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1. 发明申请

WO1998021337A3 C3 BINDING PROTEIN OF STREPTOCOCCUS PNEUMONIAE 审中-公开
公开(公告)号：WO1998021337A3
公开(公告)日：1998-05-22
申请号：PCT/US1997020586
申请日：1997-11-12
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , HOSTETTER, Margaret, K. , CHENG, Qi , FINKEL, David, J. , SMITH, Beverly
发明人： REGENTS OF THE UNIVERSITY OF MINNESOTA
IPC分类号： C12N15/31

2. 发明申请

WO2006050343A3 MONOCLONAL ANTIBODIES TO THE PROPEPTIDE OF CANDIDA ALBICANS AND METHODS OF USE 审中-公开
标题翻译：对甘地酸阿片剂的单克隆抗体和使用方法
公开(公告)号：WO2006050343A3
公开(公告)日：2006-11-02
申请号：PCT/US2005039431
申请日：2005-10-31
申请人： UNIV YALE , HOSTETTER MARGARET K
发明人： HOSTETTER MARGARET K
IPC分类号： A61K39/395 , A61K39/40 , C07K16/00
CPC分类号： G01N33/56961 , A61K2039/505 , C07K16/14 , G01N2333/40 , G01N2469/10
摘要： Monoclonal antibodies which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which can be useful in methods for treating or preventing infections arising from such microorganisms. In particular, monoclonal antibodies are provided which can recognize the epitope located at amino acids 252-260 on the Intl p protein, and such monoclonal antibodies can recognize the propeptide region of Int1 p as well as the complete Int1 p protein. Such antibodies are effective in blocking of the activation of T-lymphocytes, blocking the expansion of T-cells bearing V-beta subsets, such as 2, 3, 14 or others, and blocking the secretion of interferongamma, so as to be effective in treating or preventing infection from yeast such as Candida albicans.
摘要翻译：提供可以结合酵母微生物如白色假丝酵母的Int1p蛋白的前肽的单克隆抗体，其可用于治疗或预防由这些微生物引起的感染的方法。特别地，提供能够识别位于Intl p蛋白上的氨基酸252-260的表位的单克隆抗体，并且这些单克隆抗体可以识别Int1p的前肽区以及完整的Int1p蛋白。这种抗体有效阻断T淋巴细胞的活化，阻止携带V-β亚型的T细胞如2,3,4等的扩增，并阻断干扰素的分泌，从而有效地治疗或预防酵母如白色念珠菌感染。

3. 发明申请

WO2013158276A8 ANTIBODY BINDING MICROBIAL HEPARIN BINDING MOTIF TO RETARD OR PREVENT MICROBIAL BIOFILM FORMATION ON IMPLANTED MEDICAL DEVICES 审中-公开
标题翻译：抗体结合微生物HEPARIN结合力减少或预防植入式医疗器械中的微生物生物膜
公开(公告)号：WO2013158276A8
公开(公告)日：2013-11-21
申请号：PCT/US2013031499
申请日：2013-03-14
申请人： CHILDRENS HOSP MEDICAL CENTER , HOSTETTER MARGARET K , LU LONG , GREEN JULIANNE VERNADETTE , POROLLO ALEXEY , ORSBORN KRIS I , TAN KHOON GHEE QUEENIE , GREIS KENNETH , ANDES DAVID
发明人： HOSTETTER MARGARET K , LU LONG , GREEN JULIANNE VERNADETTE , POROLLO ALEXEY , ORSBORN KRIS I , TAN KHOON GHEE QUEENIE , GREIS KENNETH , ANDES DAVID
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/14 , A61K39/00 , A61K2039/505 , A61K2039/575 , C07K7/08 , C07K16/1271 , C07K2317/34 , C07K2317/76
摘要： Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
摘要翻译：用于改善患者的留置或植入装置的表面上的生物膜形成的方法和试剂，导致微生物（例如假丝酵母属物种和/或葡萄球菌属物种）的毒力降低。

4. 发明申请

WO2006050343A2 MONOCLONAL ANTIBODIES TO THE PROPEPTIDE OF CANDIDA ALBICANS AND METHODS OF USE 审中-公开
标题翻译：白色念珠菌丙酸杆菌的单克隆抗体和使用方法
公开(公告)号：WO2006050343A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039431
申请日：2005-10-31
申请人： YALE UNIVERSITY , HOSTETTER, Margaret, K.
发明人： HOSTETTER, Margaret, K.
IPC分类号： C07K16/14
CPC分类号： G01N33/56961 , A61K2039/505 , C07K16/14 , G01N2333/40 , G01N2469/10
摘要： Monoclonal antibodies which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which can be useful in methods for treating or preventing infections arising from such microorganisms. In particular, monoclonal antibodies are provided which can recognize the epitope located at amino acids 252-260 on the Intl p protein, and such monoclonal antibodies can recognize the propeptide region of Int1 p as well as the complete Int1 p protein. Such antibodies are effective in blocking of the activation of T-lymphocytes, blocking the expansion of T-cells bearing V-beta subsets, such as 2, 3, 14 or others, and blocking the secretion of interferongamma, so as to be effective in treating or preventing infection from yeast such as Candida albicans.
摘要翻译：提供了可结合酵母微生物（例如白色念珠菌）的Int1p蛋白前肽的单克隆抗体，其可用于以下方法：治疗或预防由这种微生物引起的感染。具体而言，提供了可识别位于Intlp蛋白质上氨基酸252-260处的表位的单克隆抗体，并且此类单克隆抗体可识别Int1p的前肽区以及完整的Int1p蛋白质。这样的抗体有效阻断T淋巴细胞的活化，阻断带有V-β亚群的T细胞例如2,3,14或其他的扩增，并阻断干扰素＆害羞;γ的分泌，从而成为有效治疗或预防酵母如白假丝酵母的感染

5. 发明申请

WO2013158276A1 ANTIBODY BINDING MICROBIAL HEPARIN BINDING MOTIF TO RETARD OR PREVENT MICROBIAL BIOFILM FORMATION ON IMPLANTED MEDICAL DEVICES 审中-公开
标题翻译：抗体结合微生物肝素结合片段延迟或防止植入医疗器械上的微生物生物膜形成
公开(公告)号：WO2013158276A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/031499
申请日：2013-03-14
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , HOSTETTER, Margaret, K. , LU, Long , GREEN, Julianne, Vernadette , POROLLO, Alexey , ORSBORN, Kris, I. , TAN, Khoon Ghee, Queenie , GREIS, Kenneth , ANDES, David
发明人： HOSTETTER, Margaret, K. , LU, Long , GREEN, Julianne, Vernadette , POROLLO, Alexey , ORSBORN, Kris, I. , TAN, Khoon Ghee, Queenie , GREIS, Kenneth , ANDES, David
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/14 , A61K39/00 , A61K2039/505 , A61K2039/575 , C07K7/08 , C07K16/1271 , C07K2317/34 , C07K2317/76
摘要： Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
摘要翻译：用于改善患者体内留置或植入装置表面上生物膜形成的方法和试剂，导致微生物如假丝酵母属物种和/或禽类的毒力降低，葡萄球菌属。

6. 发明申请

WO9848022A9 HUMAN COMPLEMENT C3-DEGRADING PROTEINASE FROM STREPTOCOCCUS PNEUMONIAE 审中-公开
标题翻译：人体补体C3菌降解蛋白酶
公开(公告)号：WO9848022A9
公开(公告)日：1999-04-15
申请号：PCT/US9808281
申请日：1998-04-24
申请人： UNIV MINNESOTA , HOSTETTER MARGARET K , DUNNY GARY , NANDIWADA LAKSHMI S
发明人： HOSTETTER MARGARET K , DUNNY GARY , NANDIWADA LAKSHMI S
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61P37/04 , C07K14/315 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/52 , C12N15/57 , C12P21/08 , C12R1/46 , A61K38/48
CPC分类号： C12N9/52 , A61K39/00
摘要： The present invention relates to the identification and use of a family of human complement C3-degrading proteinases expressed by S. pneumoniae. The proteinase has a molecular weight of about 24 kD to about 34 kD as determined on a 10 % SDS polyacrylamide gel. A preferred proteinase of this invention includes the amino acid sequence of SEQ ID NO:2.
摘要翻译：本发明涉及鉴定和使用由肺炎链球菌表达的人补体C3降解蛋白酶家族。在10％SDS聚丙烯酰胺凝胶上测定，蛋白酶的分子量约为24kD至约34kD。本发明优选的蛋白酶包括SEQ ID NO：2的氨基酸序列。

7. 发明申请

WO9821337A2 C3 BINDING PROTEIN OF STREPTOCOCCUS PNEUMONIAE 审中-公开
标题翻译： C3结合蛋白的结合蛋白
公开(公告)号：WO9821337A2
公开(公告)日：1998-05-22
申请号：PCT/US9720586
申请日：1997-11-12
申请人： UNIV MINNESOTA , HOSTETTER MARGARET K , CHENG QI , FINKEL DAVID J , SMITH BEVERLY
发明人： HOSTETTER MARGARET K , CHENG QI , FINKEL DAVID J , SMITH BEVERLY
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/395 , A61P11/00 , A61P31/04 , C07K1/22 , C07K14/315 , C07K14/74 , C07K16/12 , C07K19/00 , C12N1/21 , C12P21/08 , C12N15/31 , A61K39/09 , A61K39/40
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/70539 , C07K16/1275
摘要： This invention relates to the identification of a human complement C3 binding protein from Streptococcus pneumoniae and to its sequence and to methods for its purification and use. The protein binds but does not degrade or cleave C3 and is implicated in S. pneumoniae virulence. The protein is recognized by antibodies produced by humans recovering from pneumococcal infection.
摘要翻译：本发明涉及鉴定来自肺炎链球菌的人补体C3结合蛋白及其序列及其纯化和使用方法。蛋白质结合但不降解或切割C3，并且涉及肺炎链球菌毒力。蛋白质被从肺炎球菌感染中恢复的人产生的抗体识别。

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