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1. 发明申请

WO2004093982A1 NEUROSTIMULATION FOR TREATMENT OF SLEEP APNEA 审中-公开
标题翻译：用于治疗睡眠APNEA的神经病学
公开(公告)号：WO2004093982A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/011389
申请日：2004-04-14
申请人： MEDTRONIC, INC. , KING, Gary, W. , MIANULLI, Marcus, J. , HILL, Michael, R. S. , MULLEN, Thomas, J. , TESTERMAN, Roy, L. , BURNES, John, E. , ZHOU, Xiaohong
发明人： KING, Gary, W. , MIANULLI, Marcus, J. , HILL, Michael, R. S. , MULLEN, Thomas, J. , TESTERMAN, Roy, L. , BURNES, John, E. , ZHOU, Xiaohong
IPC分类号： A61N1/34
CPC分类号： A61N1/3601 , A61N1/36017 , A61N1/36114
摘要： Neurostimulation is delivered to one or more predetermined locations on or within a patient in order to treat effects of sleep apnea by modulating autonomic nervous activity. Delivery of neurostimulation at predetermined locations can decrease sympathetic nervous activity and/or increase parasympathetic nervous activity, countering the increased intrinsic sympathetic activity associated with apnea-arousal cycles. In some embodiments, neurostimulation is delivered to the spinal cord of the patient via an implanted electrode. In other embodiments, neurostimulation is delivered transcutaneously to the spinal cord or other locations via electrodes located on the surface of the patient. In some embodiments, delivery of neurostimulation is initiated or modified in response to detection of apneas.
摘要翻译：神经刺激被递送到患者身上或内部的一个或多个预定位置，以便通过调节自主神经活动来治疗睡眠呼吸暂停的影响。在预定位置递送神经刺激可降低交感神经活动和/或增加副交感神经活动，抵抗与呼吸暂停 - 觉醒周期相关的增加的内在交感神经活动。在一些实施方案中，神经刺激通过植入电极递送至患者的脊髓。在其他实施方案中，神经刺激通过位于患者表面上的电极经皮递送至脊髓或其它位置。在一些实施方案中，响应于呼吸暂停的检测而启动或修饰神经刺激的递送。

2. 发明申请

WO2004098698A2 METHODS AND APPARATUS FOR THE REGULATION OF HORMONE RELEASE 审中-公开
标题翻译：用于调节激素释放的方法和装置
公开(公告)号：WO2004098698A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/011736
申请日：2004-04-16
申请人： MEDTRONIC, INC. , ZHOU, xiaohong , KING, Gary, W. , MULLEN, Thomas, J. , HILL, Michael, R. S.
发明人： ZHOU, xiaohong , KING, Gary, W. , MULLEN, Thomas, J. , HILL, Michael, R. S.
IPC分类号： A61N
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes.
摘要翻译：提供了通过激素调节进行矫正治疗的方法和装置。脊髓刺激对交感神经纤维的抑制用于调节儿茶酚胺，肾素和降钙素基因相关肽等激素水平。本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定神经刺激的适当水平。电刺激部位包括但不限于在T7-L2皮层区域内的级别T7-L2的脊髓和相关联的神经纤维。

3. 发明申请

WO2004098705A1 METHOD AND APPARATUS FOR IMPROVING VENTRICULAR STATUS USING THE FORCE INTERVAL RELATIONSHIP 审中-公开
标题翻译：使用力间隔关系改善心室状态的方法和装置
公开(公告)号：WO2004098705A1
公开(公告)日：2004-11-18
申请号：PCT/US2004/012093
申请日：2004-04-19
申请人： MEDTRONIC, INC. , BURNES, John, E. , MULLIGAN, Lawrence, J. , HILL, Michael, R. S.
发明人： MULLIGAN, Lawrence, J. , HILL, Michael, R. S.
IPC分类号： A61N1/362
CPC分类号： A61N1/36514 , A61N1/3627
摘要： Methods and devices for improving ventricular contractile status of a patient suitably exploit changes in ventricular pressure and/or dP/dtmax to provide and/or optimize a response to a patient. The ventricular pressure may be appropriately correlated to intracellular calcium regulation, which is indicative of contractile status. To assess ventricular contractile status, the device suitably observes a cardiac perturbation of the patient and measures force interval potentiation following the perturbation. The contractile potentiation can then be stored and/or quantified in the implantable medical device to determine the ventricular contractile status of the patient, and an appropriate response may be provided to the patient as a function of the ventricular contractile status. Examples of responses may include administration of drug or neuro therapies, modification of a pacing rate, or the like. Force interval potentiation may also be used to optimize or improve a parameter for a response provided by the implantable medical device.
摘要翻译：用于改善患者的心室收缩状态的方法和装置适当地利用心室压力和/或dP / dtmax的变化，以提供和/或优化对患者的反应。心室压力可以适当地与细胞内钙调节相关，细胞内钙调节指示收缩状态。为了评估心室收缩状态，该装置适当地观察患者的心脏摄动，并测量扰动后的力间隔增强作用。收缩增强能随后在可植入的医疗装置中被储存和/或定量，以确定患者的心室收缩状态，并且作为心室收缩状态的函数可以向患者提供适当的响应。反应的实例可包括药物或神经疗法的施用，起搏速率的改变等。力间隔增强也可用于优化或改善由可植入医疗装置提供的响应的参数。

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