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1. 发明申请

WO2008067495A2 CHEMOTHERAPEUTIC CONJUGATES AND METHODS OF USE 审中-公开
标题翻译：化疗药物偶联物和使用方法
公开(公告)号：WO2008067495A2
公开(公告)日：2008-06-05
申请号：PCT/US2007085981
申请日：2007-11-29
申请人： UNIV RUTGERS , HU LONGQIN , WU XINGHUA
发明人： HU LONGQIN , WU XINGHUA
IPC分类号： A61K38/08
CPC分类号： A61K47/65
摘要： Chemotherapeutic conjugates of a peptide substrate to a phosphoramide chemotherapeutic agent in which a peptide substrate is covalently linked to the chemotherapeutic agent by a linker with an aminoarylmethyl or aminoheteroaryl moiety, wherein the linking of the peptide to the chemotherapeutic agent inhibits the cytotoxic activity of the chemotherapeutic agent, the peptide is a substrate for proteolytic cleavage by a tumor-specific enzyme; and the linker is capable of undergoing 1, 6-elimination in vivo upon cleavage of the peptide substrate. Methods for synthesizing and methods of using the conjugates are also disclosed.
摘要翻译：肽底物与磷酰胺化学治疗剂的化学治疗缀合物，其中肽底物通过具有氨基芳基甲基或氨基杂芳基部分的接头与化学治疗剂共价连接，其中所述肽与化学治疗剂的连接抑制化学治疗剂的细胞毒性活性该肽是通过肿瘤特异性酶进行蛋白水解切割的底物; 并且该接头在肽底物裂解时能够在体内经历1,6-去除。还公开了用于合成的方法和使用该缀合物的方法。

2. 发明申请

WO2008067495A3 CHEMOTHERAPEUTIC CONJUGATES AND METHODS OF USE 审中-公开
公开(公告)号：WO2008067495A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/085981
申请日：2007-11-29
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , HU, Longqin , WU, Xinghua
发明人： HU, Longqin , WU, Xinghua
IPC分类号： A01N57/00 , A61K38/00 , C07K16/00
摘要： Chemotherapeutic conjugates of a peptide substrate to a phosphoramide chemotherapeutic agent in which a peptide substrate is covalently linked to the chemotherapeutic agent by a linker with an aminoarylmethyl or aminoheteroaryl moiety, wherein the linking of the peptide to the chemotherapeutic agent inhibits the cytotoxic activity of the chemotherapeutic agent, the peptide is a substrate for proteolytic cleavage by a tumor-specific enzyme; and the linker is capable of undergoing 1, 6-elimination in vivo upon cleavage of the peptide substrate. Methods for synthesizing and methods of using the conjugates are also disclosed.

3. 发明申请

WO2012145420A1 COMPOSITION, SYNTHETIC PROCESS AND USE OF NEW ANTIOXIDANT INFLAMMATION MODULATORS 审中-公开
标题翻译：组合物，合成方法和新型抗氧化剂溶解调节剂的应用
公开(公告)号：WO2012145420A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/034112
申请日：2012-04-18
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , HU, Longqin , KONG, Ah-Ng, Tony , CHEN, Lin , MAGESH, Sadagopan , SAW, Constance, Lay-Lay
发明人： HU, Longqin , KONG, Ah-Ng, Tony , CHEN, Lin , MAGESH, Sadagopan , SAW, Constance, Lay-Lay
IPC分类号： A01N43/18 , A01N43/42
CPC分类号： C07D239/40 , C07D279/04 , C07D405/06 , C07D417/12 , C07D495/04
摘要： This application discloses novel compounds and compositions for modulating in vitro and in vivo processes mediated by Nuclear Factor - Erythroid 2-Related Factor 2 (Nrf2), and as a new class of antioxidant inflammation modulators (AIM). The application also discloses methods of making and using these novel compounds, especially iminothiazinylbutadienols, divinylpyrimidinethiones and thiopyranopyridinediones, as therapeutic agents for various Nrf2, oxidative stress or inflammation related diseases or disorders.
摘要翻译：本申请公开了用于调节由核因子 - 红细胞2相关因子2（Nrf2）介导的体外和体内过程的新型化合物和组合物，并且作为新类型的抗氧化剂炎症调节剂（AIM）。本申请还公开了制备和使用这些新化合物，特别是亚氨基噻嗪基丁二烯醇，二乙烯基嘧啶硫酮和噻喃吡啶并二酮作为各种Nrf2，氧化应激或炎症相关疾病或病症的治疗剂的方法。

4. 发明申请

WO2011066416A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PROTOZOAN INFECTIONS 审中-公开
标题翻译：化合物，组合物和治疗原生动物感染的方法
公开(公告)号：WO2011066416A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/058043
申请日：2010-11-24
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , HU, Longqin , WILKINSON, Shane, R. , WU, Xinghua , HALL, Belinda, S.
发明人： HU, Longqin , WILKINSON, Shane, R. , WU, Xinghua , HALL, Belinda, S.
IPC分类号： A01N57/00 , A61K31/66
CPC分类号： A61K31/66 , C07F9/2429 , C07F9/2458 , C07F9/2462 , C07F9/65846 , C07F9/65848 , Y02A50/414
摘要： Provided are compounds, compositions and methods for treating protozoan infections.
摘要翻译：提供用于治疗原生动物感染的化合物，组合物和方法。

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