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1. 发明申请

WO2013043640A1 METHOD AND SYSTEM FOR PRODUCING AT LEAST ONE PATIENT-SPECIFIC SURGICAL AID 审中-公开
标题翻译：用于生产至少一例患者特异性外科手术的方法和系统
公开(公告)号：WO2013043640A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/055982
申请日：2012-09-19
申请人： THE CLEVELAND CLINIC FOUNDATION , IANNOTTI, Joseph, P. , BARSOUM, Wael, K. , BRYAN, Jason
发明人： IANNOTTI, Joseph, P. , BARSOUM, Wael, K. , BRYAN, Jason
IPC分类号： A61B17/17 , A61B17/15
CPC分类号： A61B17/15 , A61B17/17 , A61B2017/568 , A61B2034/108 , A61F2002/30957 , B33Y80/00
摘要： A method for producing at least one patient-specific surgical aid includes providing a physical model of a native patient tissue. The physical model has at least one surface of interest. A constraining wall is placed in contact with at least a portion of the physical model. A moldable substance is placed into contact with at least a portion of the surface of interest. An impression of the surface of interest is maintained upon the moldable substance. The moldable substance is solidified into a patient- specific surgical aid. The patient-specific surgical aid is removed from the physical model. A system for producing at least one patient- specific surgical aid is also disclosed.
摘要翻译：用于产生至少一个患者特异性手术辅助的方法包括提供天然患者组织的物理模型。物理模型至少有一个感兴趣的表面。约束壁放置成与物理模型的至少一部分接触。将可模制物质放置成与感兴趣的表面的至少一部分接触。感兴趣的表面的印象保持在可模制物质上。可模塑物质固化成患者特异性手术辅助剂。从物理模型中移除患者特异性外科辅助。还公开了一种用于生产至少一个患者特异性手术辅助的系统。

2. 发明申请

WO2012058353A1 SYSTEM AND METHOD FOR ASSISTING WITH ARRANGEMENT OF A STOCK INSTRUMENT WITH RESPECT TO A PATIENT TISSUE 审中-公开
标题翻译：用于协助装配有关患者组织的仪器的系统和方法
公开(公告)号：WO2012058353A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057954
申请日：2011-10-27
申请人： THE CLEVELAND CLINIC FOUNDATION , IANNOTTI, Joseph, P. , BARSOUM, Wael, K. , BRYAN, Jason, A.
发明人： IANNOTTI, Joseph, P. , BARSOUM, Wael, K. , BRYAN, Jason, A.
IPC分类号： A61B19/00
CPC分类号： A61B17/88 , A61B17/1739 , A61B17/1778 , A61B17/8872 , A61B34/10 , A61B2034/107 , A61B2034/108 , A61B2090/3916
摘要： A stock instrument (316) includes at least one guide interacting feature. A lower instrument surface of the stock instrument is placed into contact with the patient tissue. A guide (530) has a lower guide surface contoured to substantially mate with at least a portion of an upper instrument surface of the stock instrument. A predetermined instrument orientation upon the patient tissue is defined, which is preselected responsive to preoperative imaging of the patient tissue (100,102). The guide and instrument are mated in a predetermined relative guide/instrument orientation wherein at least one guide interacting feature of the instrument is placed into engagement with at least one instrument guiding feature of the guide. The guide is moved into a predetermined guide orientation with respect to the patient tissue and concurrently the instrument is moved into a predetermined instrument orientation with respect to the patient tissue.
摘要翻译：股票工具（316）包括至少一个指导交互特征。存放仪器的较低仪器表面与患者组织接触。引导件（530）具有较低的引导表面，其轮廓形成为与该库存工具的上部仪器表面的至少一部分基本配合。定义了患者组织上的预定的仪器取向，其被预先选择为对患者组织（100,102）的术前成像。导向器和仪器以预定的相对引导/仪器取向配合，其中仪器的至少一个引导器相互作用特征被放置成与引导件的至少一个仪器引导特征接合。引导件相对于患者组织移动到预定的引导方向，并且同时使器械相对于患者组织移动到预定的仪器取向。

3. 发明申请

WO2012058355A4 SYSTEM OF PREOPERATIVE PLANNING AND PROVISION OF PATIENT-SPECIFIC SURGICAL AIDS 审中-公开
标题翻译：预防性规划和患者特异性手术艾滋病的提供制度
公开(公告)号：WO2012058355A4
公开(公告)日：2012-07-26
申请号：PCT/US2011057957
申请日：2011-10-27
申请人： CLEVELAND CLINIC FOUNDATION , IANNOTTI JOSEPH P , BARSOUM WAEL K , BRYAN JASON A , O'NEILL PETER D
发明人： IANNOTTI JOSEPH P , BARSOUM WAEL K , BRYAN JASON A , O'NEILL PETER D
IPC分类号： A61B17/17 , A61B19/00
CPC分类号： A61B17/1739 , A61B17/1778 , A61B34/10 , A61B34/25 , A61B2017/568 , A61B2034/105 , A61B2034/108 , A61F2/4081 , A61F2002/4633
摘要： A method of preoperative planning and provision of patient-specific surgical aids includes creating a virtual model of a native patient tissue. A virtual device is placed into a predetermined device orientation relative to the virtual model (422) of the native patient tissue. At least one predetermined landmark orientation is specified for placement of at least one virtual landmark relative to the native patient tissue. A virtual patient-specific template containing the predetermined landmark orientation and having a landmark guiding feature is generated. At least one virtual patient-specific placement guide configured to interact simultaneously with at least one previously placed virtual landmark and the virtual device when the virtual device is in the predetermined device orientation is generated. A physical patient-specific template is created as a tangible representation of the virtual patient-specific template. A physical patient-specific placement guide is created as a tangible representation of the virtual patient-specific placement guide.
摘要翻译：术前规划和提供患者特异性手术辅助装置的方法包括创建本地患者组织的虚拟模型。将虚拟设备相对于本机患者组织的虚拟模型（422）放置成预定的设备方位。为至少一个虚拟地标相对于本机患者组织的放置指定至少一个预定的标记取向。生成包含预定的标记取向并具有地标引导特征的虚拟患者特定模板。至少一个虚拟患者特定的放置引导件被配置为当虚拟设备处于预定的设备取向时与至少一个先前放置的虚拟地标和虚拟设备同时交互。创建具体的患者特定模板作为虚拟患者特定模板的有形表示。身体特定的物理位置指南被创建为虚拟患者特定放置指南的有形表示。

4. 发明申请

WO2012047338A2 REINFORCED TISSUE GRAFT 审中-公开
标题翻译：加强组织格子
公开(公告)号：WO2012047338A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/042138
申请日：2011-06-28
申请人： THE CLEVELAND CLINIC FOUNDATION , DERWIN, Kathleen, A. , IANNOTTI, Joseph, P. , SAHOO, Sambit
发明人： DERWIN, Kathleen, A. , IANNOTTI, Joseph, P. , SAHOO, Sambit
CPC分类号： A61L27/3633 , A61L27/3804 , A61L27/54 , A61L27/58 , A61L2300/00 , A61L2430/10 , A61L2430/30 , A61L2430/40
摘要： A biocompatible tissue graft includes a first layer of a bioremodelable collageneous material, a second layer of biocompatible synthetic or natural remodelable or substantially remodelable material attached to the first layer; and at least one fiber that is stitched in a reinforcing pattern in the first layer and/or second layer to mitigate tearing and/or improve fixation retention of the graft, and substantially maintain the improved properties while one or more of the layers is remodeling.
摘要翻译：生物相容性组织移植物包括生物可重塑的胶原材料的第一层，附着到第一层的生物相容性合成或天然可重塑或基本可重塑材料的第二层; 以及至少一个缝合在第一层和/或第二层中的增强图案中的纤维，以减轻撕裂和/或改善移植物的固定保持力，并且在一个或多个层重塑时基本保持改进的性质。

5. 发明申请

WO2009120966A3 REINFORCED TISSUE GRAFT 审中-公开
标题翻译：加强组织格子
公开(公告)号：WO2009120966A3
公开(公告)日：2010-03-25
申请号：PCT/US2009038570
申请日：2009-03-27
申请人： CLEVELAND CLINIC FOUNDATION , DERWIN KATHLEEN , AURORA AMIT , IANNOTTI JOSEPH P , MCCARRON JESSE A
发明人： DERWIN KATHLEEN , AURORA AMIT , IANNOTTI JOSEPH P , MCCARRON JESSE A
IPC分类号： A61K35/12
CPC分类号： A61L27/40 , A61F2/08 , A61L27/54
摘要： A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
摘要翻译：提供生物相容性组织移植物。组织移植物包括细胞外基质贴片和用于加强贴片的装置。

6. 发明申请

WO2013148229A1 STEMLESS HUMERAL COMPONENT AND ASSOCIATED SURGICAL INSTRUMENTS AND METHODS 审中-公开
公开(公告)号：WO2013148229A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/031164
申请日：2013-03-14
申请人： DEPUY PRODUCTS, INC. , JENSEN, Kirk L. , IANNOTTI, Joseph P. , ZANCHIN, Laurent , EKELUND, Anders , STONE, Matthew T. , LEWIS, Jeremiah M.
发明人： JENSEN, Kirk L. , IANNOTTI, Joseph P. , ZANCHIN, Laurent , EKELUND, Anders , STONE, Matthew T. , LEWIS, Jeremiah M. , ANTHONY, Sarah , LONG, Jack F. , PONCET, Didier , WARLOP, David M. , LAWRENCE, Chad , LUBENSKY, Scott A.
IPC分类号： A61F2/40
CPC分类号： A61F2/4612 , A61B17/15 , A61B17/16 , A61B17/1604 , A61B17/1684 , A61B17/1739 , A61B17/1778 , A61B17/32053 , A61B17/842 , A61B90/06 , A61B90/50 , A61B2090/034 , A61B2090/3945 , A61F2/40 , A61F2/4003 , A61F2/4014 , A61F2/4637 , A61F2/4684 , A61F2002/30235 , A61F2002/30332 , A61F2002/30574 , A61F2002/30579 , A61F2002/30604 , A61F2002/30616 , A61F2002/30772 , A61F2002/30904 , A61F2002/4007 , A61F2002/4018 , A61F2002/4022 , A61F2002/4029 , A61F2002/4033 , A61F2002/4037 , A61F2002/4619 , A61F2002/4624 , A61F2002/4627 , A61F2002/4628 , A61F2002/4629 , A61F2002/4658 , A61F2002/4681
摘要： A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.
摘要翻译：用于更换患者肱骨的肱骨头的无肱骨部件包括具有多个从其底表面向远侧延伸的悬臂的支撑凸缘。还公开了用于手术安装无茎肱骨组件的仪器和方法。

7. 发明申请

WO2012058344A1 SYSTEM FOR ASSISTING WITH ATTACHMENT OF A STOCK IMPLANT TO A PATIENT TISSUE 审中-公开
标题翻译：用于辅助植入植入物到患者组织的系统
公开(公告)号：WO2012058344A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057944
申请日：2011-10-27
申请人： THE CLEVELAND CLINIC FOUNDATION , IANNOTTI, Joseph, P. , BARSOUM, Wael, K. , BRYAN, Jason, A.
发明人： IANNOTTI, Joseph, P. , BARSOUM, Wael, K. , BRYAN, Jason, A.
IPC分类号： A61B17/17 , A61B17/90 , A61B19/00 , A61F2/34 , A61B17/88
CPC分类号： A61B17/1728 , A61B17/1746 , A61B17/1753 , A61B17/1778 , A61B17/8061 , A61B17/8897 , A61B34/10 , A61B2017/00526 , A61B2017/568 , A61B2017/90 , A61F2/34 , A61F2/4609 , A61F2002/3401 , A61F2002/3403 , A61F2002/3408
摘要： A guide for assisting with attachment of a stock prosthetic implant to a patient tissue includes a lower guide surface configured to contact an upper implant surface of the stock prosthetic implant when a lower implant surface of the stock prosthetic implant contacts the patient tissue. An upper guide surface is accessible to a user when the lower guide surface is in contact with the upper implant surface. At least one guiding aperture extends through the guide body between the upper and lower guide surfaces at a predetermined aperture location with respect to the guide body and defines a predetermined target trajectory through the guide body. At least one of the target trajectory and the aperture location of each guiding aperture is preselected responsive to preoperative imaging of the patient tissue. A method of assisting with attachment of a stock prosthetic implant to a patient tissue is also provided.
摘要翻译：用于辅助将股票假体植入物附着到患者组织的引导件包括下部引导表面，所述下部引导表面构造成当股票假体植入物的下部植入物表面接触患者组织时接触股票假体植入物的上部植入物表面。当下引导表面与上植入物表面接触时，使用者可以访问上引导表面。至少一个引导孔在相对于引导体的预定孔位置处延伸穿过上引导表面和下引导表面之间的引导体，并且通过引导体限定预定的目标轨迹。响应于患者组织的术前成像，预先选择每个引导孔的目标轨迹和孔位置中的至少一个。还提供了一种辅助将股票假体植入物附着到患者组织的方法。

8. 发明申请

WO2009120966A2 REINFORCED TISSUE GRAFT 审中-公开
标题翻译：加强组织格子
公开(公告)号：WO2009120966A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/038570
申请日：2009-03-27
申请人： THE CLEVELAND CLINIC FOUNDATION , DERWIN, Kathleen , AURORA, Amit , IANNOTTI, Joseph, P. , MCCARRON, Jesse, A.
发明人： DERWIN, Kathleen , AURORA, Amit , IANNOTTI, Joseph, P. , MCCARRON, Jesse, A.
IPC分类号： A61F2/02 , A61K39/00
CPC分类号： A61L27/40 , A61F2/08 , A61L27/54
摘要： A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
摘要翻译：提供生物相容性组织移植物。组织移植物包括细胞外基质贴片和用于加强贴片的装置。

9. 发明申请

WO2012142032A1 METHODS AND DEVICES FOR BONE PREPARATION 审中-公开
标题翻译：用于骨制备的方法和装置
公开(公告)号：WO2012142032A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/032908
申请日：2012-04-10
申请人： THE CLEVELAND CLINIC FOUNDATION , IANNOTTI, Joseph, P. , BONUTTI, Peter, M.
发明人： IANNOTTI, Joseph, P. , BONUTTI, Peter, M.
IPC分类号： A61B17/88
CPC分类号： A61B17/8816 , A61B17/88 , A61B17/8802 , A61F2002/30677
摘要： A manifold has at least one manifold aperture extending therethrough and selectively placed in fluid communication with a fluid source. An insertion structure has at least one interior cavity at least partially defined by a structure shell and is selectively placed in fluid communication with a corresponding manifold aperture. The insertion structure is configured for selective placement in a penetrating relationship with a patient tissue below a surface of the patient tissue. At least one shell perforation extends through the structure shell and places the interior cavity in fluid communication with a surrounding ambient space. At least one fluid path extends from the fluid source, through the manifold aperture, into the interior cavity, through at least one shell perforation, and at least one of a proximate relationship and a contacting relationship with the patient tissue beneath the outer surface thereof. A fluid is directed along the fluid path.
摘要翻译：歧管具有延伸穿过其中的至少一个歧管孔，并且选择性地放置成与流体源流体连通。插入结构具有至少一个至少部分地由结构壳限定的内腔，并且选择性地放置成与相应的歧管孔流体连通。插入结构被配置为与病人组织的表面下方的患者组织的穿透关系选择性地放置。至少一个外壳穿孔延伸穿过结构外壳并使内部空腔与周围环境空间流体连通。至少一个流体路径从流体源通过歧管孔延伸到内腔中，穿过至少一个外壳穿孔，以及与其外表面下方的患者组织的接近关系和接触关系中的至少一个。流体沿着流体路径被引导。

10. 发明申请

WO2012097040A1 DISTANCE INDICATOR 审中-公开
标题翻译：距离指示器
公开(公告)号：WO2012097040A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/020898
申请日：2012-01-11
申请人： THE CLEVELAND CLINIC FOUNDATION , BRYAN, Jason, A. , IANNOTTI, Joseph, P. , BARSOUM, Wael, K.
发明人： BRYAN, Jason, A. , IANNOTTI, Joseph, P. , BARSOUM, Wael, K.
IPC分类号： A61B17/17 , A61B19/00
CPC分类号： A61B90/06 , A61B17/8897 , A61B2090/062 , A61B2090/0811
摘要： A distance indicator (100) for indicating the distance that a device has traveled includes an elongate housing (102) with a guidewire connector (110) configured for operative connection to a guidewire to hold the housing stationary with respect thereto. A plunger (112) is operatively connected to the housing for longitudinal motion with respect to the housing. A first plunger end (114) is configured to operatively contact the device. As the guidewire connector is holding the housing stationary with respect to the guidewire, the first plunger end is placed into operative contact with the device with the plunger and housing in a first relative plunger/housing position. The device moves longitudinally. The plunger moves into a second relative plunger/housing position assisted by the operative connection between the first plunger end and the device. The longitudinal difference between the first and second relative plunger/housing positions indicates a distance that the device has moved longitudinally with respect to the guidewire.
摘要翻译：用于指示设备行进的距离的距离指示器（100）包括具有导丝连接器（110）的细长壳体（102），该引导线连接器被配置为可操作地连接到导丝，以将壳体相对于其固定。柱塞（112）可操作地连接到壳体，用于相对于壳体的纵向运动。第一柱塞端（114）构造成可操作地接触该装置。由于导丝连接器将壳体相对于导丝固定住，所以第一柱塞端被放置成与装置工作接触，柱塞和壳体处于第一相对柱塞/壳体位置。设备纵向移动。柱塞移动到由第一柱塞端和装置之间的操作连接辅助的第二相对柱塞/壳体位置。第一和第二相对柱塞/壳体位置之间的纵向差表示装置相对于导丝纵向移动的距离。

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