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1. 发明申请

WO1994019334A1 PF1022 DERIVATIVE, CYCLIC DEPSIPEPTIDE 审中-公开
标题翻译： PF1022衍生物，循环抑制剂
公开(公告)号：WO1994019334A1
公开(公告)日：1994-09-01
申请号：PCT/JP1994000252
申请日：1994-02-18
申请人： MEIJI SEIKA KAISHA, LTD. , OHYAMA, Makoto , OHISHI, Maki , OKADA, Yumiko , KOYAMA, Masao , SUMI, Shinjiro , MURAI, Yasushi , TAKAGI, Masauki , OKADA, Tadaaki , SAKANAKA, Osamu , YONETA, Toshio , IINUMA, Katsuharu , SHIBAHARA, Seiji
发明人： MEIJI SEIKA KAISHA, LTD.
IPC分类号： C07D273/00
CPC分类号： C07D273/00 , A61K38/00 , C07K11/02
摘要： A novel PF1022 derivative as a cyclic depsipeptide, represented by general formula (I), or a salt thereof, having the vermifugal activity against various parasites living in man, domestic and pet animals, and the like and thus being useful as a vermicide for preventing or treating infectious diseases caused by parasites. In formula (I) R , R , R and R represent each independently alkyl, cyclohexylmethyl, optionally substituted benzyl, etc; and X, Y, Z and Q represent each independently methyl or hydrogen, excluding the case where all of the R , R , X, Y, Z and Q represent methyl groups and R and R represent benzyl groups at the same time.
摘要翻译：一种作为由通式（I）表示的环状缩酚酸酯的新型PF1022衍生物或其盐，其具有针对生活在人类，家畜和宠物动物等中的各种寄生虫的诱发活性，因此可用作防止或治疗由寄生虫引起的传染病。在式（I）中，R 1，R 2，R 3和R 4各自独立地表示烷基，环己基甲基，任意取代的苄基等; X，Y，Z和Q各自独立地表示甲基或氢，不包括所有R 1，R 3，X，Y，Z和Q表示甲基，R 2和R 2， 4>同时代表苄基。

2. 发明申请

WO1998012200A1 A CRYSTALLINE SUBSTANCE OF CEFDITOREN PIVOXYL AND THE PRODUCTION OF THE SAME 审中-公开
标题翻译： CEFDITOREN PIVOXYL的晶体物质及其生产
公开(公告)号：WO1998012200A1
公开(公告)日：1998-03-26
申请号：PCT/JP1997003340
申请日：1997-09-19
申请人： MEIJI SEIKA KAISHA LTD. , YASUI, Kiyoshi , ONODERA, Masahiro , SUKEGAWA, Masamichi , WATANABE, Tatsuo , YAMAMOTO, Yuichi , MURAI, Yasushi , IINUMA, Katsuharu
发明人： MEIJI SEIKA KAISHA LTD.
IPC分类号： C07D501/00
CPC分类号： C07D501/00
摘要： As a novel substance is provided a new, crystalline substance of Cefditoren pivoxyl which has a high purity and an enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving amorphous substance of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous substance well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15 DEG C under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0 - 10 DEG C. The resulting admixture of the concentrated solution of Cefditoren pivoxyl in alkanol with added water and the deposited Cefditoren pivoxyl is then agitated 10 DEG C or below, to effect a complete crystallization of Cefditoren pivoxyl.
摘要翻译：作为一种新型物质，提供了一种具有高纯度和增加的储存热稳定性的新戊酸头孢托仑的结晶物质。这种结晶的匹戊头孢托仑新戊酰基可以通过包括以下步骤的方法来制备，所述方法包括将新戊酰氧基新戊酰氧基的无定形物质溶解在能够很好地溶解所述无定形物质的无水的第一有机溶剂中，以及将所得溶液的第一有机溶剂组分置换为将具有1至5个碳原子的无水链烷醇作为第二有机溶剂，使得将首次制备的在第一有机溶剂中的新戊酰氧基头孢托仑的溶液与一定体积的链烷醇混合，然后在15℃下浓缩，压力等等。由此，进行该处理，以产生溶解在单独的链烷醇中的含有50mg / ml至250mg / ml的新戊酰氧基甲脒基替他啶的溶液。从后者的溶液中，通过在0-10℃的温度下加入水引发新戊酸头孢托仑的晶体沉淀。然后搅拌所得的新戊酰氧基甲基头孢地托仑在链烷醇中与加入的水的混合物和沉淀的新戊酰氧基新戊酰基 10℃或以下，以实现新戊酰氧基甲酰头孢托仑的完全结晶。

3. 发明申请

WO1997011064A1 NOVEL CYCLIC DEPSIPEPTIDE PF1022 DERIVATIVES 审中-公开
标题翻译：新型循环抑制剂PF1022衍生物
公开(公告)号：WO1997011064A1
公开(公告)日：1997-03-27
申请号：PCT/JP1996002730
申请日：1996-09-20
申请人： MEIJI SEIKA KAISHA, LTD. , SAKANAKA, Osamu , OKADA, Yumiko , OHYAMA, Makoto , MATSUMOTO, Maki , TAKAHASHI, Masaaki , MURAI, Yasushi , IINUMA, Katsuharu , ACHIM, Harder , NORBERT, Mencke
发明人： MEIJI SEIKA KAISHA, LTD.
IPC分类号： C07D273/00
CPC分类号： C07D273/00 , Y02P20/55
摘要： Novel PF1022 derivatives which are cyclic depsipeptides represented by general formula (I) or their salts are useful as a vermicide in the prevention or treatment of vermination.
摘要翻译：由通式（I）表示的环状缩酚酸肽或其盐的新型PF1022衍生物可用作防止或治疗萌发的杀菌剂。

4. 发明申请

WO9934832A8 CRYSTALLOGRAPHICALLY STABLE AMORPHOUS CEPHALOSPORIN COMPOSITIONS AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：晶体稳定的无定形酚酞组合物及其制备方法
公开(公告)号：WO9934832A8
公开(公告)日：1999-10-28
申请号：PCT/JP9900020
申请日：1999-01-07
申请人： MEIJI SEIKA KAISHA , ONODERA MASAHIRO , SUKEGAWA MASAMICHI , YASUI KIYOSHI , WATANABE TATSUO , SATO TOYOMI , MURAI YASUSHI , IINUMA KATSUHARU
发明人： ONODERA MASAHIRO , SUKEGAWA MASAMICHI , YASUI KIYOSHI , WATANABE TATSUO , SATO TOYOMI , MURAI YASUSHI , IINUMA KATSUHARU
IPC分类号： A61K9/14 , A61K31/545 , A61K31/546 , A61K47/38 , A61P31/00 , C07D501/00 , C07D501/24
CPC分类号： C07D501/00 , A61K9/146 , A61K31/545 , A61K31/546 , Y10S514/96
摘要： Yellow and powdery compositions consisting of particles composed of a homogeneous mixture of amorphous cefditoren pivoxil with a water-soluble polymer additive and being orally administrable. These compositions can be obtained by dissolving crystalline cefditoren pivoxil and the water-soluble polymer additive in an aqueous solution of an acid, neutralizing, coprecipitating, and then drying the thus obtained precipitate followed by the recovery of the above-mentioned product in the form of particles.
摘要翻译：由由无定形头孢托仑匹酯与水溶性聚合物添加剂的均匀混合物组成的颗粒组成的黄色和粉末组合物并且可口服施用。这些组合物可以通过将结晶头孢托仑匹酯和水溶性聚合物添加剂溶解在酸的水溶液中，中和，共沉淀，然后干燥所得到的沉淀物，然后以上述形式回收上述产物，粒子。

5. 发明申请

WO1995005171A1 ANTI-MRSA COMPOSITION 审中-公开
标题翻译：抗MRSA组合物
公开(公告)号：WO1995005171A1
公开(公告)日：1995-02-23
申请号：PCT/JP1994001353
申请日：1994-08-16
申请人： MEIJI SEIKA KABUSHIKI KAISHA , BIOMATERIAL CO., LTD. , YONETA, Toshio , FUJII, Naoyuki , OOISHI, Maki , IINUMA, Katsuharu , SATO, Atsuyuki , YASUDA, Kimiaki
发明人： MEIJI SEIKA KABUSHIKI KAISHA , BIOMATERIAL CO., LTD.
IPC分类号： A61K31/415
CPC分类号： D21H21/36 , A01N43/50 , A61K31/415 , A61L31/16 , A61L2300/204 , A61L2300/404 , D06M13/352 , D06M16/00 , D06N3/0059 , A01N25/34 , A01N2300/00
摘要： An anti-methicillin-resistant Staphylococcus aureus (MRSA) composition containing an imidazole derivative represented by general formula (I), wherein R , R , R and R represent each independently hydrogen or halogen. Since the above compound has an anti-MRSA activity, it can provide a composition efficacious in preventing infection with MRSA and a textile product bearing the composition.
摘要翻译：含有由通式（I）表示的咪唑衍生物的抗甲氧西林抗性金黄色葡萄球菌（MRSA）组合物，其中R 1，R 2，R 3和R 4各自独立地表示氢或卤素。由于上述化合物具有抗MRSA活性，因此可以提供有效预防感染MRSA的组合物和具有该组合物的纺织品。

6. 发明申请

WO1998005655A1 PROCESS FOR PRODUCING CYCLODEPSIPEPTIDE COMPOUNDS AND NOVEL CYCLODEPSIPEPTIDE 审中-公开
标题翻译：生产环磷酰胺化合物和新型环磷酰胺的方法
公开(公告)号：WO1998005655A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002772
申请日：1997-08-07
申请人： MEIJI SEIKA KAISHA, LTD. , OHYAMA, Makoto , TAKAHASHI, Masaaki , SHIGEMATSU, Yoshiya , SAKANAKA, Osamu , MURAI, Yasushi , IINUMA, Katsuharu
发明人： MEIJI SEIKA KAISHA, LTD.
IPC分类号： C07D273/00
CPC分类号： C07D273/00 , C12P17/14
摘要： Substance PF1022G, a novel cyclodepsipeptide represented by formula (D), is produced together with known cyclodepsipeptides, i.e., Substances PF1022F and PF1022H by culturing a bacterium which produces the Substances PF1022F, PF1022G and PF1022H, typified by the known PF1022 strain (deposited under the accession number FERM BP-2671) which is a filamentous fungus belonging to the order Agonomycetales and which is presumed to belong to the genus Xylaria or Rosellinea of the family Xylariaceae.
摘要翻译：通过培养产生PF1022F，PF1022G和PF1022H物质的细菌，通过已知的PF1022F（PF1022F）和PF1022H的物质PF1022F和PF1022H，通过公知的PF1022菌株（保藏在登录号为FERM BP-2671），其是属于农业龙叶藻属的丝状真菌，并且被认为属于Xylariaceae科的Xylaria属或Rosellinea属。

7. 发明申请

WO1997020945A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED ARYL LACTIC ACID CONTAINING CYCLODEPSIPEPTIDES WITH 24 RING ATOMS 审中-公开
标题翻译：用于生产取代ARYLMILCHSÄURE含环缩酚酸肽24个环原子
公开(公告)号：WO1997020945A1
公开(公告)日：1997-06-12
申请号：PCT/EP1996005190
申请日：1996-11-25
申请人： BAYER AKTIENGESELLSCHAFT , JESCHKE, Peter , BONSE, Gerhard , THIELKING, Gerhard , ETZEL, Winfried , HARDER, Achim , MENCKE, Norbert , KLEINKAUF, Horst , ZOCHER, Rainer , IINUMA, Katsuharu , MIYAMOTO, Kouichi
发明人： BAYER AKTIENGESELLSCHAFT
IPC分类号： C12P17/14
CPC分类号： C07D273/00 , C12P1/00 , C12P17/14 , Y10S435/911
摘要： The invention relates to a new process for the preparation of substituted aryl lactic acid containing cyclodepsipeptides with 24 ring atoms of the formula (I), in which R , R , R , R have the meanings given in the description, with the aid of fungal strains of the Agonomycetales class or enzymatic preparations isolated therefrom.
摘要翻译：本发明涉及一种新的制备具有式（I）的24个环原子的取代的含Arylmilchsäure-环缩酚酸肽的制备，其中R <1>，R <2>，R <3>，R <4>如说明书中所定义具有意义，与物种Agonomycetales的真菌菌株的辅助或从酶制剂中分离。

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