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1. 发明申请

WO2004077012A3 METHODS AND SYSTEMS FOR CONTROLLING AND/OR INCREASING IONTOPHORETIC FLUX 审中-公开
标题翻译：用于控制和/或增加IOPOPHORETIC FLUX的方法和系统
公开(公告)号：WO2004077012A3
公开(公告)日：2006-09-08
申请号：PCT/US2004004126
申请日：2004-02-13
申请人： ACIONT INC , HIGUCHI WILLIAM I , MILLER DAVID J , LI KEVIN S
发明人： HIGUCHI WILLIAM I , MILLER DAVID J , LI KEVIN S
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/30 , A61N1/327
摘要： An iontophoretic method is provided to selectively transport a compound of interest through a localized region of an individual's body tissue that exhibits a low electrical resistance and/or a high permeability. The method involves placing a permselective material, typically having a resistance comparable or higher than the resistance of the localized region, in ion-conducting relation to the localized region. An electrical current is then applied through the permselective material to the localized region, thereby transporting the compound of interest iontophoretically through the localized region. When the permselective material is capable of hindering iontophoretic transport of a competing ion, the transference efficiency of the compound of interest is increased during iontophoresis. As a result, the compound of interest is delivered into or extracted from the localized region at an enhanced rate. As transport efficiencies approach unity, absolute predictivity of transport also becomes possible. Also provided are electrode assemblies and iontophoretic systems capable of carrying out the iontophoretic method.
摘要翻译：提供离子电渗疗法以选择性地将感兴趣的化合物输送通过显示低电阻和/或高渗透性的个体身体组织的局部区域。该方法包括将通常具有与局部区域的电阻相当或更高的电阻的选择性选择材料置于与局部区域的离子传导关系中。然后通过选择选择材料将电流施加到局部区域，从而通过局部区域输送离子电渗透的化合物。当选择选择性材料能够阻碍竞争离子的离子电渗转运时，在离子电渗中增加感兴趣的化合物的转移效率。结果，感兴趣的化合物以增强的速率被递送到局部区域或从局部区域提取。随着运输效率达到统一，运输的绝对预测也成为可能。还提供了能够进行离子电渗法的电极组件和离子电渗系统。

2. 发明申请

WO2004077012A2 METHODS AND SYSTEMS FOR CONTROLLING AND/OR INCREASING IONTOPHORETIC FLUX 审中-公开
标题翻译：用于控制和/或增加IOPOPHORETIC FLUX的方法和系统
公开(公告)号：WO2004077012A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/004126
申请日：2004-02-13
申请人： ACIONT, INC. , HIGUCHI, William, I. , MILLER, David, J. , LI, Kevin, S.
发明人： HIGUCHI, William, I. , MILLER, David, J. , LI, Kevin, S.
IPC分类号： G01N
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/30 , A61N1/327
摘要： An iontophoretic method is provided to selectively transport a compound of interest through a localized region of an individual's body tissue that exhibits a low electrical resistance and/or a high permeability. The method involves placing a permselective material, typically having a resistance comparable or higher than the resistance of the localized region, in ion-conducting relation to the localized region. An electrical current is then applied through the permselective material to the localized region, thereby transporting the compound of interest iontophoretically through the localized region. When the permselective material is capable of hindering iontophoretic transport of a competing ion, the transference efficiency of the compound of interest is increased during iontophoresis. As a result, the compound of interest is delivered into or extracted from the localized region at an enhanced rate. As transport efficiencies approach unity, absolute predictivity of transport also becomes possible. Also provided are electrode assemblies and iontophoretic systems capable of carrying out the iontophoretic method.
摘要翻译：提供离子电渗疗法以选择性地将感兴趣的化合物输送通过显示低电阻和/或高渗透性的个体身体组织的局部区域。该方法包括将通常具有与局部区域的电阻相当或更高的电阻的选择性选择材料置于与局部区域的离子传导关系中。然后通过选择选择材料将电流施加到局部区域，从而通过局部区域输送离子电渗透的化合物。当选择选择性材料能够阻碍竞争离子的离子电渗转运时，在离子电渗中增加感兴趣的化合物的转移效率。结果，感兴趣的化合物以增强的速率被递送到局部区域或从局部区域提取。随着运输效率达到统一，运输的绝对预测也成为可能。还提供了能够进行离子电渗法的电极组件和离子电渗系统。

3. 发明申请

WO1990015568A2 APPARATUS AND METHODS FOR NONINVASIVE BLOOD GLUCOSE MONITORING 审中-公开
标题翻译：非血液葡萄糖监测的装置和方法
公开(公告)号：WO1990015568A2
公开(公告)日：1990-12-27
申请号：PCT/US1990002940
申请日：1990-05-24
申请人： STANLEY, Theodore, H. , EBERT, Charles, Dewey , HIGUCHI, William, I. , ZHANG, Jie
IPC分类号： A61B0
CPC分类号： A61B5/14532
摘要： The present invention is directed to novel methods and apparatus for noninvasive blood glucose monitoring. Blood glucose is monitored noninvasively by correlation with amount of glucose which permeates an epithelial membrane (14), such as skin or a mucosal membrane, into a glucose receiving medium (12) over a specified time period. The glucose receiving (12) medium preferably includes a glucose permeation enhancer capable of increasing the glucose permeability across the epithelial membrane (14). The glucose receiving medium (12) is positioned against the epithelial membrane (14) so that the permeation enhancer alters the permeability of the membrane (14). After sufficient time delay, the glucose receiving medium (12) is removed and analyzed for the presence of glucose using conventional analytical techniques. The apparatus within the scope of the present invention includes means for supporting the glucose receiving medium. Such means for supporting the glucose receiving medium may include a housing (18) defining a receiving chamber therein which holds the glucose receiving medium (12) and an opening to the receiving chamber. The means for supporting the glucose receiving medium may also include a hydrogel. The apparatus also preferably includes means (20) for temporarily positioning the glucose receiving medium against the epithelial membrane.
摘要翻译：本发明涉及用于无创血糖监测的新颖方法和装置。通过与指定时间段内渗透到葡萄糖接受培养基（12）的上皮膜（14）如葡萄糖（例如皮肤或粘膜）的葡萄糖的量相关联来监测血糖。葡萄糖接收（12）培养基优选包括能够增加穿过上皮膜（14）的葡萄糖渗透性的葡萄糖渗透增强剂。葡萄糖接收介质（12）抵靠上皮膜（14）定位，使得渗透增强剂改变膜（14）的渗透性。在足够的时间延迟之后，使用常规分析技术去除葡萄糖接收介质（12）并分析葡萄糖的存在。本发明范围内的装置包括用于支撑葡萄糖接收介质的装置。用于支撑葡萄糖接收介质的这种装置可以包括在其中限定其中容纳葡萄糖接收介质（12）的接收室和到接收室的开口的壳体（18）。支持葡萄糖接收介质的方法还可以包括水凝胶。该装置还优选地包括用于将葡萄糖接收介质临时定位在上皮膜上的装置（20）。

4. 发明申请

WO9015568A3 APPARATUS AND METHODS FOR NONINVASIVE BLOOD GLUCOSE MONITORING 审中-公开
标题翻译：非血液葡萄糖监测的装置和方法
公开(公告)号：WO9015568A3
公开(公告)日：1991-04-18
申请号：PCT/US9002940
申请日：1990-05-24
申请人： STANLEY THEODORE H , EBERT CHARLES DEWEY , HIGUCHI WILLIAM I , ZHANG JIE
发明人： STANLEY THEODORE H , EBERT CHARLES DEWEY , HIGUCHI WILLIAM I , ZHANG JIE
IPC分类号： A61B5/00 , A61B
CPC分类号： A61B5/14532
摘要： The present invention is directed to novel methods and apparatus for noninvasive blood glucose monitoring. Blood glucose is monitored noninvasively by correlation with amount of glucose which permeates an epithelial membrane (14), such as skin or a mucosal membrane, into a glucose receiving medium (12) over a specified time period. The glucose receiving (12) medium preferably includes a glucose permeation enhancer capable of increasing the glucose permeability across the epithelial membrane (14). The glucose receiving medium (12) is positioned against the epithelial membrane (14) so that the permeation enhancer alters the permeability of the membrane (14). After sufficient time delay, the glucose receiving medium (12) is removed and analyzed for the presence of glucose using conventional analytical techniques. The apparatus within the scope of the present invention includes means for supporting the glucose receiving medium. Such means for supporting the glucose receiving medium may include a housing (18) defining a receiving chamber therein which holds the glucose receiving medium (12) and an opening to the receiving chamber. The means for supporting the glucose receiving medium may also include a hydrogel. The apparatus also preferably includes means (20) for temporarily positioning the glucose receiving medium against the epithelial membrane.

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