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1. 发明申请

WO0102400A8 FUSED IMIDAZOLE COMPOUNDS AND REMEDIES FOR DIABETES MELLITUS 审中-公开
标题翻译：熔化的咪唑化合物和糖尿病患者的补救措施
公开(公告)号：WO0102400A8
公开(公告)日：2001-04-05
申请号：PCT/JP0004358
申请日：2000-06-30
申请人： EISAI CO LTD , ASANO OSAMU , HARADA HITOSHI , YOSHIKAWA SEIJI , WATANABE NOBUHISA , INOUE TAKASHI , HORIZOE TATSUO , YASUDA NOBUYUKI , OHASHI KAYA , MINAMI HIROE , NAGAOKA JUNSAKU , MURAKAMI MANABU , KOBAYASHI SEIICHI , TANAKA ISAO , KAWATA TSUTOMU , SHIMOMURA NAOYUKI , AKAMATSU HIROFUMI , OZEKI NAOKI , SHIMIZU TOSHIKAZU , HAYASHI KENJI , HAGA TOYOKAZU , NEGI SHIGETO , NAITO TOSHIHIKO
发明人： ASANO OSAMU , HARADA HITOSHI , YOSHIKAWA SEIJI , WATANABE NOBUHISA , INOUE TAKASHI , HORIZOE TATSUO , YASUDA NOBUYUKI , OOHASHI KAYA , MINAMI HIROE , NAGAOKA JUNSAKU , MURAKAMI MANABU , KOBAYASHI SEIICHI , TANAKA ISAO , KAWATA TSUTOMU , SHIMOMURA NAOYUKI , AKAMATSU HIROFUMI , OZEKI NAOKI , SHIMIZU TOSHIKAZU , HAYASHI KENJI , HAGA TOYOKAZU , NEGI SHIGETO , NAITO TOSHIHIKO
IPC分类号： A61P3/10 , A61P43/00 , C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40 , A61K31/437 , A61K31/52 , A61K31/522 , C07D213/73 , C07D213/75 , C07D235/18 , C07D239/48 , C07D471/08 , C07D473/18 , C07D487/04
CPC分类号： C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40
摘要： Novel fused imidazole compounds of general formula (I), pharmacologically acceptable salts thereof, or hydrates of both, exhibiting adenosine A2 receptor antagonism and being effective in the prevention and treatment of diabetes mellitus and complications of diabetes; wherein R is optionally alkylated amino or the like; R is hydrogen, alkyl, or the like; R is optionally substituted aryl, a pyridinone group, a pyrimidinone group, or the like; Ar is an optionally sybstituted aryl or heteroaryl group, or the like; and Q and W are each independently N or CH.
摘要翻译：通式（I）的新型稠合咪唑化合物，其药理学上可接受的盐或两者的水合物，显示出腺苷A2受体拮抗作用，并且有效预防和治疗糖尿病以及糖尿病并发症; 其中R 1任选地是烷基化的氨基等; R 2是氢，烷基等; R 3是任选取代的芳基，吡啶酮基，嘧啶酮基等; Ar是任选取代的芳基或杂芳基等; Q和W各自独立地为N或CH。

2. 发明申请

WO1996014302A1 PYRAZOLE DERIVATIVES EXHIBITING ANTI-INFLAMMATORY AND ANALGESIC EFFECTS 审中-公开
标题翻译：展示抗炎和麻醉效应的吡唑衍生物
公开(公告)号：WO1996014302A1
公开(公告)日：1996-05-17
申请号：PCT/JP1995002250
申请日：1995-11-06
申请人： EISAI CO., LTD. , NUMATA, Hirotoshi , OKAMOTO, Yasushi , SHINODA, Masanobu , KOBAYASHI, Naoki , MIYAZAWA, Shuhei , KAWAHARA, Tetsuya , SHIROTA, Hiroshi , NAGAKURA, Naoki , HORIZOE, Tatsuo , ABE, Shinya , KOBAYASHI, Seiichi , YAMANAKA, Takashi
发明人： EISAI CO., LTD.
IPC分类号： C07D231/12
CPC分类号： C07D231/12 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D413/10 , C07D419/06
摘要： Pyrazole derivatives represented by formula (I) and physiologically acceptable salts thereof can suppress the production of both of prostaglandins and leukotrienes simultaneously, and, therefore, exhibit anti-inflammatory and analgesic effects.
摘要翻译：由式（I）表示的吡唑衍生物及其生理学上可接受的盐可以同时抑制前列腺素和白三烯两者的产生，因此具有抗炎和镇痛作用。

3. 发明申请

WO2004082715A8 CONCOMITANT DRUG AS THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：作为治疗诱发剂的治疗药物的可持续药物
公开(公告)号：WO2004082715A8
公开(公告)日：2005-05-12
申请号：PCT/JP2004003662
申请日：2004-03-18
申请人： EISAI CO LTD , HORIZOE TATSUO
发明人： HORIZOE TATSUO
IPC分类号： A61K31/00 , A61K38/13 , A61K45/06 , A61P1/04 , C07K16/24 , A61K45/00
CPC分类号： C07K16/241 , A61K31/00 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： A drug having enhanced efficacy against inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. In particular, a therapeutic agent for inflammatory bowel diseases comprising active ingredient (a) consisting of at least one compound having inflammation inhibiting activity selected from the group consisting of an aminosalicylic acid derivative, an antiinflammatory glucocorticoid, an immunosuppressive compound, an anti-TNFalpha antibody, a neurohypophysial hormone and an antiinfective compound, combined with active ingredient (b) consisting of at least one compound having PPARgamma agonist activity. In the application of this therapeutic agent for inflammatory bowel diseases, compound (a) and compound (b) can be administered simultaneously, separately or with intervals.
摘要翻译：一种具有增强的抗炎症性肠病如溃疡性结肠炎和克罗恩病的功效的药物。特别地，涉及炎症性肠病的治疗剂，其含有由至少一种具有炎症抑制活性的化合物组成的活性成分（a），所述化合物具有选自氨基水杨酸衍生物，抗炎糖皮质激素，免疫抑制化合物，抗TNFα抗体，神经嗜睡激素和抗感染化合物，与由至少一种具有PPARγ激动剂活性的化合物组成的活性成分（b）组合。在该治疗剂用于炎性肠病的应用中，化合物（a）和化合物（b）可以同时，分开地或间隔地施用。

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