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1. 发明申请

WO2006000401A1 SUBSTITUTED OXAZINES AS GLUCOCORTICOID RECEPTOR MODULATORS 审中-公开
标题翻译：作为胆固醇受体调节剂的替代氧化物
公开(公告)号：WO2006000401A1
公开(公告)日：2006-01-05
申请号：PCT/EP2005/006762
申请日：2005-06-22
申请人： GLAXO GROUP LIMITED , HOUSE, David , INGLIS, Graham, George, Adam , JOHNSTON, Michael, John , JONES, Haydn, Terence , MACDONALD, Simon, John, Fawcett , SKONE, Philip, Alan
发明人： HOUSE, David , INGLIS, Graham, George, Adam , JOHNSTON, Michael, John , JONES, Haydn, Terence , MACDONALD, Simon, John, Fawcett , SKONE, Philip, Alan
IPC分类号： C07D265/36
CPC分类号： C07D265/36 , C07D307/46
摘要： The present invention is directed to compounds of formula (I), wherein R 1 represents a C 3-6 cycloalkyl group; or a physiologically functional derivative thereof, pharmaceutical compositions comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.
摘要翻译：本发明涉及式（I）化合物，其中R 1表示C 3-6环烷基; 或其生理功能衍生物，包含所述化合物的药物组合物，所述化合物在制备药物中的用途，特别是用于治疗炎性和/或过敏性疾病，用于制备化合物的方法和化学中间体化合物的制造。

2. 发明申请

WO2008000777A3 PHENYL- PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：苯并吡唑衍生物及其制备方法及其药物应用
公开(公告)号：WO2008000777A3
公开(公告)日：2008-02-07
申请号：PCT/EP2007056448
申请日：2007-06-27
申请人： GLAXO GROUP LTD , BARNETT HEATHER ANNE , CAMPBELL IAN BAXTER , COE DIANE MARY , COOPER ANTHONY WILLIAM JAMES , INGLIS GRAHAM GEORGE ADAM , JONES HAYDN TERENCE , KEELING STEVEN PHILIP , MACDONALD SIMON JOHN FAWCETT , MCLAY IAIN MCFARLANE , SKONE PHILIP ALAN , WEINGARTEN GORDON GAD , WOOLVEN JAMES MICHAEL
发明人： BARNETT HEATHER ANNE , CAMPBELL IAN BAXTER , COE DIANE MARY , COOPER ANTHONY WILLIAM JAMES , INGLIS GRAHAM GEORGE ADAM , JONES HAYDN TERENCE , KEELING STEVEN PHILIP , MACDONALD SIMON JOHN FAWCETT , MCLAY IAIN MCFARLANE , SKONE PHILIP ALAN , WEINGARTEN GORDON GAD , WOOLVEN JAMES MICHAEL
IPC分类号： C07D231/38 , A61K31/415 , A61P19/02 , A61P29/00 , A61P37/08
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译：本发明提供式（I）化合物，其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是治疗炎症和/或过敏症状。

3. 发明申请

WO2007042299A1 PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS 审中-公开
标题翻译：作为SYK抑制剂的吡咯并嘧啶衍生物
公开(公告)号：WO2007042299A1
公开(公告)日：2007-04-19
申请号：PCT/EP2006/009870
申请日：2006-10-11
申请人： GLAXO GROUP LIMITED , ANCLIFF, Rachael, Ann , ATKINSON, Francis, Louis , BARKER, Michael, David, , BOX, Philip, Charles , DANIEL, Carla , GORE, Paul, Martin , GUNTRIP, Stephen, Barry , HASEGAWA, Masaichi , INGLIS, Graham, George, Adam , KANO, Kazuya , MIYAZAKI, Yasushi , PATEL, Vipulkumar, Kantibhai , RITCHIE, Timothy, John , SWANSON, Stephen , WALKER, Ann, Louise , WELLAWAY, Christopher, Roland , WOODROW, Michael
发明人： ANCLIFF, Rachael, Ann , ATKINSON, Francis, Louis , BARKER, Michael, David, , BOX, Philip, Charles , DANIEL, Carla , GORE, Paul, Martin , GUNTRIP, Stephen, Barry , HASEGAWA, Masaichi , INGLIS, Graham, George, Adam , KANO, Kazuya , MIYAZAKI, Yasushi , PATEL, Vipulkumar, Kantibhai , RITCHIE, Timothy, John , SWANSON, Stephen , WALKER, Ann, Louise , WELLAWAY, Christopher, Roland , WOODROW, Michael
IPC分类号： C07D487/04 , A61K31/519 , A61P37/08
CPC分类号： C07D487/04
摘要： Pyrrolopyrimidine derivatives of formula (I) are inhibitors of Spleen Tyrosine kinase (Syk) and therefore of potential therapeutic benefit in the treatment of diseases and conditions associated with inappropriate Syk activity, in particular in the treatment of inflammatory and allergic diseases.
摘要翻译：式（I）的吡咯并嘧啶衍生物是脾酪氨酸激酶（Syk）的抑制剂，因此在治疗与不适当的Syk活性相关的疾病和病症中具有潜在的治疗益处，特别是在治疗炎症和过敏性疾病。

4. 发明申请

WO2006000398A1 2,3-BENZOXAZIN DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS 审中-公开
标题翻译： 2,3-苯并恶唑衍生物作为非甾体葡糖苷酸受体调节剂
公开(公告)号：WO2006000398A1
公开(公告)日：2006-01-05
申请号：PCT/EP2005/006758
申请日：2005-06-22
申请人： GLAXO GROUP LIMITED , HOUSE, David , INGLIS, Graham, George, Adam , JOHNSTON, Michael, John , JONES, Haydn, Terence , MACDONALD, Simon, John, Fawcett , SKONE, Philip, Alan
发明人： HOUSE, David , INGLIS, Graham, George, Adam , JOHNSTON, Michael, John , JONES, Haydn, Terence , MACDONALD, Simon, John, Fawcett , SKONE, Philip, Alan
IPC分类号： C07D265/02
CPC分类号： C07C59/86 , C07C17/2635 , C07C25/24 , C07C45/004 , C07C45/49 , C07C49/233 , C07C49/255 , C07D265/02 , C07D307/46
摘要： The present invention provides compounds of formula (I), wherein R 1 represents 1-ethylpropyl, 1-methylethyl or 2-methylpropyl; or a physiologically functional derivative thereof; pharmaceutical compositions comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.
摘要翻译：本发明提供式（I）化合物，其中R 1表示1-乙基丙基，1-甲基乙基或2-甲基丙基; 或其生理功能衍生物; 包含该化合物的药物组合物，该化合物在制备药物中的用途，特别是用于治疗炎性和/或过敏性疾病，用于制备化合物的方法和化合物的制备方法中的化学中间体。

5. 发明申请

WO2003022841A1 INTERMEDIATES FOR PREPARING NEURAMINIDASE INHIBITOR CONJUGATES 审中-公开
标题翻译：制备神经酰胺胺酶抑制剂的中间体
公开(公告)号：WO2003022841A1
公开(公告)日：2003-03-20
申请号：PCT/AU2002/001187
申请日：2002-08-30
申请人： BIOTA SCIENTIFIC MANAGEMENT PTY LTD , JUDKINS, Brian, David , MACDONALD, Simon, John Fawcett , DEMAINE, Derek, Anthony , INGLIS, Graham, George Adam , HAMBLIN, Julie, Nicole
发明人： JUDKINS, Brian, David , MACDONALD, Simon, John Fawcett , DEMAINE, Derek, Anthony , INGLIS, Graham, George Adam , HAMBLIN, Julie, Nicole
IPC分类号： C07D407/06
CPC分类号： C07D407/06 , C07D309/28 , Y02P20/55
摘要： Compounds of formula (I), methods for their preparation and their use in the manufacture of neuraminidase inhibitor conjugates. Wherein R represents as carboxylic acid protecting group; P 1 and P 2 can be the same or different and are selected from amine protecting groups; P 3 represents a protecting group for 1, 2 diols; and LG represents a leaving group.
摘要翻译：式（I）的化合物，其制备方法及其在制备神经氨酸酶抑制剂缀合物中的用途。其中R表示羧酸保护基; P1和P2可以相同或不同，并且选自胺保护基; P3表示1,2二醇的保护基; LG代表离职团体。

6. 发明申请

WO2007054294A1 PYRAZOLO-PYRIMIDINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：吡唑并吡啶衍生物作为抗炎剂
公开(公告)号：WO2007054294A1
公开(公告)日：2007-05-18
申请号：PCT/EP2006/010730
申请日：2006-11-07
申请人： GLAXO GROUP LIMITED , BIGGADIKE, Keith , HOUSE, David , INGLIS, Graham, George, Adam , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , SKONE, Philip, Alan
发明人： BIGGADIKE, Keith , HOUSE, David , INGLIS, Graham, George, Adam , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , SKONE, Philip, Alan
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention is directed to compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译：本发明涉及式（I）的化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的中间体和用途，特别是用于治疗炎症和/或过敏症状。

7. 发明申请

WO2004071389A3 NON-STEROIDAL INFALMMATION INHIBITORS 审中-公开
标题翻译：非立体感染抑制剂
公开(公告)号：WO2004071389A3
公开(公告)日：2004-12-02
申请号：PCT/EP2004001507
申请日：2004-02-13
申请人： GLAXO GROUP LTD , BARKER MICHAEL DAVID , DEMAINE DEREK ANTHONY , HOUSE DAVID , INGLIS GRAHAM GEORGE ADAM , JOHNSTON MICHAEL JOHN , JONES HAYDN TERENCE , MACDONALD SIMON JOHN FAWCETT , MCLAY IAIN MCFARLANE , SHANAHAN STEPHEN , SKONE PHILIP ALAN , VINADER MARIA VICTORIA
发明人： BARKER MICHAEL DAVID , DEMAINE DEREK ANTHONY , HOUSE DAVID , INGLIS GRAHAM GEORGE ADAM , JOHNSTON MICHAEL JOHN , JONES HAYDN TERENCE , MACDONALD SIMON JOHN FAWCETT , MCLAY IAIN MCFARLANE , SHANAHAN STEPHEN , SKONE PHILIP ALAN , VINADER MARIA VICTORIA
IPC分类号： A61P29/00 , C07D265/02 , C07D413/12 , A61K31/536
CPC分类号： C07D265/02 , C07D413/12
摘要： A compound of formula (I) wherein: n represents an integer 0, 1 or 2; X represents, O, S, NR , or CHR ; R represents hydrogen, halogen such as F, Cl or Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR R such as NH2, NR COR such as -NHCHO or -NHCOCH3, COOR or CONR R ; R represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR R such as NH2, NR COR such as -NHCHO or -NHCOCH3, COOR or CONR R ; R represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR R such as NH2, NR COR such as -NHCHO or -NHCOCH3, COOR , CONR R ; R represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR R such as NH2, NR COR such as -NHCHO or -NHCOCH3, COOR or CONR R ; R represents H, C1-6 alkyl, or C1-6 alkenyl; R represents hydrogen, C1-6 alkyl, CO2C1-3 alkyl, COC1-3 alkyl or SO2C1-3 alkyl; R represents hydrogen, or C1-6 alkyl; R represents hydrogen, C1-6 alkyl, C1-3 alkyleneSiC1-3 alkyl such as -CH2CH2Si(CH3)3; R and R independently represent hydrogen or C1-6 alkyl; including pharmaceutically acceptable esters, amides and carbamates thereof, salts thereof, solvates thereof, and solvates of such pharmaceutically acceptable esters, amides, carbamates and salts.
摘要翻译：式（I）的化合物，其中：n表示整数0,1或2; X表示O，S，NR 6a或CHR 6b; R 1表示氢，卤素如F，Cl或Br，NO 2，羟基，氰基，-OC 1-6烷氧基如甲氧基，C 1-6烷基如甲基，NR 8 R 9如NH 2 NR 8 COR 9如-NHCHO或-NHCOCH 3，COOR 7或CONR 8 R 9; R 2表示氢，卤素如F，Cl，Br，NO 2，羟基，氰基，-OC 1-6烷氧基如甲氧基，C 1-6烷基如甲基，NR 8 R 9如NH 2 NR 8 COR 9如-NHCHO或-NHCOCH 3，COOR 7或CONR 8 R 9; R 3表示氢，卤素如F，Cl，Br，NO 2，羟基，氰基，-OC 1-6烷氧基如甲氧基，C 1-6烷基如甲基，NR 8 R 9如NH 2 NR 8 COR 9如-NHCHO或-NHCOCH 3，COOR 7，CONR 8 R 9; R 4表示氢，卤素如F，Cl，Br，NO 2，羟基，氰基，-OC 1-6烷氧基如甲氧基，C 1-6烷基如甲基，NR 8 R 9如NH 2 NR 8 COR 9如-NHCHO或-NHCOCH 3，COOR 7或CONR 8 R 9; R 5表示H，C 1-6烷基或C 1-6烯基; R 6a表示氢，C 1-6烷基，CO 2 C 1-3烷基，COC 1-3烷基或SO 2 C 1-3烷基; R 6b表示氢或C 1-6烷基; R 7表示氢，C 1-6烷基，C 1-3亚烷基，C 1-3烷基如-CH 2 CH 2 Si（CH 3）3; R 8和R 9独立地表示氢或C 1-6烷基; 包括其药学上可接受的酯，酰胺和氨基甲酸酯，其盐，溶剂合物和这些药学上可接受的酯，酰胺，氨基甲酸酯和盐的溶剂合物。

8. 发明申请

WO2004071389A2 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2004071389A2
公开(公告)日：2004-08-26
申请号：PCT/EP2004/001507
申请日：2004-02-13
申请人： GLAXO GROUP LIMITED , BARKER, Michael, David , DEMAINE, Derek, Anthony , HOUSE, David , INGLIS, Graham, George, Adam , JOHNSTON, Michael, John , JONES, Haydn, Terence , MACDONALD, Simon, John, Fawcett , MCLAY, Iain McFarlane , SHANAHAN, Stephen , SKONE, Philip, Alan , VINADER, Maria, Victoria
发明人： BARKER, Michael, David , DEMAINE, Derek, Anthony , HOUSE, David , INGLIS, Graham, George, Adam , JOHNSTON, Michael, John , JONES, Haydn, Terence , MACDONALD, Simon, John, Fawcett , MCLAY, Iain McFarlane , SHANAHAN, Stephen , SKONE, Philip, Alan , VINADER, Maria, Victoria
IPC分类号： A61K
CPC分类号： C07D265/02 , C07D413/12
摘要： A compound of formula (I) wherein: n represents an integer 0, 1 or 2; X represents, O, S, NR 6a , or CHR 6b ; R 1 represents hydrogen, halogen such as F, Cl or Br, NO 2 , hydroxy, cyano, -OC 1-6 alkoxy such as methoxy, C 1-6 alkyl such as methyl, NR 8 R 9 such as NH 2 , NR 8 COR 9 such as -NHCHO or -NHCOCH 3 , COOR 7 or CONR 8 R 9 ; R 2 represents hydrogen, halogen such as F, Cl, Br, NO 2 , hydroxy, cyano, -OC 1-6 alkoxy such as methoxy, C 1-6 alkyl such as methyl, NR 8 R 9 such as NH 2 , NR 8 COR 9 such as -NHCHO or -NHCOCH 3 , COOR 7 or CONR 8 R 9 ; R 3 represents hydrogen, halogen such as F, Cl, Br, NO 2 , hydroxy, cyano, -OC 1-6 alkoxy such as methoxy, C 1-6 alkyl such as methyl, NR 8 R 9 such as NH 2 , NR 8 COR 9 such as -NHCHO or -NHCOCH 3 , COOR 7 , CONR 8 R 9 ; R 4 represents hydrogen, halogen such as F, Cl, Br, NO 2 , hydroxy, cyano, -OC 1-6 alkoxy such as methoxy, C 1-6 alkyl such as methyl, NR 8 R 9 such as NH 2 , NR 8 COR 9 such as -NHCHO or -NHCOCH 3 , COOR 7 or CONR 8 R 9 ; R 5 represents H, C 1-6 alkyl, or C 1-6 alkenyl; R 6a represents hydrogen, C 1-6 alkyl, CO 2 C 1-3 alkyl, COC 1-3 alkyl or SO 2 C 1-3 alkyl; R 6b represents hydrogen, or C 1-6 alkyl; R 7 represents hydrogen, C 1-6 alkyl, C 1-3 alkyleneSiC 1-3 alkyl such as -CH 2 CH 2 Si(CH 3 ) 3 ; R 8 and R 9 independently represent hydrogen or C 1-6 alkyl; including pharmaceutically acceptable esters, amides and carbamates thereof, salts thereof, solvates thereof, and solvates of such pharmaceutically acceptable esters, amides, carbamates and salts.
摘要翻译：式（I）的化合物，其中：n表示整数0,1或2; X表示O，S，NR 6a或CHR 6b; R 1表示氢，卤素如F，Cl或Br，NO 2，羟基，氰基，-OC 1-6烷氧基如甲氧基，C 1-6烷基如甲基，NR 8 R 9如NH 2 NR 8 COR 9如-NHCHO或-NHCOCH 3，COOR 7或CONR 8 R 9; R 2表示氢，卤素如F，Cl，Br，NO 2，羟基，氰基，-OC 1-6烷氧基如甲氧基，C 1-6烷基如甲基，NR 8 R 9如NH 2 NR 8 COR 9如-NHCHO或-NHCOCH 3，COOR 7或CONR 8 R 9; R 3表示氢，卤素如F，Cl，Br，NO 2，羟基，氰基，-OC 1-6烷氧基如甲氧基，C 1-6烷基如甲基，NR 8 R 9如NH 2 ，NR 8 COR 9如-NHCHO或-NHCOCH 3，COOR 7，CONR 8 R 9; R 4表示氢，卤素如F，Cl，Br，NO 2，羟基，氰基，-OC 1-6烷氧基如甲氧基，C 1-6烷基如甲基，NR 8 R 9如NH 2 NR 8 COR 9如-NHCHO或-NHCOCH 3，COOR 7或CONR 8 R 9; R 5表示H，C 1-6烷基或C 1-6烯基; R 6a表示氢，C 1-6烷基，CO 2 C 1-3烷基，COC 1-3烷基或SO 2 C 1-3烷基; R 6b表示氢或C 1-6烷基; R 7表示氢，C 1-6烷基，C 1-3亚烷基，C 1-3烷基如-CH 2 CH 2 Si（CH 3）3; R 8和R 9独立地表示氢或C 1-6烷基; 包括其药学上可接受的酯，酰胺和氨基甲酸酯，其盐，溶剂化物，和这些药学上可接受的酯，酰胺，氨基甲酸酯和盐的溶剂合物。

9. 发明申请

WO9912933A3 PYRROLOPYRROLONE DERIVATIVES AS INHIBITORS OF NEUTROPHIL ELASTASE 审中-公开
标题翻译：吡咯并吡喃酮衍生物作为中性粒细胞弹性蛋白酶抑制剂
公开(公告)号：WO9912933A3
公开(公告)日：1999-05-27
申请号：PCT/EP9805609
申请日：1998-09-07
申请人： GLAXO GROUP LTD , CLARKE GEOFFREY DUKE EDWARD , DOWLE MICHAEL DENNIS , FINCH HARRY , HARRISON LEE ANDREW , INGLIS GRAHAM GEORGE ADAM , JOHNSON MARTIN REDPATH , MACDONALD SIMON JOHN FAWCETT , SHAH PRITOM , SMITH ROBIN ANDREW
发明人： CLARKE GEOFFREY DUKE EDWARD , DOWLE MICHAEL DENNIS , FINCH HARRY , HARRISON LEE ANDREW , INGLIS GRAHAM GEORGE ADAM , JOHNSON MARTIN REDPATH , MACDONALD SIMON JOHN FAWCETT , SHAH PRITOM , SMITH ROBIN ANDREW
IPC分类号： A61K31/407 , A61K31/4188 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/501 , A61K31/5377 , A61P1/02 , A61P9/00 , A61P11/00 , A61P11/06 , A61P17/00 , A61P43/00 , C07D487/04 , A61K31/40 , C07D413/06 , C07D413/12
CPC分类号： C07D487/04
摘要： There are provided according to the invention compounds of formula (I) wherein R , R and R are as defined in the specification. Compounds of formula (I) are useful, inter alia, in the treatment of inflammatory disorders of the respiratory tract.
摘要翻译：根据本发明提供了式（I）的化合物，其中R 1，R 2和R 3如说明书中所定义。式（I）化合物尤其可用于治疗呼吸道炎症。

10. 发明申请

WO2008074814A1 PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS 审中-公开
标题翻译：吡唑衍生物作为非甾体葡萄糖激素受体配体
公开(公告)号：WO2008074814A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/064167
申请日：2007-12-19
申请人： GLAXO GROUP LIMITED , CAMPBELL, Ian, Baxter , COE, Diane, Mary , COOPER, Anthony, William, James , INGLIS, Graham, George, Adam , JONES, Haydn, Terence , KEELING, Steven, Philip , MACDONALD, Simon, John, Fawcett , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad
发明人： CAMPBELL, Ian, Baxter , COE, Diane, Mary , COOPER, Anthony, William, James , INGLIS, Graham, George, Adam , JONES, Haydn, Terence , KEELING, Steven, Philip , MACDONALD, Simon, John, Fawcett , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad
IPC分类号： C07D231/38 , C07D401/12 , A61K31/415 , A61K31/4155 , A61P25/00 , C07C233/77 , C07C233/78 , C07D303/36
CPC分类号： C07D231/38 , C07C233/78 , C07D303/36 , C07D401/12
摘要： The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation.
摘要翻译：本发明提供式（I）化合物，其制备方法，包含所述化合物的药物组合物，所述组合物的制备，中间体和用途，用于制备用于治疗性治疗的药物，特别是用于治疗炎症。

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