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1. 发明申请

WO1997042952A1 PERCUTANEOUS TAPE PREPARATION CONTAINING FENTANYL 审中-公开
标题翻译：包含FENTANYL的PERCUTANEOUS TAPE制剂
公开(公告)号：WO1997042952A1
公开(公告)日：1997-11-20
申请号：PCT/JP1997001595
申请日：1997-05-13
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , CHONO, Hideharu , TERAHARA, Takaaki , SUZUKI, Tatsuaki , HIGO, Naruhito
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K31/445
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/4453 , A61K31/4468 , A61K47/12
摘要： A percutaneous tape preparation containing fentanyl or its salt, a pressure-sensitive adhesive and sodium acetate. It is preferable that the salt of fentanyl is fentanyl citrate. This preparation is little irritative to the skin and excellent in the percutaneous permeation of fentanyl and has a high stability even after the passage of time.
摘要翻译：含有芬太尼或其盐的经皮胶带制剂，压敏粘合剂和乙酸钠。芬太尼的盐优选为柠檬酸芬太尼。该制剂对皮肤刺激性很小，芬太尼的经皮渗透性优异，即使经过时也具有高稳定性。

2. 发明申请

WO1997034657A1 ELECTRODE DEVICE FOR IONTOPHORESIS 审中-公开
标题翻译：电极装置
公开(公告)号：WO1997034657A1
公开(公告)日：1997-09-25
申请号：PCT/JP1997000113
申请日：1997-01-20
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIGO, Naruhito , MENO, Tatsuya
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61N01/30
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0444
摘要： A reusable electrode device for iontophoresis, which prevents metal ions originated from an electrode from entering a human body, minimizes the generation of a gas which causes polarization, greatly increases a transmission current, and prevents damage to the skin which is ascribed to the variation of pH occurring when the device is used for a long period of time. This electrode device for iontophoresis comprises a packing member (1) having an edge portion (1a) of an opening and a chamber (4) to be packed on the inner side of the opening; an electrode terminal (2) provided in the chamber (4); non-adhesive gel (5) containing an electrolytic solvent, a depolarizer, a pH regulator and chemicals and packed in the chamber (4); an inactive electrode (3) covering a base portion of the electrode terminal (2); and a liner (7) bonded to an adhesive layer (6) laminated on the edge portion (1a) to cover the opening.
摘要翻译：用于离子电渗疗法的可重复使用的电极装置，其防止源自电极的金属离子进入人体，使产生极化的气体的产生最小化，大大增加透射电流，并且防止由于变化引起的对皮肤的损伤当器件长时间使用时发生pH。该离子电渗电极装置包括具有开口部的边缘部分（1a）和填充在开口内侧的室（4）的包装部件（1）设置在所述室（4）中的电极端子（2）; 包含电解溶剂的非粘性凝胶（5），去极化剂，pH调节剂和化学品并包装在室（4）中; 覆盖电极端子（2）的基部的无源电极（3）; 以及粘合到层压在边缘部分（1a）上以覆盖开口的粘合剂层（6）的衬垫（7）。

3. 发明申请

WO1997007853A1 IONTOPHORESIS DEVICE AND METHOD OF CURRENT CONTROL THEREFOR 审中-公开
标题翻译：电流控制装置及其电流控制方法
公开(公告)号：WO1997007853A1
公开(公告)日：1997-03-06
申请号：PCT/JP1996002286
申请日：1996-08-12
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , MORI, Kenji , NAKAMURA, Katsuhiro , HIGO, Naruhito , KUZUMAKI, Noriyuki
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61N01/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0448 , A61N1/325
摘要： An iontophoresis device which is capable of reducing variations in drug delivery caused by the individual difference in the impedances of the skin or mucous membrane and inhibiting a decrease in drug delivery at a different electrode and is excellent in pharmacological effects, safety, reliability, and mass-producibility. The device comprises a different electrode, an indifferent electrode, a current detection section for determining an active current value as a difference between the value of an applied current flowing between the different and indifferent electrodes when pulse voltage/current are applied and the value of a discharge current flowing when the electric charge accumulated in the living organism is discharged as a result of short-circuiting in the different and indifferent electrodes occurring when the application of pulse voltage/current is suspended, and a feedback control section for controlling the active current value by making pulse voltage/current amplitudes variable. The method of current control for the device comprises the step of determining the active current value and the feedback control step for controlling the active current value.
摘要翻译：一种离子电渗装置，其能够减少由皮肤或粘膜的阻抗的个体差异引起的药物递送的变化，并且抑制不同电极的药物递送的降低，并且药理作用，安全性，可靠性和质量优异 -producibility。该装置包括不同的电极，无关电极，电流检测部分，用于将脉冲电压/电流施加时，将有效电流值确定为在不同电极和不同电极之间流动的施加电流的值之间的差值，由于在暂时施加脉冲电压/电流时发生的不同电位和不相关电极的短路，积蓄在生物体中的电荷的放电电流流过的放电电流，以及用于控制有功电流值的反馈控制部通过使脉冲电压/电流幅度变化。该装置的电流控制方法包括确定有功电流值和用于控制有功电流值的反馈控制步骤的步骤。

4. 发明申请

WO1996015776A1 PERCUTANEOUSLY ABSORBABLE PATCH 审中-公开
公开(公告)号：WO1996015776A1
公开(公告)日：1996-05-30
申请号：PCT/JP1995002336
申请日：1995-11-15
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIRANO, Munehiko , SHINMURA, Miyuki , KOJIMA, Masaki
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K09/70
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7076 , A61K31/565 , A61K31/57 , A61K31/165 , A61K2300/00
摘要： A percutaneously absorbable patch containing an elastic polymer (A-B)n-A (wherein A represents substantially a monovinylaromatic polymer block, B represents substantially a conjugated diolefin copolymer block, and n represents an integer of 3 to 7) as the base ingredient, crotamiton and an emollient each as the essential ingredient, and at least two types of hormones, particularly an estrogen and a progesterone, each as the active ingredient.
摘要翻译：包含弹性聚合物（AB）nA（其中A表示基本上单乙烯基芳族聚合物嵌段，B表示基本上为共轭二烯烃共聚物嵌段，n表示3〜7的整数）作为基础成分的经皮吸收性贴剂，克罗他米通和润肤剂每种作为必需成分，以及至少两种类型的激素，特别是雌激素和孕酮，各自作为活性成分。

5. 发明申请

WO1996011022A1 DRUG COMPOUNDING INGREDIENTS COMPRISING N-SUBSTITUTED-o-TOLUIDINE DERIVATIVE AND PERCUTANEOUSLY ABSORBABLE PREPARATION 审中-公开
标题翻译：包含N-取代的奥托洛尔衍生物和可可吸收制剂的药物组合物成分
公开(公告)号：WO1996011022A1
公开(公告)日：1996-04-18
申请号：PCT/JP1995002033
申请日：1995-10-04
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HIRANO, Munehiko , KURIBAYASHI, Mitsuru , KIDO, Mitsuhiko
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K47/16
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K47/18
摘要： A drug resolvent and a drug sorbefacient each comprising at least one N-substituted-o-toluidine derivative represented by general formula (I), and a percutaneously absorbable preparation containing a drug and the resolvent or the sorbefacient, wherein R1 represents C1-C4 alkyl; and R2 represents C1-C8 alkyl.
摘要翻译：药物溶解剂和药物吸收剂，各自包含至少一种由通式（I）表示的N-取代邻甲苯胺衍生物和含有药物和溶剂或吸收剂的经皮吸收制剂，其中R1表示C1-C4烷基 ; 并且R 2表示C 1 -C 8烷基。

6. 发明申请

WO1995030755A1 RECOMBINANT HUMAN IMMUNODEFICIENCY VIRUS VECTOR AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：重组人免疫缺陷病毒载体及其生产方法
公开(公告)号：WO1995030755A1
公开(公告)日：1995-11-16
申请号：PCT/JP1995000893
申请日：1995-05-10
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SHIMADA, Takashi , AKIYAMA, Katsuhiko
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C12N15/49
CPC分类号： C12N15/86 , C12N2740/16043
摘要： A recombinant HIV vector which retains the foreign DNA sequence antagonistic against HIV growth and/or gene expression and wherein the U3 domain of the LTR sequence on the genome 5' side has been replaced by the promoter sequence of a cytomegalovirus. As this vector can express an anti-HIV sequence of, for example, antisense, ribozyme or TAR decoy in HIV-infected cells without fail, it is useful as a material for gene therapy of HIV infection.
摘要翻译：保留与HIV生长和/或基因表达拮抗的外源DNA序列的重组HIV载体，其中基因组5'侧的LTR序列的U3结构域被巨细胞病毒的启动子序列替代。由于该载体可以在HIV感染的细胞中表达例如反义，核酶或TAR诱饵的抗HIV序列，因此它可用作HIV感染的基因治疗的材料。

7. 发明申请

WO1994010983A1 PERORAL PHARMACEUTICAL PREPARATION RELEASABLE IN LOWER DIGESTIVE TRACT 审中-公开
标题翻译：在低消耗性诱导下可释放的精细制剂制剂
公开(公告)号：WO1994010983A1
公开(公告)日：1994-05-26
申请号：PCT/JP1993001608
申请日：1993-11-05
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , OKAYAMA, Minenobu; , NAKANISHI, Masaru;
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K09/30
CPC分类号： A61K9/5073 , A61K9/2018 , A61K9/2886
摘要： A peroral pharmaceutical preparation releasable in the lower digestive tract, having a double-layer coating structure wherein a solid drug comprising a core containing an active ingredient is coated with an inner layer comprising a cationic polymer and an outer layer comprising an anionic polymer.
摘要翻译：可在下消化道中释放的口服药物制剂，具有双层包衣结构，其中包含含有活性成分的核心的固体药物涂覆有包含阳离子聚合物和包含阴离子聚合物的外层的内层。

8. 发明申请

WO1994010117A1 CYCLOHEXANOL DERIVATIVE, AGENT AND COMPOSITION CONTAINING THE SAME FOR IMPARTING PLEASANTLY COOL FEELING, PROCESS FOR PRODUCING THE DERIVATIVE, AND INTERMEDIATE THEREFOR 审中-公开
标题翻译：环己烷衍生物，含有相同的代谢产物和组合物，用于产生干燥性感冒，生产衍生物及其中间体的方法
公开(公告)号：WO1994010117A1
公开(公告)日：1994-05-11
申请号：PCT/JP1993001562
申请日：1993-10-28
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , NAKAGAWA, Akira , HIRANO, Munehiko , ODA, Hideshi , KURIBAYASHI, Mitsuru , TANOUE, Yoshihiro
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： C07C43/13
CPC分类号： C07C43/13 , C07C43/188 , C07C43/196 , C07C2601/14
摘要： A cyclohexanol derivative represented by general formula (1), preferably by general formula (1a) (wherein R represents C1-C5 linear or branched alkyl). It can impart a sufficient, pleasantly cool feeling to not only the oral mucous membrane but also the skin and is odorless. Further it can provide nearly odorless agent and various compositions for imparting a pleasantly cool feeling.
摘要翻译：由通式（1）表示的环己醇衍生物，优选通式（1a）（其中R表示C1-C5直链或支链烷基）。它可以赋予不仅口腔粘膜，而且赋予皮肤足够，舒适的凉爽感，并且无臭。此外，它可以提供几乎无臭的剂和各种组合物，以赋予令人愉快的凉爽感觉。

9. 发明申请

WO1993010855A1 LOW-FREQUENCY THERAPEUTIC DEVICE HAVING PLASTER SHAPE 审中-公开
标题翻译：具有塑料形状的低频治疗装置
公开(公告)号：WO1993010855A1
公开(公告)日：1993-06-10
申请号：PCT/JP1992001590
申请日：1992-12-04
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , HATTORI, Hidenori , TAKIZAWA, Naoto , HADATE, Hidenori , KONDOU, Tomoko
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61N01/32
CPC分类号： A61N1/0452 , A61N1/0456 , A61N1/0492 , A61N1/322 , A61N1/36021
摘要： A handy low-frequency therapeutic device which can effectively make therapy by application to a stiff portion without particularly specifying an effective spot for therapy. The therapeutic device includes a main body with built-in low-frequency pulse output means, a power supply fitted to the main body, a flexible sheet electrode having an area greater than that of the bottom surface of the therapeutic device main body, and an adhesive pad spread on the sheet electrode.
摘要翻译：一种方便的低频治疗装置，其可以有效地通过应用于硬部分进行治疗，而无需特别指定治疗的有效点。治疗装置包括具有内置的低频脉冲输出装置的主体，装配到主体的电源，具有大于治疗装置主体的底面的面积的柔性片状电极，以及粘合剂垫在片状电极上扩散。

10. 发明申请

WO1992016237A1 COMPOSITION FOR RELIEVING SKIN IRRITATION AND EXTERNAL PREPARATION FOR PERCUTANEOUS ADMINSTRATION CONTAINING THE SAME 审中-公开
标题翻译：用于消除皮肤刺激和外用制剂的组合物，用于包含其的胰腺炎
公开(公告)号：WO1992016237A1
公开(公告)日：1992-10-01
申请号：PCT/JP1992000225
申请日：1992-02-28
申请人： HISAMITSU PHARMACEUTICAL CO., INC. , SATO, Syuji , MUKAE, Katsuya , HIGASHI, Yoshinobu , SUZUKI, Tatsuaki , MIZUMACHI, Mitsuhiro , SAKAGUCHI, Hirofumi
发明人： HISAMITSU PHARMACEUTICAL CO., INC.
IPC分类号： A61K47/14
CPC分类号： A61K8/37 , A61K8/34 , A61K9/0014 , A61K47/10 , A61K47/14 , A61K2800/75 , A61Q17/00
摘要： A composition for relieving skin irritation comprising 1 to 50 wt % of trialkyl citrate, 1 to 70 wt % of a lower alcohol and 1 to 90 wt % of water, and an external preparation for percutaneous administration comprising the above composition and further containing 0.001 to 20 wt % of a pharmacologically active substance, both of which can lower and relieve skin irritation and promote the absorption of the pharmacologically active substance.

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