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1. 发明申请

WO2004037773A8 PHENETHANOLAMINE DERIVATIVE FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
标题翻译：苯乙醇胺衍生物治疗呼吸系统疾病
公开(公告)号：WO2004037773A8
公开(公告)日：2004-07-22
申请号：PCT/EP0312035
申请日：2003-10-24
申请人： GLAXO GROUP LTD , CHAPMAN ALAN MICHAEL , GUNTRIP STEPHEN BARRY , LOOKER BRIAN EDGAR , PROCOPIOU PANAYIOTIS ALEXANDRO
发明人： CHAPMAN ALAN MICHAEL , GUNTRIP STEPHEN BARRY , LOOKER BRIAN EDGAR , PROCOPIOU PANAYIOTIS ALEXANDRO
IPC分类号： A61K31/145 , A61K31/435 , A61P11/00 , C07C317/22 , C07C323/19 , C07D213/65 , C07D213/66 , C07D215/22 , C07D215/227 , C07D215/26 , C07D261/10 , C07D263/22 , C07D309/40 , C07D319/08
CPC分类号： C07D213/66 , C07C317/22 , C07C323/19 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D215/227 , C07D215/26 , C07D261/10 , C07D263/22 , C07D309/40 , C07D319/08
摘要： The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译：本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物，以及它们在治疗中的用途，特别是它们在预防和治疗呼吸疾病中的用途。

2. 发明申请

WO2004037773A1 PHENETHANOLAMINE DERIVATIVE FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
标题翻译：用于治疗呼吸道疾病的苯乙醇胺衍生物
公开(公告)号：WO2004037773A1
公开(公告)日：2004-05-06
申请号：PCT/EP2003/012035
申请日：2003-10-24
申请人： GLAXO WELLCOME HOUSE , CHAPMAN, Alan, Michael , GUNTRIP, Stephen, Barry , LOOKER, Brian, Edgar , PROCOPIOU, Panayiotis, Alexandrou
发明人： CHAPMAN, Alan, Michael , GUNTRIP, Stephen, Barry , LOOKER, Brian, Edgar , PROCOPIOU, Panayiotis, Alexandrou
IPC分类号： C07C317/22
CPC分类号： C07D213/66 , C07C317/22 , C07C323/19 , C07C2601/08 , C07C2601/14 , C07D213/65 , C07D215/227 , C07D215/26 , C07D261/10 , C07D263/22 , C07D309/40 , C07D319/08
摘要： The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译：本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。

3. 发明申请

WO2004103998A1 QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：喹啉衍生物作为磷酸二酯酶抑制剂
公开(公告)号：WO2004103998A1
公开(公告)日：2004-12-02
申请号：PCT/EP2004/005494
申请日：2004-05-19
申请人： GLAXO GROUP LIMITED , BALDWIN, Ian, Robert , BARKER, Michael, David , DEAN, Anthony, William , ELDRED, Colin, David , EVANS, Brian , GOUGH, Sharon, Lisa , GUNTRIP, Stephen, Barry , HAMBLIN, Julie, Nicole , HOLMAN, Stuart , JONES, Paul , LINDVALL, Mika, Kristian , LUNNISS, Christopher, James , REDFERN, Tracy, Jane , REDGRAVE, Alison, Judith , ROBINSON, John, Edward , WOODROW, Michael
发明人： BALDWIN, Ian, Robert , BARKER, Michael, David , DEAN, Anthony, William , ELDRED, Colin, David , EVANS, Brian , GOUGH, Sharon, Lisa , GUNTRIP, Stephen, Barry , HAMBLIN, Julie, Nicole , HOLMAN, Stuart , JONES, Paul , LINDVALL, Mika, Kristian , LUNNISS, Christopher, James , REDFERN, Tracy, Jane , REDGRAVE, Alison, Judith , ROBINSON, John, Edward , WOODROW, Michael
IPC分类号： C07D417/12
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20 and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译：根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R1，R2，R19，R20和R34如说明书中所述，其制备方法，含有它们的制剂及其在治疗中的用途用于治疗炎性疾病。

4. 发明申请

WO2004037807A9 MEDICINAL ARYLETHANOLAMINE COMPOUNDS 审中-公开
标题翻译：药用芳香胺化合物
公开(公告)号：WO2004037807A9
公开(公告)日：2004-08-19
申请号：PCT/EP0311648
申请日：2003-10-20
申请人： GLAXO GROUP LTD , COE DIANE MARY , GUNTRIP STEPHEN BARRY
发明人： COE DIANE MARY , GUNTRIP STEPHEN BARRY
IPC分类号： A61P11/08 , C07D319/20 , C07D405/12 , C07D413/12 , A61K31/357
CPC分类号： C07D405/12 , C07D319/20 , C07D413/12
摘要： The present invention relates to novel compounds of formula (I), and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译：本发明涉及新的式（I）化合物及其盐，溶剂化物和生理上可接受的衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防中的用途并治疗呼吸系统疾病。

5. 发明申请

WO2004037807A3 MEDICINAL ARYLETHANOLAMINE COMPOUNDS 审中-公开
标题翻译：药用芳香胺化合物
公开(公告)号：WO2004037807A3
公开(公告)日：2004-06-24
申请号：PCT/EP0311648
申请日：2003-10-20
申请人： GLAXO GROUP LTD , COE DIANE MARY , GUNTRIP STEPHEN BARRY
发明人： COE DIANE MARY , GUNTRIP STEPHEN BARRY
IPC分类号： A61P11/08 , C07D319/20 , C07D405/12 , C07D413/12 , A61K31/357
CPC分类号： C07D405/12 , C07D319/20 , C07D413/12
摘要： The present invention relates to novel compounds of formula (I),and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译：本发明涉及新的式（I）化合物及其盐，溶剂化物和生理上可接受的衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防中的用途并治疗呼吸系统疾病。

6. 发明申请

WO2004039762A1 PHENETHANOLAMINE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
标题翻译：用于治疗呼吸道疾病的苯酚胺衍生物
公开(公告)号：WO2004039762A1
公开(公告)日：2004-05-13
申请号：PCT/EP2003/012194
申请日：2003-10-30
申请人： GLAXO GROUP LIMITED , GUNTRIP, Stephen, Barry
发明人： GUNTRIP, Stephen, Barry
IPC分类号： C07C217/10
CPC分类号： C07D257/04 , C07C217/10 , C07C233/43 , C07C235/42 , C07C275/32 , C07C311/29 , C07C2601/02 , C07D263/22 , C07D295/26 , C07D413/04
摘要： The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译：本发明涉及式（I）的新化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防和治疗呼吸系统疾病中的用途。

7. 发明申请

WO1998002434A1 FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：熔化的杂环化合物作为蛋白酪氨酸激酶抑制剂
公开(公告)号：WO1998002434A1
公开(公告)日：1998-01-22
申请号：PCT/EP1997003672
申请日：1997-07-11
申请人： GLAXO GROUP LIMITED , COCKERILL, George, Stuart , CARTER, Malcolm, Clive , GUNTRIP, Stephen, Barry , SMITH, Kathryn, Jane
发明人： GLAXO GROUP LIMITED
IPC分类号： C07D405/04
CPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14
摘要： Substituted heteroaromatic compounds of formula (I) and in particular substituted quinolines and quinazolines, are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of cancer and psoriasis, or a salt or solvate thereof; wherein X is N or CH; Y is a group W(CH2), (CH2)W, or W, in which W is O, S(O)m wherein m is 0, 1 or 2, or NR wherein R is hydrogen or a C1-8 alkyl group; R represents a phenyl group or a 5- or 6-membered heterocyclic ring containing 1 to 4 heteroatoms selected from N, O or S(O)m, wherein m is as defined above, with the provisos that the ring does not contain two adjacent O or S(O)m atoms and that where the ring contains only N as heteroatom(s) the ring is C-linked to the quinazoline or quinoline ring, R being optionally substituted by one or more R groups; P = 0 to 3; U, R , R are as defined in the application.
摘要翻译：取代的式（I）的杂芳族化合物，特别是取代的喹啉和喹唑啉是蛋白质酪氨酸激酶抑制剂。这些化合物被描述为它们的制备方法，包括这些化合物的药物组合物及其在药物中的用途，例如治疗癌症和牛皮癣，或其盐或溶剂合物; 其中X是N或CH; Y是基团W（CH 2），（CH 2）W或W，其中W是O，S（O）m，其中m是0,1或2，或NR a，其中R a是氢或 C 1-8烷基; R 1表示苯基或含有1至4个选自N，O或S（O）m的杂原子的5或6元杂环，其中m如上所定义，条件是该环不是含有两个相邻的O或S（O）m原子，并且当环仅含有N作为杂原子时，该环与喹唑啉或喹啉环C-连接，R 1任选地被一个或多个R' 3>组 P = 0〜3; U，R 2，R 3如本申请中所定义。

8. 发明申请

WO2007042299A1 PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS 审中-公开
标题翻译：作为SYK抑制剂的吡咯并嘧啶衍生物
公开(公告)号：WO2007042299A1
公开(公告)日：2007-04-19
申请号：PCT/EP2006/009870
申请日：2006-10-11
申请人： GLAXO GROUP LIMITED , ANCLIFF, Rachael, Ann , ATKINSON, Francis, Louis , BARKER, Michael, David, , BOX, Philip, Charles , DANIEL, Carla , GORE, Paul, Martin , GUNTRIP, Stephen, Barry , HASEGAWA, Masaichi , INGLIS, Graham, George, Adam , KANO, Kazuya , MIYAZAKI, Yasushi , PATEL, Vipulkumar, Kantibhai , RITCHIE, Timothy, John , SWANSON, Stephen , WALKER, Ann, Louise , WELLAWAY, Christopher, Roland , WOODROW, Michael
发明人： ANCLIFF, Rachael, Ann , ATKINSON, Francis, Louis , BARKER, Michael, David, , BOX, Philip, Charles , DANIEL, Carla , GORE, Paul, Martin , GUNTRIP, Stephen, Barry , HASEGAWA, Masaichi , INGLIS, Graham, George, Adam , KANO, Kazuya , MIYAZAKI, Yasushi , PATEL, Vipulkumar, Kantibhai , RITCHIE, Timothy, John , SWANSON, Stephen , WALKER, Ann, Louise , WELLAWAY, Christopher, Roland , WOODROW, Michael
IPC分类号： C07D487/04 , A61K31/519 , A61P37/08
CPC分类号： C07D487/04
摘要： Pyrrolopyrimidine derivatives of formula (I) are inhibitors of Spleen Tyrosine kinase (Syk) and therefore of potential therapeutic benefit in the treatment of diseases and conditions associated with inappropriate Syk activity, in particular in the treatment of inflammatory and allergic diseases.
摘要翻译：式（I）的吡咯并嘧啶衍生物是脾酪氨酸激酶（Syk）的抑制剂，因此在治疗与不适当的Syk活性相关的疾病和病症中具有潜在的治疗益处，特别是在治疗炎症和过敏性疾病。

9. 发明申请

WO2004037807A2 MEDICINAL COMPOUNDS 审中-公开
标题翻译：药物化合物
公开(公告)号：WO2004037807A2
公开(公告)日：2004-05-06
申请号：PCT/EP2003/011648
申请日：2003-10-20
申请人： GLAXO GROUP LIMITED , COE, Diane, Mary , GUNTRIP, Stephen, Barry
发明人： COE, Diane, Mary , GUNTRIP, Stephen, Barry
IPC分类号： C07D319/00
CPC分类号： C07D405/12 , C07D319/20 , C07D413/12
摘要： The present invention relates to novel compounds of formula (I),and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
摘要翻译：本发明涉及新的式（I）化合物及其盐，溶剂化物和生理上可接受的衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是其在预防中的用途并治疗呼吸系统疾病。

10. 发明申请

WO1998002437A1 BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：双相异构化合物作为蛋白酪氨酸激酶抑制剂
公开(公告)号：WO1998002437A1
公开(公告)日：1998-01-22
申请号：PCT/EP1997003673
申请日：1997-07-11
申请人： GLAXO GROUP LIMITED , COCKERILL, George, Stuart , CARTER, Malcolm, Clive , GUNTRIP, Stephen, Barry , SMITH, Kathryn, Jane
发明人： GLAXO GROUP LIMITED
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07C217/86 , C07C317/36
摘要： Substituted heteroaromatic compounds, and in particular substituted bicyclic heteroaromatic compounds in which one ring is a pyridine or pyrimidine of formula (I) are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of cancer and psoriasis.
摘要翻译：取代的杂芳族化合物，特别是其中一个环是式（I）的吡啶或嘧啶的取代的双环杂芳族化合物是蛋白质酪氨酸激酶抑制剂。这些化合物被描述为它们的制备方法，包括这些化合物的药物组合物及其在药物中的用途，例如治疗癌症和牛皮癣。

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