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1. 发明申请

WO2021231327A2 METHODS FOR DE-CLOAKING CANCER FROM THE IMMUNE SYSTEM 审中-公开
公开(公告)号：WO2021231327A2
公开(公告)日：2021-11-18
申请号：PCT/US2021/031628
申请日：2021-05-10
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK , INSTITUTE FOR ADVANCED STUDY
发明人： MATHEWS, James C. , NADEEM, Saad , POURYAHYA, Maryam , BELKHATIR, Zehor , DEASY, Joseph O. , TANNENBAUM, Allen Robert , LEVINE, Arnold
IPC分类号： C07K14/47 , C12N15/12 , A61K39/395 , A61P35/00 , A61P35/02 , A61K2039/505 , A61K31/7088 , A61K39/001111 , A61K39/001166 , A61K45/06 , C07K14/70503
摘要： Disclosed are treatments for cancer that enhance a patient immune systems' ability to detect and attack cancer. The present disclosure provides methods for treating cancer in a subject in need thereof comprising administering to the subject an effective amount of a pregnancy specific glycoprotein (PSG) inhibitor.

2. 发明申请

WO2022177989A1 MODELS FOR PREDICTING MUTANT P53 FITNESS AND THEIR IMPLICATIONS IN CANCER THERAPY 审中-公开
公开(公告)号：WO2022177989A1
公开(公告)日：2022-08-25
申请号：PCT/US2022/016594
申请日：2022-02-16
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , INSTITUTE FOR ADVANCED STUDY , ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人： GREENBAUM, Benjamin , HOYOS, David , MERGHOUB, Taha , WOLCHOK, Jedd , ZAPPASODI, Roberta , HELLMANN, Matthew D. , SETHNA, Zachary , SCHULZE, Isabell , BALACHANDRAN, Vinod , LEVINE, Arnold , LUKSZA, Marta
IPC分类号： A61K39/00 , A61K35/15 , G01N33/574 , A61K35/17 , C12Q1/68 , G01N33/68 , A61K39/395 , A61P35/00
摘要： The present technology relates to methods, computing devices, and systems for predicting the fitness of mutant p53 based on the loss of transcription factor function and immunogenicity of a particular TP53 mutation. The fitness of mutant p53 may be used to determine whether a patient will benefit from a particular anti-cancer therapy such as immune checkpoint inhibitor therapy, adoptive T-cell therapy, or prophylactic cancer vaccine therapy.

3. 发明申请

WO2018136664A1 NEOANTIGENS AND USES THEREOF FOR TREATING CANCER 审中-公开
公开(公告)号：WO2018136664A1
公开(公告)日：2018-07-26
申请号：PCT/US2018/014282
申请日：2018-01-18
申请人： ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI , THE SIMONS CENTER FOR SYSTEMS BIOLOGY AT THE INSTITUTE FOR ADVANCED STUDY , MEMORIAL SLOAN KETTERING CANCER CENTER , UNIVERSITÄT ZU KÖLN | UNIVERSITY OF COLOGNE , LUKSZA, Marta , BALACHANDRAN, Vinod, P. , LEVINE, Arnold, J. , WOLCHOK, Jedd, D. , MERGHOUB, Taha , LEACH, Steven, D. , CHAN, Timothy, A. , GREENBAUM, Benjamin, D. , LAESSIG, Michael
发明人： LUKSZA, Marta , BALACHANDRAN, Vinod, P. , LEVINE, Arnold, J. , WOLCHOK, Jedd, D. , MERGHOUB, Taha , LEACH, Steven, D. , CHAN, Timothy, A. , GREENBAUM, Benjamin, D. , LAESSIG, Michael
IPC分类号： A61K39/00 , G01N33/574 , C12Q1/68 , G06F19/22 , A61P35/00 , A61K35/15 , A61K35/17 , G01N33/68 , A61K39/395
摘要： Systems and methods for determining the likely responsiveness of a human cancer subject to a checkpoint blockade immunotherapy regimen are provided. Sequencing reads are obtained from samples from the subject representative of the cancer. A human leukocyte antigen type and a plurality of clones is determined from the sequencing reads. For each clone, an initial frequency Xα in the one or more samples is determined and a corresponding clone fitness score of the clone is computed, thereby computing clone fitness scores. Each such fitness score is computed by identifying neoantigens in the respective clone, computing a recognition potential for each neoantigen, and determining the corresponding clone fitness score of the respective clone as an aggregate of these recognition potentials. A total fitness, quantifying the likely responsiveness of the subject to the regimen, is computed by summing the clone fitness scores across the plurality of clones.

4. 发明申请

WO2007139584A2 METHODS FOR IDENTIFYING SEQUENCE MOTIFS, AND APPLICATIONS THEREOF 审中-公开
标题翻译：识别序列运动的方法及其应用
公开(公告)号：WO2007139584A2
公开(公告)日：2007-12-06
申请号：PCT/US2006/045848
申请日：2006-11-30
申请人： INSTITUTE FOR ADVANCED STUDY , ROBINS, Harlan , KRASNITZ, Michael , LEVINE, Arnold
发明人： ROBINS, Harlan , KRASNITZ, Michael , LEVINE, Arnold
IPC分类号： G06F19/00
CPC分类号： G06F19/22 , C12P21/00 , G06F19/14
摘要： The present invention relates to methods and algorithms that can be used to identify sequence motifs that are either under- or over-represented in a given nucleotide sequence as compared to the frequency of those sequences that would be expected to occur by chance, or that are either under- or over-represented as compared to the frequency of those sequences that occur in other nucleotide sequences, and to methods of scoring sequences based on the occurrence of these sequence motifs. Such sequence motifs may be biologically significant, for example they may constitute transcription factor binding sites, mRNA stability/instability signals, epigenetic signals, and the like. The methods of the invention can also be used, inter alia, to classify sequences or organisms in terms of their phylogenetic relationships, or to identify the likely host of a pathogenic organism. The methods of the present invention can also be used to optimize expression of proteins.
摘要翻译：本发明涉及可用于鉴定在给定核苷酸序列中低于或过表达的序列基序的方法和算法，与预期偶然发生的那些序列的频率相比，或者与其他核苷酸序列中发生的那些序列的频率相比，低于或过度表达，以及基于这些序列基序的出现对序列进行评分的方法。这样的序列基序可能是生物学上重要的，例如它们可能构成转录因子结合位点，mRNA稳定性/不稳定性信号，表观遗传信号等。本发明的方法还可以用于根据其系统发育关系对序列或生物体进行分类，或鉴定病原体的可能宿主。本发明的方法也可用于优化蛋白质的表达。

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