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1. 发明申请

WO2004035614A1 SYNTHETIC OR PARTIALLY PURIFIED PEPTIDES WHICH CAN BIND TO SPECIFIC SUBUNITS OF G PROTEINS AND USES THEREOF 审中-公开
标题翻译：合成或部分纯化的肽可以与G蛋白的特定亚类和其用途相结合
公开(公告)号：WO2004035614A1
公开(公告)日：2004-04-29
申请号：PCT/EP2003/000352
申请日：2003-01-15
申请人： KARO BIO AB , FOWLKES, Dana, M. , CHRISTENSEN, Dale, J. , HAMILTON, Paul, T. , BLAESIUS, Rainer , RAMER, J., Kevin , HYDE-DeRUYSCHER, Robin , DUFFIN, David , FREDERICKS, Zoey
发明人： FOWLKES, Dana, M. , CHRISTENSEN, Dale, J. , HAMILTON, Paul, T. , BLAESIUS, Rainer , RAMER, J., Kevin , HYDE-DeRUYSCHER, Robin , DUFFIN, David , FREDERICKS, Zoey
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , C07K7/08 , C07K14/00 , G01N2333/726 , G01N2500/04 , G01N2500/10
摘要： Various Gα conformation specific peptides are disclosed. These may be used in assays to detect activation or deactivation of a G protein-coupled receptor.
摘要翻译：公开了各种Galpha构象特异性肽。这些可以用于检测G蛋白偶联受体的激活或失活的测定中。

2. 发明申请

WO2006098744A3 IFBM'S TO PROMOTE ATTACHMENT OF TARGET ANALYTES 审中-公开
标题翻译： IFBM致力于推动目标分析
公开(公告)号：WO2006098744A3
公开(公告)日：2006-11-30
申请号：PCT/US2005021270
申请日：2005-06-15
申请人： AFFINERGY INC , HAMILTON PAUL T , GRINSTAFF MARK W , KENAN DANIEL J , CHRISTENSEN DALE J , BEYER WAYNE FL JR , HYDE-DERUYSCHER ROBIN , BENSON RAY EDWARD
发明人： HAMILTON PAUL T , GRINSTAFF MARK W , KENAN DANIEL J , CHRISTENSEN DALE J , BEYER WAYNE FL JR , HYDE-DERUYSCHER ROBIN , BENSON RAY EDWARD
IPC分类号： A61L27/22 , A61L27/34 , G01N33/543
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material ("implant module") and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect ("analyte module"). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
摘要翻译：本发明提供了用于医疗植入物表面的改进的涂层。所述涂层包含至少一种界面生物材料（IFBM），所述至少一种界面生物材料（IFBM）由至少一个结合模块组成，所述至少一个结合模块结合植入物或植入物相关材料（“植入物模块”）的表面，以及至少一个结合模块，目标分析物或被设计为具有期望效果（“分析物模块”）。模块通过链接器连接。在一些实施方案中，IFBM涂层用于促进目标分析物识别和附着到装置的表面。 IFBM涂层改善植入医疗装置的性能，例如通过促进植入物的骨整合。

3. 发明申请

WO2006007368A2 BIOFUNCTIONAL COATINGS 审中-公开
标题翻译：生物功能涂料
公开(公告)号：WO2006007368A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/021147
申请日：2005-06-15
申请人： AFFINERGY, INC. , HAMILTON, Paul, T. , GRINSTAFF, Mark, W. , KENAN, Daniel, J. , CHRISTENSEN, Dale, J. , BEYER, Wayne, F., Jr. , HYDE-DERUYSCHER, Robin , BENSON, Ray, Edward
发明人： HAMILTON, Paul, T. , GRINSTAFF, Mark, W. , KENAN, Daniel, J. , CHRISTENSEN, Dale, J. , BEYER, Wayne, F., Jr. , HYDE-DERUYSCHER, Robin , BENSON, Ray, Edward
IPC分类号： A61L31/00
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial (“IFBM”) which comprises at least one binding module that binds to the surface of a device (“surface-binding module”) and at least one binding module that performs another function (“affector module”) and which acts to inhibit biofilm formation.
摘要翻译：本发明提供用于医疗装置的改进涂层的组合物和方法。该涂层是界面生物材料（“IFBM”），其包括至少一个结合到装置的表面的结合模块（“表面结合模块”）和至少一个执行另一功能的装订模块（“影响模块”））并且其作用是抑制生物膜形成。

4. 发明申请

WO2006098744A2 IFBM’S TO PROMOTE THE SPECIFIC ATTACHMENT OF TARGET ANALYTES TO THE SURFACE OF ORTHOPEDIC IMPLANTS 审中-公开
标题翻译： IFBM致力于将目标分析的具体附件推广到正交植入物的表面
公开(公告)号：WO2006098744A2
公开(公告)日：2006-09-21
申请号：PCT/US2005/021270
申请日：2005-06-15
申请人： AFFINERGY, INC. , HAMILTON, Paul, T. , GRINSTAFF, Mark, W. , KENAN, Daniel, J. , CHRISTENSEN, Dale, J. , BEYER, Wayne, Fl., Jr. , HYDE-DeRUYSCHER, Robin , BENSON, Ray, Edward
发明人： HAMILTON, Paul, T. , GRINSTAFF, Mark, W. , KENAN, Daniel, J. , CHRISTENSEN, Dale, J. , BEYER, Wayne, Fl., Jr. , HYDE-DeRUYSCHER, Robin , BENSON, Ray, Edward
IPC分类号： A61L27/22 , A61L27/34 , G01N33/543
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (“implant module”) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (“analyte module”). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.
摘要翻译：本发明提供了用于医疗植入物表面的改进的涂层。所述涂层包括至少一种界面生物材料（IFBM），所述至少一种界面生物材料（IFBM）由至少一个结合模块组成，所述结合模块结合植入物或植入物相关材料（“植入物模块”）的表面，以及至少一个选择性结合目标分析物或被设计为具有期望效果（“分析物模块”）。模块通过链接器连接。在一些实施方案中，IFBM涂层起促进目标分析物识别和附着到装置表面上的作用。 IFBM涂层通过促进植入物的骨整合来改善植入的医疗装置的性能。

5. 发明申请

WO2006007368A3 BIOFUNCTIONAL COATINGS 审中-公开
标题翻译：生物功能涂层
公开(公告)号：WO2006007368A3
公开(公告)日：2006-05-18
申请号：PCT/US2005021147
申请日：2005-06-15
申请人： AFFINERGY INC , HAMILTON PAUL T , GRINSTAFF MARK W , KENAN DANIEL J , CHRISTENSEN DALE J , BEYER WAYNE F JR , HYDE-DERUYSCHER ROBIN , BENSON RAY EDWARD
发明人： HAMILTON PAUL T , GRINSTAFF MARK W , KENAN DANIEL J , CHRISTENSEN DALE J , BEYER WAYNE F JR , HYDE-DERUYSCHER ROBIN , BENSON RAY EDWARD
IPC分类号： A61L27/22 , A61L27/34 , G01N33/543
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial ("IFBM") which comprises at least one binding module that binds to the surface of a device ("surface-binding module") and at least one binding module that performs another function ("affector module") and which acts to inhibit biofilm formation.
摘要翻译：本发明提供了用于医疗器械的改进涂层的组合物和方法。涂层是界面生物材料（“IFBM”），其包括至少一个结合模块（“表面结合模块”）和至少一个执行另一功能的结合模块（“影响模块”）并且其起到抑制生物膜形成的作用。

6. 发明申请

WO1998019162A1 IDENTIFICATION OF DRUGS USING COMPLEMENTARY COMBINATORIAL LIBRARIES 审中-公开
标题翻译：使用补充组合图书馆鉴定药物
公开(公告)号：WO1998019162A1
公开(公告)日：1998-05-07
申请号：PCT/US1997019638
申请日：1997-10-31
申请人： NOVALON PHARMACEUTICAL CORPORATION , FOWLKES, Dana, M. , KAY, Brian, K. , FRELINGER, Jeffrey, A. , HYDE-DERUYSCHER, Robin, Parish
发明人： NOVALON PHARMACEUTICAL CORPORATION
IPC分类号： G01N33/53
CPC分类号： C07K1/047 , G01N33/53
摘要： The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which mediate that activity through binding to that receptor are not already known. The method comprises three steps: (1) Screen at least one potential surrogate combinatorial library for members (preferably peptides or nucleic acids) binding to the target protein (TP) and hence capable of use as surrogates for the unknown ligand in steps (2) and (3). (2) Screen at least one complementary library, preferably a combinatorial library (which is not limited to, and may not even include, peptides, or nucleic acids and hence is referred to on occasion as a "compound library"), for compounds which inhibit the binding of one or more surrogates from step (1) to TP, and, optionally, (3) determine whether the inhibitory compound mediates the biological activity of the said TP.
摘要翻译：本发明涉及可以介导靶受体蛋白的生物活性的化合物文库中的化合物的鉴定，即使当通过结合该受体介导该活性的配体不是已知的时。该方法包括三个步骤：（1）筛选结合靶蛋白（TP）并因此能够用作步骤（2）中未知配体的替代物的成员（优选肽或核酸）的至少一个潜在替代组合文库，和（3）。（2）筛选至少一个互补文库，优选组合文库（其不限于，甚至可以不包括肽或核酸，因此有时称为“化合物文库”），对于化合物抑制来自步骤（1）的一种或多种替代物与TP的结合，以及任选地（3）确定抑制性化合物是否介导所述TP的生物活性。

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