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1. 发明申请

WO2012067523A1 HEADGEAR, INTERFACE AND AN ASSEMBLY 审中-公开
标题翻译： HEADGEAR，INTERFACE和大会
公开(公告)号：WO2012067523A1
公开(公告)日：2012-05-24
申请号：PCT/NZ2011/000242
申请日：2011-11-16
申请人： FISHER & PAYKEL HEALTHCARE LIMITED , GULLIVER, Laurence , RONAYNE, Michael Paul , IRVING, Charles William Douglas
发明人： GULLIVER, Laurence , RONAYNE, Michael Paul , IRVING, Charles William Douglas
IPC分类号： A61M16/00 , A61M15/08 , A61M16/06
CPC分类号： A61M16/0683 , A61M16/0666 , A61M2240/00
摘要： This invention relates to a headgear comprising a semi-rigid frame engageable with the head of a user and a releasable connection system for releasable connection with a user interface, wherein the frame extends generally about a rear region of a user's head, generally about an upper region of a user's head, and generally about an ear or both ears of a user.
摘要翻译：本发明涉及一种头盔，其包括可与使用者头部接合的半刚性框架和用于与使用者接口可释放连接的可释放连接系统，其中框架大致围绕使用者头部的后部区域延伸，大体上约为上部用户头部的区域，并且通常围绕用户的耳朵或双耳。

2. 发明申请

WO03022202A9 COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO03022202A9
公开(公告)日：2004-04-22
申请号：PCT/IL0200765
申请日：2002-09-12
申请人： YISSUM RES DEV CO , OVCURE INC , ZAKAY-RONES ZICHRIA , PANET AMOS , IRVING CHARLES
发明人： ZAKAY-RONES ZICHRIA , PANET AMOS , IRVING CHARLES
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K38/16 , A61K48/00 , A61P35/00 , C07K14/125 , C12N5/10 , C12N7/00 , C12N7/08 , A01N43/04 , A01N61/00 , A61K31/70 , C07H21/04
CPC分类号： C07K14/005 , A61K35/768 , A61K48/00 , C12N7/00 , C12N2760/18122 , C12N2760/18132 , C12N2760/18164
摘要： The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. According to an alternative preferred embodiment the use of at least one isolated viral protein or subunit or analog thereof, or an isolated polynucleotide encoding same, is used in the treatment of cancer.
摘要翻译：本发明公开了用于治疗癌症的易感基因病毒株。新城疫病毒（NDV）的优选病毒株特异性地表现在生物活性方面。本发明还公开了通过将NDV菌株应用于肿瘤来治疗癌症。根据另一优选实施方案，使用至少一种分离的病毒蛋白或其亚单位或其类似物或其编码的分离的多核苷酸用于治疗癌症。

3. 发明申请

WO2005113013A2 COMPOSITIONS OF NDV AND METHODS OF USE THEREOF FOR TREATMENT OF CANCER 审中-公开
标题翻译： NDV的组合物及其用于治疗癌症的方法
公开(公告)号：WO2005113013A2
公开(公告)日：2005-12-01
申请号：PCT/IL2005/000518
申请日：2005-05-19
申请人： THERAVIR MANAGEMENT L.P. , ZAKAY-RONES, Zichria , PANET, Amos , GREENBAUM, Evgeniya , GALUN, Eithan , FREEMAN, Arnold, I. , RASOOLY, Linda , IRVING, Charles, S.
发明人： ZAKAY-RONES, Zichria , PANET, Amos , GREENBAUM, Evgeniya , GALUN, Eithan , FREEMAN, Arnold, I. , RASOOLY, Linda , IRVING, Charles, S.
IPC分类号： A61K48/00
CPC分类号： A61K35/768 , C12N2760/18132
摘要： The present invention discloses methods for inducing regression of a tumor in a subject comprising administering a pharmaceutical composition comprising a lentogenic strain of Newcastle disease virus (NDV). A preferred viral strain of NDV for inducing regression of a tumor in a subject is a clonal strain of NDV, the NDV HUJ. The methods of the present invention are particularly useful for inducing regression of tumors in patients unresponsive to conventional anti-cancer therapies.
摘要翻译：本发明公开了诱导受试者肿瘤消退的方法，其包括施用包含新城疫病毒（NDV）的微生物菌株的药物组合物。用于诱导受试者肿瘤消退的NDV的优选病毒株是NDV（NDV HUJ）的克隆菌株。本发明的方法特别可用于诱导对常规抗癌疗法无反应的患者的肿瘤消退。

4. 发明申请

WO2003022202A2 COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2003022202A2
公开(公告)日：2003-03-20
申请号：PCT/IL2002/000765
申请日：2002-09-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY , OVCURE INC. , ZAKAY-RONES, Zichria , PANET, Amos , IRVING, Charles
发明人： ZAKAY-RONES, Zichria , PANET, Amos , IRVING, Charles
IPC分类号： A61K
CPC分类号： C07K14/005 , A61K35/768 , A61K48/00 , C12N7/00 , C12N2760/18122 , C12N2760/18132 , C12N2760/18164
摘要： The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. According to an alternative preferred embodiment the use of at least one isolated viral protein or subunit or analog thereof, or an isolated polynucleotide encoding same, is used in the treatment of cancer.
摘要翻译：本发明公开了用于治疗癌症的易感基因病毒株。新城疫病毒（NDV）的优选病毒株特异性地表现在生物活性方面。本发明还公开了通过将NDV菌株应用于肿瘤来治疗癌症。根据另一优选实施方案，使用至少一种分离的病毒蛋白或其亚单位或其类似物或其编码的分离的多核苷酸用于治疗癌症。

5. 发明申请

WO2012049495A1 AN IMPROVED BRAKING SYSTEM FOR A CARAVAN OR TRAILER 审中-公开
标题翻译：用于卡车或拖车的改进的制动系统
公开(公告)号：WO2012049495A1
公开(公告)日：2012-04-19
申请号：PCT/GB2011/051962
申请日：2011-10-11
申请人： INSYNC SYSTEMS LIMITED , IRVING, Charles , BRADBURY, Andrew
发明人： IRVING, Charles , BRADBURY, Andrew
IPC分类号： B60T7/20 , B60T13/08
CPC分类号： B60T7/203 , B60T13/08
摘要： Vehicles intended to be drawn are often provided with an over-run braking system which activates brakes of the drawn vehicle in response to a mechanical braking action of the towing vehicle. This system can be augmented with a second system comprising a compressed air actuator which is activated to apply the drawn vehicles brakes upon receiving an electrical braking signal from the towing vehicle. The second system is retrofitted by pivotally connecting the actuator to the brake rod of the run-over system. This can reduce the effectiveness of the over-run system when the second system fails. This problem is overcome by connecting the actuator to the brake rod via a clamp connected through a flexible linkage.
摘要翻译：要被牵引的车辆通常设置有过载制动系统，其响应于牵引车辆的机械制动动作来启动被牵引的车辆的制动器。该系统可以用包括压缩空气致动器的第二系统进行增强，压缩空气致动器在从牵引车辆接收到电制动信号时被启动以施加所拉出的车辆制动器。第二个系统通过将致动器枢转地连接到越过系统的制动杆来改进。当第二个系统发生故障时，这可以降低超跑系统的有效性。通过通过柔性连杆连接的夹具将致动器连接到制动杆来克服这个问题。

6. 发明申请

WO2005113013A3 COMPOSITIONS OF NDV AND METHODS OF USE THEREOF FOR TREATMENT OF CANCER 审中-公开
标题翻译： NDV的组合物及其用于治疗癌症的方法
公开(公告)号：WO2005113013A3
公开(公告)日：2006-05-18
申请号：PCT/IL2005000518
申请日：2005-05-19
申请人： THERAVIR MAN L P , ZAKAY-RONES ZICHRIA , PANET AMOS , GREENBAUM EVGENIYA , GALUN EITHAN , FREEMAN ARNOLD I , RASOOLY LINDA , IRVING CHARLES S
发明人： ZAKAY-RONES ZICHRIA , PANET AMOS , GREENBAUM EVGENIYA , GALUN EITHAN , FREEMAN ARNOLD I , RASOOLY LINDA , IRVING CHARLES S
IPC分类号： A61K35/76 , A61K48/00 , A61K35/00 , C12N7/00 , C12N15/00
CPC分类号： A61K35/768 , C12N2760/18132
摘要： The present invention discloses methods for inducing regression of a tumor in a subject comprising administering a pharmaceutical composition comprising a lentogenic strain of Newcastle disease virus (NDV). A preferred viral strain of NDV for inducing regression of a tumor in a subject is a clonal strain of NDV, the NDV HUJ. The methods of the present invention are particularly useful for inducing regression of tumors in patients unresponsive to conventional anti-cancer therapies.
摘要翻译：本发明公开了诱导受试者肿瘤消退的方法，其包括施用包含新城疫病毒（NDV）的微生物菌株的药物组合物。用于诱导受试者肿瘤消退的NDV的优选病毒株是NDV（NDV HUJ）的克隆菌株。本发明的方法特别可用于诱导对常规抗癌疗法无反应的患者的肿瘤消退。

7. 发明申请

WO2013022356A1 CONDUIT CONNECTOR FOR A PATIENT BREATHING DEVICE 审中-公开
标题翻译：患者呼吸装置的导管连接器
公开(公告)号：WO2013022356A1
公开(公告)日：2013-02-14
申请号：PCT/NZ2012/000142
申请日：2012-08-10
申请人： FISHER & PAYKEL HEALTHCARE LIMITED , GULLIVER, Laurence , RONAYNE, Michael Paul , IRVING, Charles William Douglas
发明人： GULLIVER, Laurence , RONAYNE, Michael Paul , IRVING, Charles William Douglas
IPC分类号： A61M16/00
CPC分类号： A61M39/1011 , A61B5/082 , A61M16/0051 , A61M16/021 , A61M16/0666 , A61M16/0816 , A61M16/0825 , A61M16/0833 , A61M16/0841 , A61M16/085 , A61M16/0875 , A61M16/161 , A61M2016/0033 , A61M2016/102 , A61M2016/1025 , A61M2016/103 , A61M2039/1027 , A61M2039/1044 , A61M2205/3368 , A61M2205/581 , A61M2205/584 , A61M2205/6045 , A61M2209/088
摘要： In an embodiment, a connector or connector assembly for attaching a nasal cannula with a gas delivery hose includes a sensor port for a sensor probe positioned near an end of a nasal cannula, which can allow the sensor probe to be placed closer to the patient's nostrils than previous connector parts allowed. In an embodiment, the connector is configured to advantageously allow the nasal cannula to rotate relative to the gas delivery hose, thereby allowing a patient or healthcare provider to untangle or otherwise straighten the hose or the cannula. In an embodiment, the connector assembly is configured to automatically align locking protrusions on a first component with locking recesses on a second component, where insertion of the second component within the first component causes the second component to rotate relative to the first component, thereby aligning the locking protrusions with associated locking recesses.
摘要翻译：在一个实施例中，用于将鼻插管与气体输送软管连接的连接器或连接器组件包括用于传感器探针的传感器端口，其位于鼻插管的端部附近，该传感器端口可以使传感器探针放置得更靠近患者的鼻孔比以前的连接器部件允许。在一个实施例中，连接器被配置为有利地允许鼻插管相对于气体输送软管旋转，从而允许患者或医护人员解开或以其他方式矫正软管或插管。在一个实施例中，连接器组件被配置为使第一部件上的锁定突起自动对准在第二部件上的锁定凹部，其中第二部件在第一部件内的插入使得第二部件相对于第一部件旋转，锁定突起具有相关联的锁定凹槽。

8. 发明申请

WO2012053910A1 A NASAL CANNULA, CONDUIT AND SECUREMENT SYSTEM 审中-公开
标题翻译： NASAL CANNULA，CONDIIT和SECUREMENT系统
公开(公告)号：WO2012053910A1
公开(公告)日：2012-04-26
申请号：PCT/NZ2011/000218
申请日：2011-10-18
申请人： FISHER & PAYKEL HEALTHCARE LIMITED , O'CONNOR, Mark Thomas , EATON-EVANS, Jimmy Edward , DUTHIE, Neil Gray , LAING, Brent Ian , ZHANG, Puqing , NICCOL, Andrew Grant , IRVING, Charles William Douglas , WHITE, Craig Karl , RONAYNE, Michael Paul , GULLIVER, Laurence , HOPKINS, Caroline Geraldine , SPENCE, Callum James Thomas , KORNER, Steven Charles
发明人： O'CONNOR, Mark Thomas , EATON-EVANS, Jimmy Edward , DUTHIE, Neil Gray , LAING, Brent Ian , ZHANG, Puqing , NICCOL, Andrew Grant , IRVING, Charles William Douglas , WHITE, Craig Karl , RONAYNE, Michael Paul , GULLIVER, Laurence , HOPKINS, Caroline Geraldine , SPENCE, Callum James Thomas , KORNER, Steven Charles
IPC分类号： A61M16/00 , A61M16/08
CPC分类号： A61M16/0683 , A61M16/0666 , A61M16/0688 , A61M16/0875 , A61M2205/0216 , A61M2205/0238 , A61M2205/7536 , A61M2207/10 , A61M2210/0618
摘要： This invention relates to medical breathing tubes comprising a tubular body, the body defining a lumen extending between open terminal ends of the body and an internal form enclosed within the lumen and supportive of the tubular body. The internal form may be of a coated encapsulated internal form, the coating securing the internal form to the tubular body. The internal form may also or separately provide for a series of alternative crests and troughs (e.g. corrugations) of the tubular body. Patient interfaces (such as masks or nasal cannula) can be connected to such tubing. A system for securing patient interfaces in an operational position may also be utilised.
摘要翻译：本发明涉及包括管状体的医用呼吸管，该主体限定在主体的开放终端之间延伸的内腔和封闭在内腔内并支撑管体的内部形式。内部形式可以是涂覆的包封的内部形式，所述涂层将内部形式固定到管状体。内部形式还可以或单独地提供管状体的一系列备选的波峰和槽（例如波纹）。患者接口（如面罩或鼻插管）可连接到这种管路。还可以使用用于将患者界面固定在操作位置的系统。

9. 发明申请

WO2003022202A3 COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2003022202A3
公开(公告)日：2003-03-20
申请号：PCT/IL2002/000765
申请日：2002-09-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY , OVCURE INC. , ZAKAY-RONES, Zichria , PANET, Amos , IRVING, Charles
发明人： ZAKAY-RONES, Zichria , PANET, Amos , IRVING, Charles
IPC分类号： A01N43/04
摘要： The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. According to an alternative preferred embodiment the use of at least one isolated viral protein or subunit or analog thereof, or an isolated polynucleotide encoding same, is used in the treatment of cancer.

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