专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2022226055A1 PERSONALIZED ALLOGENEIC IMMUNOTHERAPY 审中-公开
公开(公告)号：WO2022226055A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025527
申请日：2022-04-20
申请人： IOGENETICS, LLC
发明人： HOMAN, Jane , BREMEL, Robert D.
IPC分类号： A61K39/35 , A61K39/00 , G01N33/50 , C12Q1/6886
摘要： The present invention provides methods for treating cancer by T cell therapy comprising the steps of obtaining a biopsy from a subject affected by cancer, identifying mutated amino acids in the tumor and the T cell exposed amino acid motifs which contain the mutated amino acids, identifying a donor with matching alleles, generating an array of alternate peptides in which the T cell exposed motifs are maintained constant, but the other amino acids are substituted, selecting one or more peptides from the array of alternative peptides, each having a desired binding affinity to the MHC allele while maintaining the tumor specific T cell exposed motif, contacting antigen presenting cells with the selected alternative peptides so that the peptide is presented by the MHC of the antigen presenting cells, contacting the antigen presenting cells carrying the selected peptide with T cells harvested from the donor, and infusing the subject with stimulated T cells responding to the peptide of interest presented by the dendritic cell MHC.

2. 发明申请

WO2017156395A1 EPITOPE MIMICS 审中-公开
公开(公告)号：WO2017156395A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/021781
申请日：2017-03-10
申请人： IOGENETICS, LLC
发明人： BREMEL, Robert D. , HOMAN, Jane
IPC分类号： A61K38/17 , A61K39/00 , A61P25/16 , G06F19/18 , G06F19/24 , G06N3/08
摘要： This invention pertains to the identification of antibody mediated epitope mimics and applications of the identification of said mimic peptides in the design of biotherapeutics and vaccines.
摘要翻译：本发明涉及鉴定抗体介导的表位模拟物和鉴定所述模拟肽在设计生物治疗剂和疫苗中的应用。

3. 发明申请

WO2019217655A1 IMMUNE REPERTOIRE PATTERNS 审中-公开
公开(公告)号：WO2019217655A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031484
申请日：2019-05-09
申请人： IOGENETICS,LLC
发明人： BREMEL, Robert D. , HOMAN, Jane
IPC分类号： G01N33/68 , G06F19/18 , G06F19/20
摘要： The present invention provides methods and systems for identifying and classifying patterns comprising the T cell exposed motifs and the frequencies of such motifs in collections of proteins that make up the human proteome, immunoglobulinome, T cell receptor repertoire or microbiome, and other proteomes of environmental of microbial origin, or subsets thereof. It further provides graphical representations that facilitate comparisons of T cell exposed motif patterns between samples or between time points. The present invention also provides methods and systems for identifying and classifying patterns in repertoires of cells including receptor bearing cells and cells of tissue samples and detecting patterns of utility in diagnosis and monitoring of health and disease.

4. 发明申请

WO2014200910A2 BIOINFORMATIC PROCESSES FOR DETERMINATION OF PEPTIDE BINDING 审中-公开
标题翻译：用于测定肽结合的生物信息学过程
公开(公告)号：WO2014200910A2
公开(公告)日：2014-12-18
申请号：PCT/US2014041523
申请日：2014-06-09
申请人： IOGENETICS LLC
发明人： BREMEL ROBERT D , HOMAN JANE
IPC分类号： G06F19/18
CPC分类号： G06F19/12 , A61K39/098 , A61K2039/572 , C07K7/06 , C07K7/08 , C12N9/0051 , C12Y108/00 , G06F17/16 , G06F19/18 , G06F19/24
摘要： This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.
摘要翻译：本发明涉及鉴定与配体结合的肽，特别是鉴定由微生物和哺乳动物细胞表达的表位。本发明提供了包含表位的多肽，以及利用表位开发的疫苗，抗体和诊断产品。

5. 发明申请

WO2014078373A1 ANTIMICROBIAL COMPOSITIONS 审中-公开
标题翻译：抗微生物组合物
公开(公告)号：WO2014078373A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069828
申请日：2013-11-13
申请人： IOGENETICS, LLC
发明人： BREMEL, Robert Duane , HOMAN, Jane , IMBODEN, Michael , KEOUGH, Brendan
IPC分类号： C07K16/46 , C12N15/13 , A61K39/395
CPC分类号： C07K16/1271 , C07K2317/56 , C07K2319/33 , C12N9/52 , C12Y304/24075
摘要： The present invention relates antimicrobial compositions, and in particular to antigen binding proteins comprising one or more domains that provide antimicrobial activity.
摘要翻译：本发明涉及抗微生物组合物，特别涉及包含提供抗微生物活性的一个或多个结构域的抗原结合蛋白。

6. 发明申请

WO2011119484A1 BIOINFORMATIC PROCESSES FOR DETERMINATION OF PEPTIDE BINDING 审中-公开
标题翻译：用于确定肽结合的生物工艺
公开(公告)号：WO2011119484A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029192
申请日：2011-03-21
申请人： IOGENETICS, LLC , BREMEL, Robert, D. , HOMAN, Jane
发明人： BREMEL, Robert, D. , HOMAN, Jane
IPC分类号： G01N33/48 , C40B50/02
CPC分类号： G06F19/18 , G06F19/24
摘要： Methods of identification of peptide binding to ligands, such as epitopes expressed by microorganisms and by mammalian cells. A method for identification in silico of peptides and sets of peptides internal to or on the surface of microorganisms and cells which have a high probability of being effective in stimulating humoral and cell mediated immune responses. The method combines multiple predictive tools to provide a composite of both topology and multiple sets of binding or affinity characteristics of specific peptides within an entire proteome. With a composite having topological distribution and spatial relationship, the method identifies regions which have a high probability of being B-cell or MHC binding sites comprising T-cell epitopes on the surface of microorganisms or cells, or MHC binding sites comprising T cell epitopes internal to microorganisms or cells. Polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products are developed using the epitopes.
摘要翻译：识别与配体结合的肽的方法，例如由微生物和哺乳动物细胞表达的表位。用于鉴定微生物和细胞内部或表面上的多肽和肽集合的方法，其具有很有可能有效刺激体液和细胞介导的免疫应答的可能性。该方法结合了多种预测工具，以提供整个蛋白质组中特定肽的拓扑结构和多组结合或亲和特性的复合物。具有拓扑分布和空间关系的复合物，该方法识别在微生物或细胞表面上包含T细胞表位的B细胞或MHC结合位点的高概率的区域，或包含内含T细胞表位的MHC结合位点到微生物或细胞。使用表位开发了包含表位的多肽和疫苗，抗体和诊断产物。

7. 发明申请

WO2006053245A3 RETROVIRAL VECTORS WITH INTRONS 审中-公开
标题翻译：具有INTRONS的退步矢量
公开(公告)号：WO2006053245A3
公开(公告)日：2006-11-16
申请号：PCT/US2005041001
申请日：2005-11-14
申请人： IOGENETICS LLC , BREMEL ROBERT , HARMS JEROME
发明人： BREMEL ROBERT , HARMS JEROME
IPC分类号： C12N5/10 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/86 , C12N7/00 , C12N2740/13043 , C12N2740/13052 , C12N2760/16043 , C12N2830/48
摘要： The present invention relates to improved retroviral vectors. In particular, the present invention relates to retroviral vectors that retain introns in genes of interest during vector production. The present invention further provides host cells and animals comprising gene delivered by the vectors. The present invention additionally provides methods of using such retroviral vectors, host cells and animals in research, diagnostic and therapeutic applications.
摘要翻译：本发明涉及改良的逆转录病毒载体。特别地，本发明涉及在载体生产过程中将目的基因中保留内含子的逆转录病毒载体。本发明还提供宿主细胞和动物，其包含由载体递送的基因。本发明另外提供了在研究，诊断和治疗应用中使用这种逆转录病毒载体，宿主细胞和动物的方法。

8. 发明申请

WO2017132210A1 INTERVENTIONS FOR FLAVIVIRUS INFECTIONS 审中-公开
标题翻译：对黄病毒感染的干预
公开(公告)号：WO2017132210A1
公开(公告)日：2017-08-03
申请号：PCT/US2017/014852
申请日：2017-01-25
申请人： IOGENETICS, LLC
发明人： BREMEL, Robert, D. , HOMAN, Jane , IMBODEN, Michael
IPC分类号： A61K38/02 , A61K39/12 , A61P37/04 , C07K14/08 , C12N15/40
CPC分类号： A61K38/02 , A61K39/00 , A61K39/015 , A61K39/12 , C07K14/08 , C12N2770/24134 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/392 , Y02A50/394 , Y02A50/396 , Y02A50/412
摘要： The present invention relates to vaccine compositions and therapeutic interventions for treating and preventing infections and diseases caused by flaviviruses, including Zika, dengue, and Usutu virus. It also relates to compositions and methods for diagnosis and differential diagnosis of flaviviruses and co-endemic pathogens.
摘要翻译：本发明涉及用于治疗和预防由黄病毒引起的感染和疾病的疫苗组合物和治疗性干预，所述黄病毒包括Zika，登革热和Usutu病毒。它还涉及黄病毒和共同流行病原体的诊断和鉴别诊断的组合物和方法。

9. 发明申请

WO2016007870A3 IMMUNE RECOGNITION MOTIFS 审中-公开
标题翻译：免疫识别MOTIFS
公开(公告)号：WO2016007870A3
公开(公告)日：2016-04-07
申请号：PCT/US2015039969
申请日：2015-07-10
申请人： IOGENETICS LLC
发明人： BREMEL ROBERT D , HOMAN JANE , IMBODEN MICHAEL
IPC分类号： G06F19/18 , G06F19/24 , G06N3/08
CPC分类号： G06F19/22 , G01N33/6854 , G01N33/6878 , G01N2800/24 , G06F19/18 , G06F19/28
摘要： The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.
摘要翻译：本发明提供了用于鉴定和分类表位以及使用该信息分析蛋白质中的蛋白质和肽，特别是潜在表位，并使用该信息设计合成肽和蛋白质，分析生物药物蛋白质并诊断自身免疫病症的方法和系统。结合在MHC凹槽中的肽包含两组氨基酸：面向内凹槽并确定对MHC分子（凹槽暴露的基序或GEM）的结合亲和力的那些氨基酸以及不与凹槽相互作用的那些氨基酸，而是在正面暴露于T细胞（T细胞暴露的基序或TCEM）。本发明利用与GEM和TCEM的身份和生理化学特征相关的信息。

10. 发明申请

WO2016007870A2 IMMUNE RECOGNITION MOTIFS 审中-公开
标题翻译：免疫识别运动
公开(公告)号：WO2016007870A2
公开(公告)日：2016-01-14
申请号：PCT/US2015/039969
申请日：2015-07-10
申请人： IOGENETICS, LLC
发明人： BREMEL, Robert D. , HOMAN, Jane , IMBODEN, Michael
IPC分类号： G06F19/20
CPC分类号： G06F19/22 , G01N33/6854 , G01N33/6878 , G01N2800/24 , G06F19/18 , G06F19/28
摘要： The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.
摘要翻译：本发明提供用于鉴定和分类表位的方法和系统，以及该信息的使用以分析蛋白质，特别是潜在表位内的蛋白质和肽，并使用该信息来设计合成肽和蛋白质，分析生物药物蛋白质并诊断自身免疫病症。在MHC槽中结合的肽包含两组氨基酸：那些面向内槽并确定与MHC分子（凹槽暴露图案或GEM）的结合亲和力以及不与凹槽相互作用的那些氨基酸在外侧暴露于T细胞（T细胞暴露的基序或TCEM）的正面上。本发明利用与GEM和TCEM的身份和物理化学特性相关的信息。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式