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1. 发明申请

WO9804702A3 PROTEINS, IN PARTICULAR MEMBRANE PROTEINS, OF HELICOBACTER PYLORI, THEIR PREPARATION AND USE 审中-公开
标题翻译：蛋白质，特异性膜蛋白，HELICOBACTER PYLORI，其制备和使用
公开(公告)号：WO9804702A3
公开(公告)日：1998-04-23
申请号：PCT/IB9700981
申请日：1997-07-25
申请人： CHIRON BEHRING GMBH & CO , KNAPP BERNHARD , HUNDT ERIKA , SCHMIDT KARL HEINZ
发明人： KNAPP BERNHARD , HUNDT ERIKA , SCHMIDT KARL-HEINZ
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61K48/00 , A61P1/04 , A61P35/00 , C07K14/205 , C07K16/12 , C12N15/09 , C12N15/31 , C12P21/08 , A61K31/70 , A61K39/106
CPC分类号： C07K14/205 , A61K38/00 , A61K39/00 , A61K2039/51
摘要： The present invention relates to novel proteins, in particular membrane proteins or proteins which are firmly associated with the membrane, which are derived from Helicobacter pylori (H. pylori) and which contain one of the peptide sequences selected from SEQ ID NO: 1, 2, 3, 6, 10, 11, 12, 14, 15, 16, 17, 18 or 19 according to Tables 1a-1c, or to parts or homologues thereof having a minimum length of five amino acids, and to their preparation and use as pharmaceutical compositions, in particular as vaccines, or as a diagnostic agent. Based on these data, genes coding for these and related proteins were also isolated as shown in SEQ ID NOS: 20, 21, 22, 23, 24, 25, 26 and 27.

2. 发明申请

WO2003029478A3 CULTIVATION OF DISPERSED MYCOBACTERIA 审中-公开
公开(公告)号：WO2003029478A3
公开(公告)日：2003-04-10
申请号：PCT/EP2002/010772
申请日：2002-09-25
申请人： CHIRON BEHRING GMBH & CO. , DIETRICH, Guido , HUNDT, Erika , WEBER, Heinz
发明人： DIETRICH, Guido , HUNDT, Erika , WEBER, Heinz
IPC分类号： C12N1/20
摘要： The present invention relates to a culture medium for disperse mycobacteria comprising at least one detergent and an antifoam agent, whereby said antifoam agent is a member of the silicone family. In addition, the invention provides for methods for the activation of dipressed mycobacteria, for obtaining a standardized mycobyterial culture or for the production of (a), purified protein derivates(s) (PDD) which comprise the cultivation of mycobacteria in the active medium disclosed herein. Furthermore, the use of standardized mycobacterial cultures obtained by the method of the invention for the preparation of pharmaceutical or diagnostic compositions is described.

3. 发明申请

WO03029478A2 CULTIVATION OF MYCOBACTERIA 审中-公开
标题翻译： MYCOBACTERIA的培育
公开(公告)号：WO03029478A2
公开(公告)日：2003-04-10
申请号：PCT/EP0210772
申请日：2002-09-25
申请人： CHIRON BEHRING GMBH & CO , DIETRICH GUIDO , HUNDT ERIKA , WEBER HEINZ
发明人： DIETRICH GUIDO , HUNDT ERIKA , WEBER HEINZ
IPC分类号： C12N1/20 , C12Q
CPC分类号： C12N1/20
摘要： The present invention relates to a culture medium for disperse mycobacteria comprising at least one detergent and an antifoam agent, whereby said antifoam agent is a member of the silicone family. In addition, the invention provides for methods for the activation of dipressed mycobacteria, for obtaining a standardized mycobyterial culture or for the production of (a), purified protein derivates(s) (PDD) which comprise the cultivation of mycobacteria in the active medium disclosed herein. Furthermore, the use of standardized mycobacterial cultures obtained by the method of the invention for the preparation of pharmaceutical or diagnostic compositions is described.
摘要翻译：本发明涉及一种用于分散分枝杆菌的培养基，其包含至少一种洗涤剂和消泡剂，其中所述消泡剂是硅酮族的成员。此外，本发明提供了激活被分解细菌的方法，用于获得标准化的骨髓间充质培养物或（a）纯化的蛋白质衍生物（PDD）的生产，所述纯化的蛋白质衍生物（PDD）包括在所述活性培养基中培养分枝杆菌于此。此外，描述了通过本发明的方法获得的用于制备药物或诊断组合物的标准化分枝杆菌培养物的使用。

4. 发明申请

WO1998004702A2 PROTEINS, IN PARTICULAR MEMBRANE PROTEINS, OF HELICOBACTER PYLORI, THEIR PREPARATION AND USE 审中-公开
标题翻译：蛋白质，特异性蛋白质，HELICOBACTER PYLORI，其制备和使用
公开(公告)号：WO1998004702A2
公开(公告)日：1998-02-05
申请号：PCT/IB1997000981
申请日：1997-07-25
申请人： CHIRON BEHRING GMBH & CO. , KNAPP, Bernhard , HUNDT, Erika , SCHMIDT, Karl-Heinz
发明人： CHIRON BEHRING GMBH & CO.
IPC分类号： C12N15/31
CPC分类号： C07K14/205 , A61K38/00 , A61K39/00 , A61K2039/51
摘要： The present invention relates to novel proteins, in particular membrane proteins or proteins which are firmly associated with the membrane, which are derived from Helicobacter pylori (H. pylori) and which contain one of the peptide sequences selected from SEQ ID NO: 1, 2, 3, 6, 10, 11, 12, 14, 15, 16, 17, 18 or 19 according to Tables 1a-1c, or to parts or homologues thereof having a minimum length of five amino acids, and to their preparation and use as pharmaceutical compositions, in particular as vaccines, or as a diagnostic agent. Based on these data, genes coding for these and related proteins were also isolated as shown in SEQ ID NOS: 20, 21, 22, 23, 24, 25, 26 and 27.
摘要翻译：本发明涉及从幽门螺杆菌（幽门螺杆菌）衍生的新型蛋白质，特别是与膜牢固结合的膜蛋白质或蛋白质，其含有选自SEQ ID NO：1,2 ，3,6,10,11,12,14,15,16,17,18或19，或其至少具有5个氨基酸长度的部分或同系物，以及它们的制备和用途作为药物组合物，特别是作为疫苗，或作为诊断剂。基于这些数据，也分离编码这些和相关蛋白的基因，如SEQ ID NO：20,21,22,23,24,25,26和27所示。

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