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1. 发明申请

WO2011157428A3 IN-SITU LECITHIN MICROEMULSION GEL FORMULATION 审中-公开
标题翻译：原位卵磷脂微乳
公开(公告)号：WO2011157428A3
公开(公告)日：2012-07-26
申请号：PCT/EP2011002982
申请日：2011-06-16
申请人： HOLZER GMBH F , HOLZER DOMINIK
发明人： HOLZER DOMINIK
IPC分类号： A61K9/00 , A61K9/107 , A61K31/685 , A61K47/24
CPC分类号： A61K31/00 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K31/01 , A61K31/685
摘要： The present invention relates to an in situ lecithin microemulsion gel formulation comprising as gel-forming phase at least one lecithin in a concentration of 0.1% to 50% by weight, based on an apolar continuous phase, and also, optionally, at least one polar agent; when there is at least one polar agent present, it is present at a concentration lower than the concentration needed for complete gelling. The formulation is intended for use as a therapeutic agent or diagnostic agent in ophthalmology and/or rhinology and/or in the ENT field.
摘要翻译：本发明涉及含有作为凝胶形成阶段，至少一个在0.1的浓度的卵磷脂，以50重量％的原位卵磷脂微乳制剂，相对于非极性连续相，而任选的至少一种极性药剂，其中该至少一种极性药剂被包括的情况下，存在这样的浓度小于完全凝胶化所需的浓度，用作眼科和/或鼻科学和/或在耳鼻喉科领域的治疗剂或诊断剂。

2. 发明申请

WO2012031775A8 METERING DEVICE 审中-公开
标题翻译：加药
公开(公告)号：WO2012031775A8
公开(公告)日：2012-06-14
申请号：PCT/EP2011004558
申请日：2011-09-09
申请人： HOLZER GMBH F , LEE HYECK HEE , HOLZER FRANK , STEINFELD UTE , MAHLER MARKUS
发明人： LEE HYECK HEE , HOLZER FRANK , STEINFELD UTE , MAHLER MARKUS
IPC分类号： B05B11/00 , B05B11/02 , B05B11/04
CPC分类号： B65D83/0061 , B05B11/0043 , B05B11/0064 , B05B11/0067 , B05B11/007 , B05B11/3001 , B05B11/3046 , B05B11/305 , B05B11/3069 , B05B11/3074 , B05B11/3077
摘要： The invention relates to a metering device for dispensing a metered quantity of a fluid, in which device a storage container is connected to a metering head, wherein a spindle which has a through-passage for the fluid to be conveyed is guided within the metering head.
摘要翻译：用于计量输送流体的计量装置技术领域本发明涉及一种用于计量输送流体的计量装置，其中储存器与计量装置连接，其中在计量头中引导主轴，该主轴具有用于待输送流体的通道。

3. 发明申请

WO2011104037A2 PROCESS FOR PREPARING A READY-TO-USE PRODUCT WHICH CAN BE METERED 审中-公开
标题翻译：用于生产计量应用已制成的制剂
公开(公告)号：WO2011104037A2
公开(公告)日：2011-09-01
申请号：PCT/EP2011000973
申请日：2011-02-28
申请人： KIST EUROPE FORSCHUNGSGES MBH , HOLZER GMBH F , LEE HYECK-HEE , STEINFELD UTE , KIM JUNGTAE , KRAUSE HOLGER
发明人： LEE HYECK-HEE , STEINFELD UTE , KIM JUNGTAE , KRAUSE HOLGER
IPC分类号： A61K9/00
CPC分类号： A61K9/08 , A61K9/0048 , A61K9/06 , A61K9/19 , A61K31/557 , A61K31/5575 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/36 , A61M5/282 , A61M5/284 , B05B11/0043 , B05B11/0048 , B05B11/0081 , B05B11/0083 , B05B11/02 , B05B11/30 , B05B11/3021 , B05B11/3074 , B65D51/2821 , B65D83/0022 , B65D83/0027
摘要： The present invention relates to a process for the preparation of liquid and/or semi-solid dosage forms/formulations which have an improved storage stability and improved shelf life and which are better tolerated upon application. Dosage forms which can be prepared and administered/applied according to the invention are, for example, solutions, suspensions and emulsions, syrup, solutions for injection, solutions for infusion, fluids and the like; semi-solid dosage forms are, for example, suspensions, creams, pastes and in particular gels.
摘要翻译：本发明涉及到用于生产的液体和/或半固体剂型/具有改进的储存稳定性，以及更好的耐用性和兼容性与应用程序的制剂的方法。根据本发明的剂型可以，例如，溶液，混悬液和乳剂，糖浆剂，注射液，输注液，流体，等; 半固体剂型是例如悬浮液，霜剂，糊剂，凝胶，和具体地示出和给药/施用。

4. 发明申请

WO2011029604A8 METERING DEVICE FOR THE METERED DISPENSION OF FLUID PREPARATIONS, METHOD FOR FILLING AND USE OF A METERING DEVICE ACCORDING TO THE INVENTION 审中-公开
标题翻译：服药期发行剂量的液体制剂，方法填充性和创造性的给药USE
公开(公告)号：WO2011029604A8
公开(公告)日：2011-05-05
申请号：PCT/EP2010005557
申请日：2010-09-09
申请人： KIST EUROP FORSCHUNGSGESELLSCHAF MBH , HOLZER GMBH F , LEE HYECK HEE , STEINFELD UTE , KIM JUNGTAE , KRAUSE HOLGER , PARK JIHWANG , KIM KWANG HO , SCHWEIGER BIANCA , BECK SEBASTIAN
发明人： LEE HYECK HEE , STEINFELD UTE , KIM JUNGTAE , KRAUSE HOLGER , PARK JIHWANG , KIM KWANG HO , SCHWEIGER BIANCA , BECK SEBASTIAN
IPC分类号： B05B11/00 , A61M5/14 , A61M5/24 , A61M5/28 , A61M5/315
CPC分类号： B05B11/0083 , A61M5/282 , A61M5/284 , A61M5/288 , A61M5/344 , A61M2005/3104 , B05B11/0043 , B05B11/0048 , B05B11/0081 , B05B11/02 , B05B11/3001 , B05B11/3074
摘要： The present invention relates to a metering device (1, 11, 111) for the metered dispension of a fluid preparation comprising at least one first (81) and one second (82) starting substance. The metering device (1, 11, 111) comprises a reservoir receptacle (2) for receiving the first starting substance (81), an inner receptacle for receiving the second starting substance (82), and a dispensing unit (4, 40) having a penetrating unit (410). The invention further relates to a method for filling and to the use of a metering device according to the invention.
摘要翻译：本发明涉及一种计量装置（1，11，111），用于至少一个第一（81）的液体制剂的计量分配和第二（82）的起始材料。计量装置（1，11，111）包括一个Vorratsgef AESS（2），用于接收所述第一Ausganssubstanz（81），用于与穿孔单元，其接收所述第二输出物质（82）和输出单元（4，40），一个内部容器（410），此外，本发明涉及用于填充的方法和根据本发明的用途的计量装置的。

5. 发明申请

WO2013171204A3 OPHTHALMOLOGICAL VEHICLE SYSTEM 审中-公开
标题翻译：眼科车辆系统
公开(公告)号：WO2013171204A3
公开(公告)日：2014-01-09
申请号：PCT/EP2013059927
申请日：2013-05-14
申请人： HOLZER GMBH F
发明人： STEINFELD UTE , HOLZER FRANK , LEE HYECK HEE , MAHLER MARKUS
IPC分类号： A61K31/202 , A61K9/00 , A61K9/06 , A61K9/107 , A61K31/355 , A61K33/00 , A61P27/02
CPC分类号： A61K9/0048 , A61F9/0008 , A61K9/107 , A61K9/1075 , A61K31/05 , A61K31/122 , A61K31/197 , A61K31/202 , A61K31/355 , A61K31/375 , A61K31/573 , A61K45/06 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/44 , A61K2300/00
摘要： The present invention relates to an ophthalmological vehicle system for permeation and/or active substance transport of ophthalmological active substances through the cornea and/or the sclera of the eye of a mammal. This vehicle system promotes the transport of active substances through the cornea and/or the connective tissue of the eye. The vehicle system is suitable for prophylaxis and/or treatment of illness of the front and/or rear portion of the eye. The present invention also relates to an ophthalmological kit comprising a special ophthalmological composition and an ophthalmological active substance as a separate formulation. The invention further relates to the use of a special ophthalmological composition as a vehicle system, penetration accelerator, penetration enhancer, absorption enhancer/improver/accelerator for the permeation and/or for the active substance transport of ophthalmological active ingredients through the cornea and/or the sclera of the eye of a mammal. The invention further relates to a fluid dispenser which contains an ophthalmological vehicle system according to the invention.
摘要翻译：本发明涉及用于哺乳动物的眼睛的ophthalmoiogisches渗透和/或通过角膜药物递送的眼用药物（角膜）和/或结膜（巩膜）的车辆系统。该车辆系统有利于通过角膜和/或眼睛的结缔组织活性成分的输送。车辆系统适用于前部和/或后段的疾病的预防和/或治疗。另外，本发明涉及一种眼用试剂盒，包括一个专门E！眼用组合物，以及作为单独的制剂中的眼科药物。此外，使用特定的眼用组合物的车辆系统，渗透增强剂，渗透增强剂，Absorptionsenhancer /的是增强剂/ - 的眼睛的穿过角膜beschleutger至渗透和/或ophthaimo逻辑剂Wirkstofftranport（角膜）和/或结膜（巩膜）本发明的哺乳动物。此外，本发明涉及一种流体分配器，其包括根据本发明的眼用载体系统。

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