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1. 发明申请

WO2011000054A1 IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM 审中-公开
标题翻译：免疫调节剂及其生产方法
公开(公告)号：WO2011000054A1
公开(公告)日：2011-01-06
申请号：PCT/AU2010/000847
申请日：2010-07-02
申请人： AVIPEP PTY LTD , HUDSON, Peter, John , SANDERS, Paul, Robert , TAMVAKIS, Debra , TURATTI, Fabio , WHEATCROFT, Michael, Paul , LEONG, David
发明人： HUDSON, Peter, John , SANDERS, Paul, Robert , TAMVAKIS, Debra , TURATTI, Fabio , WHEATCROFT, Michael, Paul , LEONG, David
IPC分类号： C07K16/00 , C07K16/18
CPC分类号： C07K16/30 , A61K47/6879 , A61K51/10 , A61K51/1093 , A61K2039/505 , C07K16/3092 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2319/31
摘要： The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region 1 such that if at least two of the cysteine residues are not conjugated to another compound a disulphide bond forms between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides a protein that binds to TAG72. The present invention also provides conjugates of the protein and another compound.
摘要翻译：本发明提供了包含免疫球蛋白可变区的分离蛋白，其包含位于框架区域1内的至少两个半胱氨酸残基，使得如果至少两个半胱氨酸残基不与另一化合物结合，则在半胱氨酸残基之间形成二硫键。优选地，蛋白质包含免疫球蛋白重链可变区和免疫球蛋白轻链可变区，其中至少一个可变区包含两个半胱氨酸残基。本发明还提供了结合TAG72的蛋白质。本发明还提供蛋白质和另一种化合物的缀合物。

2. 发明申请

WO2005058956A1 CYTOKINE BINDING DOMAINS 审中-公开
标题翻译：细胞因子结合域
公开(公告)号：WO2005058956A1
公开(公告)日：2005-06-30
申请号：PCT/AU2004/001762
申请日：2004-12-16
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , VARGHESE, Joseph, Noozhumutry , HUDSON, Peter, John , POWERS, Barbara, Elaine
发明人： VARGHESE, Joseph, Noozhumutry , HUDSON, Peter, John , POWERS, Barbara, Elaine
IPC分类号： C07K14/715
CPC分类号： C07K14/715
摘要： The present invention relates a method of generating modified binding moieties comprising a cytokine binding domain consisting of a first FnIII-like domain and a second FnIII-like domain in which at least one amino acid residue within the cytokine binding domain in modified such that the binding characteristics of the cytokine binding domain are altered, and/or, the solubility and/or stability of the binding moiety is improved. The invention also relates to binding moieties and to the use of such binding moieties as affinity reagents, diagnostic reagents, therapeutic agents and protein scaffolds.
摘要翻译：本发明涉及产生修饰的结合部分的方法，其包含由第一FnIII样结构域和第二FnIII样结构域组成的细胞因子结合结构域，其中细胞因子结合结构域内的至少一个氨基酸残基被修饰，使得结合改变细胞因子结合结构域的特征，和/或结合部分的溶解度和/或稳定性得到改善。本发明还涉及结合部分以及这些结合部分如亲和试剂，诊断试剂，治疗剂和蛋白质支架的用途。

3. 发明申请

WO1997033908A1 LYTIC PEPTIDES 审中-公开
公开(公告)号：WO1997033908A1
公开(公告)日：1997-09-18
申请号：PCT/AU1997000160
申请日：1997-03-13
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , RIVETT, Donald, Edward , HUDSON, Peter, John , WERKMEISTER, Jerome, Anthony
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： C07K07/08
CPC分类号： C07K14/001 , A61K38/00 , A61K47/62 , A61K47/68 , A61K47/6817 , C07K14/43572
摘要： The invention provides a peptide with lytic activity, having an amphipathic alpha -helix of sufficient length and character to allow the peptide to function lytically, wherein the N-terminal and/or C-terminal of said peptide comprises one or more moieties which result in an increased positive charge compared to the charge of a peptide of identical amino acid sequence and structure but not comprising said moiety. Methods of activation to provide activity and for inactivation of lytic activity, pharmaceutical compositions, and methods of treatment are described.
摘要翻译：本发明提供具有裂解活性的肽，其具有足够长度和特性的两亲性α-螺旋，以允许肽功能裂解，其中所述肽的N-末端和/或C-末端包含一个或多个部分，其导致与相同氨基酸序列和结构但不包含所述部分的肽的电荷相比，增加的正电荷。描述了提供活性和灭活活性的方法，药物组合物和治疗方法。

4. 发明申请

WO1993024630A1 REAGENT FOR AGGLUTINATION ASSAYS 审中-公开
标题翻译：试剂测定
公开(公告)号：WO1993024630A1
公开(公告)日：1993-12-09
申请号：PCT/AU1993000228
申请日：1993-05-19
申请人： AGEN LIMITED , LILLEY, Glenn, George , HUDSON, Peter, John , HILLYARD, Carmel, Judith
发明人： AGEN LIMITED
IPC分类号： C12N15/13
CPC分类号： C07K14/005 , C07K14/47 , C07K2319/00 , C12N15/62 , C12N2740/16122 , G01N33/531 , G01N33/6857
摘要： The invention provides a bifunctional recombinant protein comprising a particle-binding antibody or antibody fragment (PBM), and an analyte-binding moiety or molecule (ABM). Preferably, the particle-binding antibody or antibody fragment is an erythrocyte-binding antibody or antibody fragment (EBM), and/or the ABM is selected from the group consisting of an antigenic peptide from an immunodominant region of an env protein of HIV-1 or HIV-2, a gag protein of HIV-1 or HIV-2, and an immunodominant region of the surface antigen of Hepatitis B. Alternatively, the ABM is a single chain Fv region of an antibody directed against an antigen selected from the group consisting of Hepatitis B surface antigen, D-dimer and canine heartworm antigen. In a particularly preferred embodiment, the EBM is a single chain Fv region of an anti-erythrocyte antibody, such as an anti-glycophorin antibody. The protein of the invention is particularly suitable for use in agglutination immunoassays. Methods for producing the protein of the invention, DNA sequences, and assay methods and reagent kits therefor are also provided.
摘要翻译：本发明提供了包含颗粒结合抗体或抗体片段（PBM）和分析物结合部分或分子（ABM）的双功能重组蛋白。优选地，所述颗粒结合抗体或抗体片段是红细胞结合抗体或抗体片段（EBM），和/或所述ABM选自HIV-1的env蛋白的免疫显性区域的抗原肽或HIV-2，HIV-1或HIV-2的gag蛋白，以及乙型肝炎表面抗原的免疫显性区。或者，ABM是针对选自组中的抗原的抗体的单链Fv区由乙型肝炎表面抗原，D-二聚体和犬心丝虫抗原组成。在特别优选的实施方案中，EBM是抗红细胞抗体的单链Fv区，例如抗血型糖蛋白抗体。本发明的蛋白质特别适用于凝集免疫测定。还提供了制备本发明蛋白质的方法，DNA序列和测定方法及其试剂盒。

5. 发明申请

WO2004055182A1 IN VIVO AFFINITY MATURATION SCHEME 审中-公开
标题翻译：在生活方式成熟计划
公开(公告)号：WO2004055182A1
公开(公告)日：2004-07-01
申请号：PCT/AU2003/001697
申请日：2003-12-18
申请人： DIATECH PTY LTD , IRVING, Robert, Alexander , HUDSON, Peter, John , MUSTAFA, Huseyin , WARK, Kim , ABREGU, Matias, Ezequiel
发明人： IRVING, Robert, Alexander , HUDSON, Peter, John , MUSTAFA, Huseyin , WARK, Kim , ABREGU, Matias, Ezequiel
IPC分类号： C12N15/10
CPC分类号： C40B40/02 , C12N15/102 , C12N15/1037
摘要： The present invention relates to the field of evolution of nucleic acids in vivo and provides methods and compositions for introducing diversity into gene products. The present invention allows generation of new sequences that have desirable properties by virtue of high frequency mutation events within a cell. The high frequency mutation of a polynucleotide sequence results in the production of a large population of new sequence variants. Appropriate selection and/or screening permits identification and isolation of mutant forms of the polynucleotide sequence as well as products resulting from expression of the mutant sequences.
摘要翻译：本发明涉及体内核酸进化领域，并提供了将多样性引入基因产物的方法和组合物。本发明允许通过细胞内的高频突变事件产生具有期望特性的新序列。多核苷酸序列的高频突变导致大量新序列变体的产生。适当的选择和/或筛选允许鉴定和分离突变形式的多核苷酸序列以及由突变序列的表达产生的产物。

6. 发明申请

WO1994007921A1 TARGET BINDING POLYPEPTIDE 审中-公开
标题翻译：目标结合多肽
公开(公告)号：WO1994007921A1
公开(公告)日：1994-04-14
申请号：PCT/AU1993000491
申请日：1993-09-24
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , HUDSON, Peter, John , LAH, Maria , KORTT, Alex, Andrew , IRVING, Robert, Alexander , ATWELL, John, Leslie , MALBY, Robyn, Louise , POWER, Barbara, Elaine , COLMAN, Peter, Malcolm
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ...
IPC分类号： C07K15/12
CPC分类号： C07K16/1018 , A61K38/00 , C07K16/00 , C07K16/18 , C07K2317/55 , C07K2317/622 , C07K2319/02 , C07K2319/43
摘要： A target-binding polypeptide having (a) a stable core polypeptide region (SCR); and (b) at least one target-binding region (TBR), in which the target-binding region(s) are covalently attached to the SCR and which have optionally been subjected to a maturation step in order to modify the specificity, the affinity or the avidity of binding to the target. The polypeptides may self associate to form stable dimers, aggregates or arrays. The polypeptides of the invention have utility in the diagnostic, therapeutic, predictive or preventative fields of the pharmaceutical and health care industries, as well as more general application in the detection and assay of chemical entities.
摘要翻译：具有（a）稳定核心多肽区域（SCR）的靶结合多肽; 和（b）至少一个靶结合区域（TBR），其中靶结合区域共价连接到SCR，并且其任选地进行成熟步骤以改变特异性，亲和力或绑定到目标的亲合力。多肽可以自身缔合以形成稳定的二聚体，聚集体或阵列。本发明的多肽可用于制药和保健行业的诊断，治疗，预测或预防领域，以及在化学实体的检测和测定中更一般的应用。

7. 发明申请

WO2011075786A1 IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM 2 审中-公开
标题翻译：免疫组合及其生产方法2
公开(公告)号：WO2011075786A1
公开(公告)日：2011-06-30
申请号：PCT/AU2010/001737
申请日：2010-12-23
申请人： AVIPEP PTY LTD , HUDSON, Peter, John , TAMVAKIS, Debra , WHEATCROFT, Michael, Paul , TURATTI, Fabio
发明人： HUDSON, Peter, John , TAMVAKIS, Debra , WHEATCROFT, Michael, Paul , TURATTI, Fabio
IPC分类号： C07K16/00 , C07K16/18
CPC分类号： C07K16/30 , A61K47/60 , A61K49/0002 , C07K16/3092 , C07K16/32 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2319/21
摘要： The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region (FR) 2 and/or at least two cysteine residues positioned within framework region (FR3), wherein if at least two of the cysteine residues in FR2 and/or FR3 are not conjugated to a compound then an intra-framework disulphide bond is capable of forming between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region (V H ) and an immunoglobulin light chain variable region (V L ), wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides conjugates of the protein and another compound.
摘要翻译：本发明提供了分离的蛋白质，其包含免疫球蛋白可变区，其包含位于框架区（FR）2内的至少两个半胱氨酸残基和/或位于框架区（FR3）内的至少两个半胱氨酸残基），其中如果半胱氨酸 FR2和/或FR3中的残基不与化合物缀合，则骨架内二硫键能够在半胱氨酸残基之间形成。优选地，蛋白质包含免疫球蛋白重链可变区（VH）和免疫球蛋白轻链可变区（VL），其中至少一个可变区包含两个半胱氨酸残基。本发明还提供了蛋白质和另一种化合物的缀合物。

8. 发明申请

WO1986007060A1 CLONING AND EXPRESSION OF HOST-PROTECTIVE IMMUNOGENS OF IBDV 审中-公开
标题翻译：克隆和表达IBDV的保护性免疫原
公开(公告)号：WO1986007060A1
公开(公告)日：1986-12-04
申请号：PCT/AU1986000156
申请日：1986-05-30
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , AZAD, Ahmed, Abdullah , HUDSON, Peter, John , FAHEY, Kevin, John
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ...
IPC分类号： C07H21/04
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C12N2720/10022
摘要： A recombinant DNA molecule comprising a nucleotide sequence substantially corresponding to all or a portion of IBDV RNA, particularly the IBDV RNA segment of approximately 3400 b.p. In particular, a DNA molecule coding for all or a part of at least one structural protein of IBDV, for example, the 32Kd and/or the 41/37Kd structural proteins. Synthetic peptides or polypeptides, and fused polypeptides, prepared by expression of host cells containing these DNA molecules are also disclosed.
摘要翻译：重组DNA分子，其包含基本上对应于IBDV RNA的全部或部分的核苷酸序列，特别是约3400bp的IBDV RNA片段。特别地，编码IBDV的全部或部分至少一种结构蛋白的DNA分子，例如32Kd和/或41 / 37Kd结构蛋白。还公开了通过表达含有这些DNA分子的宿主细胞制备的合成肽或多肽和融合多肽。

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