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1. 发明申请

WO03045229A2 METHODS AND COMPOSITIONS FOR TREATING CANCER USING 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882,10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 AND 94710 审中-公开
标题翻译：用于治疗癌症的方法和组合物使用2192,2193,6568,8895,9138,9217,9609,9857,9882,10025,20657,21163,25848,25968,32603,32670,33794,54476和94710
公开(公告)号：WO03045229A2
公开(公告)日：2003-06-05
申请号：PCT/US0238348
申请日：2002-11-26
申请人： MILLENNIUM PHARM INC , HUNTER JOHN JOSEPH , WILLIAMSON MARK , MACBETH KYLE J , RUDOLPH-OWEN LAURA A , TSAI FONG-YING
发明人： HUNTER JOHN JOSEPH , WILLIAMSON MARK , MACBETH KYLE J , RUDOLPH-OWEN LAURA A , TSAI FONG-YING
IPC分类号： A61K45/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P15/00 , A61P35/00 , C12Q1/68 , G01N33/15 , G01N33/50 , A61B
CPC分类号： G01N33/5011 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 genes in tissues relating to cancer, relative to their expression in normal, or non−cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a cancer or cancer. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cancer.
摘要翻译：本发明涉及癌症或癌症的诊断和治疗方法。具体而言，本发明鉴定组织中的2192,2133,6568,8895,9138,9217,9609,9857,9882,10025,20657,21163,25848,25968,32603,32670,3797,45476和94710基因的差异表达涉及癌症，相对于它们在正常或非癌症疾病状态中的表达，和/或响应于与癌症相关的操作。本发明描述了各种癌症的诊断评价和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能够调节癌症或癌症的化合物的方法。本发明还提供了鉴定和治疗化合物作为癌症治疗的方法。

2. 发明申请

WO2003044218A1 METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF CELLULAR PROLIFERATIVE DISORDERS USING 32222 审中-公开
标题翻译：使用32222治疗和诊断细胞增殖性疾病的方法和组合
公开(公告)号：WO2003044218A1
公开(公告)日：2003-05-30
申请号：PCT/US2002/034818
申请日：2002-10-30
申请人： MILLENNIUM PHARMACEUTICALS, INC. , HUNTER, John Joseph
发明人： HUNTER, John Joseph
IPC分类号： C12Q1/00
CPC分类号： G01N33/57484 , A61K38/00 , A61K47/6805 , A61K47/6809 , A61K47/6821 , A61K2039/505 , C07K2319/00 , C12N9/14 , G01N33/5011
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of cellular proliferative disorders, including, but not limited to, lung, breast, ovary, and colon tumors. The invention further provides methods for identifying a compound capable of treating a cellular proliferative disorder or modulating tumorigenesis. The invention also provides a method for modulating tumorigenesis, e.g., modulating tumorigenesis in a subject. In addition, the invention provides a method for treating a subject having a cellular proliferative disorder characterized by aberrant 32222 polypeptide activity or aberrant 32222 nucleic acid expression.
摘要翻译：本发明涉及用于治疗和诊断细胞增殖性疾病的方法和组合物，包括但不限于肺，乳腺，卵巢和结肠肿瘤。本发明还提供了鉴定能够治疗细胞增殖性疾病或调节肿瘤发生的化合物的方法。本发明还提供了调节肿瘤发生的方法，例如调节受试者的肿瘤发生。此外，本发明提供了治疗具有以异常32222多肽活性或异常32222核酸表达为特征的细胞增殖性疾病的受试者的方法。

3. 发明申请

WO0190329A3 A NOVEL HUMAN ACYLTRANSFERASE FAMILY MEMBER AND USES THEREOF 审中-公开
标题翻译：一个新的人类ACYLTRANSFERASE家族成员及其用途
公开(公告)号：WO0190329A3
公开(公告)日：2002-06-06
申请号：PCT/US0116771
申请日：2001-05-23
申请人： MILLENNIUM PHARM INC , MEYERS RACHEL A , WILLIAMSON MARK , HUNTER JOHN JOSEPH
发明人： MEYERS RACHEL A , WILLIAMSON MARK , HUNTER JOHN JOSEPH
IPC分类号： C12N9/10 , C12N15/54 , A61K39/395 , A61K48/00 , C12N5/16 , G01N33/68
CPC分类号： C12N9/1025
摘要： The invention provides isolated nucleic acids molecules, designated 46745 nucleic acid molecules, which encode novel acyltransferase family members. Elevated expression of 46745 mRNA was detected in lung, breast, and colon tumors as compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 46745 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 46745 gene has been introduced or disrupted. The invention still further provides isolated 46745 proteins, fusion proteins, antigenic peptides and anti-46745 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent and/or diagnose neoplastic conditions, are also provided.
摘要翻译：本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为46745核酸分子。与来自这些组织的正常细胞相比，在肺，乳腺和结肠肿瘤中检测到46745mRNA的表达升高。本发明还提供了反义核酸分子，含有46745个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及导入或破坏了46745基因的非人转基因动物。本发明还进一步提供分离的46745蛋白，融合蛋白，抗原肽和抗-46745抗体。还提供了利用本发明组合物治疗和诊断方法，例如治疗，预防和/或诊断肿瘤病症。

4. 发明申请

WO2003065006A3 METHODS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
公开(公告)号：WO2003065006A3
公开(公告)日：2003-08-07
申请号：PCT/US2003/002588
申请日：2003-01-30
申请人： MILLENNIUM PHARMACEUTICALS, INC. , HUNTER, John, Joseph , MACBETH, Kyle, J. , TSAI, Fong-Ying , LESOON, Andrea , LIGHTCAP, Eric, S. , WILLIAMSON, Mark, W. , RUDOLPH-OWEN, Laura, A.
发明人： HUNTER, John, Joseph , MACBETH, Kyle, J. , TSAI, Fong-Ying , LESOON, Andrea , LIGHTCAP, Eric, S. , WILLIAMSON, Mark, W. , RUDOLPH-OWEN, Laura, A.
IPC分类号： C12Q1/68
摘要： The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480, 20893, 33230, 1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 and 66428 genes in tissue relating to cancer, relative to their expression in normal, or non-cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a cancer or cancer. The present invention also provides methods for the identification and therapeutic use of compounds as treatment of cancer.

5. 发明申请

WO2003045229A3 METHODS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
公开(公告)号：WO2003045229A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/038348
申请日：2002-11-26
申请人： MILLENNIUM PHARMACEUTICALS, INC. , HUNTER, John, Joseph , WILLIAMSON, Mark , MACBETH, Kyle, J. , RUDOLPH-OWEN, Laura, A. , TSAI, Fong-Ying
发明人： HUNTER, John, Joseph , WILLIAMSON, Mark , MACBETH, Kyle, J. , RUDOLPH-OWEN, Laura, A. , TSAI, Fong-Ying
IPC分类号： C12Q1/00
摘要： The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 genes in tissues relating to cancer, relative to their expression in normal, or non-cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a cancer or cancer. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cancer.

6. 发明申请

WO2003076565A3 METHODS OF USING 46828, A HUMAN ACYL-COA SYNTHETASE 审中-公开
公开(公告)号：WO2003076565A3
公开(公告)日：2003-09-18
申请号：PCT/US2002/029456
申请日：2002-09-17
申请人： MILLENNIUM PHARMACEUTICALS, INC. , HUNTER, John, Joseph
发明人： HUNTER, John, Joseph
IPC分类号： C12Q1/68
摘要： Isolated nucleic acids molecules, designated 46828 nucleic acid molecules, which encode AMP-binding enzymes, and in particular acyl-CoA synthases are disclosed. The invention provides methods of modulating the differentiation, proliferation, and/or inducing the cell killing of 46828-expressing hyperproliferative cells, e.g., 46828-expressing malignant cells from the lung, colon and ovaries. The invention further provides methods of treating, preventing and diagnosing solid tumors, soft tissue tumors, and/or metastatic lesions.

7. 发明申请

WO2003065006A2 METHODS AND COMPOSITIONS FOR TREATING CANCER USING 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894 审中-公开
标题翻译：使用140,1470,1686,2089,2427,3702,5891,64828,7181,7660,25641,69583,49863,8897,1682,177667,9235,3703,14171,10359,1660,1450的治疗癌症的方法和组合物，18894
公开(公告)号：WO2003065006A2
公开(公告)日：2003-08-07
申请号：PCT/US2003/002588
申请日：2003-01-30
申请人： MILLENNIUM PHARMACEUTICALS, INC. , HUNTER, John, Joseph , MACBETH, Kyle, J. , TSAI, Fong-Ying , LESOON, Andrea , LIGHTCAP, Eric, S. , WILLIAMSON, Mark, W. , RUDOLPH-OWEN, Laura, A.
发明人： HUNTER, John, Joseph , MACBETH, Kyle, J. , TSAI, Fong-Ying , LESOON, Andrea , LIGHTCAP, Eric, S. , WILLIAMSON, Mark, W. , RUDOLPH-OWEN, Laura, A.
IPC分类号： G01N
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N2500/00
摘要： The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480, 20893, 33230, 1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 and 66428 genes in tissue relating to cancer, relative to their expression in normal, or non-cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a cancer or cancer. The present invention also provides methods for the identification and therapeutic use of compounds as treatment of cancer.
摘要翻译：本发明涉及癌症或癌症的诊断和治疗方法。具体地说，本发明鉴定了140,1470,1686,2089,2427,3702,5891,62828,7181,7660,25641,69583,49863,8897,1682,17676,92935,3703,14171,10359的差异表达， 1660,1450,18894,2088,32427,2160,9252,9389,1642,85269,10297,1584,9525,14124,4469,8990,2100,92988,64698,104080,20893,33230,1586,99943,16334， 68862,9011,14031,6178,21225,1420,32236,2099,2150,26583,2784,8891,99811,27444,50566和66428个关于癌症的组织中的基因，相对于它们在正常或非癌症疾病中的表达状态和/或响应于与癌症相关的操作。本发明描述了各种癌症的诊断评价和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能够调节癌症或癌症的化合物的方法。本发明还提供了鉴定和治疗化合物作为癌症治疗的方法。

8. 发明申请

WO2003033660A2 9136, A HUMAN ALDEHYDE DEHYDROGENASE FAMILY MEMBER AND USES THEREFOR 审中-公开
标题翻译： 9136，一种人醛脱氢酶家族成员并用于此目的
公开(公告)号：WO2003033660A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/032971
申请日：2002-10-16
申请人： MILLENIUM PHARMACEUTICALS, INC. , HUNTER, John, Joseph
发明人： HUNTER, John, Joseph
IPC分类号： C12N
CPC分类号： C12N9/0008
摘要： The invention provides isolated nucleic acids molecules, designated 9136 nucleic acid molecules, which encode novel aldehyde dehydrogenase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 9136 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 9136 gene has been introduced or disrupted. The invention still further provides isolated 9136 proteins, fusion proteins, antigenic peptides and anti-9136 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的核酸分子，命名为9136核酸分子，其编码新的醛脱氢酶家族成员。本发明还提供了反义核酸分子，含有9136个核酸分子的重组表达载体，导入了表达载体的宿主细胞和导入或破坏了9136基因的非人转基因动物。本发明还提供分离的9136蛋白，融合蛋白，抗原肽和抗9136抗体。还提供了利用本发明组合物的诊断和治疗方法。

9. 发明申请

WO2003025200A3 METHODS OF USING 22417, A NOVEL HUMAN AMINOPROTEASE FAMILY MEMBER 审中-公开
公开(公告)号：WO2003025200A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/029454
申请日：2002-09-17
申请人： MILLENNIUM PHARMACEUTICALS, INC. , HUNTER, John, Joseph
发明人： HUNTER, John, Joseph
IPC分类号： A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated 22417 nucleic acid molecules, which encode novel aminoprotease members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 22417 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 22417 gene has been introduced or disrupted. The invention still further provides isolated 22417 proteins, fusion proteins, antigenic peptides and anti-22417 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

10. 发明申请

WO2003025200A2 METHODS OF USING 22417, A NOVEL HUMAN AMINOPROTEASE FAMILY MEMBER 审中-公开
标题翻译：使用22417的一种新型人类氨基酸家族成员的方法
公开(公告)号：WO2003025200A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029454
申请日：2002-09-17
申请人： MILLENNIUM PHARMACEUTICALS, INC. , HUNTER, John, Joseph
发明人： HUNTER, John, Joseph
IPC分类号： C12Q
CPC分类号： C12N9/6421 , C07K16/40
摘要： The invention provides isolated nucleic acids molecules, designated 22417 nucleic acid molecules, which encode novel aminoprotease members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 22417 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 22417 gene has been introduced or disrupted. The invention still further provides isolated 22417 proteins, fusion proteins, antigenic peptides and anti-22417 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新的氨基蛋白酶成员的分离的核酸分子，命名为22417核酸分子。本发明还提供了反义核酸分子，含有22417个核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及22417基因导入或破坏的非人类转基因动物。本发明还进一步提供了分离的22417蛋白，融合蛋白，抗原肽和抗22417抗体。还提供了利用本发明组合物的诊断方法。

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