（I）可用作MRSA的抗微生物剂，一般抗微生物剂对其无效。

2. 发明申请

WO1992003443A1 ANTIBACTERIAL PENEM COMPOUNDS 审中-公开
标题翻译：抗生素化合物
公开(公告)号：WO1992003443A1
公开(公告)日：1992-03-05
申请号：PCT/JP1991001099
申请日：1991-08-16
申请人： SUNTORY LIMITED , IWATA, Hiromitsu , NATAKSUKA, Takashi , TANAKA, Rie , ISHIGURO, Masaji
发明人： SUNTORY LIMITED
IPC分类号： C07D499/88
CPC分类号： C07D499/88
摘要： Antibiotic penem coumpounds are represented by formula (I), wherein R represents a physiologically-hydrolyzable, ester-forming group. The physiologically hydrolyzable, ester-forming group useful in the penem compound of the present invention means a group which can be removed easily by in vivo hydrolysis, such as an acetyloxymethyl, 1-(acetyloxy)ethyl, pivaloyloxymethyl, 1-(ethoxycarbonyloxy)ethyl, 1-(isopropyloxycarbonyloxy)-ethyl, 1-(cyclohexyloxycarbonyloxy)ethyl or 3-phthalidyl group. Antibiotic compositions for oral administration are also described.
摘要翻译：抗生素penem coumpounds由式（I）表示，其中R表示生理上可水解的酯形成基团。可用于本发明青霉烯化合物的生理上可水解的酯形成基是指通过体内水解容易除去的基团，例如乙酰氧基甲基，1-（乙酰氧基）乙基，新戊酰氧基甲基，1-（乙氧基羰基氧基）乙基，1-（异丙氧基羰基氧基） - 乙基，1-（环己基氧基羰基氧基）乙基或3-苯二酰基。还描述了用于口服给药的抗生素组合物。

3. 发明申请

WO1994018163A1 PROCESS FOR SYNTHESIZING 4-SUBSTITUTED AZETIDINONE DERIVATIVE 审中-公开
标题翻译：合成4-取代的AZETIDINONE衍生物的方法
公开(公告)号：WO1994018163A1
公开(公告)日：1994-08-18
申请号：PCT/JP1994000195
申请日：1994-02-10
申请人： SUNTORY LIMITED , ISHIGURO, Masaji , NAKATSUKA, Takashi , TANAKA, Rie , SHIMAMOTO, Tetsuo , YOSHIDA, Takuro
发明人： SUNTORY LIMITED
IPC分类号： C07D205/08
CPC分类号： C07D205/08
摘要： The invention relates to a process for synthesizing a 4-substituted azetidinone derivative represented by the general formula (3) (wherein OR1 represents a protected hydroxyl group; CO2R3 represents an esterified carboxyl group; and X and Y represent each independently alkyl, alkenyl, aralkyl, aryl, alkylthio, alkoxy, heterocycle, acyl, amino, hydrogen or halogen, or alternatively X and Y are combined together to represent cycloalkan-2-on-2-yl) by the reaction of an azetidinone derivative represented by general formula (1) (wherein OR1 is as defined above; and R2 represents alkyl, alkenyl or aryl) with an ester compound represented by general formula (2): (wherein CO2R3, X and Y are each as defined above) in the presence of zinc and copper compounds. The invention relates also to a compound represented by general formula (3) and further to a compound prepared by decarboxylating the compound (3), both being useful as an intermediate for synthesizing antibacterial carbapenem compounds.
摘要翻译：本发明涉及一种合成由通式（3）表示的4-取代氮杂环丁酮衍生物的方法（其中OR 1表示被保护的羟基; CO 2 R 3表示酯化羧基; X和Y各自表示烷基，烯基，芳烷基，芳基，烷硫基，烷氧基，杂环，酰基，氨基，氢或卤素，或者X和Y组合在一起代表环烷-2- -2-基），通过通式（1）表示的氮杂环丁酮衍生物）（其中OR 1如上所定义; R 2表示烷基，烯基或芳基）与通式（2）表示的酯化合物：（其中CO 2 R 3，X和Y各自如上所定义）在锌和铜存在下化合物。本发明还涉及由通式（3）表示的化合物，还涉及通过使化合物（3）脱羧制备的化合物，两者都可用作合成抗菌碳青霉烯化合物的中间体。

4. 发明申请

WO1997016421A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE TRANS-VINYL SULFIDE ALCOHOLS 审中-公开
标题翻译：用于生产光学活性的转乙酰硫醇的方法
公开(公告)号：WO1997016421A1
公开(公告)日：1997-05-09
申请号：PCT/JP1996003185
申请日：1996-10-30
申请人： SUNTORY LIMITED , SEKIUCHI, Kazuto , IMOTO, Masahiro , ISHIGURO, Masaji , NAKATSUKA, Takashi , TANAKA, Rie , INOUE, Hidekazu
发明人： SUNTORY LIMITED
IPC分类号： C07C323/14
CPC分类号： C07B53/00 , C07C319/20 , C07C323/14
摘要： A process for producing optically active trans-vinyl sulfide alcohols represented by general formula (III), wherein R represents alkyl or aryl; which comprises reducing trans-vinyl sulfide ketones with a borane reducing agent in the presence of an optically active oxazaborolidine and an additive.
摘要翻译：一种制备由通式（III）表示的光学活性的反式 - 乙烯基硫醇的方法，其中R 1表示烷基或芳基; 其包括在光学活性的恶唑硼烷和添加剂的存在下用硼烷还原剂还原反式 - 乙烯基硫醚酮。

5. 发明申请

WO1992003444A1 PENEM COMPOUNDS 审中-公开
标题翻译： PENEM化合物
公开(公告)号：WO1992003444A1
公开(公告)日：1992-03-05
申请号：PCT/JP1991001100
申请日：1991-08-16
申请人： SUNTORY LIMITED , IWATA, Hiromitsu , NAKATSUKA, Takashi , TANAKA, Rie , ISHIGURO, Masaji
发明人： SUNTORY LIMITED
IPC分类号： C07D499/88
CPC分类号： C07D499/88
摘要： Antibiotic penem compounds are represented by formula (I), wherein R represents a group of formulae (II) or (III) in which R1 is a linear or branched, C1-C6 alkyl group, R2 is a particular substituted or unsubstituted alkyl, aryl or aralkyl group, n is an integer of 1 or 2, and R3 represents a specific substituted or unsubstituted alkyl, aryl or aralkyl group. Antibiotic compositions for oral administration are also described.
摘要翻译：抗生素penem化合物由式（I）表示，其中R表示式（II）或（III）的基团，其中R 1是直链或支链的C 1 -C 6烷基，R 2是特定的取代或未取代的烷基，芳基或芳烷基，n为1或2的整数，R 3表示特定的取代或未取代的烷基，芳基或芳烷基。还描述了用于口服给药的抗生素组合物。

6. 发明申请

WO1992003442A1 ANTIBACTERIAL PENEM ESTERS DERIVATIVES 审中-公开
标题翻译：抗真菌药剂衍生物
公开(公告)号：WO1992003442A1
公开(公告)日：1992-03-05
申请号：PCT/JP1991001098
申请日：1991-08-16
申请人： SUNTORY LIMITED , IWATA, Hiromitsu , NAKATSUKA, Takashi , TANAKA, Rie , ISHIGURO, Masaji
发明人： SUNTORY LIMITED
IPC分类号： C07D499/88
CPC分类号： C07D499/88
摘要： Antibiotic penem compounds are represented by formula (I), wherein R represents a group of general formulae (II), (III), or -CH2-Z, in which R1 is a linear or branched C1-C6 alkyl group, R2 is a particular substituted or unsubstituted alkyl, aryl or aralkyl group, n is an integer of 1-6, Y is a 5- or 6-membered heterocyclic aliphatic group having 1 or 2 oxygen atoms in the ring thereof, and Z is a specific 5-substituted 2-oxo-1,3-dioxolen-4-yl group. Antibiotic compositions for oral administration are also described.
摘要翻译：抗生素penem化合物由式（I）表示，其中R表示通式（II），（III）或-CH 2 -Z的基团，其中R 1是直链或支链C 1 -C 6烷基，R 2是特定的取代或未取代的烷基，芳基或芳烷基，n为1-6的整数，Y为其环中具有1或2个氧原子的5或6元杂环脂族基团，Z为特定的5- 取代的2-氧代-1,3-二氧杂环戊烯-4-基。还描述了用于口服给药的抗生素组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式