专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009064082A1 COMPOSITION COMPRISING GALLA RHOIS EXTRACT FOR PREVENTION AND TREATMENT OF OBESITY BY MEANS OF AUTOPHAGIC MECHANISM 审中-公开
标题翻译：包含GALLA RHOIS提取物的组合物，用于通过自动机械手段预防和治疗肥胖
公开(公告)号：WO2009064082A1
公开(公告)日：2009-05-22
申请号：PCT/KR2008/006294
申请日：2008-10-24
申请人： IGSBIO , KANG, Se Chan , CHOI, Han , CHEONG, Young Jun , JUNG, Young Hwan , KIM, Hee Jeong , SON, Eun Hwa
发明人： KANG, Se Chan , CHOI, Han , CHEONG, Young Jun , JUNG, Young Hwan , KIM, Hee Jeong , SON, Eun Hwa
IPC分类号： A61K36/22 , A61K31/351 , A61P3/00 , A61K31/70
CPC分类号： A61K36/22 , A61K31/351 , A61K31/70
摘要： The present invention relates to a composition comprising a Galla Rhois extract for the prevention and treatment of obesity based on the mechanism of autophagocytosis. In particular, the present invention has found that the Galla Rhois extract or fraction thereof exhibits inhibitory effects on the proliferation of adipocytes by inducing autophagocytosis thereof, and therefore, provides a method of isolating active ingredients capable of being used as a composition for the prevention and treatment of obesity from Galla Rhois, and a composition for the prevention and treatment of obesity which comprises a Galla Rhois extract or a fraction thereof. That is, the Galla Rhois extract according to the present invention exerts beneficial activities of inducing autophagocytosis of adipocytes in vitro, inhibiting body weight gain in an obesity-induced animal model, reducing the body weight of a body weight gain-induced animal model, and lowering the levels of triglycerides and low density lipoproteins in the blood. Therefore, the Galla Rhois extract according to the present invention can be effectively used as a pharmaceutical composition and health foods for the prevention of obesity and complications thereof and treating the same.
摘要翻译：本发明涉及一种包含根据自噬作用机理预防和治疗肥胖症的加洛氏提取物的组合物。特别地，本发明已经发现，加洛氏提取物或其部分通过诱导其自身吞噬作用而对脂肪细胞的增殖表现出抑制作用，因此，提供了分离能够用作预防和/或免疫的组合物的活性成分的方法治疗来自Galla Rhois的肥胖症，以及用于预防和治疗肥胖症的组合物，其包含加利罗非鱼提取物或其一部分。也就是说，根据本发明的加拉罗氏菌提取物在体外发挥诱导脂肪细胞的自噬作用的有益活性，抑制肥胖诱导的动物模型中的体重增加，减轻体重增加诱导的动物模型的体重，以及降低血液中甘油三酸酯和低密度脂蛋白的含量。因此，根据本发明的加拉罗氏菌提取物可以有效地用作药物组合物和用于预防肥胖及其并发症并进行治疗的保健食品。

IPRDB

热门服务

关于我们

友情链接

联系方式