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1. 发明申请

WO2014028777A3 METHODS OF TREATING A TAUOPATHY 审中-公开
公开(公告)号：WO2014028777A3
公开(公告)日：2014-02-20
申请号：PCT/US2013/055203
申请日：2013-08-15
申请人： IPIERIAN, INC.
发明人： GRISWOLD-PRENNER, Irene , STAGLIANO, Nancy E. , DANG, Vu
IPC分类号： A61K51/10 , C12N15/13 , C12N15/63
摘要： The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau antibodies, and formulations comprising same, for use in the methods.

2. 发明申请

WO2010042669A2 CO-CULTURE COMPOSITIONS AND METHODS 审中-公开
标题翻译：共培养组合物和方法
公开(公告)号：WO2010042669A2
公开(公告)日：2010-04-15
申请号：PCT/US2009/059910
申请日：2009-10-07
申请人： IPIERIAN, INC. , ELIAS, Guillermo, Muñoz , JAVAHERIAN, Ashkan , IRION, Stefan
发明人： ELIAS, Guillermo, Muñoz , JAVAHERIAN, Ashkan , IRION, Stefan
IPC分类号： C12Q1/02 , C12N5/071 , G01N33/15
CPC分类号： G01N33/5073 , C12N5/0619 , C12N5/0676 , C12N2500/38 , C12N2501/13 , C12N2501/385 , C12N2502/081 , C12N2502/1305 , C12N2502/1335 , C12N2502/45 , C12N2503/02 , G01N33/5058 , G01N33/507
摘要： Co-culture compositions and methods are described for identifying agents that modulate a cellular phenotype, particularly of neurons or pancreatic beta cells are provided herein, where the methods include co-culturing differentiated cells, wherein at least one of the cell-types are derived from human induced pluripotent stem cells from a subject having or predisposed to a neurodegenerative or metabolic disorder. Co-culture compositions of differentiated cells from two different human subjects are also described.
摘要翻译：描述共培养组合物和方法用于鉴定调节细胞表型，特别是神经元或胰腺β细胞的试剂，其中所述方法包括共培养分化的细胞，其中至少一种细胞类型衍生自来自具有或易患神经变性或代谢紊乱的受试者的人诱导多能干细胞。还描述了来自两个不同人类受试者的分化细胞的共培养组合物。

3. 发明申请

WO2010102267A3 TGF-BETA PATHWAY INHIBITORS FOR ENHANCEMENT OF CELLULAR REPROGRAMMING OF HUMAN CELLS 审中-公开
标题翻译：用于增强人类细胞细胞增殖的TGF-β途径抑制剂
公开(公告)号：WO2010102267A3
公开(公告)日：2014-03-13
申请号：PCT/US2010026451
申请日：2010-03-05
申请人： IPIERIAN INC , GRSKOVIC MARICA , DIMOS JOHN , STRULOVICI BERTA , BAKHTIAROVA ADEL , WANG WEIDONG
发明人： GRSKOVIC MARICA , DIMOS JOHN , STRULOVICI BERTA , BAKHTIAROVA ADEL , WANG WEIDONG
IPC分类号： A61K31/675
CPC分类号： A61K31/4709
摘要： The present disclosure provides methods and compositions to enhance reprogramming in human cells. In some cases, the method includes contacting human cells with an inhibitor of the TGFbeta pathway, for example a TGFbeta receptor (TGFbetaR) inhibitor in combination with one or more induction factors.
摘要翻译：本公开提供了增强人细胞重编程的方法和组合物。在一些情况下，该方法包括使人细胞与TGFbeta途径的抑制剂接触，例如与一种或多种诱导因子组合的TGFbeta受体（TGFbetaR）抑制剂。

4. 发明申请

WO2013169793A2 METHODS AND COMPOSITIONS FOR TDP-43 PROTEINOPATHIES 审中-公开
标题翻译： TDP-43蛋白酶的方法和组合物
公开(公告)号：WO2013169793A2
公开(公告)日：2013-11-14
申请号：PCT/US2013/039968
申请日：2013-05-07
申请人： IPIERIAN, INC.
发明人： JAVAHERIAN, Ashkan
IPC分类号： A61K31/519
CPC分类号： A61K31/365 , A61K31/473 , A61K31/58 , A61K31/63 , A61K31/7048
摘要： Provided herein are methods for treating a subject suffering from a TDP-43 proteinopathy, e.g., sporadic ALS or FTD by administering to the subject a composition comprising a therapeutically effective amount of a JNK inhibitor, a MAPK inhibitor, a proteasome inhibitor, a Topoisomerase I inhibitor, a Topoisomerase II inhibitor, a HSP-90 inhibitor, a 5-HT antagonist, a CDK inhibitor, or a transcription inhibitor. The provided methods can also be used to reduce TDP-43 aggregation in human neural progenitors or neurons in neural progenitors or neurons that exhibit TDP-43 aggregates. In addition, methods are provided to identify agents that modulate (decrease or increase) TDP-43 aggregation in human neural progenitors or neurons that exhibit TDP-43 aggregates. Also provided are human induced pluripotent stem cell (hiPSC) lines generated from sporadic ALS patients, where the hiPSC lines may be differentiated into neural progenitors or neurons (e.g., motor progenitors and motor neurons) that exhibit a TDP-43 aggregate. Further provided are isolated populations of cells containing neural progenitors or neurons derived from the aforementioned hiPSC lines.
摘要翻译：本文提供了通过向受试者施用包含治疗有效量的JNK抑制剂，MAPK抑制剂，蛋白酶体抑制剂，拓扑异构酶I的组合物来治疗患有TDP-43蛋白病的受试者的方法，例如散发性ALS或FTD 抑制剂，拓扑异构酶II抑制剂，HSP-90抑制剂，5-HT拮抗剂，CDK抑制剂或转录抑制剂。所提供的方法也可用于降低神经祖细胞或神经元中TDP-43聚集体的神经祖细胞或神经元中的TDP-43聚集。此外，提供了用于鉴定调节（降低或增加）TDP-43聚集体的人神经祖细胞或神经元中TDP-43聚集的试剂的方法。还提供了由散发性ALS患者产生的人诱导的多能干细胞（hiPSC）系，其中hiPSC系可以分化成具有TDP-43聚集体的神经祖细胞或神经元（例如运动祖细胞和运动神经元）。进一步提供了分离的含有来自上述hiPSC系的神经祖细胞或神经元的细胞群。

5. 发明申请

WO2014028777A2 METHODS OF TREATING A TAUOPATHY 审中-公开
标题翻译：治疗TAUOPATHY的方法
公开(公告)号：WO2014028777A2
公开(公告)日：2014-02-20
申请号：PCT/US2013055203
申请日：2013-08-15
申请人： IPIERIAN INC
发明人： GRISWOLD-PRENNER IRENE , STAGLIANO NANCY E , DANG VU
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K39/3955 , A61K47/60 , A61K2039/505 , C07K16/461 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/10 , G01N33/6896 , G01N2333/4709 , G01N2800/52
摘要： The present disclosure provides methods of treating a tauopathy, involving administering an anti-Tau antibody. The present disclosure also provides anti-Tau antibodies, and formulations comprising same, for use in the methods.
摘要翻译：本公开提供治疗tau蛋白病的方法，涉及施用抗Tau抗体。本公开还提供了用于该方法的抗-Tau抗体和包含其的制剂。

6. 发明申请

WO2010042669A3 CO-CULTURE COMPOSITIONS AND METHODS 审中-公开
标题翻译：共培养组合物和方法
公开(公告)号：WO2010042669A3
公开(公告)日：2010-07-01
申请号：PCT/US2009059910
申请日：2009-10-07
申请人： IPIERIAN INC , ELIAS GUILLERMO MUNOZ , JAVAHERIAN ASHKAN , IRION STEFAN
发明人： ELIAS GUILLERMO MUNOZ , JAVAHERIAN ASHKAN , IRION STEFAN
IPC分类号： C12Q1/02 , C12N5/071 , G01N33/15
CPC分类号： G01N33/5073 , C12N5/0619 , C12N5/0676 , C12N2500/38 , C12N2501/13 , C12N2501/385 , C12N2502/081 , C12N2502/1305 , C12N2502/1335 , C12N2502/45 , C12N2503/02 , G01N33/5058 , G01N33/507
摘要： Co-culture compositions and methods are described for identifying agents that modulate a cellular phenotype, particularly of neurons or pancreatic beta cells are provided herein, where the methods include co-culturing differentiated cells, wherein at least one of the cell-types are derived from human induced pluripotent stem cells from a subject having or predisposed to a neurodegenerative or metabolic disorder. Co-culture compositions of differentiated cells from two different human subjects are also described.
摘要翻译：描述了用于鉴定调节细胞表型，特别是神经元或胰腺β细胞的试剂的共培养组合物和方法，其中所述方法包括共培养分化的细胞，其中至少一种细胞类型源自人类诱导的多能干细胞来自患有或倾向于神经变性或代谢疾病的受试者。还描述了来自两个不同人类受试者的分化细胞的共培养组合物。

7. 发明申请

WO2009152485A2 METHODS OF CELL-BASED TECHNOLOGIES 审中-公开
标题翻译：基于细胞的技术方法
公开(公告)号：WO2009152485A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/047293
申请日：2009-06-12
申请人： IPIERIAN, INC. , SAKURADA, Kazuhiro
发明人： SAKURADA, Kazuhiro
IPC分类号： C12N5/08 , A61K35/12 , G06F19/00
CPC分类号： G01N33/5073
摘要： The present disclosure features methods relating to conducting a stem cell technology business such as a regenerative medicine business based on induced pluripotent stem cells (iPSCs) and cells differentiated from iPSCs. The present disclosure also provides a database of iPSC-derived cells and methods of using the database for tracking customers and samples, as well as methods for marketing and running the business.
摘要翻译：本公开特征涉及进行干细胞技术业务的方法，例如基于诱导多能干细胞（iPSC）和与iPSC分化的细胞的再生医学事业。本公开还提供了iPSC衍生的小区的数据库以及使用数据库跟踪客户和样本的方法以及用于营销和运行业务的方法。

8. 发明申请

WO2015081085A2 METHODS OF TREATING A TAUOPATHY 审中-公开
标题翻译：治疗TAUOPATHY的方法
公开(公告)号：WO2015081085A2
公开(公告)日：2015-06-04
申请号：PCT/US2014/067360
申请日：2014-11-25
申请人： IPIERIAN, INC.
发明人： GRISWOLD-PRENNER, Irene , PARRY, Graham
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/34 , C07K2317/94
摘要： The present disclosure provides methods for treating a tauopathy (e.g., an acute tauopathy) in an individual by administering an anti-Tau antibody to the individual. Also provided are methods of treating traumatic brain injury and methods of treating stroke in an individual by administering an anti-Tau antibody to the individual.
摘要翻译：本公开提供了通过向个体施用抗Tau抗体来治疗个体中的tau病变（例如，急性tau病）的方法。还提供了通过对个体施用抗Tau抗体来治疗创伤性脑损伤的方法和治疗个体中风的方法。

9. 发明申请

WO2013169793A3 METHODS AND COMPOSITIONS FOR TDP-43 PROTEINOPATHIES 审中-公开
标题翻译： TDP-43蛋白酶的方法和组合物
公开(公告)号：WO2013169793A3
公开(公告)日：2014-02-06
申请号：PCT/US2013039968
申请日：2013-05-07
申请人： IPIERIAN INC
发明人： JAVAHERIAN ASHKAN
IPC分类号： A61K31/4725
CPC分类号： A61K31/365 , A61K31/473 , A61K31/58 , A61K31/63 , A61K31/7048
摘要： Provided herein are methods for treating a subject suffering from a TDP-43 proteinopathy, e.g., sporadic ALS or FTD by administering to the subject a composition comprising a therapeutically effective amount of a JNK inhibitor, a MAPK inhibitor, a proteasome inhibitor, a Topoisomerase I inhibitor, a Topoisomerase II inhibitor, a HSP-90 inhibitor, a 5-HT antagonist, a CDK inhibitor, or a transcription inhibitor. The provided methods can also be used to reduce TDP-43 aggregation in human neural progenitors or neurons in neural progenitors or neurons that exhibit TDP-43 aggregates. In addition, methods are provided to identify agents that modulate (decrease or increase) TDP-43 aggregation in human neural progenitors or neurons that exhibit TDP-43 aggregates. Also provided are human induced pluripotent stem cell (hiPSC) lines generated from sporadic ALS patients, where the hiPSC lines may be differentiated into neural progenitors or neurons (e.g., motor progenitors and motor neurons) that exhibit a TDP-43 aggregate. Further provided are isolated populations of cells containing neural progenitors or neurons derived from the aforementioned hiPSC lines.
摘要翻译：本文提供了通过向受试者施用包含治疗有效量的JNK抑制剂，MAPK抑制剂，蛋白酶体抑制剂，拓扑异构酶I的组合物来治疗患有TDP-43蛋白病，例如散发性ALS或FTD的受试者的方法抑制剂，拓扑异构酶II抑制剂，HSP-90抑制剂，5-HT拮抗剂，CDK抑制剂或转录抑制剂。所提供的方法也可用于降低神经祖细胞或神经元中TDP-43聚集体的TDP-43聚集。此外，提供了用于鉴定调节（降低或增加）TDP-43聚集体的人类神经祖细胞或神经元中TDP-43聚集的试剂的方法。还提供了由散发性ALS患者产生的人诱导多能干细胞（hiPSC）系，其中hiPSC系可分化成具有TDP-43聚集体的神经祖细胞或神经元（例如运动祖细胞和运动神经元）。还提供了分离的含有来自上述hiPSC系的神经祖细胞或神经元的细胞群。

10. 发明申请

WO2009152485A3 METHODS OF CELL-BASED TECHNOLOGIES 审中-公开
标题翻译：基于细胞的技术方法
公开(公告)号：WO2009152485A3
公开(公告)日：2010-05-14
申请号：PCT/US2009047293
申请日：2009-06-12
申请人： IPIERIAN INC , SAKURADA KAZUHIRO
发明人： SAKURADA KAZUHIRO
IPC分类号： C12N5/071 , A61K35/12 , G06F19/00
CPC分类号： G01N33/5073
摘要： The present disclosure features methods relating to conducting a stem cell technology business such as a regenerative medicine business based on induced pluripotent stem cells (iPSCs) and cells differentiated from iPSCs. The present disclosure also provides a database of iPSC-derived cells and methods of using the database for tracking customers and samples, as well as methods for marketing and running the business.
摘要翻译：本公开特征涉及进行干细胞技术业务的方法，例如基于诱导多能干细胞（iPSC）和与iPSC分化的细胞的再生医学业务。本公开还提供了iPSC衍生的小区的数据库以及使用数据库跟踪客户和样本的方法以及用于营销和运行业务的方法。

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